Utilización de objetos de aprendizaje en asignaturas heterogéneas de la Universidad Politécnica de Madrid. Resultados y valoración de la experiencia.

Durante el curso 2007/08 un grupo de profesores de distintas Escuelas de la UPM ha participado en un proyecto coordinado cuyo objetivo principal el la generación y adaptación de materiales didácticos para transformar de forma progresiva la docencia a formato semi-presencial o completamente a distancia. Como recursos educativos se han utilizado los Objetos de Aprendizaje. La novedad de las asignaturas implicadas, no sólo por su temática, sino en otros aspectos de gran importancia práctica como la diferenca en número y procedencia de los alumnos que las cursan, nivel en el Plan de Estudos , etc. En este trabajo se describe la experiencia y se muestran algunos de los materiales proparados. También se presentan los resultados académicos alcanzados por los alumnos y la valoración cualitativa que hacen los estudiantes respecto a disponer de objetos digitales de aprendizaje

The EDGE-CALIFA Survey: Interferometric Observations of 126 Galaxies with CARMA

We present interferometric CO observations, made with the Combined Array for Millimeter-wave Astronomy (CARMA) interferometer, of galaxies from the Extragalactic Database for Galaxy Evolution survey (EDGE). These galaxies are selected from the Calar Alto Legacy Integral Field Area (CALIFA) sample, mapped with optical integral field spectroscopy. EDGE provides good-quality CO data (3σ sensitivity before inclination correction, resolution ∼1.4 kpc) for 126 galaxies, constituting the largest interferometric CO survey of galaxies in the nearby universe. We describe the survey and data characteristics and products, then present initial science results. We find that the exponential scale lengths of the molecular, stellar, and star-forming disks are approximately equal, and galaxies that are more compact in molecular gas than in stars tend to show signs of interaction. We characterize the molecular-to-stellar ratio as a function of Hubble type and stellar mass and present preliminary results on the resolved relations between the molecular gas, stars, and star-formation rate. We then discuss the dependence of the resolved molecular depletion time on stellar surface density, nebular extinction, and gas metallicity. EDGE provides a key data set to address outstanding topics regarding gas and its role in star formation and galaxy evolution, which will be publicly available on completion of the quality assessment.Fil: Bolatto, Alberto. University of Maryland; Estados UnidosFil: Wong, Tony. University of Illinois at Urbana; Estados UnidosFil: Utomo, Dyas. University of California at Berkeley; Estados UnidosFil: Blitz, Leo. University of California at Berkeley; Estados UnidosFil: Vogel, Stuart N.. University of Maryland; Estados UnidosFil: Sánchez, Sebastián F.. Universidad Nacional Autónoma de México; MéxicoFil: Barrera-Ballesteros, Jorge. University Johns Hopkins; Estados UnidosFil: Cao, Yixian. University of Illinois; Estados UnidosFil: Colombo, Dario. Max Planck Institut Fur Radioastronomie; AlemaniaFil: Dannerbauer, Helmut. Universidad de La Laguna; EspañaFil: García-Benito, Rubén. Instituto de Astrofísica de Andalucía; EspañaFil: Herrera-Camus, Rodrigo. Max Planck Institute für Extraterrestrische Physik; AlemaniaFil: Husemann, Bernd. Max-Planck-Institut für Astronomie; AlemaniaFil: Kalinova, Veselina. Max Planck Institut für Radioastronomie; AlemaniaFil: Leroy, Adam K.. Ohio State University; Estados UnidosFil: Leung, Gigi. Max-Planck-Institut für Astronomie; AlemaniaFil: Levy, Rebecca C.. University of Maryland; Estados UnidosFil: Mast, Damian. Observatorio Astronomico de la Universidad Nacional de Cordoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Ostriker, Eve. University of Princeton; Estados UnidosFil: Rosolowsky, Erik. University of Alberta; CanadáFil: Sandstrom, Karin M.. University of California at San Diego; Estados UnidosFil: Teuben, Peter. University of Maryland; Estados UnidosFil: Van De Ven, Glenn. Max-Planck-Institut für Astronomie; AlemaniaFil: Walter, Fabian. Max-Planck-Institut für Astronomie; Alemani

Transición de docencia presencial a no presencial o semipresencial en un escenario heterogéneo.

En esta comunicación se presenta una experiencia conjunta llevada a cabo por varios profesores de la Universidad Politécnica de Madrid, que ha consistido en el rediseño de asignaturas para adaptar su impartición de forma progresiva a formato semi-presencial o completamente a distancia, utilizando una metodología basada en el uso de objetos de aprendizaje. La originalidad del trabajo planteado reside precisamente en la diversidad de las asignaturas, no sólo por su temática, sino en otros aspectos de gran importancia práctica como la diferencia en número y procedencia de los alumnos que las cursan, nivel en el que se encuadran en el Plan de Estudios, etc., lo que conforma un escenario heterogéneo de planteamientos diversos que aporta a la experiencia el valor añadido

The EDGE-CALIFA Survey: Spatially Resolved 13CO(1-0) Observations and Variations in 12CO(1-0)/13CO(1-0) in Nearby Galaxies on kpc Scales

We present 13CO(1-0) observations for the EDGE-CALIFA survey, which is a mapping survey of 126 nearby galaxies at a typical spatial resolution of 1.5 kpc. Using detected 12CO(1-0) emission as a prior, we detect 13CO(1-0) in 41 galaxies via integrated line flux over the entire galaxy, and in 30 galaxies via integrated line intensity in resolved synthesized beams. Incorporating our CO observations and optical IFU spectroscopy, we perform a systematic comparison between the line ratio R12/13 and the properties of the stars and ionized gas. Higher R12/13 values are found in interacting galaxies than in non-interacting galaxies. The global R12/13 slightly increases with infrared color F60/F100, but appears insensitive to other host galaxy properties such as morphology, stellar mass, or galaxy size. We also present annulus-averaged R12/13 profiles for our sample up to a galactocentric radius of 0.4r25 (~6 kpc), taking into account the 13CO(1-0) non-detections by spectral stacking. The radial profiles of R12/13 are quite flat across our sample. Within galactocentric distances of 0.2r25, azimuthally-averaged R12/13 increases with star formation rate. However, the Spearman rank correlation tests show the azimuthally-averaged R12/13 does not strongly correlate with any other gas or stellar properties in general, especially beyond 0.2r25 from the galaxy centers. Our findings suggest that in the complex environments in galaxy disks, R12/13 is not a sensitive tracer for ISM properties. Dynamical disturbances, like galaxy interactions or the presence of a bar, also have an overall impact on R12/13, which further complicate the interpretations of R12/13 variations.Comment: 35pages, 11 figure, 6 tables, accepted for publication in ApJ

The EDGE-CALIFA survey: Using optical extinction to probe the spatially resolved distribution of gas in nearby galaxies

We present an empirical relation between the cold gas surface density (Σgas) and the optical extinction (AV) in a sample of 103 galaxies from the Extragalactic Database for Galaxy Evolution (EDGE) survey. This survey provides CARMA interferometric CO observations for 126 galaxies included in the Calar Alto Legacy Integral Field Area (CALIFA) survey. The matched, spatially resolved nature of these data sets allows us to derive the Σgas-AV relation on global, radial, and kpc (spaxel) scales. We determine AV from the Balmer decrement (H α/H β). We find that the best fit for this relation is Σgas (M☉ pc−2) ∼ 26 × AV (mag), and that it does not depend on the spatial scale used for the fit. However, the scatter in the fits increases as we probe smaller spatial scales, reflecting the complex relative spatial distributions of stars, gas, and dust. We investigate the Σgas/AV ratio on radial and spaxel scales as a function of EW(H α). We find that at larger values of EW(H α ) (i.e. actively star-forming regions) this ratio tends to converge to twice the value expected for a foreground dust screen geometry (∼30 M☉ pc−2 mag−1). On radial scales, we do not find a significant relation between the Σgas/AV ratio and the ionized gas metallicity. We contrast our estimates of Σgas using AV with compilations in the literature of the gas fraction on global and radial scales as well as with well-known scaling relations such as the radial star formation law and the Σgas-Σ∗ relation. These tests show that optical extinction is a reliable proxy for estimating Σgas in the absence of direct sub/millimeter observations of the cold gas.Fil: Barrera Ballesteros, Jorge K.. Universidad Nacional Autónoma de México; MéxicoFil: Utomo, Dyas. Ohio State University; Estados UnidosFil: Bolatto, Alberto. University of Maryland; Estados UnidosFil: Sánchez, Sebastián F.. Universidad Nacional Autónoma de México; MéxicoFil: Vogel, Stuart N.. University of Maryland; Estados UnidosFil: Wong, Tony. University of Illinois; Estados UnidosFil: Levy, Rebecca C.. University of Maryland; Estados UnidosFil: Colombo, Dario. Max Planck Institut Fur Radioastronomie; AlemaniaFil: Kalinova, Veselina. Max Planck Institut Fur Radioastronomie; AlemaniaFil: Teuben, Peter. University of Maryland; Estados UnidosFil: García Benito, Rubén. Instituto de Astrofísica de Andalucía; EspañaFil: Husemann, Bernd. Max Planck Institut Fur Astronomie; AlemaniaFil: Mast, Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Blitz, Leo. University of California at Berkeley; Estados Unido

Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome.

Despite known histological, biological, and clinical differences between lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), relatively little is known about the spatial differences in their corresponding immune contextures. Our study of over 1000 LUAD and LUSC tumors revealed that computationally derived patterns of tumor-infiltrating lymphocytes (TILs) on H&E images were different between LUAD (N = 421) and LUSC (N = 438), with TIL density being prognostic of overall survival in LUAD and spatial arrangement being more prognostically relevant in LUSC. In addition, the LUAD-specific TIL signature was associated with OS in an external validation set of 100 NSCLC treated with more than six different neoadjuvant chemotherapy regimens, and predictive of response to therapy in the clinical trial CA209-057 (n = 303). In LUAD, the prognostic TIL signature was primarily comprised of CD4+ T and CD8+ T cells, whereas in LUSC, the immune patterns were comprised of CD4+ T, CD8+ T, and CD20+ B cells. In both subtypes, prognostic TIL features were associated with transcriptomics-derived immune scores and biological pathways implicated in immune recognition, response, and evasion. Our results suggest the need for histologic subtype-specific TIL-based models for stratifying survival risk and predicting response to therapy. Our findings suggest that predictive models for response to therapy will need to account for the unique morphologic and molecular immune patterns as a function of histologic subtype of NSCLC

The EDGE-CALIFA Survey: An Extragalactic Database for Galaxy Evolution Studies

The EDGE-CALIFA survey provides spatially resolved optical integral field unit (IFU) and CO spectroscopy for 125 galaxies selected from the CALIFA Data Release 3 sample. The Extragalactic Database for Galaxy Evolution (EDGE) presents the spatially resolved products of the survey as pixel tables that reduce the oversampling in the original images and facilitate comparison of pixels from different images. By joining these pixel tables to lower dimensional tables that provide radial profiles, integrated spectra, or global properties, it is possible to investigate the dependence of local conditions on large-scale properties. The database is freely accessible and has been utilized in several publications. We illustrate the use of this database and highlight the effects of CO upper limits on the inferred slopes of the local scaling relations between stellar mass, star formation rate (SFR), and H$_2$ surface densities. We find that the correlation between H$_2$ and SFR surface density is the tightest among the three relations.Comment: 21 pages, accepted for publication in ApJS, see DOIs below for code and data acces