Alien Registration- Legge, Forrest G. (Baldwin, Cumberland County)

https://digitalmaine.com/alien_docs/32939/thumbnail.jp

Surface and subsurface structural response on the City of London cable tunnels project

This paper presents surface and subsurface ground and structural response to the excavation of an urban cable tunnel within London clay and the Lambeth Group strata. Project specific tunnelling volume losses were estimated and found to be dependent on face advance and geology. The presence of adjacent buildings reduced predicted ?greenfield? settlements. The tunnel passed below a continuous section comprising basements, box rail tunnels and other structures. These structures generally responded at the level of their foundations. The presence of a pile group through which the tunnel passed only reduced surface settlement by ~50%. Passing below two existing segmentally-lined LUL tunnels these responded immediately and as predicted, although with somewhat increased trough widths indicating a stiffening effect. A multi-span bridge directly above the LUL tunnels on deep pier foundations, part of the Holborn Viaduct, settled more slowly and twice as much as anticipated. A possible general effect of tunnelling on heavily loaded foundations including end-bearing piles is discussed

The automated array assembly task of the low-cost silicon solar array project, phase 2

Several specific processing steps as part of a total process sequence for manufacturing silicon solar cells were studied. Ion implantation was identified as the preferred process step for impurity doping. Unanalyzed beam ion implantation was shown to have major cost advantages over analyzed beam implantation. Further, high quality cells were fabricated using a high current unanalyzed beam. Mechanically masked plasma patterning of silicon nitride was shown to be capable of forming fine lines on silicon surfaces with spacings between mask and substrate as great as 250 micrometers. Extensive work was performed on advances in plated metallization. The need for the thick electroless palladium layer was eliminated. Further, copper was successfully utilized as a conductor layer utilizing nickel as a barrier to copper diffusion into the silicon. Plasma etching of silicon for texturing and saw damage removal was shown technically feasible but not cost effective compared to wet chemical etching techniques

The Principles of Proton Probe Microanalysis in Biology

The proton microprobe, more correctly described as an ion microprobe which operates at MeV energies, complements its parent instrument the electron microprobe. This paper compares the basic principles and performance of the two instruments and relates the evolution of biological analysis on such ion microprobes to that on electron microprobes, covering the development of sample handling techniques and of data handling techniques and comparing beam damage studies. The paper describes the variety of techniques available to the ion microprobe - the initial techniques of Energy Dispersive X-ray analysis, Rutherford Back Scattering and Nuclear Reaction Analysis and the rapid evolution of new techniques, from Scanning Transmission Ion Microscopy to 3-dimensional tomography. All of these new techniques required the advanced computerised data handling which has been a feature of ion microprobe development

Research Paper Youth Service

An assumption that most people would probably agree on is that service to community, on a voluntary basis, builds character, self esteem, pride toward one\u27s self and his/her community, develops personal growth and respect or compassion for others. I don\u27t think many people look beyond that. Does the service need to be voluntary? Is service a responsibility that goes with being a part of a community? Why is service a positive aspect of community life? What are the characteristics of service that make it a fulfilling experience? Should youth be required to serve their community? If so, are there other options? Is service a community or school issue? Or both? There are many more questions, however; most people just know it\u27s important, as do some of the youth that were surveyed or interviewed for this paper

Processing experiments on non-Czochralski silicon sheet

A program is described which supports and promotes the development of processing techniques which may be successfully and cost-effectively applied to low-cost sheets for solar cell fabrication. Results are reported in the areas of process technology, cell design, cell metallization, and production cost simulation

Issues for designing and evaluating a 'heroin trial': three discussion papers

Report on a workshop on trial evaluation / G. Bammer and D.N. McDonald -- An evaluation of possible designs for a heroin trial / R.G. Jarrett and P.J. Solomon -- Service provision considerations for the evaluation of a heroin trial. A discussion paper / D.N. McDonald, G. Bammer, D.G. Legge and B.M. Sibthorpe

The potential for multi-disciplinary primary health care services to take action on the social determinants of health: actions and constraints

The Commission on the Social Determinants of Health and the World Health Organization have called for action to address the social determinants of health. This paper considers the extent to which primary health care services in Australia are able to respond to this call. We report on interview data from an empirical study of primary health care centres in Adelaide and Alice Springs, Australia.This study was funded by an NH&MRC Project Grant 535041 and FB’s time is funded by an ARC Federation Fellowship. RL is funded by the Canada Research Chair program

Optimized delivery of siRNA into 3D tumor spheroid cultures in situ

3D tissue culture provides a physiologically relevant and genetically tractable system for studying normal and malignant human tissues. Despite this, gene-silencing studies using siRNA has proved difficult. In this study, we have identified a cause for why traditional siRNA transfection techniques are ineffective in eliciting gene silencing in situ within 3D cultures and proposed a simple method for significantly enhancing siRNA entry into spheroids/organoids. In 2D cell culture, the efficiency of gene silencing is significantly reduced when siRNA complexes are prepared in the presence of serum. Surprisingly, in both 3D tumour spheroids and primary murine organoids, the presence of serum during siRNA preparation rapidly promotes entry and internalization of Cy3-labelled siRNA in under 2 hours. Conversely, siRNA prepared in traditional low-serum transfection media fails to gain matrigel or spheroid/organoid entry. Direct measurement of CTNNB1 mRNA (encoding β-catenin) from transfected tumour spheroids confirmed a transient but significant knockdown of β-catenin when siRNA:liposome complexes were formed with serum, but not when prepared in the presence of reduced-serum media (Opti-MEM). Our studies suggest a simple modification to standard lipid-based transfection protocols facilitates rapid siRNA entry and transient gene repression, providing a platform for researchers to improve siRNA efficiency in established 3D cultures

Role of minimally invasive surgery versus open approach in patients with early-stage uterine carcinosarcomas: a retrospective multicentric study

Objective: The aim of this retrospective study was to compare surgical and survival outcome in only patients with early-stage UCSs managed by laparotomic surgery (LPT) versus minimally invasive surgery (MIS). Methods: Data were retrospectively collected in four Italian different institutions. Inclusion criteria were UCS diagnosis confirmed by the definitive histological examination, and stage I or II according to the FIGO staging system. Results: Between August 2000 and March 2019, the data relative to 170 patients bearing UCSs were collected: of these, 95 were defined as early-stage disease (stage I-II) based on the histological report at the primary surgery, and thus were included in this study. Forty-four patients were managed by LPT, and 51 patients were managed by MIS. The operative time was lower in the MIS group versus the LPT group (p value 0.021); the median estimated blood loss was less in the MIS group compared to the median of LPT group (p value < 0.0001). The length of hospital stay days was shorter in the MIS patients (p value < 0.0001). Overall, there were eight (8.4%) post-operative complications; of these, seven were recorded in the LPT group versus one in the MIS group (p value 0.023). There was no difference in the disease-free survival (DFS) and overall survival (OS) between the two groups. Conclusion: There was no difference of oncologic outcome between the two approaches, in face of a more favourable peri-operative and post-operative profile in the MIS group