Bullous pemphigoid associated with prostate adenocarcinoma

Bullous pemphigoid is a common autoimmune skin disease characterized by the presence of subepidermal blisters. It has been associated with underlying neoplasia in isolated reports. A 78-year-old man with generalized blisters was diagnosed as bullous pemphigoid on clinical, histopathological and direct immunofluorescence grounds. His free and total prostate specific antigen (PSA) levels were high and histopathological examination of a prostate specimen revealed prostate adenocarcinoma. We present this rare case to discuss the possible association between bullous pemphigoid and prostate adenocarcinoma

Primary chemotherapy in patients with stage II nonseminomatous germ cell testicular tumors

Testisin evre 2 nonseminomatöz germ hücreli tümörlerinin (NSGHTT) tedavisi primer kemoterapi ya da retroperitoneal lenfadenektomi seçimi bakımından tartışmalıdır. Bu çalışmada primer kemoterapi ile tedavi edilen evre 2 NSGHTT olan 27 hastanın sonuçları sunulmaktadır. Bleomisin, etoposid ve sisplatin kemoterapisi alan hastaların 18'inde (% 66.6) tam cevap gözlenirken 9'unda (% 33.3) retroperitoneal rezidüel kitlelerin varlığı ile belirlenen yetersiz cevap alındı. Ortalama izlem süresi 48 ay idi. İki hastada (% 7.4) başlangıçta primer kemoterapiye tam cevap alınmasına karşın ilk izlem yılı içinde serum tümör belirleyicilerinde yükselme saptandı. Primer kemoterapi sonrası rezidüel kitlesi olan 9 hastaya postkemoterapi cerrahi uygulandı. Bu hastaların çoğunda başlangıç tümörleri yüksek hacimli teratokarsinom idi. Evre 2 NSGHTT olan hastaların primer kemoterapi ile tedavi edilebilecekleri düşünülmektedir. Tedaviye cevapta tümör hacmi ve histolojik tipi önemli görünmektedir.Primary Chemotherapy in Patients With Stage II Nonseminomatous Germ Celi Testicular Tumors- Controversy stili exists in the treatment of stage 2 germ celi tumors ofthe testis (NSGCTT) as to ıvhether retroperitoneal lymphadenectomy or primary chemotherapy shoııld be offered. in this study, the results of 27 patients treated with primary chemotherapy are presented. With bleomicin, etoposide and cisplatinum chemotherapy 18 patients (66.6 %) had complete remissions while 9 patients (33.3 %) had persistent disease in the retroperitoneum. The mean folloıvup was 48 months. Tıvo patients (7.4 %) shoıoed biochemical relapse in thefirst year offolloıoup after initial complete response to primary chemotherapy. Nine patients ıvith reşidimi masses after primary chemotherapy undervoent postchemotherapy surgery. in the majority ofthese patients the primary tumors were high volume teratocarcinomas. Primary chemotherapy can be effective in patients zvith stage 2 NSGCTT. The tumor volume and histologic types do have impact on response to therapy

Renal oncocytoma: A case report

Renal onkositom, tüm böbrek tümörlerinin %3-5’ini oluşturan, oldukça nadir bir tümördür. Sıklıkla asemptomatiktir ve ortalama boyut 6 cm dir. Burada, 13 cm büyüklüğünde renal onkositom tanısı almış olgu sunulmuştur.Renal oncocytoma, which is diagnosed 3-5% of all renal tumors, is rare tumor. Most renal oncocitomas are asymptomatic and median size 6 cm. Here we present a case with renal oncocytoma, which size was 13 cm

Assessment of Quality of Life of Partners of Patients with Benign Prostate Hyperplasia: Does Benign Prostate Hyperplasia Disturb Female Partners?

WOS: 000287053500017Objective: Benign prostate hyperplasia (BPH) is a common health problem throughout the world. The aim of the study was to evaluate the consequence of BPH on partners by using Turkish version of a specific quality of life (QoL) scale for partners of BPH patients. Material and Methods: The study group consisted of partners of 300 BPH patients who were admitted to urology outpatient departments of two university hospitals (Duzce University and Celal Bayar University) with lower urinary tract symptoms. BPH patients were asked to fill out International Prostate Symptom Score (IPSS) form, while female partners were separately requested to complete the specific QoL questionnaire. Results: The mean age of patients with BPH was 63.8 +/- 7.2 years and it was 56.3 +/- 6.5 years for female partners. The results of the specific questionnaire showed that QoL of partners were significantly affected. Particularly, most of the the partners had the fear of cancer development and possibility of surgery for their husbands, 77% (231/300 partners) and 79% (237/300 partners), respectively. At night majority of partners woke up frequently because of their husbands, however mostly of them declared no or little disturbance in terms of being tired during the day. On the other hand, it was revealed that there was a significant correlation between QoL degrees of partners and IPSS values of BPH patients (p< 0.001; correlation coefficient 0.664). Conclusion: BPH significantly impairs the QoL of female partners. This negative impact correlates with the IPSS values of BPH patients. Therefore, the physicians should also consider burden of the female partners in the management of BPH patients

Renal oncocytoma: A case report

Renal onkositom, tüm böbrek tümörlerinin %3-5’ini oluşturan, oldukça nadir bir tümördür. Sıklıkla asemptomatiktir ve ortalama boyut 6 cm dir. Burada, 13 cm büyüklüğünde renal onkositom tanısı almış olgu sunulmuştur.Renal oncocytoma, which is diagnosed 3-5% of all renal tumors, is rare tumor. Most renal oncocitomas are asymptomatic and median size 6 cm. Here we present a case with renal oncocytoma, which size was 13 cm

Sorafenib in Metastatic Renal Cell Carcinoma With Sarcomatoid Differentiation

Targeted therapy in the management of metastatic renal cell cancer has been recently introduced to urology practice. The drugs used for management are used in a very limited number of patients and only for clear cell histology. We present a case where we administered sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, to a patient with metastatic renal cell carcinoma of clear cell histology. We found that our results were different from those of previously reported studies, because sarcomatoid differentiation was evident in a histological examination of this case. There was an excellent response to sorafenib. This case report might provide evidence that antiangiogenic agents may be active in any histological type of renal cell carcinoma. However, there are no available data to demonstrate the duration of response and survival benefit

The relationship between chronic prostatitis and postoperative urinary tract ınfection in patients with BPH

Amaç: Benign prostat hiperplazisi (BPH) nedeniyle cerrahi olarak tedavi edilen hastalarda postoperatif dönemde görülen piyüri ve bakteriürinin histopatolojik olarak saptanan kronik prostatit ile bağıntısı incelendi. Gereç ve Yöntem: Kliniğimize alt üriner sistem semptomları ile başvuran hastaların anamnezleri alınarak uluslar arası prostat semptom skorları (IPSS) not edildi. Fizik muayene sonrası idrar incelemesi, idrar kültürü yapıldı ve serum prostat spesifik antijen düzeyleri ölçüldü. Cerrahi tedavi öncesi tüm hastalara proflaktik olarak intravenöz tek doz siprofloksasin (400mg) uygulandı. Hastaların ameliyat tipine bağlı olarak ortalama 3-7 günde kateterleri çekildi. Postoperatif 15. günde idrar incelemesi ve idrar kültürleri tekrar edildi. Bulgular: Çalışmaya yaş ortalaması 68 (49-93) olan 123 hasta alındı. Patoloji sonucunda 66 (%54) hastada BPH’ne ek olarak kronik prostatit saptandı. Kronik prostatitli hastaların operasyon öncesi idrar incelemesinde ortalama lö- kosit sayısı 11.2 iken operasyon sonrası 25.8’e yükselmiş- tir (p=0.003). Patolojik olarak kronik prostatit saptanan hastaların (n=66) operasyon öncesi ve sonrası idrar incelemelerinde 5 ve üzerinde lökosit görülme oranları sırasıyla %39 ve %71 idi. (p=0.01). Bakteriüri açısından farklılık saptanmadı. Sonuç: Kronik prostatit saptanan BPH’li olgularda operasyon öncesi ve sonrasında sadece BPH olan olgulara gö- re daha yüksek oranda piyüri saptanmaktadır.Objective: The aim of this study is to evaluate the relationship between chronic prostatitis and postoperative urinary tract infection of the patients operated due to BPH. Material and Methods: The study group contains of patients who have admitted to the hospital with lower urinary tract symptoms. All patients have been questioned (including I-PSS) and phsyicially examined. Routine urine analysis, urine cultures, and serum PSA values have been measured. Patients who will be operated for BPH were given one dose of ciprofloxacine (400 mg, iv.). Urethral catheters were removed in average 3-7 days. Urine analysis and urine cultures were repeated in 15th days postoperatively. Results: One hundred twenty three patients were included to the study. The mean age was 68 (49-93). Chronic prostatitis was diagnosed in 66 (54%) of patients. In patients with chronic prostatitis, the mean leucocyte count was 11.2 in preoperatively and 25.8 in postoperatively (p=0.003). A significant pyuria (≥5) ratios were 39% and 71% in patients with histologically proven chronic prostatitis in preoperative and postoperative urine analysis, respectively (p=0.01). There was no difference in respect of bacteriuria in these patients. Conclusion: Pyuria was determined most of the patient who have chronic prostatitis with BPH

The relationship between chronic prostatitis and postoperative urinary tract ınfection in patients with BPH

Amaç: Benign prostat hiperplazisi (BPH) nedeniyle cerrahi olarak tedavi edilen hastalarda postoperatif dönemde görülen piyüri ve bakteriürinin histopatolojik olarak saptanan kronik prostatit ile bağıntısı incelendi. Gereç ve Yöntem: Kliniğimize alt üriner sistem semptomları ile başvuran hastaların anamnezleri alınarak uluslar arası prostat semptom skorları (IPSS) not edildi. Fizik muayene sonrası idrar incelemesi, idrar kültürü yapıldı ve serum prostat spesifik antijen düzeyleri ölçüldü. Cerrahi tedavi öncesi tüm hastalara proflaktik olarak intravenöz tek doz siprofloksasin (400mg) uygulandı. Hastaların ameliyat tipine bağlı olarak ortalama 3-7 günde kateterleri çekildi. Postoperatif 15. günde idrar incelemesi ve idrar kültürleri tekrar edildi. Bulgular: Çalışmaya yaş ortalaması 68 (49-93) olan 123 hasta alındı. Patoloji sonucunda 66 (%54) hastada BPH’ne ek olarak kronik prostatit saptandı. Kronik prostatitli hastaların operasyon öncesi idrar incelemesinde ortalama lö- kosit sayısı 11.2 iken operasyon sonrası 25.8’e yükselmiş- tir (p=0.003). Patolojik olarak kronik prostatit saptanan hastaların (n=66) operasyon öncesi ve sonrası idrar incelemelerinde 5 ve üzerinde lökosit görülme oranları sırasıyla %39 ve %71 idi. (p=0.01). Bakteriüri açısından farklılık saptanmadı. Sonuç: Kronik prostatit saptanan BPH’li olgularda operasyon öncesi ve sonrasında sadece BPH olan olgulara gö- re daha yüksek oranda piyüri saptanmaktadır.Objective: The aim of this study is to evaluate the relationship between chronic prostatitis and postoperative urinary tract infection of the patients operated due to BPH. Material and Methods: The study group contains of patients who have admitted to the hospital with lower urinary tract symptoms. All patients have been questioned (including I-PSS) and phsyicially examined. Routine urine analysis, urine cultures, and serum PSA values have been measured. Patients who will be operated for BPH were given one dose of ciprofloxacine (400 mg, iv.). Urethral catheters were removed in average 3-7 days. Urine analysis and urine cultures were repeated in 15th days postoperatively. Results: One hundred twenty three patients were included to the study. The mean age was 68 (49-93). Chronic prostatitis was diagnosed in 66 (54%) of patients. In patients with chronic prostatitis, the mean leucocyte count was 11.2 in preoperatively and 25.8 in postoperatively (p=0.003). A significant pyuria (≥5) ratios were 39% and 71% in patients with histologically proven chronic prostatitis in preoperative and postoperative urine analysis, respectively (p=0.01). There was no difference in respect of bacteriuria in these patients. Conclusion: Pyuria was determined most of the patient who have chronic prostatitis with BPH