93 research outputs found
Updating the mechanisms of common fragile site instability: how to reconcile the different views?
Common fragile sites (CFSs) are large chromosomal regions long identified by conventional cytogenetics as sequences prone to breakage in cells subjected to replication stress. The interest in CFSs came from their key role in the formation of DNA damage, resulting in chromosomal rearrangements. The instability of CFSs was notably correlated with the appearance of genome instability in precancerous lesions and during tumor progression. Identification of the molecular mechanisms responsible for their instability therefore represents a major challenge. A number of data show that breaks result from mitotic entry before replication completion but the mechanisms responsible for such delayed replication of CFSs and relaxed checkpoint surveillance are still debated. In addition, clues to the molecular events leading to breakage just start to emerge. We present here the results of recent reports addressing these questions
A New Phase of Matter: Quark-Gluon Plasma Beyond the Hagedorn Critical Temperature
I retrace the developments from Hagedorn's concept of a limiting temperature
for hadronic matter to the discovery and characterization of the quark-gluon
plasma as a new state of matter. My recollections begin with the transformation
more than 30 years ago of Hagedorn's original concept into its modern
interpretation as the "critical" temperature separating the hadron gas and
quark-gluon plasma phases of strongly interacting matter. This was followed by
the realization that the QCD phase transformation could be studied
experimentally in high-energy nuclear collisions. I describe here my personal
effort to help develop the strangeness experimental signatures of quark and
gluon deconfinement and recall how the experimental program proceeded soon to
investigate this idea, at first at the SPS, then at RHIC, and finally at LHC.
As it is often the case, the experiment finds more than theory predicts, and I
highlight the discovery of the "perfectly" liquid quark-gluon plasma at RHIC. I
conclude with an outline of future opportunities, especially the search for a
critical point in the QCD phase diagram.Comment: To appear in {\em Melting Hadrons, Boiling Quarks} by Rolf Hagedorn
and Johan Rafelski (editor), Springer Publishers, 2015 (open access
Measurement of the cosmic ray spectrum above eV using inclined events detected with the Pierre Auger Observatory
A measurement of the cosmic-ray spectrum for energies exceeding
eV is presented, which is based on the analysis of showers
with zenith angles greater than detected with the Pierre Auger
Observatory between 1 January 2004 and 31 December 2013. The measured spectrum
confirms a flux suppression at the highest energies. Above
eV, the "ankle", the flux can be described by a power law with
index followed by
a smooth suppression region. For the energy () at which the
spectral flux has fallen to one-half of its extrapolated value in the absence
of suppression, we find
eV.Comment: Replaced with published version. Added journal reference and DO
Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory
The Auger Engineering Radio Array (AERA) is part of the Pierre Auger
Observatory and is used to detect the radio emission of cosmic-ray air showers.
These observations are compared to the data of the surface detector stations of
the Observatory, which provide well-calibrated information on the cosmic-ray
energies and arrival directions. The response of the radio stations in the 30
to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of
the incoming electric field. For the latter, the energy deposit per area is
determined from the radio pulses at each observer position and is interpolated
using a two-dimensional function that takes into account signal asymmetries due
to interference between the geomagnetic and charge-excess emission components.
The spatial integral over the signal distribution gives a direct measurement of
the energy transferred from the primary cosmic ray into radio emission in the
AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air
shower arriving perpendicularly to the geomagnetic field. This radiation energy
-- corrected for geometrical effects -- is used as a cosmic-ray energy
estimator. Performing an absolute energy calibration against the
surface-detector information, we observe that this radio-energy estimator
scales quadratically with the cosmic-ray energy as expected for coherent
emission. We find an energy resolution of the radio reconstruction of 22% for
the data set and 17% for a high-quality subset containing only events with at
least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO
Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy
We measure the energy emitted by extensive air showers in the form of radio
emission in the frequency range from 30 to 80 MHz. Exploiting the accurate
energy scale of the Pierre Auger Observatory, we obtain a radiation energy of
15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV
arriving perpendicularly to a geomagnetic field of 0.24 G, scaling
quadratically with the cosmic-ray energy. A comparison with predictions from
state-of-the-art first-principle calculations shows agreement with our
measurement. The radiation energy provides direct access to the calorimetric
energy in the electromagnetic cascade of extensive air showers. Comparison with
our result thus allows the direct calibration of any cosmic-ray radio detector
against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI.
Supplemental material in the ancillary file
Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers
BACKGROUND: Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS: To assess the frequencies and clinical impact of amplifications, we analyzed 547 invasive breast tumors organized in a tissue microarray (TMA) by fluorescence in situ hybridization (FISH) and calculated correlations with histoclinical features and prognosis. BAC probes were designed for: (i) two 8p12 subregions centered on RAB11FIP1 and FGFR1 loci, respectively; (ii) 11q13 region centered on CCND1; (iii) 12p13 region spanning NOL1; and (iv) three 20q13 subregions centered on MYBL2, ZNF217 and AURKA, respectively. Regions 8q24 and 17q12 were analyzed with MYC and ERBB2 commercial probes, respectively. RESULTS: We observed amplification of 8p12 (amplified at RAB11FIP1 and/or FGFR1) in 22.8%, 8q24 in 6.1%, 11q13 in 19.6%, 12p13 in 4.1%, 17q12 in 9.9%, 20q13(Z )(amplified at ZNF217 only) in 9.9%, and 20q13(Co )(co-amplification of two or three 20q13 loci) in 8.5% of cases. The 8q24, 12p13, and 17q12 amplifications were correlated with high grade. The most frequent single amplifications were 8p12 (9.8%), 8q24 (3.3%) and 12p13 (3.3%), 20q13(Z )and 20q13(Co )(1.6%) regions. The 17q12 and 11q13 regions were never found amplified alone. The most frequent co-amplification was 8p12/11q13. Amplifications of 8p12 and 17q12 were associated with poor outcome. Amplification of 12p13 was associated with basal molecular subtype. CONCLUSION: Our results establish the frequencies, prognostic impacts and subtype associations of various amplifications and co-amplifications in breast cancers
Au-delà de la souveraineté du regard: l'épreuve du paysage chez Jane Urquhart
International audienc
La tradition du lieu : (in)hospitalités dans Galore (2010) de Michael Crummey
International audienceIn Michael Crummey’s Galore, whose narrative is driven by the arrivals of newcomers into a Newfoundland coastal community, the interplay between hospitality and hostility offers a lens through which the author’s concern with “the lore of the place” can be productively studied. Drawing on the contemporary reassessment of the notion of place, this paper examines how the novel’s representation of (in)hospitality evinces a critical engagement with the attachment to continuity, the search for origins and the need for emplacement, which ultimately disengages the text from discourses of autochthony
Anne-Florence Quaireau, Le Féminin en partage : Le voyage d’Anna Jameson au Canada (1836-1837)
Autrice prolifique et populaire de son vivant, figure tutélaire pour les premières féministes britanniques, proche d’Elisabeth Gaskell, de Harriet Martineau et du couple Browning, Anna Jameson est tombée dans un oubli relatif dans le domaine des études littéraires – britanniques, se doit-on de préciser, car au Canada, elle figure en bonne place dans les études sur la littérature coloniale. C’est sur ce constat que s’ouvre l’ouvrage qu’Anne-Florence Quaireau consacre au voyage canadien d’Anna..
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