Paul Hamlyn Foundation and Unbound Philanthropy Supported Options Initiative: Evaluation of Phase One

The Supported Options Initiative is one element of the Paul Hamlyn Foundation's Social Justice programme, delivered in partnership with Unbound Philanthropy (the Foundations). The first phase of the Initiative ran for two years from 2012. Its strategic goal was to 'support and encourage migrant, youth and advice organisations to better understand, respond to and reach out to young and child migrants with irregular immigration status, and capture and share learning to improve practice and policy'. In addition, three priority outcomes were specified:- Better advice services to young migrants through holistic approaches to their advice, support and information needs (legal and social)- Improved provision of online information and support to young migrants- Increased understanding of the issues facing young people leaving the UK, forcibly or voluntarily, and piloting options to better support them

Evaluation of Right Here: A Young People's Mental Health Initiative of the Paul Hamlyn and Mental Health Foundations

Right Here was a five-year initiative of the Paul Hamlyn Foundation and the Mental Health Foundation that aimed to improve preventative and early intervention approaches to supporting the mental health and wellbeing of young people in the UK.The initiative ran from 2009 - 2014 and was delivered across four local sites: Brighton and Hove, the London Borough of Newham, Sheffield and Fermanagh, Northern Ireland. Itoffered a blend of activities to raise awareness of mental health and wellbeing; build confidence and resilience through physical, creative and therapeutic activities; influence policy and practice locally; and deliver products and services that had been developed by young people.A central Right Here team with responsibility for coordinating the initiative also convened a National Youth Panel to contribute to the initiative's governance and influencing agenda; arranged showcasing and dissemination opportunities for the projects' work; and provided consultancy support to the grantholders.Youth participation was critically important to the initiative; both local projects and the central team had a variety of ways of involving young people in the planning of activities, projects and the initiative as a whole. Partnership was also an informing principle at local and national level. The initiative sought to develop new insights around these areas

The enhancement effect of lithium ions on actuation performance of ionic liquid-based IPMC soft actuators

Abstract Soft actuators are of great technological interest and one class of these is made from ionic polymer-metal composites (IPMCs). It has been established that replacement of water with an ionic liquid (IL) in IPMCs results in larger actuation response and considerably longer operating life. However, the rate of displacement of IL-based IPMCs is very low. In the current work, IPMC actuators were fabricated using Nafion membrane and an imidazolium-based IL. The effects of incorporating the IL with and without Li+ ions were followed using electromechanical and electrochemical measurements and were compared with the corresponding behavior of water-based Li+-exchanged and un-exchanged IPMC actuators. The addition of Li+ ions to the IL-based system resulted in dramatic increases in the capacitance, ionic conduction, operating life and in the displacement rate of the actuator. This strategy is of considerable interest for enabling the use of IPMC-based soft actuators in medicine and robotics.PostprintPeer reviewe

Influence of electrolytes of Li salts, EMIMBF4 and mixed phases on electrochemical and physical properties of Nafion membrane

Electrolyte-soaked Nafion is commonly used as an ionic polymer in soft actuators. Here, a multi-technique investigation was applied to correlate the electrochemical behavior of Nafion membranes with their microstructures and nanostructures as a function of electrolyte type. The influence of electrolytes of Li salts with different counteranions on the Nafion membranes was investigated in terms of hydration level, structure (using X-ray diffraction and small angle X-ray scattering), stress–strain characteristics, and electrochemical behavior (by cyclic voltammetery and electrochemical impedance spectroscopy). The effects of using ionic liquid (IL), as the electrolyte, addition of different supporting solvent and the addition of Li+ ions to water-free IL-soaked membranes on the structural and electrochemical properties of Nafion were examined. The nano- and microstructure of the Nafion changed considerably as a function of the identity of the electrolyte solution. The electrochemical behavior of the IL-soaked samples was compared with that of the water-soaked Li+-exchanged Nafion. It was seen that the ionic conductivity of the Nafion membranes was reduced significantly when water was replaced by pure IL. Using the supporting solvents increased the conductivity of IL-soaked Nafion membranes dramatically. The presence of a small amount of Li+ ions together with the IL ions caused a significant decrease in charge transfer resistance and increases in double layer capacitance and in ionic conductivity over that of the water-free sample and also over water-soaked Li+-exchanged Nafion. These findings can be useful to improve the knowledge on Nafion's microstructure and also to improve the electromechanical behavior of Nafion-based ionic polymer–metal composites actuators.PostprintPeer reviewe

Precision Antifungal Treatment Significantly Extends Voice Prosthesis Lifespan in Patients Following Total Laryngectomy

Indwelling silicone valves called voice prostheses (VPs) are the gold standard for speech rehabilitation in patients with laryngeal cancer following total laryngectomy. Reported VP lifespans amongst these patients are highly variable but when devices fail patients experience loss of voice and an increase risk of chest infection. Early failure of VP is a current clinical concern that is associated with regular hospital visits, reduced quality of life and associated medical cost. Poly-microbial biofilms comprised of both bacterial and fungal microorganisms readily colonize VPs and are linked to loss of device performance and its early failure in addition to providing a reservoir for potential infection. Our detailed analysis of poly-microbial biofilm composition on 159 early failing VPs from 48 total laryngectomy patients confirmed Candida albicans as the predominant fungal species and Staphylococcus aureus as the most common bacterial colonizer within our patient cohort. Using a combination of microbiological analysis, patient data and a high-throughput antifungal test assay mimicking in vivo conditions we established an evidence based precision antifungal treatment approach to VP management. Our approach has allowed us to implement a personalized VP management pathway, which increases device in situ lifespan by an average of 270%. Our study represents a significant step forward in both our understanding of the cause of VP failure and a new effective treatment pathway that offers tangible benefit to patients

Simulation of the 23 July 2012 Extreme Space Weather Event: What if This Extremely Rare CME Was Earth Directed?

Extreme space weather events are known to cause adverse impacts on critical modern day technological infrastructure such as high-voltage electric power transmission grids. On 23 July 2012, NASA's Solar Terrestrial Relations Observatory-Ahead (STEREO-A) spacecraft observed in situ an extremely fast coronal mass ejection (CME) that traveled 0.96 astronomical units (approx. 1 AU) in about 19 h. Here we use the SpaceWeather Modeling Framework (SWMF) to perform a simulation of this rare CME.We consider STEREO-A in situ observations to represent the upstream L1 solar wind boundary conditions. The goal of this study is to examine what would have happened if this Rare-type CME was Earth-bound. Global SWMF-generated ground geomagnetic field perturbations are used to compute the simulated induced geoelectric field at specific ground-based active INTERMAGNET magnetometer sites. Simulation results show that while modeled global SYM-H index, a high-resolution equivalent of the Dst index, was comparable to previously observed severe geomagnetic storms such as the Halloween 2003 storm, the 23 July CME would have produced some of the largest geomagnetically induced electric fields, making it very geoeffective. These results have important practical applications for risk management of electrical power grids

American Neurogastroenterology and Motility Society (ANMS) Task Force Recommendations for Resumption of Motility Laboratory Operations During the COVID-19 Pandemic

The ANMS organized a Task Force for developing guidance strategies regarding re-opening of motility laboratories. This document describes how to stratify urgency of motility physiologic procedures, screen prior to the procedures, optimize personal protective equipment (PPE) utilization, clean and prepare the motility laboratory space during the COVID-19 pandemic