89 research outputs found
Performance Overhead of Haxe Programming Language for Cross-Platform Game Development
Video game industry has become the largest entertainment based industry, surpassing both the film and the music industry in terms of revenue. Costs of game development are rising with a number of platforms one has to support. In todayās competitive industry, it is necessary to support as many platforms as possible to remain profitable. One way to cut down on time spent on porting the game to other platforms, is to use cross-platform programming languages and development frameworks. Even though such frameworks allow drastic reduction of development time spent on making sure games work on all intended platforms, they are not without cost. The cost in this case is mainly in reduced performance, compared to games developed in their native development environments. This paper evaluates performance overhead of a relatively new programming language (less than a decade old) called Haxe, which is built especially for cross-platform development. We have implemented the same game in both its native environment
and in the Haxe programming language, from which the game is cross-compiled to run in the native environment. The authors tested developed games on three different hardware configurations, with three different complexity settings, and the results show that even though performance overhead of cross-compilation is not insignificant, the overall reduction in development time attained by developing in Haxe presents a viable option for cross-platform game development, with positive aspects outweighing the negatives
Significance of sentinel - node biopsy in early - stage malignant melanoma of the head and neck
Maligni melanom je zloÄudni tumor pigmentnih stanica kože i sluznica. Jedan je od najagresivnijih tumora u Äovjeka. Iako melanom Äini tek 4 % svih zloÄudnih bolesti kože na njega otpada gotovo 80 % umrlih od kožnih tumora. Incidencija melanoma je u stalnom porastu posljednjih desetljeÄa stoga je melanom postao bolest javnozdravstvenog znaÄaja. ZahvaljujuÄi dobro razvijenoj limfnoj mreži, posebice u podruÄju glave i vrata, melanom može lako i brzo limfogeno i hematogeno metastazirati. U bolesnika u kojih su regionalni limfni Ävorovi pozitivni preživljenje je 40 % do 50 % loÅ”ije nego u onih koji ih nemaju. Donald Morton je u ranim 90-im popularizirao biopsiju limfnog Ävora stražara (SLNB) koja je danas zlatni standard u prognozi i daljnjem planiranju lijeÄenja bolesnika s melanomom. Limfni Ävor stražar (sentinel) je prvi limfni Ävor u koji se drenira podruÄje tumora. SLNB je indicirana u ranim stadijima melanoma kod kojih nema kliniÄki, radioloÅ”ki ili patohistoloÅ”ki dokazanih metastaza. Standardne tehnike koje se primjenjuju za SLNB su: preoperativna limfoscintigrafija, primjena limfotropne boje 'blue dye', te detekcija sentinela primjenom ruÄne gama kamere. U podruÄju glave i vrata SLNB se izvodi u opÄoj endotrahealnoj anesteziji. Kod pacijenata s pozitivnim sentinelom potrebno je napraviti disekciju vrata kako bi se sprijeÄio daljnji rasap bolesti. Pacijente s negativnim sentinelom treba kliniÄki pratiti.Malignant melanoma is a malignant tumor of pigment cells of the skin and mucosa. It is one of the most aggressive tumors in humans. Although melanoma makes up to 4 % of all malignant skin diseases, almost 80 % of the deaths of skin tumors are caused by it. Melanoma incidence has been steadily increasing over the last decades, so melanoma has become a public health issue. Thanks to a well developed lymphatic network, especially in the area of the head and neck, melanoma can easily and quickly limphogenously and hematogenically metastasize. In patients with positive regional lymph nodes survival is 40 % to 50 % worse than in those without them. In the early 1990s, Donald Morton popularized the sentinel lymph node biopsy (SLNB), which is today the gold standard for prognosis and further planning of treating patients with melanoma. The lymph node guard (sentinel) is the first lymph node to drain the tumor area. SLNB is indicated in early stages of melanoma with no clinical, radiological or pathohistologically proven metastases. The standard techniques used for SLNB include: preoperative lymphoscintigraphy, lymphotropic blue dye application, and sentinel detection by hand gamma camera. In the area of the head and neck, SLNB is performed in endotracheal anesthesia. In patients with a positive sentinel, neck dissection is required to prevent further disease spread. Patients with a negative sentinel should be monitored clinically
Significance of sentinel - node biopsy in early - stage malignant melanoma of the head and neck
Maligni melanom je zloÄudni tumor pigmentnih stanica kože i sluznica. Jedan je od najagresivnijih tumora u Äovjeka. Iako melanom Äini tek 4 % svih zloÄudnih bolesti kože na njega otpada gotovo 80 % umrlih od kožnih tumora. Incidencija melanoma je u stalnom porastu posljednjih desetljeÄa stoga je melanom postao bolest javnozdravstvenog znaÄaja. ZahvaljujuÄi dobro razvijenoj limfnoj mreži, posebice u podruÄju glave i vrata, melanom može lako i brzo limfogeno i hematogeno metastazirati. U bolesnika u kojih su regionalni limfni Ävorovi pozitivni preživljenje je 40 % do 50 % loÅ”ije nego u onih koji ih nemaju. Donald Morton je u ranim 90-im popularizirao biopsiju limfnog Ävora stražara (SLNB) koja je danas zlatni standard u prognozi i daljnjem planiranju lijeÄenja bolesnika s melanomom. Limfni Ävor stražar (sentinel) je prvi limfni Ävor u koji se drenira podruÄje tumora. SLNB je indicirana u ranim stadijima melanoma kod kojih nema kliniÄki, radioloÅ”ki ili patohistoloÅ”ki dokazanih metastaza. Standardne tehnike koje se primjenjuju za SLNB su: preoperativna limfoscintigrafija, primjena limfotropne boje 'blue dye', te detekcija sentinela primjenom ruÄne gama kamere. U podruÄju glave i vrata SLNB se izvodi u opÄoj endotrahealnoj anesteziji. Kod pacijenata s pozitivnim sentinelom potrebno je napraviti disekciju vrata kako bi se sprijeÄio daljnji rasap bolesti. Pacijente s negativnim sentinelom treba kliniÄki pratiti.Malignant melanoma is a malignant tumor of pigment cells of the skin and mucosa. It is one of the most aggressive tumors in humans. Although melanoma makes up to 4 % of all malignant skin diseases, almost 80 % of the deaths of skin tumors are caused by it. Melanoma incidence has been steadily increasing over the last decades, so melanoma has become a public health issue. Thanks to a well developed lymphatic network, especially in the area of the head and neck, melanoma can easily and quickly limphogenously and hematogenically metastasize. In patients with positive regional lymph nodes survival is 40 % to 50 % worse than in those without them. In the early 1990s, Donald Morton popularized the sentinel lymph node biopsy (SLNB), which is today the gold standard for prognosis and further planning of treating patients with melanoma. The lymph node guard (sentinel) is the first lymph node to drain the tumor area. SLNB is indicated in early stages of melanoma with no clinical, radiological or pathohistologically proven metastases. The standard techniques used for SLNB include: preoperative lymphoscintigraphy, lymphotropic blue dye application, and sentinel detection by hand gamma camera. In the area of the head and neck, SLNB is performed in endotracheal anesthesia. In patients with a positive sentinel, neck dissection is required to prevent further disease spread. Patients with a negative sentinel should be monitored clinically
Church in Croatia during Communism
KatoliÄka je crkva u povijesti Hrvatske Države imala veliku i važnu ulogu, Äuvala je kulturnu baÅ”tinu i njegovala duh i vjeru hrvatskoga puka od 9. stoljeÄa pa do danas. Ukorijenjenost katolicizma u Hrvata postiglo je razinu nacionalnog identiteta Å”to razlikuje Hrvate od susjednih zemalja koje su povijesno vezane za istoÄni kulturni krug i pravoslavnu vjeru.
Upravo ta vjerska razlika Äinila je kamen spoticanja u razdoblju prve Jugoslavije, ali i u āTitovojā Jugoslaviji. Dolaskom partizana na vlast u Hrvatskoj i uspostavom Federativne Hrvatske, poÄeli su se nadzirati problemi s kojima Äe se susretati KatoliÄka crkva. Naime, joÅ” za trajanja Drugoga svjetskoga rata, puno je sveÄenika odvedeno u logore i pobijeno, a stanje u Crkvi nije se posebno promijenilo niti u raznoblju āmiraā. Odmah je zapoÄeta āborbaā Crkve s vlastima, oduzimanje imovine, prava glasa (uguÅ”en vjerski tisak), suÄenje sveÄenicima, izbacivanje vjeronauka iz Å”kole, medijsko blaÄenje KatoliÄke crkve. Biskupi vlastima odgovaraju Pastirskim pismom, a odgovor vlasti donosi joÅ” jaÄe postroženje te sramotno suÄenje Alojziju Stepincu i ostalim sveÄenicima. Titova vlast ne miruje, cilj im je odijeliti KatoliÄku crkvu od Vatikana, smatraju da je Vatikan na strani neprijateljskoga Rima, te potiÄu sveÄenike na osnivanje staleÅ”kih udruženja katoliÄkih sveÄenika. Cilj im je stvoriti Narodnu crkvu sliÄnu Pravoslavnoj crkvi. Vladin gnjev na sveÄeniÄko odbijanje pristupa udruženjima, dopis Svete Stolice da nije dopuÅ”ten pristup udruženjima, kao i nerazjaÅ”njeni pritvor Alojzija Stepinca bili su uzroci prekida diplomatskih odnosa izmeÄu Jugoslavije i Svete Stolice, 1952. godine. Od 1953. do 1960. Država i dalje vodi svoju politiku nesnosnih odnosa sa Crkvom. MeÄutim, u meÄuvremenu je proglaÅ”en je novi nadbiskup, Franjo Å eper, a trn u oku Jugoslavenske vlade, kardinal Stepinac, je umro 1960. Dah novih zanosa i suvremeniji pogledi omoguÄili su otvaranje jugoslavenske diplomacije ka Svetoj Stolici, sudjelovanje hrvatskih biskupa na II. vatikanskom saboru i konaÄno potpisivanje glasovitog Protokola koji je budio razliÄite konotacije. Tito 1971. godine posjeÄuje papu, donesen je novi Ustav, kroji se nova politika otvaranja prema suvremenome svijetu.
DogaÄaj koji je uzbunio politiÄku scenu Jugoslavije svakako jest smrt Josipa Broza Tita i uvod u rascijepljenje Hrvatske od Jugoslavije Å”to je dovelo do Domovinskoga rata
Performance Evaluation of Virtualization Tools in Multi-Threaded Applications
In the last decade, virtualization technologies have become very popular. Virtualization enables a user to run multiple
operating systems on the same computer concurrently, while providing a degree of isolation between OS instances. Even though
virtualization is mostly used on servers, its popularity on desktop also rises, where it is mostly used in cross-platform development
and execution of software available to other platforms. Since both of these use cases are performance intensive, the goal of this paper
is to evaluate the performance of a couple of the most popular desktop virtualization tools on the market, i.e., VMWare Player and
Oracle VirtualBox. Benchmarks used in this paper evaluate the performance of the tools in both CPU intensive and GPU intensive
applications, with special emphasis placed on the performance of multi-threaded applications
Myoepithelial Carcinoma of the Parotid Gland
Rare malignant tumor of the salivary gland, a myoepithelial carcinoma, arose de novo in the right parotid gland. The initial tumor was composed predominantly of myoepithelial cells. Subsequently the tumor recurred three times, with infiltration of the bones of the cranial base. Histological examination showed sarcomatoid neoplasm composed of malignant spindle cells with high mitotic rate and perineural invasion. There was no involvement of cervical lymph nodes. Immunohistochemistry demonstrated myoepithelial differentiation: tumor cells were positively stained with vimentin, alpha smooth muscle actin and S-100 protein antibodies, and focal positively was noticed with cytokeratin (AE1/AE3) antibody. Large number of tumor cells nuclei was reactive with the monoclonal anti-p63 antibody, clone 4A4. Myoepithelial carcinomas exhibit a wide spectrum of morphological heterogeneity and for that reason could be confused with many tumors. Cytoarchitectural patterns and immunohistochemical profile are crucial for identification. These tumors are malignant neoplasms with diverse clinical outcomes, sometimes very aggressive
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