a list of accident scenarios for three legs skewed intersections

The term 'scenario' is used in the safety field to designate a prototype or a model of an accident process characterised by chains of facts, actions, causal relations and consequences in terms of damage to people and property. The prototypical scenarios, properly realized, provide a basis on which to consider the action to be taken, but also a concrete backup for accident information for use in information campaigns or training. The objective of this study is to define the prototypical accident scenarios for a particular configuration of road intersection: the skewed intersection. Limited sight distance at skewed intersections leads to safety issues. A non-skewed intersection provides the best operating conditions as drivers can easily sense the direction in which they are travelling, estimate the speeds of the opposing traffic and smoothly complete a maneuver in shorter time. In skewed intersections, instead, the ability of drivers to recognize any conflicting vehicles diminishes in comparison to right-angle intersections. The logical-deductive approach used in this paper for the determination of accident scenarios is based on an analysis of a large database of incidents, which occurred on several roads in eastern Sicily on 35 skewed intersections at three-legs. The skew angle of the minor leg of all the intersections studied is between 15° and 20°. This research allowed to develop accident scenarios related to particular configurations of intersections, compatible with the Italian rules. Prototypical scenarios are constructed using samples of accidents occurring on a particular type of study area, especially when they are based on files from in-depth investigations. The method used is an inductive approach, based on an examination of each case, grouping together similar cases and building a prototypical scenario using this case grouping. From the in-depth analysis of database accidents 9 prototypical accident scenarios have been identified for the skewed intersections. Keywords: Road safety, Accident scenarios, In-depth analysis, Skewed intersections, Maneuvers acciden

Apriori Algorithm for Association Rules Mining in Aircraft Runway Excursions

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Factors with the greatest influence on drivers' judgment of roundabouts safety. An analysis based on web survey in Italy

The aim of this paper is to identify the roundabout geometric characteristics affecting the safety perception while the typical maneuvers (entry, circulation, exit) are being carried out. The tool used was an on-line questionnaire, filled out by about 1.650 respondents. Four different dimensionality reduction methods (Cluster Analysis, Correspondence Analysis, Exploratory Factor Analysis and Confirmatory Factor Analysis) were used to analyze the data collected from the survey, in order to examine the key factors affecting the safety perception during the typical roundabout maneuvers. The considerations arising from the final model are the following: 1) the respondents' opinions regarding the safety perception of maneuvers are not preconceived ideas, but they originate from specific safety perceptions due to roundabout geometric configurations; 2) the users prefer definitely single lane roundabouts; this is an important confirmation of most results in the literature; 3) it was quantified the extent of the relationship between the safety perception of the typical roundabout maneuvers and the following aspects: a) maneuver type, b) geometric characteristics of the roundabouts design elements. This is the innovative aspect of the present research whose results have implications regarding theory, infrastructure and the application of new safety technologies. Keywords: Road safety, Statistical analysis, Dimensionality reduction methods, Roundabout design, Driving behavio

Italians' public opinion on road roundabouts: A web based survey

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Eucalyptus urograndis stem proteome is responsive to short-term cold stress

Eucalyptus urograndis is a hybrid eucalyptus of major economic importance to the Brazilian pulp and paper industry. Although widely used in forest nurseries around the country, little is known about the biochemical changes imposed by environmental stress in this species. In this study, we evaluated the changes in the stem proteome after short-term stimulation by exposure to low temperature. Using two-dimensional gel electrophoresis coupled to high-resolution mass spectrometry-based protein identification, 12 proteins were found to be differentially regulated and successfully identified after stringent database searches against a protein database from a closely related species (Eucalyptus grandis). The identification of these proteins indicated that the E. urograndis stem proteome responded quickly to low temperature, mostly by down-regulating specific proteins involved in energy metabolism, protein synthesis and signaling. The results of this study represent the first step in understanding the molecular and biochemical responses of E. urograndis to thermal stress382191198FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2011/11650-0; 2011/51949-5; 2013/06370-4; 2013/06352-6; 2011/23582-

Historia arácnida : Simpoiesis, archifósiles y xeno-archivos

Desde el punto de vista de la Historia, si la falta de información es un problema, la extrema abundancia también puede serlo (Caimari, 2017, p.72); como una especie de pánico que sobreviene a quien se enfrente a la monolítica pila de datos, una sensación abrumadora espera en el filo de internet. Si se dejan de lado las explícitas tendencias acumulativas para la monetización, como los casos de Google, Facebook o Amazon, uno de los más llamativos acopios de información digital actual es Internet Archive, dedicada desde mediados de los 90 a recopilar datos en forma de documentos de diversos tipos, muchos de ellos donados por bibliotecas u otras instituciones (Internet Archive, s.f.). Dentro de este inmenso proyecto se encuentra Wayback Machine, dedicada exclusivamente a guardar copias de páginas web en acceso público. Inspirada en la máquina del tiempo WABAC de la serie de animación de Peabody y Sherman (Graham, 28 de enero de 2019), Wayback Machine es al mismo tiempo una ciencia-ficción transformada en realidad y una máquina de acopio que tiende al acaparamiento de datos con una finalidad generalista y una política de adquisición no del todo clara: según sus fundadores y directores, la información que se recopila no tiene un objetivo más que estar allí por si alguien la necesita, sin expurgos ni declinaciones (Internet Archive, s.f.; Graham, 28 de enero de 2019). (Párrafo extraído del texto a modo de resumen)Este capítulo se realizó en el marco del programa de adscripción a la cátedra Teoría de la Historia (2020-2022) y del Proyecto de Investigación "Archivos, Arte y Cultura Visual entre 1980 y 2001. Acervos personales de artistas y diseñadores de la ciudad de La Plata (Segunda parte)". Acreditado como Proyecto Promocional de Investigación y Desarrollo (PPID–UNLP). Período: 2020-2022. B016Facultad de Arte

Chitosan-hydroxypropyl methylcellulose tioconazole films: A promising alternative dosage form for the treatment of vaginal candidiasis

Vaginal candidiasis is considered a frequent opportunistic mucosal infection and the second most common cause of vaginitis after bacterial vaginosis. In this work, different vaginal films based on chitosan, hydroxypropyl methylcellulose and blends of these polymers containing tioconazole, were developed and thoroughly characterized to improve the conventional therapeutics of vaginal candidiasis. Mechanical properties, swelling, adhesiveness, morphology, antifungal activity, hemocompatibility and cytotoxicity were evaluated. The drug solid state in the films was analyzed by thermal and X-ray diffraction analysis. Films showed homogeneous surfaces and presented similar mechanical properties and adhesiveness. Time-kill studies displayed that films were more active than both tioconazole pure drug and traditional tioconazole ovule against Candida albicans, which is probably related to the fact that tioconazole is in amorphous state inside the films. Although all formulations proved to be hemocompatible, films based only on chitosan exhibited a certain degree of cytotoxicity and therefore they should be avoided. The system based on chitosan-hydroxypropyl methylcellulose with 40% PEG 400 as plasticizer presented fast antimicrobial activity as well as the lowest swelling. Additionally, this formulation did not produce substantial hemolytic and cytotoxic effects, indicating that films based on chitosan-hydroxypropyl methylcellulose could be a promising alternative dosage form for the treatment of vaginal candidiasis.Fil: Calvo, Natalia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentin

Miconazole Nitrate Microparticles in Lidocaine Loaded Films as a Treatment for Oropharyngeal Candidiasis

Oral candidiasis is an opportunistic infection that affects mainly individuals with weakened immune system. Devices used in the oral area to treat this condition include buccal films, which present advantages over both oral tablets and gels. Since candidiasis causes pain, burning, and itching, the purpose of this work was to develop buccal films loaded with both lidocaine (anesthetic) and miconazole nitrate (MN, antifungal) to treat this pathology topically. MN was loaded in microparticles based on different natural polymers, and then, these microparticles were loaded in hydroxypropyl methylcellulose-gelatin-based films containing lidocaine. All developed films showed adequate adhesiveness and thickness. DSC and XRD tests suggested that the drugs were in an amorphous state in the therapeutic systems. Microparticles based on chitosan-alginate showed the highest MN encapsulation. Among the films, those containing the mentioned microparticles presented the highest tensile strength and the lowest elongation at break, possibly due to the strong interactions between both polymers. These films allowed a fast release of lidocaine and a controlled release of MN. Due to the latter, these systems showed antifungal activity for 24 h. Therefore, the treatment of oropharyngeal candidiasis with these films could reduce the number of daily applications with respect to conventional treatments.Fil: Tejada Jacob, Guillermo Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Calvo, Natalia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Morri, Mauro Gaspar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Sortino, Maximiliano Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Farmacia; ArgentinaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Farmacia; Argentin

Development and optimization of a new tioconazole vaginal mucoadhesive film using an experimental design strategy. Physicochemical and biological characterization

A new tioconazole (TCZ) mucoadhesive film, based on a biodegradable chitosan/ hydroxypropyl methylcellulose (CH/HPMC) blend, was developed for treatment of vaginal candidiasis. The formulation was optimized through an I-optimal design (minimizing the integral of the prediction variance across the factor space), where the impact of the proportion of the ingredients and processing variables on the quality of the final product was evaluated. Both, the thickness of the film and the swelling index, which affect patients’ comfort and compliance, were considered. Mechanical testing, such as load at break, elongation at break, and mucoadhesive strength were also included as dependent variables. The optimal mucoadhesive film formulation, which should be obtained at a drying temperature of 30 °C, was found to include the combination of CH and HPMC (forming polymers) at 0.25:0.75 ratio, a mixture of polyethylene glycol 400 and propylene glycol as plasticizers (0.07:0.93, 5% w/w), and TCZ loaded at 15 % w/w. The optimal preparation was subjected to exhaustive characterization studies, which revealed that the drug was entrapped in the polymeric matrix in an amorphous state and that the film exhibited a smooth and uniform surface, demonstrating excellent component compatibility. In vitro tests showed that the formulation has an excellent time to kill value (3 min) and lacks cytotoxicity, suggesting that it should be highly effective and safe.Fil: Calvo, Natalia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Tejada Jacob, Guillermo Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Universidad Nacional de Rosario; Argentin

El corazón de una comunidad : Un archivo blando del movimiento beat

A luz de los conceptos de Archivos Blandos y Archivos Flexibles, el capítulo presenta un análisis de la muestra "50 Años Cofrádicos", realizada en el espacio cultural platense Dionisia y con curaduría a cargo de Natalia Famucci. Dicha muestra expone una selección de documentos del archivo personal de Ricardo Cohen (Rocambole), figura representativa y uno de los ideólogos del colectivo La Cofradía de la Flor Solar, comunidad y grupo artístico-musical exponente del movimiento beat en la ciudad de La Plata a fines de los sesenta y principios de los setenta.Este capítulo se realizó en el marco del Proyecto de Investigación "Archivos, Arte y Cultura Visual entre 1980 y 2001. Acervos personales de artistas y diseñadores de la ciudad de La Plata (Segunda parte)". Acreditado como Proyecto Promocional de Investigación y Desarrollo (PPID–UNLP). Período: 2020-2022. B016Facultad de Arte