Fast community structure local uncovering by independent vertex-centred process

This paper addresses the task of community detection and proposes a local approach based on a distributed list building, where each vertex broadcasts basic information that only depends on its degree and that of its neighbours. A decentralised external process then unveils the community structure. The relevance of the proposed method is experimentally shown on both artificial and real data.Comment: 2015 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, Aug 2015, Paris, France. Proceedings of the 2015 IEEE/ACM International Conference on Advances in Social Networks Analysis and Minin

Study of an Abating Aggregation Operator in Many-Valued Logic

International audienceThis paper considers a parametrised aggregation operator, originally introduced in the formal framework of many-valued logic and in the applicative context of information scoring. It studies this operator, outside this applicative context, looking at specific configurations of interest: highlighting the wide range of its instantiations, from the lower to the upper extreme cases; showing some t-norms it can encode, as specific cases; and also how it allows rich and flexible intermediate behaviours

Immunomodulation stimulates the innervation of engineered tooth organ

The sensory innervation of the dental mesenchyme is essential for tooth function and protection. Sensory innervation of the dental pulp is mediated by axons originating from the trigeminal ganglia and is strictly regulated in time. Teeth can develop from cultured re-associations between dissociated dental epithelial and mesenchymal cells from Embryonic Day 14 mouse molars, after implantation under the skin of adult ICR mice. In these conditions however, the innervation of the dental mesenchyme did not occur spontaneously. In order to go further with this question, complementary experimental approaches were designed. Cultured cell re-associations were implanted together with trigeminal ganglia for one or two weeks. Although axonal growth was regularly observed extending from the trigeminal ganglia to all around the forming teeth, the presence of axons in the dental mesenchyme was detected in less than 2.5% of samples after two weeks, demonstrating a specific impairment of their entering the dental mesenchyme. In clinical context, immunosuppressive therapy using cyclosporin A was found to accelerate the innervation of transplanted tissues. Indeed, when cultured cell re-associations and trigeminal ganglia were co-implanted in cyclosporin A-treated ICR mice, nerve fibers were detected in the dental pulp, even reaching odontoblasts after one week. However, cyclosporin A shows multiple effects, including direct ones on nerve growth. To test whether there may be a direct functional relationship between immunomodulation and innervation, cell re-associations and trigeminal ganglia were co-implanted in immunocompromised Nude mice. In these conditions as well, the innervation of the dental mesenchyme was observed already after one week of implantation, but axons reached the odontoblast layer after two weeks only. This study demonstrated that immunodepression per se does stimulate the innervation of the dental mesenchyme

CYP52X1, representing new cytochrome P450 subfamily, displays fatty acid hydroxylase activity and contributes to virulence and growth on insect cuticular substrates in entomopathogenic fungus Beauveria bassiana

Infection of insects by the entomopathogenic fungus Beauveria bassiana proceeds via attachment and penetration of the host cuticle. The outermost epicuticular layer or waxy layer of the insect represents a structure rich in lipids including abundant amounts of hydrocarbons and fatty acids. A member of a novel cytochrome P450 subfamily, CYP52X1, implicated in fatty acid assimilation by B. bassiana was characterized. B. bassiana targeted gene knockouts lacking Bbcyp52x1 displayed reduced virulence when topically applied to Galleria mellonella, but no reduction in virulence was noted when the insect cuticle was bypassed using an intrahemoceol injection assay. No significant growth defects were noted in the mutant as compared with the wild-type parent on any lipids substrates tested including alkanes and fatty acids. Insect epicuticle germination assays, however, showed reduced germination of ΔBbcyp52x1 conidia on grasshopper wings as compared with the wild-type parent. Complementation of the gene-knock with the full-length gene restored virulence and insect epicuticle germination to wild-type levels. Heterologous expression of CYP52X1 in yeast was used to characterize the substrate specificity of the enzyme. CYP52X1 displayed the highest activity against midrange fatty acids (C12:0 and C14:0) and epoxy stearic acid, 4–8-fold lower activity against C16:0, C18:1, and C18:2, and little to no activity against C9:0 and C18:0. Analyses of the products of the C12:0 and C18:1 reactions confirmed NADPH-dependent regioselective addition of a terminal hydroxyl to the substrates (ω-hydroxylase). These data implicate CYP52X1 as contributing to the penetration of the host cuticle via facilitating the assimilation of insect epicuticle lipids.Fil: Zhang, Shizhu. Nanjing Normal University; China. University of Florida; Estados UnidosFil: Widemann, Emilie. Université de Strasbourg; FranciaFil: Bernard, Grausem. Université de Strasbourg; FranciaFil: Lesot, Agnes. Université de Strasbourg; FranciaFil: Pinot, Franck. Université de Strasbourg; FranciaFil: Pedrini, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Keyhani, Nemat O.. University of Florida; Estados Unido

Sparsity-Inducing Fuzzy Subspace Clustering

This paper considers a fuzzy subspace clustering problem and proposes to introduce an original sparsity-inducing regularization term. The minimization of this term, which involves a l$_{0}$ penalty, is considered from a geometric point of view and a novel proximal operator is derived. A subspace clustering algorithm, Prosecco, is proposed to optimize the cost function using both proximal and alternate gradient descent. Experiments comparing this algorithm to the state of the art in sparse fuzzy subspace clustering show the relevance of the proposed approach

Trust Dynamics: A Case-study on Railway Sensors

International audienceSensors constitute information providers which are subject to imperfections and assessing the quality of their outputs, in particular the trust that can be put in them, is a crucial task. Indeed, timely recognising a low-trust sensor output can greatly improve the decision making process at the fusion level, help solving safety issues and avoiding expensive operations such as either unnecessary or delayed maintenance. In this framework, this paper considers the question of trust dynamics, i.e. its temporal evolution with respect to the information flow. The goal is to increase the user understanding of the trust computation model, as well as to give hints about how to refine the model and set its parameters according to specific needs. Considering a trust computation model based on three dimensions, namely reliability, likelihood and credibility, the paper proposes a protocol for the evaluation of the scoring method, in the case when no ground truth is available, using realistic simulated data to analyse the trust evolution at the local level of a single sensor. After a visual and formal analysis, the scoring method is applied to real data at a global level to observe interactions and dependencies among multiple sensors