Lead levels in fur of rats treated with inorganic lead measured by inductively coupled argon plasma mass spectrometry

The aim of this study was to investigate the relationship between continuous lead exposure and the concentration of this metal in fur. The two main questions we wanted to answer were: 1) Are the fur lead concentrations different according to exposure level? 2) Is the kinetics of lead concentration linear in different compartments

Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection is heightened. Here, we show that bioengineered, fully synthetic, and robust corneal implants can be manufactured from a collagen analog (collagen-like peptide-polyethylene glycol hybrid, CLP-PEG) and inflammation-suppressing polymeric 2-methacryloyloxyethyl phosphorylcholine (MPC) when stabilized with the triazine-based crosslinker 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The resulting CLP-PEG-MPC implants led to reduced corneal swelling, haze, and neovascularization in comparison to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. Implants incorporating MPC allowed for faster nerve regeneration and recovery of corneal sensation. CLP-PEG-MPC implants appear to be at a more advanced stage of regeneration than the CLP-PEG only implants, as evidenced by the presence of higher amounts of cornea-specific type V collagen, and a corresponding decrease in the presence of extracellular vesicles and exosomes in the corneal stroma, in keeping with the amounts present in healthy, unoperated corneas

Optimisation de la production d'antigènes d'Escherichia coli entérotoxinogènes par fermentation aérobie (application en vue de la production d'un antigène vaccinal)

TOURS-BU Sciences Pharmacie (372612104) / SudocSudocFranceF

Stress assessment in occupational medicine using a visual analogue scale

Les risques psychosociaux prennent une part de plus en plus prégnante en matière de santé au travail. Le médecin du travail doit pouvoir disposer d'outil permettant d'évaluer l'état de santé des salariés. L'évaluation du stress, conséquence et facteur de risque à la fois est un marqueur particulièrement intéressant pour le médecin du travail. Ce travail vise à éclairer l'utilisateur sur les qualités psychométriques de l'échelle visuelle analogique (EVA) dans l'évaluation du stress, dans le cadre de la médecine du travail. Nous avons étudié la stabilité, la fidélité interjuge, la validité concourante, la sensibilité discriminative, mais aussi les facteurs cognitifs pouvant influencer la réponse à l'EVA tels que la présentation de Soi, la revendication, ou la représentation sociale du stress. Nous proposons aussi des modalités d'utilisation et d'interprétation de l'EVA.Psychosocial risk factors are more and more important in the field of occupational health. Occupational physicians must have some useful tools to assess the mental health. Stress assessment may be an interesting marker for the occupational physicians. One way to assess the stress is the visual analogue scale, well known in pain assessment. But what about its psychometric properties? What about the stability, inter judge reliability, fiability, agreement between visual analogue scale and perceived stress scale, discriminative sensitivity? What is the influence of cognitive factors, such as the presentation of self, the claimings, and the social representation of stress? This manuscript is a guideline of stress assessment using a visual analogue scale too

Evaluation de l'état de santé d'artisans et de commerçants

REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Evaluation de l'état de santé des artisans du bois

REIMS-BU Santé (514542104) / SudocSudocFranceF

Pathologie des musiciens instrumentistes à vent

REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

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Introduction. Exposure to passive smoking at work has been forbidden for few years in France. This study's aim is to estimate the prevalence of passive smoking at work (PSW), the characteristics of illegal passive smoking and to identify eventual respiratory effects. Methods. Occupational practitioners (OPs) of a French county of 320,000 wage earners were contacted by mail. Then OP answered questions from a standardized questionnaire. These questions concerned the practised job, exposure features linked to PSW and health effects in relationship with second-hand smoke in workplace, and the focus on nonsmoker encountered by OP during the most recent occupational medical examination. Results. Ninety-five percent of a total group of 172 OP of Champagne county filled the postal questionnaire. More than 80% of OP's replies identified illegal PSW. The average prevalence of PSW exposure was 0.7% of the total working population. Environmental tobacco smoke (ETS) levels were considered between low and medium for most passive smokers (71%). Main features exposure to ETS at work for non-smokers was associated with female gender (69.5%), age between 40 and 49 years (41.2%) and belonging to tertiary sector (75.6%). Environmental tobacco smoke exposures at work was firstly in the office for 49.7% of the subjects and secondly in the restroom for 18% of them. Main medical symptoms encountered by non-smokers were respiratory tractus irritation (81.7%). Eighty-three percent of OPs indicated solution to eradicate PSW. Illegal PSW is really weaker than fifteen years ago. However, the findings support a real ban on smoking in the workplace in order to protect all workers

Insertion professionnelle de salariés atteints d'une pathologie mentale sévère

REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF