The Effect of the 1998 Master Settlement on Prenatal Smoking

The Master Settlement Agreement (MSA) between the major tobacco companies and 46 states created an abrupt 45 cent (21%) increase in cigarette prices in November, 1998. Earlier estimates of the elasticity of prenatal smoking implied that the price rise would reduce prenatal cigarette smoking by 7% to 21%. Using birth records on 10 million U.S. births between January 1996 and February 2000, we examined the change in smoking during pregnancy and conditional smoking intensity in response to the MSA. Overall, adjusting for secular trends in smoking, prenatal smoking declined much less than predicted in response to the MSA.

A fitting guide for the Johnson & Johnson disposable contact lens

This study was conducted with the hope of establishing a fitting guide for the Vistakon disposable lens system with the existing parameters. We wanted to see if the Acuvue lens is truly a one size fits all lens system. The subjects were selected based on an averaged keratometer reading, and categorized based on their flattest meridian (Kf). We used a -2.000 and a -4.500 lens on each eye. Each lens had to pass four fitting criteria, which were: centering, movement, retinoscope reflex, and subjective statement. The lens did not seem to fit a large percentage of eyes over a wide range of corneal curvatures. We expected a bell shaped curve distribution of the data, with not many lenses fitting extreme corneal curvatures. We found lower than expected pass percentages. We are providing the eye care practitioner with a table of percentages of successful fits based on corneal curvatures. We hope that this will aid the practitioner in determining who would be a potential disposable contact lens patient

Traffic-Light Labels and Choice Architecture: Promoting Healthy Food Choices

Background: Preventing obesity requires maintenance of healthy eating behaviors over time. Food labels and strategies that increase visibility and convenience of healthy foods (choice architecture) promote healthier choices, but long-term effectiveness is unknown. Purpose: Assess effectiveness of traffic-light labeling and choice architecture cafeteria intervention over 24 months. Design: Longitudinal pre–post cohort follow-up study between December 2009 and February 2012. Data were analyzed in 2012. Setting/participants: Large hospital cafeteria with a mean of 6511 transactions daily. Cafeteria sales were analyzed for (1) all cafeteria customers and (2) a longitudinal cohort of 2285 hospital employees who used the cafeteria regularly. Intervention: After a 3-month baseline period, cafeteria items were labeled green (healthy); yellow (less healthy); or red (unhealthy) and rearranged to make healthy items more accessible. Main outcome measures: Proportion of cafeteria sales that were green or red during each 3-month period from baseline to 24 months. Changes in 12- and 24-month sales were compared to baseline for all transactions and transactions by the employee cohort. Results: The proportion of sales of red items decreased from 24% at baseline to 20% at 24 months (p\u3c0.001), and green sales increased from 41% to 46% (p\u3c0.001). Red beverages decreased from 26% of beverage sales at baseline to 17% at 24 months (p\u3c0.001); green beverages increased from 52% to 60% (p\u3c0.001). Similar patterns were observed for the cohort of employees, with the largest change for red beverages (23%–14%, p\u3c0.001). Conclusions: A traffic-light and choice architecture cafeteria intervention resulted in sustained healthier choices over 2 years, suggesting that food environment interventions can promote long-term changes in population eating behaviors

CO\u3csub\u3e2\u3c/sub\u3e and tectonic controls on Antarctic climate and ice-sheet evolution in the mid-Miocene

Antarctic ice sheet and climate evolution during the mid-Miocene has direct relevance for understanding ice sheet (in)stability and the long-term response to elevated atmospheric CO2 in the future. Geologic records reconstruct major fluctuations in the volume and extent of marine and terrestrial ice during the mid-Miocene, revealing a dynamic Antarctic ice-sheet response to past climatic variations. We use an ensemble of climate – ice sheet – vegetation model simulations spanning a range of CO2 concentrations, Transantarctic Mountain uplift scenarios, and glacial/interglacial climatic conditions to identify climate and ice-sheet conditions consistent with Antarctic mid-Miocene terrestrial and marine geological records. We explore climatic variability at both continental and regional scales, focusing specifically on Victoria Land and Wilkes Land Basin regions using a high-resolution nested climate model over these domains. We find that peak warmth during the Miocene Climate Optimum is characterized by a thick terrestrial ice sheet receded from the coastline under high CO2 concentrations. During the Middle Miocene Climate Transition, CO2 episodically dropped below a threshold value for marine-based ice expansion. Comparison of model results with geologic data support ongoing Transantarctic Mountain uplift throughout the mid-Miocene. Modeled ice sheet dynamics over the Wilkes Land Basin were highly sensitive to CO2 concentrations. This work provides a continental-wide context for localized geologic paleoclimate and vegetation records, integrating multiple datasets to reconstruct snapshots of ice sheet and climatic conditions during a pivotal period in Earth\u27s history

Does Living Near a Superfund Site Contribute to Higher Polychlorinated Biphenyl (PCB) Exposure?

We assessed determinants of cord serum polychlorinated biphenyl (PCB) levels among 720 infants born between 1993 and 1998 to mothers living near a PCB-contaminated Superfund site in Massachusetts, measuring the sum of 51 PCB congeners (∑PCB) and ascertaining maternal address, diet, sociodemographics, and exposure risk factors. Addresses were geocoded to obtain distance to the Superfund site and neighborhood characteristics. We modeled log(10)(∑PCB) as a function of potential individual and neighborhood risk factors, mapping model residuals to assess spatial correlates of PCB exposure. Similar analyses were performed for light (mono–tetra) and heavy (penta–deca) PCBs to assess potential differences in exposure pathways as a function of relative volatility. PCB-118 (relatively prevalent in site sediments and cord serum) was assessed separately. The geometric mean of ∑PCB levels was 0.40 (range, 0.068–18.14) ng/g serum. Maternal age and birthplace were the strongest predictors of ∑PCB levels. Maternal consumption of organ meat and local dairy products was associated with higher and smoking and previous lactation with lower ∑PCB levels. Infants born later in the study had lower ∑PCB levels, likely due to temporal declines in exposure and site remediation in 1994–1995. No association was found between ∑PCB levels and residential distance from the Superfund site. Similar results were found with light and heavy PCBs and PCB-118. Previously reported demographic (age) and other (lactation, smoking, diet) correlates of PCB exposure, as well as local factors (consumption of local dairy products and Superfund site dredging) but not residential proximity to the site, were important determinants of cord serum PCB levels in the study community

Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.

Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB). The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CYP) enzymes, many of which are implicated in Mtb survival and pathogenicity in the human host. Bioinformatics analysis revealed that CYP144A1 is retained exclusively within the Mycobacterium genus, particularly in species causing human and animal disease. Transcriptomic annotation revealed two possible CYP144A1 start codons, leading to expression of (i) a "full-length" 434 amino acid version (CYP144A1-FLV) and (ii) a "truncated" 404 amino acid version (CYP144A1-TRV). Computational analysis predicted that the extended N-terminal region of CYP144A1-FLV is largely unstructured. CYP144A1 FLV and TRV forms were purified in heme-bound states. Mass spectrometry confirmed production of intact, His6-tagged forms of CYP144A1-FLV and -TRV, with EPR demonstrating cysteine thiolate coordination of heme iron in both cases. Hydrodynamic analysis indicated that both CYP144A1 forms are monomeric. CYP144A1-TRV was crystallized and the first structure of a CYP144 family P450 protein determined. CYP144A1-TRV has an open structure primed for substrate binding, with a large active site cavity. Our data provide the first evidence that Mtb produces two different forms of CYP144A1 from alternative transcripts, with CYP144A1-TRV generated from a leaderless transcript lacking a 5'-untranslated region and Shine-Dalgarno ribosome binding site

The cultural side of value creation

The question of how organizations create value has become a central question for understanding inter-firm competition and performance differentials. Much of the work on the topic emphasizes the importance of technological innovation for improving operational efficiency and/or product functionality . Accordingly, much of the work in the area has focused on understanding the development of technological capabilities and the dynamics of competition among different technologies. Whereas this line of research has contributed greatly to our understanding of value creation through technology performance improvement, it has also left unexplored the strategies for differentiating products on the basis of their cultural significance. Yet, research in a wide variety of disciplines ranging from anthropology, to cultural sociology, and consumer behavior shows that consumers value products not only for their functional and technical performance, but also for their cultural meanings. The infusion of products with cultural meanings enables consumers to use these products to make statements about their personal and social identity and status. It is therefore well understood that consumers derive value not only from what products do (functional value), but also from what they signify in a given social group (symbolic value). While strategy scholars recognize that product meanings are a source of differentiation and generate price premia (Porter, 1980), they also tend to view the activities that generate them – e.g. branding – as a part of the marketing strategy of the firm. More generally, strategy research has been criticized for its reluctance to delve into the demand side of value-creation. Rooted in disciplinary assumptions about atomistic consumers with idiosyncratic preferences, strategy researchers view demand as largely exogenous and ignore its cultural embeddedness in social conventions that define the cultural meanings of objects and shape consumption choices. As a result, they have given limited attention to the question of how firms can strategically manage the symbolic value of their products. In this paper we propose a cultural perspective on value creation that can direct strategic organization research toward the systematic investigation of how producers engage with the cultural meaning systems that supply frameworks for interpretation and valuation of goods. To guide research in this direction we first discuss how products acquire cultural significance and then outline three core implications of these ideas for the strategy and organization of firms. First, we discuss how recognizing the cultural significance of products shifts attention from technological innovation that alters product functionality to cultural innovation that alters their cultural significance. Second, we explain the need to develop distinct cultural resources that enable firms to identify and exploit opportunities for cultural innovation. Third, we draw attention to the need for cultural intent defined as developing an explicit strategy for utilizing cultural resources to achieve specific cultural positioning for the firm’s products

Genome-wide association with bone mass and geometry in the Framingham Heart Study

© 2007 Kiel et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution Licens