18 research outputs found
The diseases we cause: Iatrogenic illness in a department of internal medicine
- Author
- Alhalel Gabay
- Alonso Martinez
- Bouhaja
- Brennan
- Cerecedo Cortina Vicente
- de la Sierra
- Diez Jarilla
- Dormann
- Forster
- Fradet
- Gonzales-Martin
- Goute
- Gurwitz
- Husi
- J.J. Alves Moura
- J.M. Pereira de Moura
- João Porto
- Kaushal
- Lagnaoui
- Lakshmanan
- Lazarou
- Leape
- Lee
- Lepori
- M.B. Alexandrino
- McGavock
- Miguel Melo
- Moore
- Munar Ques
- Queneau
- Riedinger
- Roblot
- Rothschild
- Runciman
- Sampereiz Legarre
- Sofia Madeira
- Starfield
- Steel
- Sílvia Monteiro
- Trunet
- Weingart
- Wiffen
- Zamir
- Zhan
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Feasibility of RNA studies on illegitimate transcription for molecular characterization of splicing mutations in the ATP7B gene: a case report.
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Approximately 520 Wilson disease-causing mutations in the ATP7B gene have been described to date. In this study we report DNA and RNA analyses carried out for molecular characterization of a consensus sequence splicing mutation found in homozygosity in a Swiss Wilson disease patient. RNA analysis of 1946 +6 T→C in both the peripheral lymphoblasts and liver resulted in the production in the propositus of only an alternative transcript lacking exons 6, 7, and 8 resulting most likely in alterations of cell biochemistry and disease. The patient presents an early form of severe hepatic disease characterized by hepatosplenomegaly, reduced hepatic function, anemia and thrombocytopenia indicating that 1946 +6 T→C is a severe mutation. Since identical results were obtained from both peripheral lymphoblasts and liver they also suggest that RNA studies of illegitimate transcripts can be safely used for molecular characterization of ATP7B splicing mutations, thus improving genetic counseling and diagnosis of Wilson disease. Moreover these studies, contribute to reveal the exact molecular mechanisms producing Wilson disease
Twenty-four novel mutations in Wilson disease patients of predominantly Italian origin
- Author
- Publication venue
- Publication date
- 01/01/2007
- Field of study
Herein we report the results of mutation analysis of the ATP7B gene in a group of 134 Wilson disease (WD) families (268 chromosomes) prevalently of Italian origin. Using the SSCP and sequencing methods we identified 71 disease-causing mutations. Twenty-four were novel, while 19 more mutations already described, were identified in new populations in this study. A known mutation G591D showed a regional distribution, since it was only detected in 38.5% of the analyzed chromosomes in WD patients originating from Apulia, a region of South Italy. Detection of new mutations in the ATP7B gene increases our capability of molecular analysis that is essential for early diagnosis and treatment of WD
Mutation analysis of the ATP7B gene in a new group of Wilson's disease patients: contribution to diagnosis.
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Wilson's disease (WD), an autosomal recessive disorder of copper transport with a broad range of genotypic and phenotypic characteristics, results from mutations in the ATP7B gene. Herein we report the results of mutation analysis of the ATP7B gene in a group of 118 Wilson disease families (236 chromosomes) prevalently of Italian origin. Using DNA sequencing we identified 83 disease-causing mutations. Eleven were novel, while twenty one already described mutations were identified in new populations in this study. In particular, mutation analysis of 13 families of Romanian origin showed a high prevalence of the p.H1069Q mutation (50%). Detection of new mutations in the ATP7B gene in new populations increases our capability of molecular analysis that is essential for early diagnosis and treatment of WD
Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Euclid. I. Overview of the Euclid mission
- Author
- Acevedo Barroso J.A.
- Achúcarro A
- Adam R
- Adamek J
- Addison G.E
- Aghanim N
- Aguena M
- Ajani V
- Akrami Y
- Al-Bahlawan A
- Alavi A
- Albuquerque I.S
- Alestas G
- Alguero G
- Allaoui A
- Allen S.W
- Allevato V
- Alonso-Tetilla A.V
- Altieri B
- Alvarez-Candal A
- Amara A
- Amendola L
- Amiaux J
- Andika I.T
- Andreon S
- Andrews A
- Angora G
- Angulo R.E
- Annibali F
- Anselmi A
- Anselmi S
- Arcari S
- Archidiacono M
- Aricò G
- Arnaud M
- Arnouts S
- Asgari M
- Asorey J
- Atayde L
- Atek H
- Atrio-Barandela F
- Aubert M
- Aubourg E
- Auphan T
- Auricchio N
- Aussel B
- Aussel H
- Avelino P.P
- Avgoustidis A
- Avila S
- Awan S
- Azzollini R
- Baccigalupi C
- Bachelet E
- Bacon D
- Baes M
- Bagley M.B
- Bahr-Kalus B
- Balaguera-Antolinez A
- Balbinot E
- Balcells M
- Baldi M
- Baldry I
- Balestra A
- Ballardini M
- Ballester O
- Balogh M
- Barbier R
- Bardelli S
- Barreiro T
- Barriere J.-C
- Barros B.J
- Barthelemy A
- Bartolo N
- Basset A
- Battaglia P
- Battisti A.J
- Baugh C.M
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- Bazzanini L
- Bañados E
- Beaulieu J.-P
- Beckmann V
- Bel J
- Belikov A.N
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- Bennett C.L
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- Bhatawdekar R
- Bisigello L
- Biviano A
- Blake R.P
- Blanchard A
- Blazek J
- Blot L
- Bodendorf C
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- Botticella M.T
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- Chaumeil F
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- Ciancetta E
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- Courtois H.M
- Cousinou M.-C
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- Cowell T
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- Cuozzo V
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- Davies J.E
- Davini S
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- de Caro B
- de Jong J.T.A
- de la Bella L.F
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- de Paolis F
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- de Vicente-Albendea J
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- Dreihahn H
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- Sánchez A.G
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- Taylor P.L
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- Viglione C
- Viitanen A
- Villaescusa-Navarro F
- Vinciguerra S
- Visticot F
- Voggel K
- von Wietersheim-Kramsta M
- Vriend W.J
- Wachter S
- Walmsley M
- Walth G
- Walton D.M
- Walton N.A
- Wander M
- Wang L
- Wang Y
- Weaver J.R
- Weller J
- Whalen D.J
- Wiesmann M
- Wilde J
- Williams O.R
- Winther H.-A
- Wittje A
- Wong J.H.W
- Wright A.H
- Yankelevich V
- Yeung H.W
- Youles S
- Yung L.Y.A
- Zacchei A
- Zalesky L
- Zamorani G
- Zamorano Vitorelli A.
- Zanoni Marc M.
- Zennaro M
- Zerbi F.M
- Zinchenko I.A
- Zoubian J
- Zucca E
- Zumalacarregui M
- Publication venue
- HAL CCSD
- Publication date
- 29/05/2024
- Field of study
International audienceThe current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance
Euclid. I. Overview of the Euclid mission
- Author
- Acevedo Barroso J.A.
- Achúcarro A
- Adam R
- Adamek J
- Addison G.E
- Aghanim N
- Aguena M
- Ajani V
- Akrami Y
- Al-Bahlawan A
- Alavi A
- Albuquerque I.S
- Alestas G
- Alguero G
- Allaoui A
- Allen S.W
- Allevato V
- Alonso-Tetilla A.V
- Altieri B
- Alvarez-Candal A
- Amara A
- Amendola L
- Amiaux J
- Andika I.T
- Andreon S
- Andrews A
- Angora G
- Angulo R.E
- Annibali F
- Anselmi A
- Anselmi S
- Arcari S
- Archidiacono M
- Aricò G
- Arnaud M
- Arnouts S
- Asgari M
- Asorey J
- Atayde L
- Atek H
- Atrio-Barandela F
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- Avgoustidis A
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- Taylor P.L
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- Vinciguerra S
- Visticot F
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- von Wietersheim-Kramsta M
- Vriend W.J
- Wachter S
- Walmsley M
- Walth G
- Walton D.M
- Walton N.A
- Wander M
- Wang L
- Wang Y
- Weaver J.R
- Weller J
- Whalen D.J
- Wiesmann M
- Wilde J
- Williams O.R
- Winther H.-A
- Wittje A
- Wong J.H.W
- Wright A.H
- Yankelevich V
- Yeung H.W
- Youles S
- Yung L.Y.A
- Zacchei A
- Zalesky L
- Zamorani G
- Zamorano Vitorelli A.
- Zanoni Marc M.
- Zennaro M
- Zerbi F.M
- Zinchenko I.A
- Zoubian J
- Zucca E
- Zumalacarregui M
- Publication venue
- HAL CCSD
- Publication date
- 29/05/2024
- Field of study
International audienceThe current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance
Euclid. I. Overview of the Euclid mission
- Author
- Acevedo Barroso J.A.
- Achúcarro A
- Adam R
- Adamek J
- Addison G.E
- Aghanim N
- Aguena M
- Ajani V
- Akrami Y
- Al-Bahlawan A
- Alavi A
- Albuquerque I.S
- Alestas G
- Alguero G
- Allaoui A
- Allen S.W
- Allevato V
- Alonso-Tetilla A.V
- Altieri B
- Alvarez-Candal A
- Amara A
- Amendola L
- Amiaux J
- Andika I.T
- Andreon S
- Andrews A
- Angora G
- Angulo R.E
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- Anselmi A
- Anselmi S
- Arcari S
- Archidiacono M
- Aricò G
- Arnaud M
- Arnouts S
- Asgari M
- Asorey J
- Atayde L
- Atek H
- Atrio-Barandela F
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- Zamorano Vitorelli A.
- Zanoni Marc M.
- Zennaro M
- Zerbi F.M
- Zinchenko I.A
- Zoubian J
- Zucca E
- Zumalacarregui M
- Publication venue
- HAL CCSD
- Publication date
- 29/05/2024
- Field of study
International audienceThe current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance
Euclid. I. Overview of the Euclid mission
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- Zumalacarregui M.
- Publication venue
- Publication date
- 22/05/2024
- Field of study
The current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance
Euclid. I. Overview of the Euclid mission
- Author
- Acevedo Barroso J.A.
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- Yeung H.W
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- Yung L.Y.A
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- Zamorano Vitorelli A.
- Zanoni Marc M.
- Zennaro M
- Zerbi F.M
- Zinchenko I.A
- Zoubian J
- Zucca E
- Zumalacarregui M
- Publication venue
- HAL CCSD
- Publication date
- 29/05/2024
- Field of study
International audienceThe current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance