Bone tissue and hyperhomocysteinemia.

Bone tissue quality is determined not only by multiple architectural variables, but also by the mechanical properties of collagen type 1. Homocysteinuria is a genetic disease whose manifestations include severe hyperhomocysteinemia and decreased bone strength. The effects of smaller homocysteine elevations on bone tissue are difficult to demonstrate in clinical studies. Studies in animals and in humans suggest that homocysteine may weaken collagen crosslinks and, if present in large amounts, interfere with bone remodeling. Whether routine homocysteine assays should be performed to detect bone frailty remains unclear. In clinical practice, the focus should be on identifying patients with potential causes of homocysteine elevation (e.g., medications), who should then be given vitamin D and folic acid supplementation if needed. This approach may improve not only bone health, but also vascular and general health

Benchmark calculations for elastic fermion-dimer scattering

We present continuum and lattice calculations for elastic scattering between a fermion and a bound dimer in the shallow binding limit. For the continuum calculation we use the Skorniakov-Ter-Martirosian (STM) integral equation to determine the scattering length and effective range parameter to high precision. For the lattice calculation we use the finite-volume method of L\"uscher. We take into account topological finite-volume corrections to the dimer binding energy which depend on the momentum of the dimer. After subtracting these effects, we find from the lattice calculation kappa a_fd = 1.174(9) and kappa r_fd = -0.029(13). These results agree well with the continuum values kappa a_fd = 1.17907(1) and kappa r_fd = -0.0383(3) obtained from the STM equation. We discuss applications to cold atomic Fermi gases, deuteron-neutron scattering in the spin-quartet channel, and lattice calculations of scattering for nuclei and hadronic molecules at finite volume.Comment: 16 pages, 5 figure

Extraspinal sciatica revealing late metastatic disease from parotid carcinoma

Sciatica is a clinical symptom usually caused by a disk herniation and less often by other conditions such as tumors, infections, or inflammatory diseases. We report the case of a woman in whom sciatica led to the identification of a large pelvic metastasis from a carcinoma of the parotid gland

TRADUCTION DU CODE CIVIL FRANÇAIS EN ANGLAIS VERSION BILINGUE

Traduction du code civil français, dans sa version en vigueur le 1er juillet 2013, en anglais, version bilingue alignée, accompagnée du lexique des équivalences terminologiques retenues par les traducteurs et les experts scientifiquesDepuis 1999, le Gouvernement français fait procéder à la traduction des grands codes français en anglais et en espagnol aux fins de publication sur le site http://www.legifrance.gouv.fr. Pour assurer leur qualité, ces traductions font l'objet d'un accompagnement scientifique associant des experts, juristes bilingues, spécialistes de la discipline qui fait l'objet du texte traduit, et une ingénierie spécialisée, une juriste-linguiste, spécialiste de traduction et de terminologie juridique. La juriste-linguiste a pour mission de faciliter la collaboration et les échanges entre les linguistes et les juristes, dont les approches méthodologiques et conceptuelles diffèrent. Sa connaissance des deux domaines scientifiques facilite le rapprochement des points de vue et le travail transdisciplinaire.La traduction est précédée d'opérations de pré-traduction menées par l'ingénieur qui conduisent notamment à élaborer un lexique d'équivalences terminologiques validé conjointement par les experts et les traducteurs de la combinaison linguistique retenue. Cet outil est indispensable à la traduction d'un texte long intégré dans un programme comportant plus de 10 codes, qui fait par ailleurs l'objet de mises à jour.La traduction réalisée est soumise à l'expertise des juristes et au contrôle qualité de l'ingénieur spécialisé. Après discussion et échanges scientifiques, la version définitive de la traduction est adoptée, la mémoire de traduction nettoyée, ainsi que le lexique des équivalences terminologiques.En 2013-2014, les traductions du code civil et du code de commerce français en anglais et en espagnol ont été mises à jour.Pour favoriser l’analyse et le débat scientifique autour de ces traductions, et conformément à la politique de diffusion en accès ouvert des données de la recherche produites sur fonds publics, la version bilingue de la traduction du code civil en anglais est ici mise à disposition de la communauté scientifique, accompagnée du lexique d'équivalences terminologiques. Ce travail de traduction a été conduit en parallèle de la traduction en anglais des entrées de droit civil du Vocabulaire juridique, dirigé par Gérard Cornu, publié sous le titre Vocabulary of the Civil Code

Seawater osmium isotope evidence for a middle Miocene flood basalt event in ferromanganese crust records

Three ferromanganese crusts from the northeast, northwest and central Atlantic were re-dated using osmium (Os) isotope stratigraphy and yield ages from middle Miocene to the present. The three Os isotope records do not show evidence for growth hiatuses. The reconstructed Os isotope-based growth rates for the sections older than 10 Ma are higher than those determined previously by the combined beryllium isotope (10Be/9Be) and cobalt (Co) constant-flux methods, which results in a decrease in the maximum age of each crust. This re-dating does not lead to significant changes to the interpretation of previously determined radiogenic isotope neodymium, lead (Nd, Pb) time series because the variability of these isotopes was very small in the records of the three crusts prior to 10 Ma. The Os isotope record of the central Atlantic crust shows a pronounced minimum during the middle Miocene between 15 and 12 Ma, similar to a minimum previously observed in two ferromanganese crusts from the central Pacific. For the other two Atlantic crusts, the Os isotope records and their calibration to the global seawater curve for the middle Miocene are either more uncertain or too short and thus do not allow for a reliable identification of an isotopic minimum. Similar to pronounced minima reported previously for the Cretaceous/Tertiary and Eocene/Oligocene boundaries, possible interpretations for the newly identified middle Miocene Os isotope minimum include changes in weathering intensity and/or a meteorite impact coinciding with the formation of the Nördlinger Ries Crater. It is suggested that the eruption and weathering of the Columbia River flood basalts provided a significant amount of the unradiogenic Os required to produce the middle Miocene minimum

Near-equivalence of the role of structural unpinning number, basicity and reciprocal average electronegativity in determining the conductivity of glasses

The chemical approach made to investigate the origin of fast ion conduction in Agl-based fast ion conducting (FIC) glasses has been extended to various ionically conducting systems containing Na+ ion. An index known as structural unpinning number (SUN), S, has been defined for this purpose based on the unscreened nuclear charge on the cation and the average electronegativity of all the anions. Variation of the log(conductivity), at a given temperature, as a function of structural unpinning number, optical basicity, λ, and the reciprocal average electronegativity of all the anions, l/χa, has been examined for a number of Na+-ion conducting glasses and a nearly identical variation has been noticed in all the cases. The equivalence of these chemical parameters as determinants of the conductivity behavior of glasses has thus been established and the origin of this equivalence has been discussed

Aneuploidy in oocytes is prevented by sustained CDK1 activity through degron masking in cyclin B1

Successful mitosis requires that cyclin B1:CDK1 kinase activity remains high until chromosomes are correctly aligned on the mitotic spindle. It has therefore been unclear why, in mammalian oocyte meiosis, cyclin B1 destruction begins before chromosome alignment is complete. Here, we resolve this paradox and show that mouse oocytes exploit an imbalance in the ratio of cyclin B1 to CDK1 to control CDK1 activity; early cyclin B1 destruction reflects the loss of an excess of non-CDK1-bound cyclin B1 in late prometaphase, while CDK1-bound cyclin B1 is destroyed only during metaphase. The ordered destruction of the two forms of cyclin B1 is brought about by a previously unidentified motif that is accessible in free cyclin B1 but masked when cyclin B1 is in complex with CDK1. This protects the CDK1-bound fraction from destruction in prometaphase, ensuring a period of prolonged CDK1 activity sufficient to achieve optimal chromosome alignment and prevent aneuploidy

Story Telling and Truth-Telling: Personal Reflections on the Native American Experience in Law Schools

In January of 2021, the American Association of Law Schools (“AALS”) theme was Freedom, Equality and the Common Good. The Indian Nations and Indigenous Peoples Section of the AALS embraced the theme and announced a call for personal reflections incorporating the experiences of Native Americans in law schools. The theme of striving for academic freedom and equality allows for an in-depth questioning of whether Native Americans have been adequately and appropriately represented in legal curricula in the nation’s approximately two hundred law schools. The aspirational goal of realizing the common good must be inclusive of Native American voices as students, faculty, staff, and graduates and in curricula choices in law schools across the country. There has been sparse legal scholarship on the experience of Native American applicants, law students, faculty, and staff in law schools. The Indigenous perspective essays in this compilation are an opportunity to hear the voices of Indigenous peoples on their lived experiences in seeking law degrees and careers in law-related fields. Words such as resiliency, endurance, and perseverance often come to mind when Native Americans discuss their personal experiences in the legal academy. The following collection of essays are a contribution to the legal academy in the Indigenous tradition of storytelling shared as firsthand accounts through the seven authors’ perspectives. Within the personal reflections, the tenacity of Native people to succeed and overcome barriers is a common theme. Many of the contributors speak to the value of mentoring or becoming a Native lawyer to serve as a mentor. The compilation provides insight into the experience the authors share of a deep commitment to their Indigenous communities and to trailblazing for the next generation of Native lawyers