Diffuse large B-cell lymphomas, not otherwise specified, and emerging entities

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogenous group of diseases and the most common subtype of non-Hodgkin lymphoma. In the past decade, there has been an explosion in molecular profiling that has helped to identify subgroups and shared oncogenic driving mechanisms. Since the 2017 World Health Organization (WHO) classification, additional studies investigating these genomic abnormalities and phenotypic findings have been reported. Here we review these findings in DLBCL and address the proposed changes by the 2022 International Consensus Classification

Solitary cystic lymph neck node metastasis of occult thyroid papillary carcinoma

The appearance of a solitary lateral cervical cystic mass as the only initial presenting symptom of occult thyroid carcinoma is uncommon. Its presence is often misdiagnosed due to the more frequent branchial cyst in young people. Although oronasopharyngeal squamous cell carcinoma has been reported as the main cause of lymph neck node metastasis, thyroid papillary carcinoma may be responsible for solitary cervical cystic masses as the initial manifestation of the disease. This situation has been rarely reported, although solid masses are much more frequent. In most of these cases all such lesions may initially be considered as metastatic foci from a primary thyroid lesion. However, an alternative explanation by means of which ectopic thyroid tissue is associated with a branchial cyst has to be considered, especially if no primary tumour is observed in the histological examination of the thyroid gland. We present a rare case of solitary cystic lymph node metastasis of occult papillary carcinoma of the thyroid. We also discuss possible ethiology for thyroid papillary carcinoma in lateral neck cysts

Historiografía, metodología y problemática en el estudio de la frecuentación de las cuevas naturales en época romana entre el Ebro y el Garona

International audienceEl estudio de la frecuentación de cuevas en época histórica ha sido muy poco tratado por la bibliografía. Desde el proyecto de investigación POEM de la Université de Pau et des Pays de l’Adour, llevamos a cabo desde 2014 una investigación sobre este tema, centrándonos en el periodo romano. En el presente artículo presentamos una breve revisión bibliográfica, la metodología, la problemática que conlleva nuestro estudio, y las perspectivas que nos planteamos

Fréquentations des grottes durant l’époque romaine: le cas de la Navarre

El estudio de la ocupación de las cuevas ha copado el interés de los investigadores desde el siglo XIX. Sin embargo, han sido los niveles prehistóricos los que han gozado de un mayor protagonismo, dejando en un segundo plano los vestigios postpaleolíticos. Si bien en los últimos años se está aumentando el número de publicaciones sobre la frecuentación de las cuevas en época romana y medieval, en Navarra es un tema muy poco estudiado. Es por ello que el siguiente artículo pretende cubrir, al menos en parte, ese vacío historiográfico. Así, en este texto, presentamos una primera aproximación al estudio de la frecuentación de las cuevas en época romana en Navarra.The study of the caves occupation has cornered the interest of the researchers since the 19th century. Nevertheless, their prehistoric levels are which have been the biggest interest, leaving in a background the post‐Paleolithic vestiges. Although, the last years, the number of publications about the frequentness of the caves in roman and medieval epoch has increased. However, in Navarre it is a topic very slightly studied. The following article tries to cover this emptiness of the research. This text is our first approximation to the study about the frequentness of the caves in roman epoch in Navarre.

Evaluación del color en pollo amarillo tipo broiler

En este estudio se han valorado tres estrategias de pigmentación con productos diferentes aportados en el pienso, evaluando el color obtenido en pollos broiler. Los productos utilizados han sido: Dos fuentes de xantofilas amarillas naturales (Capsantal y Colortek)y otra sintética de carotenoides protegidos apo-éster-carotenoico (Carophyll). Se ha valorado el efecto que tiene la edad, el sexo y el tipo de dieta sobre la expresión de color valorado en dos localizaciones del animal: bajo ala y en la zona tarsotibial. Los resultados han concluido que el color varía a lo largo de la crianza, aumentando la deposición de color a medida que los animales crecen. Dicha deposición se realiza de forma diferente para los efectos estudiados. Además, ha habido diferencia de color en función de las diferentes dietas ya que los animales alimentados con xantófilas naturales han expresado un color más anaranjado que los animales alimentados con xantófilas sintéticas. Por contra, los animales que han consumido en su dieta apo-ester, han obtenido un color más amarillo. No obstante, se ha demostrado que el sexo tiene un efecto significativo en la expresión de color, sobre todo en animales jóvenes, debido a la precocidad en su desarrollo por parte de las hembras.<br /

A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples

Multiplexed immunofluorescence provides an unprecedented opportunity for studying specific cell-to-cell and cell microenvironment interactions. We employ graph neural networks to combine features obtained from tissue morphology with measurements of protein expression to profile the tumour microenvironment associated with different tumour stages. Our framework presents a new approach to analysing and processing these complex multi-dimensional datasets that overcomes some of the key challenges in analysing these data and opens up the opportunity to abstract biologically meaningful interactions

The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing

Plasmacytic differentiation may occur in almost all small B cell lymphomas (SBLs), although it varies from being uniformly present (as in lymphoplasmacytic lymphoma (LPL)) to very uncommon (as in mantle cell lymphomas (MCLs)). The discovery of MYD88 L265P mutations in the vast majority of LPLs has had a major impact on the study of these lymphomas. Review of the cases contributed to the 2014 European Association for Haematopathology/Society for Hematopathology slide workshop illustrated how mutational testing has helped refine the diagnostic criteria for LPL, emphasizing the importance of identifying a clonal monotonous lymphoplasmacytic population and highlighting how LPL can still be diagnosed with extensive nodal architectural effacement, very subtle plasmacytic differentiation, follicular colonization, or uncommon phenotypes such as CD5 or CD10 expression. MYD88 L265P mutations were found in 11/11 LPL cases versus only 2 of 28 other SBLs included in its differential diagnosis. Mutational testing also helped to exclude other cases that would have been considered LPL in the past. The workshop also highlighted how plasmacytic differentiation can occur in chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, SOX11 negative MCL, and particularly in marginal zone lymphomas, all of which can cause diagnostic confusion with LPL. The cases also highlighted the difficulty in distinguishing lymphomas with marked plasmacytic differentiation from plasma cell neoplasms. Some SBLs with plasmacytic differentiation can be associated with amyloid, other immunoglobulin deposition, or crystal-storing histiocytosis, which may obscure the underlying neoplasm. Finally, although generally indolent, LPL may transform, with the workshop cases suggesting a role for TP53 abnormalities

Posibilidades educadoras de familias jornaleras agrícolas migrantes en México ante las condiciones de la pandemia del SARS-CoV-2

The objective of this paper is to show some of the conditions that will make possible or complicate the access to the right to education, as well as the permanence of school for migrant farm-worker families in the times of SARS-CoV-2, considering that a large part of the learning process relies on the families themselves. It is analyzed from the school culture and school grammar, considering the characteristics of the school for these families and the possibilities they have for respond to the conditions derived from the "Learn at home" Mexican program. A qualitative study of descriptive scope was carried out, with interviews with men and women of these families, in relation to the knowledge they have about the pandemic, about the conditions to make the necessary care to avoid contagion possible as well as schooling for girls and boys. Information about families from previous research was considered. It was found that some have access to information and that those assume the responsibility of care according to their material possibilities; and that from what they know, there are few possibilities for schooling at this time, it is concluded with the need to generate collective strategies and seek the support of businessmen, civil society and educational authorities.Este texto tiene por objetivo mostrar algunas de las condiciones que facilitan o complican el acceso al derecho a la educación, así como la permanencia de la escuela para familias jornaleras agrícolas migrantes en los tiempos del SARS-CoV- 2, considerando que gran parte del proceso de aprendizaje recae sobre las propias familias. Se realiza un análisis desde la cultura y la gramática escolar, contemplando las características de la escuela para estas familias y las posibilidades que tienen de responder a las condiciones derivadas del programa oficial mexicano “Aprende en casa”. Se realizó un estudio cualitativo de alcance descriptivo, con entrevistas a hombres y mujeres de estas familias, con relación al conocimiento que tienen acerca de la pandemia, sobre las condiciones para hacer posible el cuidado necesario para no contagiarse y la escolarización para niñas y niños; se retomó información sobre las características de las familias y sus dinámicas, derivadas de investigaciones anteriores. Se encontró que algunos jornaleros y sus familias tienen acceso a información, que asumen la consigna de cuidado en tanto posibilidades materiales; y que por lo que ellos y ellas conocen, son pocas las posibilidades de escolarización en esta época. Se concluye con la necesidad de generar estrategias colectivas y buscar el apoyo de empresarios, sociedad civil y autoridades educativas