97 research outputs found
Interpersonal Engagement Mediates the Relation between Maternal Affect and Externalising Behaviour in Young Children with Type 1 Diabetes
Mother-child interactions around a shared activity have been shown to play a key role in the development of young children's capacity to interact cooperatively with others. This evidence is particularly germane to type 1 diabetes (T1D) management in younger children where cooperation with parental treatment efforts is crucial for treatment success and where maternal distress and child behavioural problems are risk factors for treatment management, biomedical and psychological outcomes. In 49 4-to-8 year old children with T1D, we investigated whether the association between maternal affect and child problematic behaviour is mediated by mother-child interactions in the context of a T1D-relevant collaborative problem-solving activity. Mothers completed standardised measures of maternal and child psychological adjustment and interacted with their children in the problem-solving activity, analysed for quality of interpersonal engagement based on evaluations of maternal (sensitivity and cognitive stimulation) and dyadic (joint attention and warmth) behaviours. Mediation analyses confirmed the hypothesis that interpersonal engagement mediates the relation between maternal affective state and child behavioural problems. Specifically, more negative maternal affect is associated with lower levels of interpersonal engagement; these less engaged interactions in turn are associated with more behavioural problems in children. These findings are consistent with research involving typically developing children. The implications of our findings are twofold. First, in the context of psychological adjustment to T1D, maternal affect and mother-child interactions are 2 potential targets for interventions which promote cooperative interactions. Second, understanding and caring for children at biological risk requires attention to developmental psychology theory and method; in particular, research addressing parent-child cooperation carries both conceptual and clinical relevance.div_PaS1. Maccoby E (1992) The role of parents in the socialization of children: An
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Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability
Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized. Human CASPR2 autoantibodies, when injected into mice, were peripherally restricted and resulted in mechanical pain-related hypersensitivity in the absence of neural injury. We therefore investigated the mechanism by which CASPR2 modulates nociceptive function. Mice lacking CASPR2 (Cntnap2 ) demonstrated enhanced pain-related hypersensitivity to noxious mechanical stimuli, heat, and algogens. Both primary afferent excitability and subsequent nociceptive transmission within the dorsal horn were increased in Cntnap2 mice. Either immune or genetic-mediated ablation of CASPR2 enhanced the excitability of DRG neurons in a cell-autonomous fashion through regulation of Kv1 channel expression at the soma membrane. This is the first example of passive transfer of an autoimmune peripheral neuropathic pain disorder and demonstrates that CASPR2 has a key role in regulating cell-intrinsic dorsal root ganglion (DRG) neuron excitability
Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
Despite increasing knowledge on microRNAs, their role in the pathogenesis of neonatal encephalopathy remains to be elucidated. Herein, we identify let-7b-5p as a significant microRNA in neonates with moderate to severe encephalopathy from dried blood spots using next generation sequencing. Validation studies using Reverse Transcription and quantitative Polymerase Chain Reaction on 45 neonates showed that let-7b-5p expression was increased on day 1 in neonates with moderate to severe encephalopathy with unfavourable outcome when compared to those with mild encephalopathy. Mechanistic studies performed on glucose deprived cell cultures and the cerebral cortex of two animal models of perinatal brain injury, namely hypoxic-ischaemic and intrauterine inflammation models confirm that let-7b-5p is associated with the apoptotic Hippo pathway. Significant reduction in neuronal let-7b-5p expression corresponded with activated Hippo pathway, with increased neuronal/nuclear ratio of Yes Associated Protein (YAP) and increased neuronal cleaved caspase-3 expression in both animal models. Similar results were noted for let-7b-5p and YAP expression in glucose-deprived cell cultures. Reduced nuclear YAP with decreased intracellular let-7b-5p correlated with neuronal apoptosis in conditions of metabolic stress. This finding of the Hippo-YAP association with let-7b needs validation in larger cohorts to further our knowledge on let-7b-5p as a biomarker for neonatal encephalopathy
Asymmetric Wolbachia Segregation during Early Brugia malayi Embryogenesis Determines Its Distribution in Adult Host Tissues
Wolbachia are required for filarial nematode survival and
fertility and contribute to the immune responses associated with human filarial
diseases. Here we developed whole-mount immunofluorescence techniques to
characterize Wolbachia somatic and germline transmission
patterns and tissue distribution in Brugia malayi, a nematode
responsible for lymphatic filariasis. In the initial embryonic divisions,
Wolbachia segregate asymmetrically such that they occupy
only a small subset of cells in the developing embryo, facilitating their
concentration in the adult hypodermal chords and female germline.
Wolbachia are not found in male reproductive tissues and
the absence of Wolbachia from embryonic germline precursors in
half of the embryos indicates Wolbachia loss from the male
germline may occur in early embryogenesis. Wolbachia rely on
fusion of hypodermal cells to populate adult chords. Finally, we detect
Wolbachia in the secretory canal lumen suggesting living
worms may release bacteria and/or their products into their host
Maternal Programming of Sexual Behavior and Hypothalamic-Pituitary-Gonadal Function in the Female Rat
Variations in parental care predict the age of puberty, sexual activity in adolescence and the age at first pregnancy in humans. These findings parallel descriptions of maternal effects on phenotypic variation in reproductive function in other species. Despite the prevalence of such reports, little is known about potential biological mechanisms and this especially true for effects on female reproductive development. We examined the hypothesis that parental care might alter hypothalamic-pituitary-ovarian function and thus reproductive function in the female offspring of rat mothers that vary pup licking/grooming (LG) over the first week postpartum. As adults, the female offspring of Low LG mothers showed 1) increased sexual receptivity; 2) increased plasma levels of luteinizing hormone (LH) and progesterone at proestrus; 3) an increased positive-feedback effect of estradiol on both plasma LH levels and gonadotropin releasing-hormone (GnRH) expression in the medial preoptic region; and 4) increased estrogen receptor α (ERα) expression in the anterioventral paraventricular nucleus, a system that regulates GnRH. The results of a cross-fostering study provide evidence for a direct effect of postnatal maternal care as well as a possible prenatal influence. Indeed, we found evidence for increased fetal testosterone levels at embryonic day 20 in the female fetuses of High compared to Low LG mothers. Finally, the female offspring of Low LG mothers showed accelerated puberty compared to those of High LG mothers. These data suggest maternal effects in the rat on the development of neuroendocrine systems that regulate female sexual behaviour. Together with studies revealing a maternal effect on the maternal behavior of the female offspring, these findings suggest that maternal care can program alternative reproductive phenotypes in the rat through regionally-specific effects on ERα expression
Ciliated cells and chaetotaxy of the larvae of seven species of monocotylid monogeneans (Platyhelminthes) from Heron Island, Great Barrier Reef, Australia
On the Morphology and Taxonomy of \u3ci\u3eGriphobilharzia amoena\u3c/i\u3e Platt and Blair, 1991 (Schistosomatoidea), a Dioecious Digenetic Trematode Parasite of the Freshwater Crocodile, \u3ci\u3eCrocodylus johnstoni\u3c/i\u3e, in Australia [Critical Comment]
Griphobilharzia amoena Platt and Blair, 1991 was originally described was originally described as a dioecious trematode, parasitic in the circulatory system of the Australian freshwater crocodile, Crocodylus johnstoni, with the female completely enclosed in a gynecophoric chamber of the male and the two worms orientated anti-parallel to each other. A recent publication questions the original description, arguing that G. amoena is monoecious and, as a consequence, the species was transferred to Vasotrema Stunkard, 1928 (Spirorchiidae) as Vasotrema amoena n. comb. We provide photomicrographic evidence that the original description of G. amoena is correct and that Griphobilharzia Platt and Blair, 1991, is a valid monotypic genus containing G. amoena. An accurate understanding of the anatomy of G. amoena is not trivial and has implications for revealing the complex origins and evolution of the dioecious condition within the Schistosomatoidea
Capsaloides cornutus (Verrill, 1875) Price 1938
Capsaloides cornutus (Verrill, 1875) Price, 1938 (Figs 1 A, 2 A) Synonyms: Tristoma cornutum Verill, 1875; Capsala cornuta (Verrill, 1875) Johnston, 1929; Capsaloides cornutum (Verrill, 1875) Price, 1938. TypeÂhost: Tetrapterus albidus Poey, 1860 (Istiophoridae). TypeÂlocality: Block Island, Rhode Island, USA [Atlantic Ocean]. Additional records: Tetrapterus imperator (Bloch & Schneider, 1801) (Istiophoridae), Woods Hole, Massachusetts, USA [Atlantic Ocean] (see Price 1939). Site: Gills. Specimens examined: Two vouchers (USNPC 35136). Remarks Capsaloides cornutus is the typeÂspecies of the genus. It was poorly described and not illustrated when first proposed by Verrill (1875). Verrill (1885) provided a diagrammatic figure which unfortunately does not assist with identification. Price (1939), who located the typeÂspecimen and 2 other specimens from the same host species in the USNPC, provided a detailed description and illustrations. The haptoral accessory sclerites have a relatively narrow shaft (Fig. 1 A). The margin of the body is sinuous and a single dorsomarginal body sclerite comprising approximately 20 cusps (Fig. 2 A) surmounts each marginal sinuation. The left anterior isolated group of dorsomarginal body sclerites comprises 4–6 sclerites each with approximately 10 cusps. The right anterior isolated group of dorsomarginal body sclerites comprises 3 sclerites each with 7–10 cusps.Published as part of Chisholm, Leslie A. & Whittington, Ian D., 2006, Revision of Capsaloides (Monogenea: Capsalidae) with a redescription of C. magnaspinosus Price, 1939 from the nasal tissue of Tetrapterus audax (Istiophoridae) collected off Nelson Bay, New South Wales, Australia, pp. 1-20 in Zootaxa 1160 on page 4, DOI: 10.5281/zenodo.17230
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