East River\u27s Country Cookin\u27 with Doris Leraas, Volume IV

Recipes in this booklet were contributed by the readers. Included are Apple, Asparagus, Fish & Seafood, Pork, Potato and Party Food recipes.https://openprairie.sdstate.edu/sd_cookbooks/1037/thumbnail.jp

East River\u27s Country Cookin\u27 with Doris Leraas, Volume III

Recipes in this booklet were ontributed by the readers. Included are Coffee Cake, Fruit Salad, Ham, Chicken, Vegetables, Bars, Yeast Bread and Barbecue Sauce recipes.https://openprairie.sdstate.edu/sd_cookbooks/1034/thumbnail.jp

Mountain Man : Fact and Fiction

155 leaves. Advisor: Dr. Norman R. HaneThe problem. The purpose of this dissertation is to examine representative factual and fictional accounts of the mountain man, a pioneer to the Rockies in the early and mid-nineteenth century. Certain components are examined and weighed against each other in an attempt to ascertain the authentic image of the mountain man. Procedure. Initially the historical mountain man is examined: his motives, his attitudes, his skills, his habits, his relations with the Indians. Next, the disagreement between William Goetzmann ("The Mountain Man as Jacksonian Man") and Harvey Lewis Carter and Marcia Carpenter Spencer ("Stereotypes of the Mountain Man") -is explored, and each image illustrated by examples from both history and fiction. Finally, through analysis of journals, accounts of travelers to the frontier, novels, poetry, and film, the building of this sometime roughneck into an alltime hero is demonstrated. Extensive study is given to Hugh Glass, one of the first mountain men, and to John Johnston, one of the last. The major sources dealing with Hugh Glass are Pirate, Pawnee and Mountain Man by John Myers Myers, The Song of Hugh Glass by John G. Neihardt, and Lord Grizzly by Frederick Manfred. Those dealing with John Johnston are Crow Killer: The saga of Liver-eating Johnson by Raymond W. Thorp and Robert Bunker, Mountain Man by Vardis Fisher, and Jeremiah Johnson, a film directed by Sydney Pollack. Conclusions. In the brief career of the mountain man (1822-1850) America found a culture hero. He was a loner and a wanderer, symbolizing the frontier spirit and American freedom. His thoroughness in trapping nearly exterminated his prey, the beaver. His expeditions led him deep into the Rocky Mountains where he discovered the mountain passes and river routes that would make possible western emigration. These two conditions signaled the end of his days in the Rockies and showed him to be the unwitting agent of his own demise. He left little written record. One must therefore turn to the journals of company men, accounts of travelers to the western frontier, and later research. Four images occur separately and in combination: the Jacksonian man engaging in economic exploitation of the wilderness, the daring degenerate illustrating the effect of Frederick Jackson Turner's "corrosive influences" of the frontier, the explorer probing the Rockies, and the romantic hero moving away from the corruption of civilization to experience a oneness with Nature. Rather than being a new type in American literature, he is an extension of the frontier hero seen in Davy Crockett and in Cooper's Leatherstocking. His life and habits are refined to suit public taste, and he emerges the romantic hero who is, most of all, free

Gender and Student Participation

Active class participation has been associated with student engagement and can be an important aspect of a successful learning experience in college classrooms. Several factors influence student participation including classroom dynamics (such as classroom connectedness, instructor-student rapport) and individual characteristics (such as biological sex and psychological gender).  With respect to individual characteristics, previous research has evaluated sex differences in participation and has yielded inconsistent findings. The present study investigated the relationship between psychological gender and student participation both in- and out-of-class. Classroom connectedness and professor-student rapport were assessed as possible moderating factors. Results indicated that masculinity and androgyny were associated with more in-class participation while femininity and androgyny were associated with student professor interaction outside of class. While both classroom connectedness and instructor-student rapport were correlated with student participation, there was no evidence of them moderating the relationship between gender and participation. Professor gender type was not associated with student participation. Implications for college classrooms and higher education are discussed

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.

Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)-many of which are refractory to current standard-of-care treatments-from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer

The Integrated Genomic Landscape of Thymic Epithelial Tumors

Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival and World Health Organization histological subtype. We further demonstrate a marked prevalence of a thymoma-specific mutated oncogene, GTF2I, and explore its biological effects on multi-platform analysis. We further observe enrichment of mutations in HRAS, NRAS, and TP53. Last, we identify a molecular link between thymoma and the autoimmune disease myasthenia gravis, characterized by tumoral overexpression of muscle autoantigens, and increased aneuploidy

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin