Freedom to Work, Nothing More nor Less: The Freedmen’s Bureau, White Planters, and Black Contract Laborers in Postwar Tennessee, 1865-1868

This thesis explores the black labor situation in postwar Tennessee from 1865 to 1868. Using a wide array of primary sources from Tennessee, the research unveils an inherent bias in the Freedmen’s Bureau’s forced contract system of labor. My conclusions highlight the collusion and complacency of bureau officials and planters who confined freedpeople to agricultural labor during the initial years of African-American freedom. Whites—Northern and Southern—worked cohesively toward common goals of agricultural prosperity, law and order, and white supremacy. The bureau’s contract system was devised as an emergency measure to put idle blacks back in their “appropriate” positions as agricultural laborers, but bureau officials failed to recognize that freedpeople refusing to work on farms were not lazy and irresponsible; rather, they were discontented with former slaveholders and desperate for non-plantation work. Contracts served the needs of the planter class and the free-labor proponents of the North. The bureau restored order and productivity to Tennessee by providing ex-slaveowners with the legal means to acquire cheap and exploitable labor. Formal stipulations codified the old system of enslavement through a new medium, and bureau-approved contracts became the new figurative overseers of African-American agricultural laborers in the post-emancipation South

A novel human glucocorticoid receptor SNP results in increased transactivation potential.

Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or those that need higher dosages. Polymorphisms in the glucocorticoid receptor (GR) have been implicated in this variability. In this study, ninety-seven volunteers were surveyed for polymorphisms in the human GR-alpha (hGRα), the accepted biologically active reference isoform. One isoform identified in our survey, named hGR DL-2, had four single nucleotide polymorphisms (SNPs), one synonymous and three non-synonymous, and a four base pair deletion resulting in a frame shift and early termination to produce a 743 amino acid putative protein. hGR DL-2 had a decrease in transactivation potential of more than 90%. Upon further analysis of the individual SNPs and deletion, one SNP, A829G, which results in a lysine to glutamic acid amino acid change at position 277, was found to increase the transactivation potential of hGR more than eight times the full-length reference. Furthermore, the hGRα-A829G isoform had a differential hyperactive response to various exogenous steroids. Increasing our knowledge as to how various SNPs affect hGR activity may help in understanding the unpredictable patient response to steroid treatment, and is a step towards personalizing patient care

The Geography of Opiate Addiction, Overdose, and Treatment in Tennessee

Opioid addiction and overdose has become a national epidemic in the United States over the past 30 years. According to the Centers for Disease Control and Prevention, more than 20,000 Americans died from prescription drugs alone in 2014. Tennessee ranks especially high in the number of opioid prescriptions and overdoses when compared to the rest of the US. The Volunteer State is one of only 13 where doctors issued between 96-143 opioid prescriptions per 100 people. This project maps opiate prescription rates and overdose death rates in Tennessee to identify trends in the geospatial, socioeconomic, and demographic makeup of victims, and plots the locations of opiate-addiction treatment centers to assess their accessibility in hotspots of opiate abuse. While the opioid epidemic has plagued all of Tennesseans, the data proves that four counties in a fairly isolated and depressed area in the northeastern region have been significantly affected and have few options for meaningful detox and treatment programs. Our queen’s method hotspot analysis in ArcMap reveals that 4 adjacent counties – Anderson, Campbell, Knox, and Union – saw the highest rate of prescriptions written and the highest rate of overdose deaths. Outpatient and office-based opiate abuse treatment facilities exist across the region, but they are spatially limited, have low capacities, and offer minimal support. The closest inpatient facilities are located only in cities such as Knoxville, Kingsport, and Johnson City, the closest of which can be over an hour away for some residents along the fringes of the region

State of the World's Volunteerism Report: Universal Values for Global Well-being

The focus of this report is on the universal values that motivate people the world over to volunteer for the common good and on the impact of volunteer action on societies and individuals. The authors advocate the power of volunteering to promote cooperation, encourage participation and contribute to the well-being of individuals and of society as a whole

A comparison of the illness beliefs of people with angina and their peers: a questionnaire study

BACKGROUND: What people believe about their illness may affect how they cope with it. It has been suggested that such beliefs stem from those commonly held within society . This study compared the beliefs held by people with angina, regarding causation and coping in angina, with the beliefs of their friends who do not suffer from angina. METHODS: Postal survey using the York Angina Beliefs Questionnaire (version 1), which elicits stress attributions and misconceived beliefs about causation and coping. This was administered to 164 people with angina and their non-cohabiting friends matched for age and sex. 132 people with angina and 94 friends completed the questionnaire. RESULTS: Peers are more likely than people with angina to believe that angina is caused by a worn out heart (p <0.01), angina is a small heart attack (p = 0.02), and that it causes permanent damage to the heart (p <0.001). Peers were also more likely to believe that people with angina should take life easy (p <0.01) and avoid exercise (p = 0.04) and excitement (p <0.01). CONCLUSIONS: The beliefs of the peer group about causation and coping in angina run counter to professional advice. Over time this may contribute to a reduction in patient concordance with risk factor reduction, and may help to create cardiac invalids

Relationship Between Sleep and Behavior in Autism Spectrum Disorder: Exploring the Impact of Sleep Variability.

Objective:The relationship between sleep (caregiver-reported and actigraphy-measured) and other caregiver-reported behaviors in children and adults with autism spectrum disorder (ASD) was examined, including the use of machine learning to identify sleep variables important in predicting anxiety in ASD. Methods:Caregivers of ASD (n = 144) and typically developing (TD) (n = 41) participants reported on sleep and other behaviors. ASD participants wore an actigraphy device at nighttime during an 8 or 10-week non-interventional study. Mean and variability of actigraphy measures for ASD participants in the week preceding midpoint and endpoint were calculated and compared with caregiver-reported and clinician-reported symptoms using a mixed effects model. An elastic-net model was developed to examine which sleep measures may drive prediction of anxiety. Results:Prevalence of caregiver-reported sleep difficulties in ASD was approximately 70% and correlated significantly (p &lt; 0.05) with sleep efficiency measured by actigraphy. Mean and variability of actigraphy measures like sleep efficiency and number of awakenings were related significantly (p &lt; 0.05) to ASD symptom severity, hyperactivity and anxiety. In the elastic net model, caregiver-reported sleep, and variability of sleep efficiency and awakenings were amongst the important predictors of anxiety. Conclusion:Caregivers report problems with sleep in the majority of children and adults with ASD. Reported problems and actigraphy measures of sleep, particularly variability, are related to parent reported behaviors. Measuring variability in sleep may prove useful in understanding the relationship between sleep problems and behavior in individuals with ASD. These findings may have implications for both intervention and monitoring outcomes in ASD

What do coronary artery disease patients think about their treatments? An assessment of patients' treatment representations

This article investigates patients' beliefs about the intervention offered to manage their illness. Coronary artery disease (CAD) patients, 70 of whom were undergoing medication, 71 to undergo angioplasty and 73 to undergo surgery, completed a 58-item questionnaire regarding their treatment beliefs. Responses were subject to principal components analysis, which indicated four factors accounting for 36.7 per cent of the variance. After excluding extraneous items, the final questionnaire consisted of 27 items, clustered around four components: treatment-value, treatment-concerns, decision-satisfaction and cure. A coherent set of subscale inter-correlations and ANCOVAs examining treatment group differences on these sub-scales showed a logical, explicable pattern of group differences reflecting the distinctive natures of each treatment and demonstrated discriminant validity. Correlations with other scales provided evidence of construct validity