1,171 research outputs found
Switchable lasing in coupled multimode microcavities
We propose the new concept of a switchable multimode microlaser. As a
generic, realistic model of a multimode microresonator a system of two coupled
defects in a two-dimensional photonic crystal is considered. We demonstrate
theoretically that lasing of the cavity into one selected resonator mode can be
caused by injecting an appropriate optical pulse at the onset of laser action
(injection seeding). Temporal mode-to-mode switching by re-seeding the cavity
after a short cool-down period is demonstrated by direct numerical solution. A
qualitative analytical explanation of the mode switching in terms of the laser
bistability is presented.Comment: Accepted for publication in Physical Review Letters. Published,
somewhat shortened versio
The Toxicity of Copper to Crocosphaera watsonii and Other Marine Phytoplankton: A Systematic Review
The cupric ion (Cu2+) plays a dual role as both nutrient and toxicant to freshwater and marine phytoplankton, functioning in multiple photochemical processes, as well as reactive oxygen species (ROS) production. This duality has been investigated through a variety of methods to determine the consequences of natural and anthropogenic copper introduction to algal ecosystem composition. Studies conducted over the past few decades have described the growth responses of many unique organisms to copper availability. Such observations are critical for describing the global distributions of major phytoplankton species in terms of global trace metal abundance; however, highly variable experimental practices impede direct inter-study comparison. The aim of this systematic review is to summarize the available data regarding the effects of copper concentration on diverse marine phytoplankton growth rates. Through extensive literary comparison, 143 studies were systematically reviewed, and data on copper concentrations and growth rates reported were extracted. From the data available, we conclude that trends in phytoplankton sensitivity to copper are mainly driven by a single study. We discuss the obstacles to inter-study comparison and detail both the concurring and conflicting results to date, with an emphasis on taxonomic trends and methodologies employed. Finally, we present the first copper sensitivity measurements for marine unicellular diazotrophs using three representative strains of the unicellular nitrogen-fixing cyanobacterium, Crocosphaera watsonii
Strangeness Conservation in Hot Nuclear Fireballs
A constraint between thermal fireball parameters arises from the requirement
that the balance of strangeness in a fireball is (nearly) zero. We study the
impact of this constraint on (multi-)strange (anti-)baryon multiplicities and
compare the hadron gas and quark-gluon plasma predictions. We explore the
relation between the entropy content and particle multiplicities and show that
the data are compatible with the quark-gluon plasma hypothesis, but appear to
be inconsistent with the picture of an equilibrated hadron gas fireball. We
consider the implications of the results on the dynamics of evolution and decay
of the particle source.Comment: 35 pages, 11 postscript figures, report PAR/LPTHE/92--2
Observing Quark-Gluon Plasma with Strange Hadrons
We review the methods and results obtained in an analysis of the experimental
heavy ion collision research program at nuclear beam energy of 160-200A GeV. We
study strange, and more generally, hadronic particle production experimental
data. We discuss present expectations concerning how these observables will
perform at other collision energies. We also present the dynamical theory of
strangeness production and apply it to show that it agrees with available
experimental results. We describe strange hadron production from the
baryon-poor quark-gluon phase formed at much higher reaction energies, where
the abundance of strange baryons and antibaryons exceeds that of nonstrange
baryons and antibaryons.Comment: 39 journal pages (155kb text), 8 postscript figures, 8 table
Janus monolayers of transition metal dichalcogenides.
Structural symmetry-breaking plays a crucial role in determining the electronic band structures of two-dimensional materials. Tremendous efforts have been devoted to breaking the in-plane symmetry of graphene with electric fields on AB-stacked bilayers or stacked van der Waals heterostructures. In contrast, transition metal dichalcogenide monolayers are semiconductors with intrinsic in-plane asymmetry, leading to direct electronic bandgaps, distinctive optical properties and great potential in optoelectronics. Apart from their in-plane inversion asymmetry, an additional degree of freedom allowing spin manipulation can be induced by breaking the out-of-plane mirror symmetry with external electric fields or, as theoretically proposed, with an asymmetric out-of-plane structural configuration. Here, we report a synthetic strategy to grow Janus monolayers of transition metal dichalcogenides breaking the out-of-plane structural symmetry. In particular, based on a MoS2 monolayer, we fully replace the top-layer S with Se atoms. We confirm the Janus structure of MoSSe directly by means of scanning transmission electron microscopy and energy-dependent X-ray photoelectron spectroscopy, and prove the existence of vertical dipoles by second harmonic generation and piezoresponse force microscopy measurements
Planet Hunters. VIII. Characterization of 41 Long-Period Exoplanet Candidates from Kepler Archival Data
The census of exoplanets is incomplete for orbital distances larger than 1
AU. Here, we present 41 long-period planet candidates in 38 systems identified
by Planet Hunters based on Kepler archival data (Q0-Q17). Among them, 17
exhibit only one transit, 14 have two visible transits and 10 have more than
three visible transits. For planet candidates with only one visible transit, we
estimate their orbital periods based on transit duration and host star
properties. The majority of the planet candidates in this work (75%) have
orbital periods that correspond to distances of 1-3 AU from their host stars.
We conduct follow-up imaging and spectroscopic observations to validate and
characterize planet host stars. In total, we obtain adaptive optics images for
33 stars to search for possible blending sources. Six stars have stellar
companions within 4". We obtain high-resolution spectra for 6 stars to
determine their physical properties. Stellar properties for other stars are
obtained from the NASA Exoplanet Archive and the Kepler Stellar Catalog by
Huber et al. (2014). We validate 7 planet candidates that have planet
confidence over 0.997 (3-{\sigma} level). These validated planets include 3
single-transit planets (KIC-3558849b, KIC-5951458b, and KIC-8540376c), 3
planets with double transits (KIC-8540376b, KIC-9663113b, and KIC-10525077b),
and 1 planet with 4 transits (KIC-5437945b). This work provides assessment
regarding the existence of planets at wide separations and the associated false
positive rate for transiting observation (17%-33%). More than half of the
long-period planets with at least three transits in this paper exhibit transit
timing variations up to 41 hours, which suggest additional components that
dynamically interact with the transiting planet candidates. The nature of these
components can be determined by follow-up radial velocity and transit
observations.Comment: Published on ApJ, 815, 127 Notations of validated planets are changed
in accordance with naming convention of NASA Exoplanet Archiv
Following Mitochondrial Footprints through a Long Mucosal Path to Lung Cancer
BACKGROUND:Mitochondrial DNA (mtDNA) mutations are reported in different tumors. However, there is no information on the temporal development of the mtDNA mutations/content alteration and their extent in normal and abnormal mucosa continuously exposed to tobacco smoke in lung cancer patients. METHODOLOGY:We examined the pattern of mtDNA alteration (mtDNA mutation and content index) in 25 airway mucosal biopsies, corresponding tumors and normal lymph nodes obtained from three patients with primary lung cancers. In addition, we examined the pattern of mtDNA mutation in corresponding tumors and normal lymph nodes obtained from eight other patients with primary lung cancers. The entire 16.5 kb mitochondrial genome was sequenced on Affymetrix Mitochip v2.0 sequencing platform in every sample. To examine mtDNA content index, we performed real-time PCR analysis. PRINCIPAL FINDINGS:The airway mucosal biopsies obtained from three lung cancer patients were histopathologically negative but exhibited multiple clonal mtDNA mutations detectable in the corresponding tumors. One of the patients was operated twice for the removal of tumor from the right upper and left lower lobe respectively within a span of two years. Both of these tumors exhibited twenty identical mtDNA mutations. MtDNA content increased significantly (P<0.001) in the lung cancer and all the histologically negative mucosal biopsies except one compared to the control lymph node. CONCLUSIONS/SIGNIFICANCE:Our results document the extent of massive clonal patches that develop in lifetime smokers and ultimately give rise to clinically significant cancers. These observations shed light on the extent of disease in the airway of smokers traceable through mtDNA mutation. MtDNA mutation could be a reliable tool for molecular assessment of respiratory epithelium exposed to continuous smoke as well as disease detection and monitoring. Functional analysis of the pathogenic mtDNA mutations may be useful to understand their role in lung tumorigenesis
Altered splicing of the BIN1 muscle-specific exon in humans and dogs with highly progressive centronuclear myopathy
Amphiphysin 2, encoded by BIN1, is a key factor for membrane sensing and remodelling in different cell types. Homozygous BIN1 mutations in ubiquitously expressed exons are associated with autosomal recessive centronuclear myopathy (CNM), a mildly progressive muscle disorder typically showing abnormal nuclear centralization on biopsies. In addition, misregulation of BIN1 splicing partially accounts for the muscle defects in myotonic dystrophy (DM). However, the muscle-specific function of amphiphysin 2 and its pathogenicity in both muscle disorders are not well understood. In this study we identified and characterized the first mutation affecting the splicing of the muscle-specific BIN1 exon 11 in a consanguineous family with rapidly progressive and ultimately fatal centronuclear myopathy. In parallel, we discovered a mutation in the same BIN1 exon 11 acceptor splice site as the genetic cause of the canine Inherited Myopathy of Great Danes (IMGD). Analysis of RNA from patient muscle demonstrated complete skipping of exon 11 and BIN1 constructs without exon 11 were unable to promote membrane tubulation in differentiated myotubes. Comparative immunofluorescence and ultrastructural analyses of patient and canine biopsies revealed common structural defects, emphasizing the importance of amphiphysin 2 in membrane remodelling and maintenance of the skeletal muscle triad. Our data demonstrate that the alteration of the muscle-specific function of amphiphysin 2 is a common pathomechanism for centronuclear myopathy, myotonic dystrophy, and IMGD. The IMGD dog is the first faithful model for human BIN1-related CNM and represents a mammalian model available for preclinical trials of potential therapies
From research to practice: Lay adherence counsellors' fidelity to an evidence-based intervention for promoting adherence to antiretroviral treatment in the Western Cape, South Africa
In the Western Cape, lay counsellors are tasked
with supporting antiretroviral (ARV) adherence in public
healthcare clinics. Thirty-nine counsellors in 21 Cape
Town clinics were trained in Options for Health (Options),
an evidence-based intervention based on motivational
interviewing (MI). We evaluated counsellors’ ability to
deliver Options for addressing poor adherence following
5 days training. Audio-recordings of counselling sessions
collected following training were transcribed and translated
into English. Thirty-five transcripts of sessions conducted
by 35 counsellors were analysed for fidelity to the Options
protocol, and using the Motivational Interviewing
Treatment and Integrity (MITI) code. Counsellors struggled
with some of the strategies associated with MI, such as
assessing readiness-to-change and facilitating change talk.
Overall, counsellors failed to achieve proficiency in the
approach of MI according to the MITI. Counsellors were
able to negotiate realistic plans for addressing patients’
barriers to adherence. Further efforts aimed at strengthening
the ARV adherence counselling programme are
needed.Department of HE and Training approved lis
Electroosmotic flow reversal outside glass nanopores.
We report observations of a striking reversal in the direction of electroosmotic flow (EOF) outside a conical glass nanopore as a function of salt concentration. At high ionic strengths (>100 mM), we observe EOF in the expected direction as predicted by classical electrokinetic theory, while at low salt concentrations (<1 mM) the direction of the flow is reversed. The critical crossover salt concentration depends on the pore diameter. Finite-element simulations indicate a competition between the EOF generated from the inner and outer walls of the pore, which drives flows in opposite directions. We have developed a simple analytical model which reveals that, as the salt concentration is reduced, the flow rates inside the pore are geometrically constrained, whereas there is no such limit for flows outside the pore. This model captures all of the essential physics of the system and explains the observed data, highlighting the key role the external environment plays in determining the overall electroosmotic behavior
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