Consensus report: E. coli O104:H4 (HUSEC041) and the potential threat to European water supplies.

Among the 3rd Seminar for PhD students working on Water and Health which was held in Cannes on 27–29 June 2011, experts from a number of universities and research institutes took the opportunity to discuss the emergence of Escherichia coli O104:H4 in Europe. Especially, possible threats for European water suppliers were considered. The consensus is summarized in this report. The main conclusion was that E. coli O104:H4 would not pose a substantial risk to well managed water supplies, especially where regular monitoring of indicator E. coli is negative. However, this may not apply for small and very small water systems which are quite common in Europe. New strategies like the Water Safety Plan approach are needed to protect also small scale drinking water systems and private wells in Europe. Water used in the processing of foods likely to be eaten raw, especially sprouts, should be of drinking water quality

Yellow laser performance of Dy3+^{3+} in co-doped Dy,Tb:LiLuF4_4

We present laser results obtained from a Dy$^{3+}$-Tb$^{3+}$ co-doped LiLuF$_{4}$ crystal, pumped by a blue emitting InGaN laser diode, aiming for the generation of a compact 578 nm source. We exploit the yellow Dy$^{3+}$ transition $^{4}$F$_{9/2}$ $\Longrightarrow$ $^{6}$H$_{13/2}$ to generate yellow laser emission. The lifetime of the lower laser level is quenched via energy transfer to co-doped Tb$^{3+}$ ions in the fluoride crystal. We report the growth technique, spectroscopic study and room temperature continuous wave (cw) laser results in a hemispherical cavity at 574 nm and with a highly reflective output coupler at 578 nm. A yellow laser at 578 nm is very relevant for metrological applications, in particular for pumping of the forbidden $^{1}$S$_{0} \Longrightarrow ^{3}$P$_{0}$ Ytterbium clock transition, which is recommended as a secondary representation of the second in the international system (SI) of units. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.39.006628. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.Comment: 8 pages, 5 figure

Solutions to the Optical Cascading Equations

Group theoretical methods are used to study the equations describing \chi^{(2)}:\chi^{(2)} cascading. The equations are shown not to be integrable by inverse scattering techniques. On the other hand, these equations do share some of the nice properties of soliton equations. Large families of explicit analytical solutions are obtained in terms of elliptic functions. In special cases, these periodic solutions reduce to localized ones, i.e., solitary waves. All previously known explicit solutions are recovered, and many additional ones are obtainedComment: 21 page

Energy, macronutrients and laryngeal cancer risk

BACKGROUND: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. PATIENTS AND METHODS: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. RESULTS: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). CONCLUSIONS: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol. [authors]]]> eng https://serval.unil.ch/resource/serval:BIB_26D8787AF96A.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_26D8787AF96A3 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_26D8787AF96A3 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_26D8AFEA3D4D 2022-05-07T01:13:16Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_26D8AFEA3D4D Symbiose et sénescence: étude du cycle glyoxylique chez le soja (Glycine max. L., var. Maple arrow) et Bradyrhizobium japonicum Fargeix, C. Université de Lausanne, Faculté des sciences info:eu-repo/semantics/doctoralThesis phdthesis 2001 fre oai:serval.unil.ch:BIB_26D955FDA835 2022-05-07T01:13:16Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_26D955FDA835 New emerging tasks for microRNAs in the control of β-cell activities info:doi:10.1016/j.bbalip.2016.05.003 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbalip.2016.05.003 info:eu-repo/semantics/altIdentifier/pmid/27178175 Guay, Claudiane Regazzi, Romano info:eu-repo/semantics/review article 2016-12 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1861, no. 12, pp. 2121-2129 info:eu-repo/semantics/altIdentifier/pissn/1388-1981 urn:issn:1879-2618 <![CDATA[MicroRNAs are key regulators of β-cell physiology. They participate to the differentiation of insulin-producing cells and are instrumental for the acquisition of their unique secretory properties. Moreover, they contribute to the adaptation of β-cells to conditions of increased insulin demand and, if expressed at inappropriate levels, certain microRNAs cause β-cell dysfunction and promote the development of different forms of diabetes mellitus. While these functions are increasingly better understood, additional tasks for these small non-coding RNAs have been recently unveiled. Thus, microRNAs are emerging as signaling molecules of a novel exosome-mediated cell-to-cell communication mode permitting a coordinated response of the β-cells to inflammatory conditions and to modifications in the insulin demand. These discoveries raise a number of important issues that once addressed promise to shed new light on the molecular mechanism governing the functions of the β-cells under normal and disease states. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez

Trends in laryngeal cancer mortality in Europe

After a steady increase since the 1950s, laryngeal cancer mortality had tended to level off since the early 1980s in men from most European countries. To update trends in laryngeal cancer mortality in Europe, age-standardized (world standard) mortality rates per 100,000 were derived from the WHO mortality database for 33 European countries over the period 1980-2001. Jointpoint analysis was used to identify significant changes in mortality rates. In the European Union (EU) as a whole, male mortality declined by 0.8% per year between 1980 and 1989, by 2.8% between 1989 and 1995, by 5.3% between 1995 and 1998, and by 1.5% thereafter (rates were 5.1/100,000 in 1980-1981 and 3.3/100,000 in 2000-2001). This mainly reflects a decrease in rates in men from western and southern European countries, which had exceedingly high rates in the past. Male laryngeal mortality rose up to the early 1990s, and leveled off thereafter in several countries from central and eastern Europe. In 2000-2001 there was still a 10-15-fold variation in male laryngeal mortality between the highest rates in Croatia (7.9/100,000) and Hungary (7.7/100,000) and the lowest ones in Sweden (0.5/100,000) and Finland (0.8/100,000). Laryngeal cancer mortality was comparatively low in women from most European countries, with stable rates around 0.3/100,000 in the EU as a whole over the last 2 decades. Laryngeal cancer trends should be interpreted in terms of patterns and changes in exposure to alcohol and tobacco. Despite recent declines, the persistence of a wide variability in male laryngeal cancer mortality indicates that there is still ample scope for prevention of laryngeal cancer in Europe. [Ed.]]]> Laryngeal Neoplasms; Mortality eng oai:serval.unil.ch:BIB_E23DFD6660FA 2022-05-07T01:28:48Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E23DFD6660FA Why is there philosophy in India? Johannes, Bronkhorst Johannes, Bronkhorst (ed.) info:eu-repo/semantics/book book 1999 Indian philosophy, Indian history eng https://serval.unil.ch/resource/serval:BIB_E23DFD6660FA.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E23DFD6660FA3 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E23DFD6660FA3 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_E23E086D3432 2022-05-07T01:28:48Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E23E086D3432 Compte-rendu : « Gwénola Réto, La bienveillance à l’école » https://halshs.archives-ouvertes.fr/halshs-03452642 Camille, Roelens info:eu-repo/semantics/article article 2021 Le Télémaque. Philosophie, Education, Société, no. 60 fre oai:serval.unil.ch:BIB_E23F61C3E477 2022-05-07T01:28:48Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E23F61C3E477 Bioterrorism: myth or reality? info:doi:10.1111/1469-0691.12713 info:eu-repo/semantics/altIdentifier/doi/10.1111/1469-0691.12713 info:eu-repo/semantics/altIdentifier/pmid/24920295 Greub, G. Grobusch, M.P. info:eu-repo/semantics/article article 2014 Clinical Microbiology and Infection, vol. 20, no. 6, pp. 485-487 info:eu-repo/semantics/altIdentifier/eissn/1469-0691 urn:issn:1198-743X eng https://serval.unil.ch/resource/serval:BIB_E23F61C3E477.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E23F61C3E4776 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E23F61C3E4776 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/restrictedAccess Restricted: indefinite embargo Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_E24085AADE3D 2022-05-07T01:28:48Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E24085AADE3D De la communauté à l’utopie : l’impact sociopolitique des théâtres postdramatiques https://www.fabula.org/revue/document12988.php Aurélien, Maignant info:eu-repo/semantics/article article 2020-06-01 Acta Fabula, vol. 6, no. 21 info:eu-repo/semantics/altIdentifier/pissn/1496-9610 fre https://serval.unil.ch/resource/serval:BIB_E24085AADE3D.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E24085AADE3D7 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E24085AADE3D7 info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_E24153DBE7DF 2022-05-07T01:28:48Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E24153DBE7DF Assurance maladie et dépenses de santé : présentation Mougeot, Michel info:eu-repo/semantics/article article 2000 Revue d'économie politique, vol. 110, no. 4, pp. 447-456 info:eu-repo/semantics/altIdentifier/pissn/0373-2630 oai:serval.unil.ch:BIB_E241922E4472 2022-05-07T01:28:48Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_E241922E4472 Energy expenditure and whole body protein synthesis in very low birth weight (VLBW) infants info:eu-repo/semantics/altIdentifier/pmid/6580179 Schutz, Y. Catzeflis, C. Gudinchet, F. Micheli, J. Welsch, C. Arnaud, M. J. Jequier, E. info:eu-repo/semantics/article article 1983 Experientia Suppl, vol. 44, pp. 45-56 info:eu-repo/semantics/altIdentifier/pissn/0071-335X <![CDATA[To examine the rates of whole body protein synthesis and energy expenditure during the rapid growing period, premature infants of very low birth weight (VLBW) (less than 1500 g), appropriate for gestational age were kept under standard thermoneutrality conditions and received a formula diet providing 110 kcal/kg.d metabolisable energy (ME) and 3.3 g protein/kg.d. Their energy expenditure was measured by open circuit indirect calorimetry. Nitrogen turnover and whole body protein synthesis and catabolism were determined using repeated oral administration of 15N-glycine for 60-72 h followed by the analysis of 15N-enrichment in urinary urea. These VLBW infants grew at an average rate of 15 g/kg.d. About half of the ME intake (i.e. 50 kcal/kg.d) was invested in weight gain while the remainder (i.e. 60 kcal/kg.d) was oxidised. The energy equivalent of the weight gain (i.e. the amount of energy stored per g weight gain) and the N balance indicated that lean tissue made up approximately 2/3 of the weight gained and fat tissue the remaining 1/3. The plateau value for 15N enrichment reached on the third day of administration allowed us to calculate a rate of protein synthesis of 14 g/kg.d and protein breakdown of 12 g/kg.d in five VLBW fed a formula diet. The elevated energy expenditure of the very low birth weight infant seems to be related to its rapid rate of weight gain which is accompanied by a high rate of body protein synthesis. More than 20% of the total energy expenditure of the VLBW infants was accounted for by whole body protein synthesis

SO(5) Theory of Antiferromagnetism and Superconductivity

Antiferromagnetism and superconductivity are both fundamental and common states of matter. In many strongly correlated systems, including the high Tc cuprates, the heavy fermion compounds and the organic superconductors, they occur next to each other in the phase diagram and influence each other's physical properties. The SO(5) theory unifies these two basic states of matter by a symmetry principle and describes their rich phenomenology through a single low energy effective model. In this paper, we review the framework of the SO(5) theory, and its detailed comparison with numerical and experimental results.Comment: Review article. 81 page

FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder

While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive disease. FGFR3 protein and mRNA expression, mutational status, and copy number variation were retrospectively analyzed in 231 patients with formalin-fixed paraffin-embedded primary UCs, 33 metastases, and 14 paired primary and metastatic tumors using the following methods: immunohistochemistry, NanoString nCounterTM, OncoMap or Affymetrix OncoScanTM array, and Gain and Loss of Analysis of DNA and Genomic Identification of Significant Targets in Cancer software. FGFR3 immunohistochemistry staining was present in 29% of primary UCs and 49% of metastases and did not impact overall survival (P = 0.89, primary tumors; P = 0.78, metastases). FGFR3 mutations were observed in 2% of primary tumors and 9% of metastases. Mutant tumors expressed higher levels of FGFR3 mRNA than wild-type tumors (P < 0.001). FGFR3 copy number gain and loss were rare events in primary and metastatic tumors (0.8% each; 3.0% and 12.3%, respectively). FGFR3 immunohistochemistry staining is present in one third of primary muscle-invasive UCs and half of metastases, while FGFR3 mutations and copy number changes are relatively uncommon