Playing with numbers: Using Top Trumps as an ice-breaker and introduction to quantitative methods

Statistics anxiety has been widely documented among both postgraduate and undergraduate social science students and shown to be an obstacle in engaging students in quantitative methods. This article builds on previous studies that have highlighted the utility of fun and games in productive learning and overcoming anxiety. A personalised version of the game Top Trumps was developed for use with a class of postgraduate sociology students in the UK. This game provides an ideal way for students to inductively learn about basic statistical concepts, such as range and dispersion. The game also creates opportunities to engage students in critical discussion of measurement and social categorisation. The article suggests that the employment of such hands-on learning exercises, especially when used in the first week of a quantitative methods module, can stimulate student interest, ameliorate statistics anxiety and encourage critical discussion, thereby positively impacting learning goals in the rest of the module. The article ends by briefly outlining how to adapt the game for use within an undergraduate module

Relationship between Funding Source and Conclusion among Nutrition-Related Scientific Articles

BACKGROUND: Industrial support of biomedical research may bias scientific conclusions, as demonstrated by recent analyses of pharmaceutical studies. However, this issue has not been systematically examined in the area of nutrition research. The purpose of this study is to characterize financial sponsorship of scientific articles addressing the health effects of three commonly consumed beverages, and to determine how sponsorship affects published conclusions. METHODS AND FINDINGS: Medline searches of worldwide literature were used to identify three article types (interventional studies, observational studies, and scientific reviews) about soft drinks, juice, and milk published between 1 January, 1999 and 31 December, 2003. Financial sponsorship and article conclusions were classified by independent groups of coinvestigators. The relationship between sponsorship and conclusions was explored by exact tests and regression analyses, controlling for covariates. 206 articles were included in the study, of which 111 declared financial sponsorship. Of these, 22% had all industry funding, 47% had no industry funding, and 32% had mixed funding. Funding source was significantly related to conclusions when considering all article types (p = 0.037). For interventional studies, the proportion with unfavorable conclusions was 0% for all industry funding versus 37% for no industry funding (p = 0.009). The odds ratio of a favorable versus unfavorable conclusion was 7.61 (95% confidence interval 1.27 to 45.73), comparing articles with all industry funding to no industry funding. CONCLUSIONS: Industry funding of nutrition-related scientific articles may bias conclusions in favor of sponsors' products, with potentially significant implications for public health

A real-time assay for monitoring nucleic acid cleavage by quadruplex formation

Direct and straightforward methods to follow nucleic acid cleavage are needed. A spectrophotometric quadruplex formation assay (QFA) was developed, which allows real-time monitoring of site-specific cleavage of nucleic acids. QFA was applied to study both protein and nucleic acid restriction enzymes, and was demonstrated to accurately determine Michaelis–Menten parameters for the cleavage reaction catalyzed by EcoRI. QFA can be used to study the mechanisms of protein–nucleic acid recognition. QFA is also a useful tool for dissecting individual nicking rates of a double-stranded cleavage

Harvesting Icebergs and Space Rocks: Small Scale Resource Extraction Entrepreneurship in Areas Beyond National Jurisdictions

New opportunities for small-scale, but potentially highly profitable, extractive industries either arise or have the potential to grow, both in the Arctic and in outer space. In the Arctic, icebergs which have broken off from Greenland’s glaciers and which have been transported south through the Davis Strait by the water currents are being harvested off the coast of Canada. The perceived purity of the water and the exotic origin make this risky endeavor commercially interesting. Iceberg harvesting has been undertaken for some time and is likely to become more important: along with increased melting of Greenland’s ice sheet and calving into icebergs, also the Arctic sea ice is melting rapidly due to climate change. Icebergs are an attraction in cruise tourism, too, but also pose threats particularly in the uninhabited sea routes where rescue preparedness is low and distances to help are long. Also Arcticrelated products and services are gaining the attention of consumers and investors from outside the region, in particular when high-priced luxury items and services are concerned. It therefore seems a fair assumption that iceberg harvesting off the coast of Canada is likely to remain relevant for the foreseeable future. Meanwhile, outer space is becoming the latest frontier for extractive industries, not only for the minerals and metals found on celestial bodies but also regarding water and materials which will be needed to give human activities there some degree of permanence

Downsizing food: A systematic review and meta-analysis examining the effect of reducing served food portion sizes on daily energy intake and body weight

Portion sizes of many foods have increased over time. However, the size of effect that reducing food portion sizes has on daily energy intake and body weight is less clear. We used systematic review methodology to identify eligible articles that used an experimental design to manipulate portion size served to human participants and measured energy intake for a minimum of one day. Searches were conducted in September 2020 and again in October 2021. Fourteen eligible studies contributing 85 effects were included in the primary meta-analysis. There was a moderate-to-large reduction in daily energy intake when comparing smaller vs. larger portions (SMD = -.709 [95% CI: -.956 to -.461], 1/4235kcal). Larger reductions to portion size resulted in larger decreases in daily energy intake. There was evidence of a curvilinear relationship between portion size and daily energy intake; reductions to daily energy intake were markedly smaller when reducing portion size from very large portions. In a subset of studies that measured body weight (4 studies contributing 5 comparisons), being served smaller vs. larger portions was associated with less weight gain (0.58kg). Reducing food portion sizes may be an effective population level strategy to prevent weight gain

Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.

Study objectivesCurrent evidence in adults suggests that, independent of obesity, obstructive sleep apnea (OSA) can lead to autonomic dysfunction and impaired glucose metabolism, but these relationships are less clear in children. The purpose of this study was to investigate the associations among OSA, glucose metabolism, and daytime autonomic function in obese pediatric subjects.MethodsTwenty-three obese boys participated in: overnight polysomnography; a frequently sampled intravenous glucose tolerance test; and recordings of spontaneous cardiorespiratory data in both the supine (baseline) and standing (sympathetic stimulus) postures.ResultsBaseline systolic blood pressure and reactivity of low-frequency heart rate variability to postural stress correlated with insulin resistance, increased fasting glucose, and reduced beta-cell function, but not OSA severity. Baroreflex sensitivity reactivity was reduced with sleep fragmentation, but only for subjects with low insulin sensitivity and/or low first-phase insulin response to glucose.ConclusionsThese findings suggest that vascular sympathetic activity impairment is more strongly affected by metabolic dysfunction than by OSA severity, while blunted vagal autonomic function associated with sleep fragmentation in OSA is enhanced when metabolic dysfunction is also present

Calorie reformulation: a systematic review and meta-analysis examining the effect of manipulating food energy density on daily energy intake

Background: Dietary energy density is thought to be a contributor to obesity, but the extent to which different magnitudes and types of reductions to food energy density decreases daily energy intake is unclear. The primary objective was to systematically review and meta-analyse experimental studies that have examined the effect that manipulating energy density of food has on total daily energy intake. Secondary objectives were to examine moderators of the effect that altering energy density has on daily energy intake and effects on body weight. Methods: A systematic review and multi-level meta-analysis of studies on human participants that used an experimental design to manipulate the energy density of foods served and measured energy intake for a minimum of 1 day. Results: Thirty-one eligible studies sampling both children (n = 4) and adults (n = 27) contributed 90 effects comparing the effect of higher vs. lower energy density of served food on daily energy intake to the primary meta-analysis. Lower energy density of food was associated with a large decrease in daily energy intake (SMD = − 1.002 [95% CI: − 0.745 to − 1.266]). Findings were consistent across studies that did vs. did not manipulate macronutrient content to vary energy density. The relation between decreasing energy density and daily energy intake tended to be strong and linear, whereby compensation for decreases to energy density of foods (i.e. by eating more at other meals) was minimal. Meta-analysis of (n = 5) studies indicated that serving lower energy dense food tended to be associated with greater weight loss than serving higher energy dense food, but this difference was not significant (− 0.7 kg difference in weight change, 95% CIs: − 1.34, 0.04). Conclusions: Decreasing the energy density of food can substantially reduce daily energy intake and may therefore be an effective public health approach to reducing population level energy intake. Trial registration: Registered on PROSPERO (CRD42020223973)

Strong Lensing Analysis of A1689 from Deep Advanced Camera Images

We analyse deep multi-colour Advanced Camera images of the largest known gravitational lens, A1689. Radial and tangential arcs delineate the critical curves in unprecedented detail and many small counter-images are found near the center of mass. We construct a flexible light deflection field to predict the appearance and positions of counter-images. The model is refined as new counter-images are identified and incorporated to improve the model, yielding a total of 106 images of 30 multiply lensed background galaxies, spanning a wide redshift range, 1.0$<$z$<$5.5. The resulting mass map is more circular in projection than the clumpy distribution of cluster galaxies and the light is more concentrated than the mass within $r<50kpc/h$. The projected mass profile flattens steadily towards the center with a shallow mean slope of $d\log\Sigma/d\log r \simeq -0.55\pm0.1$, over the observed range, r$<250kpc/h$, matching well an NFW profile, but with a relatively high concentration, $C_{vir}=8.2^{+2.1}_{-1.8}$. A softened isothermal profile ($r_{core}=20\pm2$\arcs) is not conclusively excluded, illustrating that lensing constrains only projected quantities. Regarding cosmology, we clearly detect the purely geometric increase of bend-angles with redshift. The dependence on the cosmological parameters is weak due to the proximity of A1689, $z=0.18$, constraining the locus, $\Omega_M+\Omega_{\Lambda} \leq 1.2$. This consistency with standard cosmology provides independent support for our model, because the redshift information is not required to derive an accurate mass map. Similarly, the relative fluxes of the multiple images are reproduced well by our best fitting lens model.Comment: Accepted by ApJ. For high quality figures see http://wise-obs.tau.ac.il/~kerens/A168