Aplicabilidade da média das forças musculares respiratórias como parte da escala de risco cirúrgico baseada na escala de Torrington e Henderson

ObjectiveEvaluate the applicability of mean percentage from the predicted value of respiratory muscle strength (maximal inspiratory pressure-MIP; maximal expiratory pressure-MEP), as (% MIP + % MEP)/2, as well as the peak expiratory flow (% PEF) preoperatively, as part of a surgical risk scale for predicting the risk of postoperative pulmonary complications (PPC). MethodData on patients undergoing elective surgery of chest, abdomen and limbs were assessed preoperatively using the items and the scoring system proposed by the Torrington and Henderson, and replacing spirometry by the mean values of both (% MIP + % MEP)/2 and % PEF. ResultThe proposed scale applied to 108 patients with a mean age of 55.2 ± 14.0 presented PPC rate of 37.0% (p = 0.0001), of which 20.0% were classified as high risk (HR), and 62.5% moderate risk (MR). The mean value of respiratory muscle strength showed a statistically significant correlation with PPC (p = 0.000). ConclusionThe proposed scale allowed the appropriate stratification of patients at risk for development of PPC. The use of the mean values of (% MIP + % MEP)/2 and % PEF based on the predicted values can be easily applied, making spirometry unnecessary.ObjetivoAvaliar a aplicabilidade da média do percentual do valor predito das forças musculares respiratórias (pressão inspiratória máxima-PImax; pressão expiratória máxima-PEmax), sendo % PImax + % PEmax/2, e do pico de fluxo expiratório (% PFE) no pré-operatório, como parte de uma escala de risco cirúrgico para predizer o risco de complicação pulmonar pós-operatória (CPP). MétodoDados de pacientes submetidos à cirurgia eletiva de tórax, abdômen e membros foram analisados no pré-operatório utilizando os itens e a pontuação proposta pela escala de Torrington e Henderson, e substituindo a espirometria pela média do % PImax + % PEmax / 2 e do % PFE. ResultadoNa escala proposta aplicada a 108 pacientes com idade média de 55,2 ± 14,0 a taxa de CPP foi de 37,0% (p = 0,0001), onde 20,0% foram classificados como de alto risco (RA) e 62,5% risco moderado (RM). O percentual da média da força muscular respiratória apresentou uma correlação significante em relação à CPP na escala proposta (p = 0,000). ConclusãoA escala proposta permitiu estratificar de maneira adequada pacientes com risco de CPP. A utilização da média do % PImax + % PEmax / 2 e do % PFE, baseados nos valores preditos, podem ser facilmente aplicáveis, tornando-se desnecessária a realização da espirometria.Federal University of São Paulo Paulista Medical SchoolUniversity of Northern ParanáIrmandade da Santa Casa de LondrinaUniversity of Northern Paraná Hospital PhysiotherapyHospital Zona SulUNIFESP, EPMSciEL

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD

Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from nicotinamide. Since its expression is upregulated during inflammation, NAMPT represents a novel clinical biomarker in acute lung injury, rheumatoid arthritis, and Crohn's disease. However, its role in disease progression remains unknown. We report here that NAMPT is a key player in inflammatory arthritis. Increased expression of NAMPT was confirmed in mice with collagen-induced arthritis, both in serum and in the arthritic paw. Importantly, a specific competitive inhibitor of NAMPT effectively reduced arthritis severity with comparable activity to etanercept, and decreased pro-inflammatory cytokine secretion in affected joints. Moreover, NAMPT inhibition reduced intracellular NAD concentration in inflammatory cells and circulating TNFα levels during endotoxemia in mice. In vitro pharmacological inhibition of NAMPT reduced the intracellular concentration of NAD and pro-inflammatory cytokine secretion by inflammatory cells. Thus, NAMPT links NAD metabolism to inflammatory cytokine secretion by leukocytes, and its inhibition might therefore have therapeutic efficacy in immune-mediated inflammatory disorders

Em busca da identidade dos instrumentos musicais no Brasil: um estudo exploratório da literatura de cordel

Based on a collection of 2340 poems, the present article aims to explore the identity of musical instruments considered most popular by the printed Literatura de Cordel (Cordel Literature) in the countryside of Northeastern and Northern regions of Brazil, from the end of the 19th Century to present days. The Cordel Literature is known for representing the views of the social group from which it is originated rather than the creative work of its poets/writers. In search of musical instruments mentioned in the text, some of them were selected due to frequency and relevance of the context found: e.g. the Brazilian viola (a five course guitar), the violão (the six string guitar), the violin, the mandolin, the rabeca (Brazilian fiddle), the electric guitar and the piano. The violão and the Brazilian viola, which are similar in shape, are seen by that population in quite different ways. The fiddle is a popular instrument, but had only a few mentions. Other instruments like the violin, the mandolin, the piano and the electric guitar are described as urban instruments, thus less known in that context.O presente trabalho procura, em consulta a uma coleção de 2340 obras da Literatura de Cordel, explorar identidades culturais presentes nos instrumentos musicais aparentemente mais populares junto à população cultora de tal forma literária - sertão nordestino e parte da Região Norte do Brasil - desde o final do século XIX até o presente. Há no trabalho o pressuposto de que a Literatura de Cordel representa, muito mais que o trabalho criativo dos seus autores, as práticas vigentes no grupo social que a origina. Assim, à procura de menções a instrumentos musicais, este estudo detém-se em alguns deles, pela frequência e relevância da sua caracterização: viola caipira, violão, violino, bandolim, rabeca, guitarra elétrica e piano. Instrumentos aparentemente próximos como a viola e o violão são vistos de formas muito distintas pela população considerada. A rabeca, instrumento popular, poucas vezes é citada. Outros instrumentos, como violino, bandolim, piano e guitarra elétrica, são retratados como instrumentos urbanos e menos conhecidos

A Vulnerabilidade do Consumidor Idoso à Luz dos Ordenamentos Jurídicos Brasileiro e Português

Dissertação de Mestrado em Direito, Especialidade em Ciências Juridico-Forenses, apresentada à Faculdade de Direito da Universidade de Coimbr

Aplicability of respiratory muscle strength as part of the surgical risk scale based on Tonrrington and Henderson scoring system

Objective: Evaluate the applicability of mean percentage from the predicted value of respiratory muscle strength (maximal inspiratory pressure-MIP; maximal expiratory pressure-MEP), as (% MIP + % MEP)/2, as well as the peak expiratory flow (% PEF) preoperatively, as part of a surgical risk scale for predicting the risk of postoperative pulmonary complications (PPC). Methods: Data on patients undergoing elective surgery of chest, abdomen and limbs were assessed preoperatively using the items and the scoring system proposed by the Torrington and Henderson, and replacing spirometry by the mean values of both (% MIP + % MEP)/2 and % PEF. Results: The proposed scale applied to 108 patients with a mean age of 55.2 ± 14.0 presented PPC rate of 37.0% (p = 0.0001), of which 20.0% were classified as high risk (HR), and 62.5% moderate risk (MR). The mean value of respiratory muscle strength showed a statistically significant correlation with PPC (p = 0.000). Conclusion: The proposed scale allowed the appropriate stratification of patients at risk for development of PPC. The use of the mean values of (% MIP + % MEP)/2 and % PEF based on the predicted values can be easily applied, making spirometry unnecessary

Aplicability of respiratory muscle strength as part of the surgical risk scale based on Tonrrington and Henderson scoring system

Objective Evaluate the applicability of mean percentage from the predicted value of respiratory muscle strength (maximal inspiratory pressure-MIP; maximal expiratory pressure-MEP), as (% MIP + % MEP)/2, as well as the peak expiratory flow (% PEF) preoperatively, as part of a surgical risk scale for predicting the risk of postoperative pulmonary complications (PPC). Methods Data on patients undergoing elective surgery of chest, abdomen and limbs were assessed preoperatively using the items and the scoring system proposed by the Torrington and Henderson, and replacing spirometry by the mean values of both (% MIP + % MEP)/2 and % PEF. Results The proposed scale applied to 108 patients with a mean age of 55.2 ± 14.0 presented PPC rate of 37.0% (p = 0.0001), of which 20.0% were classified as high risk (HR), and 62.5% moderate risk (MR). The mean value of respiratory muscle strength showed a statistically significant correlation with PPC (p = 0.000). Conclusion The proposed scale allowed the appropriate stratification of patients at risk for development of PPC. The use of the mean values of (% MIP + % MEP)/2 and % PEF based on the predicted values can be easily applied, making spirometry unnecessary

Validation of the Portuguese version of the London Chest Activity of Daily Living Scale (LCADL) in chronic obstructive pulmonary disease patients

INTRODUCTION: While there are several subjective English tools, such as the London Chest Activity of Daily Living scale (LCADL), aimed at assessing dyspnoea during activities of daily living (ADL) in patients with Chronic Obstructive Pulmonary Di- sease (COPD), none of these questionnaires has ever been translated into Portuguese. The aim of this study was to investigate the validity and reproducibility of the LCADL's Portuguese version in patients with COPD. METHODS: 31 patients with COPD (17 male; 69+/-7 years; FEV1 44+/-15 %predicted) completed the Portuguese version of the LCADL twice with a 1-week interval. The traditional Saint George Respiratory Questionnaire (SGRQ), already validated in Portuguese, was used as the criterion method. RESULTS: There were no significant differences between test and retest of the LCADL. Intraclass Correlation Coefficient between test and retest concerning the different scale components was Self-care r=0.96; Domestic r=0.99; Physical r=0.92; Leisure r=0.95; Total Score r=0.98. There were significant correlations of the LCADL Total Score with the SGRQ's different components and total score (0.36<r<0.74; p<0.05 for all). The LCADL Total Score was also significantly correlated with the 6-minute walking distance test (r= -0.48; p=0.006). CONCLUSION: The Portuguese version of the LCADL is valid and reproducible in patients with COPD, making this study a new and important tool for assessing the limitations of performing ADL in this population

Artigo Original Original Article Validação da versão em português da escala London Chest Activity of Daily Living (LCADL) em DOentes com Doença Pulmonar Obstrutiva Crónica

Resumo Introdução: Diversos questionários desenvolvidos em língua inglesa visam avaliar especificamente a limitação pela dispnéia durante actividades da vida diá ria (AVD) em doentes com doença pulmonar obstrutiva crónica (DPOC), como a escala London . A estreita relação entre actividade física, morbidade e mortalidade em doentes com DPOC 6-9 demonstra a importância da avaliação adequada das limitações na realização de AVD. O método mais simples e mais comummente utilizado para avaliação das limitações em AVD é o uso de questionários específicos para esse fim 10 . A literatura científica internacional mostra diversos questionários desenvolvidos especificamente para avaliação das limitações em AVD de doentes com DPO

Validação da versão em português da escala London Chest Activity of Daily Living (LCADL) em doentes com doença pulmonar obstrutiva crónica Validation of the Portuguese version of the London Chest Activity of Daily Living Scale (LCADL)in chronic obstructive pulmonary disease patients

Introdução: Diversos questionários desenvolvidos em língua inglesa visam avaliar especificamente a limitação pela dispnéia durante actividades da vida diá ria (AVD) em doentes com doença pulmonar obstrutiva crónica (DPOC), como a escala Lon Chest Activity of Daily Living (LCADL). No entanto, nenhum destes questionários foi ainda traduzido para a língua portuguesa. O objectivo desse estudo foi verificar a validade e a reprodutibilidade da versão em português da LCADL em pacientes com DPOC. Métodos: Trinta e um doentes com DPOC (17 homens; 69±7 anos; FEV1 44±15% predito) responderam por duas vezes à versão em português da LCADL com intervalo de uma semana. O tradicional questionário Saint George na doença respiratória (SGRQ), já validado em português, foi utilizado como critério de validação. Resultados: Não foram observadas diferenças significativas entre a aplicação e a reaplicação da LCADL. O coeficiente de correlação intraclasse dos domínios da escala entre o dia 1 e dia 2 foi de: Cuidado pessoal r=0,96; doméstico r=0,99; actividade física r=0,92; lazer r=0,95; escore total r=0,98. Foram observadas correlações significativas do escore total da LCADL com os domínios e o escore total do SGRQ (0,36Introduction: While there are several subjective English tools, such as the London Chest Activity of Daily Living scale (LCADL), aimed at assessing dyspnoea during activities of daily living (ADL) in patients with Chronic Obstructive Pulmonary Disease (COPD), none of these questionnaires has ever been translated into Portuguese. The aim of this study was to investigate the validity and reproducibility of the LCADL’s Portuguese version in patients with COPD. Methods: 31 patients with COPD (17 male; 69±7 years; FEV1 44±15 %predicted) completed the Portuguese version of the LCADL twice with a 1-week interval. The traditional Saint George Respiratory Questionnaire (SGRQ), already validated in Portuguese, was used as the criterion method. Results: There were no significant differences between test and retest of the LCADL. Intraclass Correlation Coefficient between test and retest concerning the different scale components was Self-care r=0.96; Domestic r=0.99; Physical r=0.92; Leisure r=0.95; Total Score r=0.98. There were significant correlations of the LCADL Total Score with the SGRQ’s different components and total score (0.36<r<0.74; p<0.05 for all). The LCADL Total Score was also significantly correlated with the 6-minute walking distance test (r= -0.48; p=0.006). Conclusion: The Portuguese version of the LCADL is valid and reproducible in patients with COPD, making this study a new and important tool for assessing the limitations of performing ADL in this population