Impact of molecular and histological subtype of breast cancer on 18FDG-PET/CT imaging: Knowledge gained from recent studies

International audienceOver the past few years, several studies have focused attention on the impact of breast cancer (BC) histological subtype or BC phenotype, as defined by hormone receptors (HR) and HER2 status, on the results of FDG-PET/CT at staging, or during neoadjuvant chemotherapy (NAC). At staging, sclerotic bone metastases from invasive lobular carcinoma (ILC) demonstrated low or no FDG uptake in comparison to metastases from invasive ductal carcinoma (IDC). The CT component of PET/CT imaging should be carefully analyzed in the staging of ILC. In patients with triple negative or HER2-positive tumors, the proportion of extraskeletal metastases is high; this must be taken into account in the diagnostic strategy. Staging based on PET/CT findings offers higher prognostic stratification value than that defined by conventional imaging workup. The yield and prognostic information are high in patients with clinical stage IIB or higher. Moreover, the intensity of tumor FDG uptake at baseline may have prognostic value for recurrence, with stronger evidence in HR-positive/HER2-negative phenotype. In the assessment of tumor response to NAC, the metabolic response, generally based on the change in SUVmax (Delta SUVmax), depends on the BC subtypes. In triple negative BC, a good metabolic response early during NAC has been shown to be predictive of pCR, and the predictive value was reinforced by combining Delta SUVmax and EGFR status. In 171 patients, no correlation was found between some recently developed PET-derived parameters, i.e. tumor heterogeneity or textural analysis, and BC subtypes. Whether these parameters offer any advantage compared to SUV measurements remains to be demonstrated. (C) 2015 Elsevier Masson SAS. All rights reserved

Segmentation d’images de lésions cérébrales primitives en TEP FET : influence du volume de travail

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Société d'histoire du Droit des pays flamands, picards et wallons. Journées d'études tenues à Arras les 22, 23 et 24 avril 1948

Lepointe Gabriel, Lemarignier Jean-François, Chevrier G., Verriest Léo, Peltier H., Dubar L., Bertin Paul, Arnould M.-A., Thelliez C. Société d'histoire du Droit des pays flamands, picards et wallons. Journées d'études tenues à Arras les 22, 23 et 24 avril 1948. In: Revue du Nord, tome 31, n°121, Janvier-mars 1949. pp. 43-52

Evaluation and Comparison of Segmentation Algorithms in Low Contrast FET-PET Scans for Gross Tumor Volume Delineation

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Société d'histoire du Droit des pays flamands, picards et wallons. Journées d'études tenues à Arras les 22, 23 et 24 avril 1948

Lepointe Gabriel, Lemarignier Jean-François, Chevrier G., Verriest Léo, Peltier H., Dubar L., Bertin Paul, Arnould M.-A., Thelliez C. Société d'histoire du Droit des pays flamands, picards et wallons. Journées d'études tenues à Arras les 22, 23 et 24 avril 1948. In: Revue du Nord, tome 31, n°121, Janvier-mars 1949. pp. 43-52

Evaluation and Comparison of Segmentation Algorithms in Low Contrast FET-PET Scans for Gross Tumor Volume Delineation

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Intérêt de la TEMP/TDM pour le repérage anatomique des ganglions sentinelles en cas de cancer de vulve

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