EXISTE UMA SOCIOLOGIA DO CORPO NO BRASIL?

This paper aims to identify the possible institution of a Sociology of the Body in Brazil. The body is understood as a social construct, as a phenomenon that exists within, and through, the social sphere, producing sense and meaning through socially located and manifest forms of embodiment. From a survey of Brazilian Social Science (specifically Sociology and Anthropology) and Physical Education papers, we identified sufficient research output to suggest the incipient nature of the Sociology of the Body in Brazil.El objetivo de este artículo es identificar la posible existencía de una sociología del cuerpo en Brasil. El cuerpo es entendido como una construcción social – como fenómeno que existe dentro y a través del social – produciendo sentidos y significados ubicados socialmente y que se manifestan en y a través de la corporeidad. A partir de uma revisión de la literatura en periódicos brasileños de los campos de conocimiento de las ciências sociales (específicamente sociología y antropología) y de la educación física, fueron identificados resultados que presentan el caracter incipiente de la sociologia del cuerpo en Brasil.O objetivo deste artigo é identificar a possível constituição de uma sociologia do corpo no Brasil. O corpo é entendido como uma construção social – como um fenômeno que existe dentro e através da esfera social – produzindo sentidos e significados localizados socialmente e manifestados na e pela corporeidade. A partir de uma pesquisa bibliográfica nos campos de conhecimento brasileiros das ciências sociais (especificamente sociologia e antropologia) e educação física, identificou-se resultados da investigação suficientes para sugerir o caráter incipiente da sociologia do corpo no Brasil

Negative MR4·0 chronic myeloid leukaemia and its possible implications for treatment-free remission

© 2019 British Society for Haematology and John Wiley & Sons Ltd.ABL1 tyrosine kinase inhibitors (TKI) have dramatically improved the outcome for chronic myeloid leukaemia (CML) patients, resulting in a life expectancy that approaches that of the general population. Nevertheless, lifelong TKI therapy may have consequences, including chronic adverse events that can substantially impact patients’ quality of life, adherence to therapy and treatment success. Recently, several clinical discontinuation trials have demonstrated that 40–60% of chronic phase CML patients (CP-CML) who have achieved a stable deep molecular response (DMR) can stop therapy without relapsing (Breccia & Foà, 2018). Laboratory recommendations for scoring DMR were previously defined as MR4·0 [either detectable disease ⩽0·01% BCR-ABLIS (MR4·0 positive) or undetectable disease in cDNA with 10 000–31 999 ABL1 transcripts or 24 000–76 999 GUSB transcripts (MR4·0 negative)], MR4·5 [either detectable disease ⩽0·0032% BCR-ABLIS (MR4·5 positive) or undetectable disease in cDNA with 32 000–99 999 ABL1 transcripts or 77 000–239 999 GUSB transcripts (MR4·5 negative)], and MR5·0 [either detectable disease ⩽0·001% BCR-ABLIS (MR5·0 positive) or undetectable disease in cDNA with ⩾100 000 ABL1 transcripts or ⩾240 000 GUSB transcripts (MR5·0 negative)] (Cross et al, 2015).info:eu-repo/semantics/publishedVersio

Effect of polysaccharide sources on the physicochemical properties of bromelainchitosan nanoparticles

Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of different chitosan sources was evaluated. Chitosan types (i.e., low molecular weight chitosan, chitosan oligosaccharide lactate, and chitosan from shrimp shells) produced nanoparticles with different physicochemical properties, however in all cases, particle size and zeta potential decreased, and polydispersity index increased after bromelain addition. Bromelain encapsulation was higher than 84% and 79% for protein content and enzymatic activity, respectively, with low molecular weight chitosan presenting the highest encapsulation efficiency. Nanoparticle suspension was also tested for accelerated stability and rheological behavior. For the chitosan–bromelain nanoparticles, an instability index below 0.3 was recorded and, in general, the loading of bromelain in chitosan nanoparticles decreased the cohesiveness of the final suspension.This research was granted by FAPESP (2016/03444-5,2017/05275-9,and2017/05333-9), CNPq and FAEPEX, and by the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the project reference M-ERA-NET/0004/2015 (PAIRED) Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersio