124 research outputs found
A 31T split-pair pulsed magnet for single crystal x-ray diffraction at low temperature
We have developed a pulsed magnet system with panoramic access for
synchrotron x-ray diffraction in magnetic fields up to 31T and at low
temperature down to 1.5 K. The apparatus consists of a split-pair magnet, a
liquid nitrogen bath to cool the pulsed coil, and a helium cryostat allowing
sample temperatures from 1.5 up to 250 K. Using a 1.15MJ mobile generator,
magnetic field pulses of 60 ms length were generated in the magnet, with a rise
time of 16.5 ms and a repetition rate of 2 pulses/hour at 31 T. The setup was
validated for single crystal diffraction on the ESRF beamline ID06
Simultaneous dynamic electrical and structural measurements of functional materials
A new materials characterization system developed at the XMaS beamline, located at the European Synchrotron Radiation Facility in France, is presented. We show that this new capability allows to measure the atomic structural evolution (crystallography) of piezoelectric materials whilst simultaneously measuring the overall strain characteristics and electrical response to dynamically (ac) applied external stimuli
Direct constraint on the distance of y2 Velorum from AMBER/VLTI observations
In this work, we present the first AMBER observations, of the Wolf-Rayet and
O (WR+O) star binary system y2 Velorum. The AMBER instrument was used with the
telescopes UT2, UT3, and UT4 on baselines ranging from 46m to 85m. It delivered
spectrally dispersed visibilities, as well as differential and closure phases,
with a resolution R = 1500 in the spectral band 1.95-2.17 micron. We interpret
these data in the context of a binary system with unresolved components,
neglecting in a first approximation the wind-wind collision zone flux
contribution. We show that the AMBER observables result primarily from the
contribution of the individual components of the WR+O binary system. We discuss
several interpretations of the residuals, and speculate on the detection of an
additional continuum component, originating from the free-free emission
associated with the wind-wind collision zone (WWCZ), and contributing at most
to the observed K-band flux at the 5% level. The expected absolute separation
and position angle at the time of observations were 5.1±0.9mas and
66±15° respectively. However, we infer a separation of
3.62+0.11-0.30 mas and a position angle of 73+9-11°. Our analysis thus
implies that the binary system lies at a distance of 368+38-13 pc, in agreement
with recent spectrophotometric estimates, but significantly larger than the
Hipparcos value of 258+41-31 pc
Near-Infrared interferometry of Eta Carinae with high spatial and spectral resolution using the VLTI and the AMBER instrument
We present the first NIR spectro-interferometry of the LBV Eta Carinae. The K
band observations were performed with the AMBER instrument of the ESO Very
Large Telescope Interferometer using three 8.2m Unit Telescopes with baselines
from 42 to 89m. The aim of this work is to study the wavelength dependence of
Eta Car's optically thick wind region with a high spatial resolution of 5 mas
(11 AU) and high spectral resolution. The medium spectral resolution
observations (R=1,500) were performed in the wavelength range around both the
HeI 2.059 micron and the Br gamma 2.166 micron emission lines, the high
spectral resolution observations (R=12,000) only in the Br gamma line region.
In the K-band continuum, a diameter of 4.0 +/-0.2 mas (Gaussian FWHM, fit range
28-89m) was measured for Eta Car's optically thick wind region. If we fit
Hillier et al. (2001) model visibilities to the observed AMBER visibilities, we
obtain 50 % encircled-energy diameters of 4.2, 6.5 and 9.6mas in the 2.17
micron continuum, the HeI, and the Br gamma emission lines, respectively. In
the continuum near the Br gamma line, an elongation along a position angle of
120+/-15 degrees was found, consistent with previous VLTI/VINCI measurements by
van Boekel et al. (2003). We compare the measured visibilities with predictions
of the radiative transfer model of Hillier et al. (2001), finding good
agreement. Furthermore, we discuss the detectability of the hypothetical hot
binary companion. For the interpretation of the non-zero differential and
closure phases measured within the Br gamma line, we present a simple geometric
model of an inclined, latitude-dependent wind zone. Our observations support
theoretical models of anisotropic winds from fast-rotating, luminous hot stars
with enhanced high-velocity mass loss near the polar regions.Comment: 22 pages, 14 figures, 2 tables; A&A in pres
Fyn Mediates Leptin Actions in the Thymus of Rodents
BACKGROUND:Several effects of leptin in the immune system rely on its capacity to modulate cytokine expression and apoptosis in the thymus. Surprisingly, some of these effects are dependent on signal transduction through the IRS1/PI3-kinase, but not on the activation of JAK2. Since all the well known effects of leptin in different cell types and tissues seem to be dependent on JAK2 activation, we hypothesized that, at least for the control of thymic function, another, unknown kinase could mediate the transduction of the leptin signal from the ObR towards the IRS1/PI3-kinase signaling cascade. METHODOLOGY/PRINCIPAL FINDINGS:Here, by employing immunoblot, real-time PCR and flow citometry we show that the tyrosine kinase, Fyn, is constitutively associated with the ObR in thymic cells. Following a leptin stimulus, Fyn undergoes an activating tyrosine phosphorylation and a transient association with IRS1. All these effects are independent of JAK2 activation and, upon Fyn inhibition, the signal transduction towards IRS1/PI3-kinase is abolished. In addition, the inhibition of Fyn significantly modifies the effects of leptin on thymic cytokine expression. CONCLUSION/SIGNIFICANCE:Therefore, in the thymus, Fyn acts as a tyrosine kinase that transduces the leptin signal independently of JAK2 activation, and mediates some of the immunomodulatory effects of leptin in this tissue
Constraining the wind launching region in Herbig Ae stars: AMBER/VLTI spectroscopy of HD 104237
This is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.Aims. We investigate the origin of the Brγ emission of the Herbig Ae star HD 104237 on Astronomical Unit (AU) scales.
Methods. Using AMBER/VLTI at a spectral resolution R = 1500 we spatially resolve the emission in both the Brγ line and the adjacent continuum.
Results. The visibility does not vary between the continuum and the Brγ line, even though the line is strongly detected in the spectrum, with a peak
intensity 35% above the continuum. This demonstrates that the line and continuum emission have similar size scales. We assume that the K-band
continuum excess originates in a “puffed-up” inner rim of the circumstellar disk, and discuss the likely origin of Brγ.
Conclusions. We conclude that this emission most likely arises from a compact disk wind, launched from a region 0.2–0.5 AU from the star, with
a spatial extent similar to that of the near infrared continuum emission region, i.e., very close to the inner rim location.This work has been partly supported by the
MIUR COFIN grant 2003/027003-001 and 025227/2004 to the INAFOsservatorio
Astrofisico di Arcetri. This project has benefited from
funding from the French Centre National de la Recherche Scientifique
(CNRS) through the Institut National des Sciences de l’Univers
(INSU) and its Programmes Nationaux (ASHRA, PNPS). The authors
from the French laboratories would like to thank the successive
directors of the INSU/CNRS directors. C. Gil work was supported
in part by the Fundac¸˜ao para a Ciˆencia e a Tecnologia through
project POCTI/CTE-AST/55691/2004 from POCTI,with funds from
the European program FEDER
Interferometric data reduction with AMBER/VLTI. Principle, estimators, and illustration
This is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.Aims. In this paper, we present an innovative data reduction method for single-mode interferometry. It has been specifically developed for the
AMBER instrument, the three-beam combiner of the Very Large Telescope Interferometer, but it can be derived for any single-mode interferometer.
Methods. The algorithm is based on a direct modelling of the fringes in the detector plane. As such, it requires a preliminary calibration of the
instrument in order to obtain the calibration matrix that builds the linear relationship between the interferogram and the interferometric observable,
which is the complex visibility. Once the calibration procedure has been performed, the signal processing appears to be a classical least-square
determination of a linear inverse problem. From the estimated complex visibility, we derive the squared visibility, the closure phase, and the
spectral differential phase.
Results. The data reduction procedures have been gathered into the so-called amdlib software, now available for the community, and are presented
in this paper. Furthermore, each step in this original algorithm is illustrated and discussed from various on-sky observations conducted with the
VLTI, with a focus on the control of the data quality and the effective execution of the data reduction procedures. We point out the present limited
performances of the instrument due to VLTI instrumental vibrations which are difficult to calibrate.The AMBER project4 was founded by the French Centre
National de la Recherche Scientifique (CNRS), the Max Planck Institute für
Radioastronomie (MPIfR) in Bonn, the Osservatorio Astrofisico di Arcetri
(OAA) in Firenze, the French Region “Provence Alpes Côte D’Azur” and
the European Southern Observatory (ESO). The CNRS funding has been
made through the Institut National des Sciences de l’Univers (INSU) and its
Programmes Nationaux (ASHRA, PNPS, PNP).
The OAA co-authors acknowledge partial support from MIUR grants to the
Arcetri Observatory: A LBT interferometric arm, and analysis of VLTI interferometric
data and From Stars to Planets: accretion, disk evolution and
planet formation and from INAF grants to the Arcetri Observatory Stellar and
Extragalactic Astrophysics with Optical Interferometry. C. Gil work was supported
in part by the Fundação para a Ciência e a Tecnologia through project
POCTI/CTE-AST/55691/2004 from POCTI, with funds from the European program
FEDER
Constraining the wind launching region in Herbig Ae stars: AMBER/VLTI spectroscopy of HD 104237
Astronomy and Astrophysics, 464, pp. 55-58, http://dx.doi.org./10.1051/0004-6361:20065719International audienc
Disk and wind interaction in the young stellar object MWC 297 spatially resolved with AMBER/VLTI
This is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.The young stellar object MWC 297 is an embedded B1.5Ve star exhibiting strong hydrogen emission lines and a strong near-infrared continuum
excess. This object has been observed with the VLT interferometer equipped with the AMBER instrument during its first commissioning run.
AMBER/VLTI is currently the only near infrared interferometer that can observe spectrally dispersed visibilities. MWC 297 has been spatially
resolved in the continuum with a visibility of 0.50+0.08
−0.10 as well as in the Brγ emission line where the visibility decreases to 0.33±0.06. This change
in the visibility with wavelength can be interpreted by the presence of an optically thick disk responsible for the visibility in the continuum and
of a stellar wind traced by the Brγ emission line and whose apparent size is 40% larger. We validate this interpretation by building a model of the
stellar environment that combines a geometrically thin, optically thick accretion disk model consisting of gas and dust, and a latitude-dependent
stellar wind outflowing above the disk surface. The continuum emission and visibilities obtained from this model are fully consistent with the
interferometric AMBER data. They agree also with existing optical, near-infrared spectra and other broad-band near-infrared interferometric
visibilities. We also reproduce the shape of the visibilities in the Brγ line as well as the profile of this line obtained at an higher spectral resolution
with the VLT/ISAAC spectrograph, and those of the Hα and Hβ lines. The disk and wind models yield a consistent inclination of the system of
approximately 20◦. A picture emerges in which MWC 297 is surrounded by an equatorial flat disk that is possibly still accreting and an outflowing
wind that has a much higher velocity in the polar region than at the equator. The AMBER/VLTI unique capability of measuring spectral visibilities
therefore allows us for the first time to compare the apparent geometry of a wind with the disk structure in a young stellar system.The AMBER project4 was founded by the French Centre National de la
Recherche Scientifique (CNRS), the Max Planck Institute für Radioastronomie
(MPIfR) in Bonn, the Osservatorio Astrofisico di Arcetri (OAA) in Firenze,
the French Region "Provence Alpes Côte D’Azur" and the European Southern
Observatory (ESO). The CNRS funding has been made through the Institut
National des Sciences de l’Univers (INSU) and its Programmes Nationaux
(ASHRA, PNPS, PNP).
The OAA co-authors acknowledge partial support from MIUR grants to
the Arcetri Observatory: A LBT interferometric arm, and analysis of VLTI interferometric
data and From Stars to Planets: accretion, disk evolution and
planet formation and from INAF grants to the Arcetri Observatory Stellar and
Extragalactic Astrophysics with Optical Interferometry. C. Gil work was supported
in part by the Fundação para a Ciência e a Tecnologia through project
POCTI/CTE-AST/55691/2004 from POCTI, with funds from the European program
FEDER
Prevalence of anaemia in older persons: systematic review
<p>Abstract</p> <p>Background</p> <p>Ageing populations will impact on healthcare provision, especially since extra years are not necessarily spent in good health. It is important to identify and understand the significance of common medical problems in older people. Anaemia may be one such problem. We report on the prevalence of anaemia in cohorts of elderly people in the general population. The presence of anaemia is associated with a worse prognosis for both morbidity and mortality.</p> <p>Methods</p> <p>Electronic searching and reference lists of published reports were used to identify studies that reported on prevalence of anaemia in cohorts of at least 100 individuals predominantly aged 65 years and over living in developed countries, together with criteria used to define anaemia. Studies of anaemia prevalence in specific disease groups or published before 1980 were excluded. Prevalence data for the entire cohort, for men and women separately and for different age bands were extracted.</p> <p>Results</p> <p>Forty-five studies contributed data. Thirty-four studies (n = 85,409) used WHO criteria to define anaemia. The weighted mean prevalence was 17% (3–50%) overall, and 12% (3–25%) in studies based in the community (27, n = 69,975), 47% (31–50%) in nursing homes (3, n = 1481), and 40% (40–72%) in hospital admissions (4, n = 13,953). Anaemia prevalence increased with age, was slightly higher in men than women, and was higher in black people than white. Most individuals classified as anaemic using WHO criteria were only mildly anaemic.</p> <p>Conclusion</p> <p>Anaemia, as defined by WHO criteria, is common in older people living in the community and particularly common in nursing home residents and hospital admissions. Predicted demographic changes underline the need to understand more about anaemia in older people.</p
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