63 research outputs found
A spectroscopic study of component C and the extended emission around I Zw 18
Long-slit Keck II, 4m Kitt Peak, and 4.5m MMT spectrophotometric data are
used to investigate the stellar population and the evolutionary status of I Zw
18C, the faint C component of the nearby blue compact dwarf galaxy I Zw 18.
Hydrogen H and H emission lines are detected in the spectra of I
Zw 18C, implying that ionizing massive stars are present. High signal-to-noise
Keck II spectra of different regions in I Zw 18C reveal H, H
and higher order hydrogen lines in absorption. Several techniques are used to
constrain the age of the stellar population in I Zw 18C. Ages derived from two
different methods, one based on the equivalent widths of the H,
H emission lines and the other on H, H absorption lines
are consistent with a 15 Myr instantaneous burst model. We find that a small
extinction in the range = 0.20 -- 0.65 mag is needed to fit the observed
spectral energy distribution of I Zw 18C with that model. In the case of
constant star formation, all observed properties are consistent with stars
forming continuously between ~ 10 Myr and < 100 Myr ago. We use all available
observational constraints for I Zw 18C, including those obtained from Hubble
Space Telescope color-magnitude diagrams, to argue that the distance to I Zw 18
should be as high as ~ 15 Mpc. The deep spectra also reveal extended ionized
gas emission around I Zw 18. H emission is detected as far as 30" from
it. To a B surface brightness limit of ~ 27 mag arcsec we find no
observational evidence for extended stellar emission in the outermost regions,
at distances > 15" from I Zw 18.Comment: 38 pages, 11 Postscript figures, accepted for publication in the
Astrophysical Journa
A Delphi process to optimize quality and performance of drug evaluation in neonates
Background
Neonatal trials remain difficult to conduct for several reasons: in particular the need for study sites to have an existing infrastructure in place, with trained investigators and validated quality procedures to ensure good clinical, laboratory practices and a respect for high ethical standards. The objective of this work was to identify the major criteria considered necessary for selecting neonatal intensive care units that are able to perform drug evaluations competently. Methodology and Main Findings
This Delphi process was conducted with an international multidisciplinary panel of 25 experts from 13 countries, selected to be part of two committees (a scientific committee and an expert committee), in order to validate criteria required to perform drug evaluation in neonates. Eighty six items were initially selected and classified under 7 headings: “NICUs description - Level of care” (21), “Ability to perform drug trials: NICU organization and processes (15), “Research Experience” (12), “Scientific competencies and area of expertise” (8), “Quality Management” (16), “Training and educational capacity” (8) and “Public involvement” (6). Sixty-one items were retained and headings were rearranged after the first round, 34 were selected after the second round. A third round was required to validate 13 additional items. The final set includes 47 items divided under 5 headings. Conclusion
A set of 47 relevant criteria will help to NICUs that want to implement, conduct or participate in drug trials within a neonatal network identify important issues to be aware of. Summary Points
1) Neonatal trials remain difficult to conduct for several reasons: in particular the need for study sites to have an existing infrastructure in place, with trained investigators and validated quality procedures to ensure good clinical, laboratory practices and a respect for high ethical standards. 2) The present Delphi study was conducted with an international multidisciplinary panel of 25 experts from 13 countries and aims to identify the major criteria considered necessary for selecting neonatal intensive care units (NICUs) that are able to perform drug evaluations competently. 3) Of the 86 items initially selected and classified under 7 headings - “NICUs description - Level of care” (21), “Ability to perform drug trials: NICU organization and processes (15), “Research Experience” (12), “Scientific competencies and area of expertise” (8), “Quality Management” (16), “Training and educational capacity” (8) and “Public involvement” (6) - 47 items were selected following a three rounds Delphi process. 4) The present consensus will help NICUs to implement, conduct or participate in drug trials within a neonatal network
Helium abundance in the most metal-deficient blue compact galaxies: I Zw 18 and SBS 0335-052
We present high-quality spectroscopic observations of the two most-metal
deficient blue compact galaxies known, I Zw 18 and SBS 0335-052 to determine
the helium abundance. The underlying stellar absorption strongly influences the
observed intensities of He I emission lines in the brightest NW component of I
Zw 18, and hence this component should not be used for primordial He abundance
determination. The effect of underlying stellar absorption, though present, is
much smaller in the SE component. Assuming all systematic uncertainties are
negligible, the He mass fraction derived in this component is Y =
0.243+/-0.007. The high signal-to-noise ratio spectrum (> 100 in the continuum)
of SBS 0335-052 allows us to measure the helium mass fraction with a precision
better than 2% -- 5% in nine different regions along the slit. Assuming all
systematic uncertainties are negligible, the weighted mean He mass fraction in
SBS 0335-052 is Y = 0.2437+/-0.0014 when the three He I 4471, 5876 and 6678
emission lines are used, and is 0.2463+/-0.0015 when the He I 4471 emission
line is excluded. The weighted mean helium mass fraction in the two most
metal-deficient BCGs I Zw 18 and SBS 0335-052, Y=0.2462+/-0.0015, after
correction for the stellar He production results in a primordial He mass
fraction Yp = 0.2452+/-0.0015. The derived Yp leads to a baryon-to-photon ratio
of (4.7+/-1.0) 10^{-10}, consistent with the values derived from the primordial
D and 7Li abundances, and supporting the standard big bang nucleosynthesis
theory. For the most consistent set of primordial D, 4He, and 7Li abundances we
derive an equivalent number of light neutrino species 3.0+/-0.3 (95% C.L.).Comment: 28 pages, 10 figures. To appear in Ap
Stellar Evolutionary Effects on the Abundances of PAH and SN-Condensed Dust in Galaxies
Spectral and photometric observations of nearby galaxies show a correlation
between the strength of their mid-IR aromatic features, attributed to PAH
molecules, and their metal abundance, leading to a deficiency of these features
in low-metallicity galaxies. In this paper, we suggest that the observed
correlation represents a trend of PAH abundance with galactic age, reflecting
the delayed injection of carbon dust into the ISM by AGB stars in the final
post-AGB phase of their evolution. AGB stars are the primary sources of PAHs
and carbon dust in galaxies, and recycle their ejecta back to the interstellar
medium only after a few hundred million years of evolution on the main
sequence. In contrast, more massive stars that explode as Type II supernovae
inject their metals and dust almost instantaneously after their formation. We
first determined the PAH abundance in galaxies by constructing detailed models
of UV-to-radio SED of galaxies that estimate the contribution of dust in
PAH-free HII regions, and PAHs and dust from photodissociation regions, to the
IR emission. All model components: the galaxies' stellar content, properties of
their HII regions, and their ionizing and non-ionizing radiation fields and
dust abundances, are constrained by their observed multiwavelength spectrum.
After determining the PAH and dust abundances in 35 nearby galaxies using our
SED model, we use a chemical evolution model to show that the delayed injection
of carbon dust by AGB stars provides a natural explanation to the dependence of
the PAH content in galaxies with metallicity. We also show that larger dust
particles giving rise to the far-IR emission follow a distinct evolutionary
trend closely related to the injection of dust by massive stars into the ISM.Comment: ApJ, 69 pages, 46 figures, Accepte
A new 3MW ECRH system at 105 GHz for WEST
The aim of the WEST experiments is to master long plasma pulses (1000s) and expose ITER-like tungsten wall to deposited heat fluxes up to 10 MW/m. To increase the margin to reach the H-Mode and to control W-impurities in the plasma, the installation of an upgraded ECRH heating system, with a gyrotron performance of 1MW/1000s per unit, is planned in 2023. With the modifications of Tore Supra to WEST, simulations at a magnetic field B∼3.7T and a central density n∼6 × 10 m show that the optimal frequency for central absorption is 105 GHz. For this purpose, a 105 GHz/1MW gyrotron (TH1511) has been designed at KIT in 2021, based on the technological design of the 140 GHz/1.5 MW (TH1507U) gyrotron for W7-X. Currently, three units are under fabrication at THALES. In the first phase of the project, some of the previous Tore Supra Electron Cyclotron (EC) system components will be re-installed and re-used whenever possible. This paper describes the studies performed to adapt the new ECRH system to 105 GHz and the status of the modifications necessary to re-start the system with a challenging schedule
Vinyl Dibromides: Versatile Partners in Cross-Coupling Reactions
FLWNAinfo:eu-repo/semantics/publishe
Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors
International audienceThyroid hormone (3,5,3'-triiodo-l-thyronine or T3) exerts a pleiotropic activity during central nervous system development. Hypothyroidism during the fetal and postnatal life results in an irreversible mental retardation syndrome. At the cellular level, T3 is known to act on neuronal and glial lineages and to control cell proliferation, apoptosis, migration, and differentiation. Oligodendrocyte precursor cells (OPC) found at birth in the optic nerves are self-renewing cells that normally differentiate during the first 3 weeks of rodent postnatal life into postmitotic myelinating oligodendrocytes. In vitro, the addition of T3 to OPC is sufficient to trigger their terminal differentiation. The present analysis of T3 receptor knockout mice reveals that the absence of all T3 receptor results in the persistence of OPC proliferation in adult optic nerves, in a default in myelination, and sometimes in the degeneration of the retinal ganglion neurons. Thus, T3 signaling is necessary in vivo to promote the complete differentiation of OPC.Thyroid hormone (3,5,3'-triiodo-l-thyronine or T3) exerts a pleiotropic activity during central nervous system development. Hypothyroidism during the fetal and postnatal life results in an irreversible mental retardation syndrome. At the cellular level, T3 is known to act on neuronal and glial lineages and to control cell proliferation, apoptosis, migration, and differentiation. Oligodendrocyte precursor cells (OPC) found at birth in the optic nerves are self-renewing cells that normally differentiate during the first 3 weeks of rodent postnatal life into postmitotic myelinating oligodendrocytes. In vitro, the addition of T3 to OPC is sufficient to trigger their terminal differentiation. The present analysis of T3 receptor knockout mice reveals that the absence of all T3 receptor results in the persistence of OPC proliferation in adult optic nerves, in a default in myelination, and sometimes in the degeneration of the retinal ganglion neurons. Thus, T3 signaling is necessary in vivo to promote the complete differentiation of OPC
La chronicité. Aspects théoriques et pratiques dans les maladies chroniques (diabète, anorexie, schizophrénie) chez les adolescents.
International audienc
La chronicité. Aspects théoriques et pratiques dans les maladies chroniques (diabète, anorexie, schizophrénie) chez les adolescents.
International audienc
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