Election proximity and representation focus in party-constrained environments

Do elected representatives have a time-constant representation focus or do they adapt their focus depending on election proximity? In this article, we examine these overlooked theoretical and empirical puzzles by looking at how reelection-seeking actors adapt their legislative behavior according to the electoral cycle. In parliamentary democracies, representatives need to serve two competing principals: their party and their district. Our analysis hinges on how representatives make a strategic use of parliamentary written questions in a highly party-constrained institutional context to heighten their reselection and reelection prospects. Using an original data set of over 32,000 parliamentary questions tabled by Portuguese representatives from 2005 to 2015, we examine how time interacts with two key explanatory elements: electoral vulnerability and party size. Results show that representation focus is not static over time and, in addition, that electoral vulnerability and party size shape strategic use of parliamentary questions

The effects of the nitrofuran furaltadone on Ulva lactuca

The use of pharmaceuticals in the food production industry as prophylatic and therapeutic agents is necessary to promote animal health, but may entail significant consequences to natural ecosystems, especially in the cases of overdosing and use of banned pharmaceuticals. The vast effects that antibiotics released into the environment have on non-target organisms are already under the scope of researchers but little attention has been given to primary producers such as macroalgae. The present study assessed furaltadone's, an antibacterial agent illegally used for veterinary purposes, uptake capacity by Ulva lactuca and its effect in the growth of this cosmopolitan macroalgae. Differences in macroalgal growth were shown when submitted to prophylactic and therapeutic concentrations of furaltadone in the water (16 and 32 μg mL⁻¹, respectively). The therapeutic concentration caused higher growth impairment than the prophylactic treatment did, with 87.5% and 58% reductions respectively. Furthermore, together with data collected from the accumulation assays, with values of internal concentrations as high as 18.84 μg g⁻¹ WW, suggest that the macroalgae U. lactuca should be included in field surveys as a biomonitor for the detection of nitrofurans.publishe

Oxytetracycline accumulation in the macroalgae Ulva: Potential risks for IMTA systems

Oxytetracycline (OTC) is one of the most used antibiotics in aquaculture. With the development of Integrated Multitrophic Aquaculture (IMTA) systems in order to mitigate some aquacultures' adverse effects, attention needs to be shifted to other co-cultured species that can also accumulate such pharmaceuticals and pose a risk to human consumption. Therefore, the present work evaluated the exposure of the seaweed Ulva to OTC at two realistic concentrations (0.040 and 0.120 mg L1 ). Oxytetracycline degradation rates in seawater were dependent on the initial concentration but were not influenced by the presence of Ulva. The macroalgae presented good assimilation rates of OTC, with internal concentrations reaching 40.9934 ng g1 WW for the lowest concentration tested and 108.6787 ng g1 WW for the highest, with a steep decrease after 48 and 24 h, respectively. Nonetheless, concentrations were still half of the Maximum Residue Limit set for fish (100 mg kg1) 48 h after C2 treatment. The highest dosage tested stimulated growth 96 h after the beginning of the trial, although some signs of decay could also be found in Ulva's fronds.info:eu-repo/semantics/publishedVersio

The added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study

Background Medication-overuse headache (MOH) is a chronic disabling condition associated with a high rate of relapse. Methods We evaluated whether the adoption of electronic-assisted monitoring, advice and communication would improve the outcome over a follow-up of 6 months in a controlled, multicentre, multinational study conducted in six headache centres located in Europe and Latin America. A total of 663 MOH subjects were enrolled and divided into two groups: the Comoestas group was monitored with an electronic diary associated with an alert system and a facilitated communication option, and the Classic group with a paper headache diary. Results We observed a significantly higher percentage of overuse-free subjects in the Comoestas group compared with the Classic group: 73.1 vs 64.1% (odds ratio 1.45, 95% confidence interval 1.07-2.09, p = 0.046). The Comoestas group performed better also regarding the number of days/month with intake of acute drugs and the level of disability [Migraine Disability Assessment Score: Comoestas group - 42.5 ± 53.6 (35.5-49.3) and Classic group - 27.5 ± 56.1 (20.6-34.3) ( p < 0.003)]. Conclusion The adoption of the electronic tool improved the outcome of patients suffering from MOH after withdrawal from overused drugs. Information and communication technology represents a valid aid for optimizing the management of chronic conditions at risk of worsening or of relapsing. Trial registration The trial was registered at ClinicalTrials.gov (no. NCT02435056)

Supplementary material Consensus protocol - Supplemental material for The added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study

<p>Supplemental material, Supplementary material Consensus protocol for The added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study by Cristina Tassorelli, Rigmor Jensen, Marta Allena, Roberto De Icco, Zaza Katsarava, J Miguel Lainez, Jorge A Leston, Ricardo Fadic, Santiago Spadafora, Marco Pagani and Giuseppe Nappi; the COMOESTAS Consortium in Cephalalgia</p

Perante a Pneumônica: a epidemia e as respostas das autoridades de saúde pública e dos agentes políticos em Portugal (1918-1919) Tackling the Flu: the epidemic and the responses from the public health officers and the political agents in Portugal (1918-1919)

A epidemia de gripe pneumónica ocorreu em Portugal num momento em que o país que enfrentava enormes dificuldades de natureza económica, política e sanitária. Chega a um país rural e pobre, envolvido na Grande Guerra de 1914-18, e que se debate com a carência de géneros e a carestia de vida, e com uma fortíssima crise social e política. Apesar de o país estar habituado a sucessivas epidemias, o carácter imprevisto e violento da pneumónica (estima-se que tenha provocado quase 140 mil mortos num país com cerca de 6 milhões de habitantes) fez com que a resposta dos agentes políticos e sanitários fosse marcada por factores ligados à conjuntura (crise económica, social e política) e de tipo estrutural (condições higiénicas e sanitárias deficientes, falta de meios em capital económico, de médicos e de medicamentos, impotência do conhecimento médico para debelar a epidemia).<br>The Spanish influenza epidemic occurred in Portugal when this country faced enormous economic, political and sanitary problems. The country was poor, living mainly from agriculture and was involved in the First World War. There were food shortages, a high cost of living, as well as a strong social and political crisis. Although people were used to deal with successive epidemic diseases, the sudden and violent character of the Spanish influenza took everybody by surprise. According to some estimation it killed about 140 thousand in a 6 million person's countryThe answer of the political and sanitary agents was marked by contextual factors (the economic, social and political crisis) as well as by structural ones (very poor hygienic and sanitary conditions, lack of financial resources, of doctors and medicines, impotence of medical knowledge in dealing with the pandemic)