10 research outputs found
Operations Research
- Author
- Publication venue
- Digital Commons IC
- Publication date
- 01/01/2014
- Field of study
BLOOM: A 176B-Parameter Open-Access Multilingual Language Model
- Author
- :
- Abdollahi Arezoo
- Abdulmumin Idris
- Abrar Nafis
- Adelani David Ifeoluwa
- Aghagol Arash
- Aji Alham Fikri
- Ajibade Benjamin
- Akiki Christopher
- Akinlolu Martha
- Al-shaibani Maged S.
- Albanie Samuel
- Alfassy Amit
- Alizadeh Samira
- allal Loubna Ben
- Almubarak Khalid
- Altay Gabriel
- Alyafeai Zaid
- Ammanamanchi Pawan Sasanka
- Amuok Priscilla
- An Ran
- Antverg Omer
- Bach Stephen H.
- Bajaj Yash Shailesh
- Bamberger Zachary
- Bari M Saiful
- Barth Fabio
- Baruwa Ahmed
- Bawden Rachel
- Baylor Emi
- Bayrak Giyaseddin
- Behroozi Bahareh
- Beilharz Benjamin
- Bekman Stas
- Belinkov Yonatan
- Belkada Younes
- Bello Imane
- Beltagy Iz
- Ben-David Srulik
- Benyamina Hamza
- Bers Tali
- Bharati Sushil
- Bhattacharjee Joydeep
- Bhattacharya Indrani
- Biderman Stella
- Bogdanov Eli
- Bommasani Rishi
- Bose Shamik
- Bourfoune Hatim
- Bras Mathilde
- Brito Caio
- Broad Nicholas Michio
- Brody Shaked
- Bulchandani Lokesh
- Burns Gully
- Burynok Mykola
- Cahyawijaya Samuel
- Callahan Alison
- Canalli Rodrigo
- Carpuat Marine
- Casper Jared
- Castagné Roman
- Castillo Maria A
- Chaffin Antoine
- Chandrasekhar Ramya
- Chang Jonathan
- Chen Kimbo
- Cheng Newton
- Cheveleva Anastasia
- Chhablani Gunjan
- Chim Jenny
- Chung Hyung Won
- Clinciu Miruna
- Clive Jordan
- Coavoux Maximin
- Colombo Pierre
- Contractor Danish
- Cornette Pierre
- Cullan Michael
- Dahlberg Nathan
- Danchev Valentin
- Dash Ishani
- Datta Debajyoti
- David Davis
- de Bykhovetz Madeleine Hahn
- de Gibert Ona
- de la Rosa Javier
- De Toni Francesco
- De Wolf Michiel
- del Moral Albert Villanova
- Deshmukh Shlok S
- Dettmers Tim
- Dey Manan
- Dodge Jesse
- Dupont Gérard
- Dutra Livia
- Eisenberg Renata
- Elbadri Maraim
- Elkott Nour
- Elsahar Hady
- Emezue Chris
- Espejel Omar
- Fahmy Nour
- Fan Angela
- Faranak Amy
- Feizpour Amir
- Ferrandis Carlos Muñoz
- Fevry Thibault
- Forde Jessica Zosa
- Fourrier Clémentine
- Freidank Moritz
- Fries Jason Alan
- Frohberg Jörg
- Fuhrimann Florian
- Fung Pascale
- Gallé Matthias
- Gandhi Sanchit
- Gao Leo
- Garda Samuele
- Garrette Dan
- Gehrmann Sebastian
- Gerchick Marissa
- Ghaleb Mustafa
- Ghauri Muhammed
- Gigant Théo
- Giorgi John
- Gokaslan Aaron
- Golde Jonas
- Gonzalez-Dios Itziar
- Grandury María
- HajiHosseini Azadeh
- Haller Patrick
- Hao Ryan
- Harliman Rheza
- Hazan Liam
- Heinzerling Benjamin
- Henderson Peter
- Hesslow Daniel
- Hevia Anthony
- Huang Max
- Ilić Suzana
- Jain Chirag
- Jauhar Mohammad A.
- Jernite Yacine
- Jiang Mike Tian-Jian
- Johnson Isaac
- Jones Hessie
- Kainuma Tomoya
- Kalo Jan-Christoph
- Kang Jihyun
- Kang Myungsun
- Kasai Jungo
- Kashyap Abhinav Ramesh
- Kasner Zdeněk
- Kassner Nora
- Kawamura Ken
- Khamis Nurulaqilla
- Khan Ammar
- Kiblawi Sid
- Kiela Douwe
- Kim Ethan
- Kim Najoung
- Kim Taewoon
- Klamm Christopher
- Kromann Rasmus
- Kruszewski Germán
- Kumar Srishti
- Kusa Wojciech
- Labrak Yanis
- Lacroix Rémi
- Laippala Veronika
- Lansky David
- Laud Tanmay
- Launay Julien
- Laurençon Hugo
- Lavallée Pierre François
- Le Thanh
- Le Trieu
- Lee Wilson Y.
- Leong Colin
- Lepercq Violette
- Levkovizh Efrat
- Lhoest Quentin
- Li Conglong
- Ligozat Anne-Laure
- Limisiewicz Tomasz
- Liu Lu
- Liu Minna
- Lo Kyle
- Longpre Shayne
- Lovering Charles
- Luccioni Alexandra Sasha
- López Roberto Luis
- Manica Matteo
- Manjavacas Enrique
- Martin Robert
- Masoud Maraim
- McKenna Michael
- McMillan-Major Angelina
- Mielke Sabrina J.
- Mieskes Margot
- Mihaljcic Mina
- Mikhailov Vladislav
- Miranda-Escalada Antonio
- Mirkin Shachar
- Mirza Fatima
- Mishra Mayank
- Mishra Shubhanshu
- Mitchell Margaret
- Molano Daniel
- Mou Chenghao
- Muellner Nikolaus
- Muennighoff Niklas
- Muhammad Shamsuddeen Hassan
- Muñoz Manuel Romero
- Nagel Sebastian
- Narayanan Deepak
- Natan Eyal Bar
- Nayak Nihal
- Neeraj Trishala
- Nejadgholi Isar
- Nezhurina Marianna
- Nguyen Duong A.
- Nguyen Huu
- Nguyen Olivier
- Nguyen Zach
- Nikoulina Vassilina
- Nikpoor Somaieh
- Nitzav Ariel Kreisberg
- Novikova Jekaterina
- Névéol Aurélie
- Ononiwu Frankline
- Osei Salomey
- Ott Simon
- Oyebade Tobi
- Ozoani Ezinwanne
- Pai Suhas
- Pais Shani
- Palasciano Alfredo
- Pandey Harshit
- Passmore Jesse
- Patil Suraj
- Patry Nicolas
- Pavlick Ellie
- Periñán Daniel León
- Pestana Amanda
- Peyrounette Myriam
- Phan Long
- Phang Jason
- Pistilli Giada
- Ponferrada Eduardo González
- Posada Jose David
- Prabhu Vrinda
- Press Ofir
- Protasov Vitaly
- Pruksachatkun Yada
- Pyysalo Sampo
- Pàmies Marc
- Qiu Mike
- Radev Dragomir
- Raffel Colin
- Raja Arun
- Rajani Nazneen
- Rajbhandari Samyam
- Rasley Jeff
- Raunak Vikas
- Reiter Ehud
- Requena Stéphane
- Rezanejad Habib
- Ribeiro Rui
- Rieser Verena
- Roberts Adam
- Rogers Anna
- Roy Sourav
- Rozen Jos
- Rueda Alice
- Rush Alexander M.
- Ruwase Olatunji
- Ryabinin Max
- Sagot Benoît
- Salesky Elizabeth
- Samagaio Mairon
- Samuel Olanrewaju
- Samwald Matthias
- Sang-aroonsiri Sinee
- Sanh Victor
- Sanseviero Omar
- Santilli Andrea
- Santos Ana
- Sanz Julio Bonis
- Saulnier Lucile
- Saxena Bharat
- Scao Teven Le
- Schick Timo
- Schoelkopf Hailey
- Schweter Stefan
- Scialom Thomas
- Sedenko Irina
- Seelam Natasha
- Seltzer Josh
- Serikov Oleg
- Sharma Abheesht
- Sharma Shanya
- Shavrina Tatiana
- Shen Sheng
- Shinzato Luisa
- Shoeybi Mohammad
- Shubber Sarmad
- Shukla Anima
- Si Chenglei
- Silberberg Stanislav
- Simhi Adi
- Singh Amanpreet
- Singh Ayush
- Singh Mayank
- Sivaraman Karthik Rangasai
- Smith Shaden
- Solaiman Irene
- Soroa Aitor
- Stiegler Arnaud
- Strobelt Hendrik
- Su Rosaline
- Su Ruisi
- Suarez Pedro Ortiz
- Subramani Nishant
- Subramonian Arjun
- Sun Zhiqing
- Sutawika Lintang
- Szczechla Eliza
- Sänger Mario
- Tae Jaesung
- Takeuchi Maiko
- Taktasheva Ekaterina
- Talat Zeerak
- Tammour Aycha
- Tan Edward
- Tan Samson
- Tan Zhe
- Tang Xiangru
- Tanguy Ludovic
- Tazi Nouamane
- Taşar Davut Emre
- Teehan Ryan
- Thakker Urmish
- Thrush Tristan
- Tobing Joseph
- Tojarieh Hadar
- Torrent Tiago Timponi
- Tow Jonathan
- Tran Hieu
- Tunuguntla Deepak
- Unldreaj Antigona
- Uri Yallow
- van der Wal Oskar
- van Strien Daniel
- Venkatraman Yash
- Viguier Sylvain
- Villegas Paulo
- Voloshina Ekaterina
- von Platen Patrick
- Von Werra Leandro
- Vrabec Helena U.
- Vu Minh Chien
- Wang Bo
- Wang Han
- Wang Silas
- Wang Thomas
- Weber Leon
- Webson Albert
- Weinberg Michael
- Winata Genta Indra
- Wolf Thomas
- Workshop BigScience
- Xie Zhongli
- Xu Canwen
- Xu Chuxin
- Xu Yifan
- Xu Yingxin
- Xu Yu
- Yang Yoyo
- Ye Zifan
- Yong Zheng-Xin
- Yu Dian
- Yu Ian
- Yun Tian
- Yvon François
- Zhang Minjia
- Zhang Rui
- Zhang Ruochen
- Zhou Chenxi
- Zhu Jian
- Zink Sydney
- Šaško Mario
- Publication venue
- Publication date
- 10/12/2022
- Field of study
Large language models (LLMs) have been shown to be able to perform new tasks
based on a few demonstrations or natural language instructions. While these
capabilities have led to widespread adoption, most LLMs are developed by
resource-rich organizations and are frequently kept from the public. As a step
towards democratizing this powerful technology, we present BLOOM, a
176B-parameter open-access language model designed and built thanks to a
collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer
language model that was trained on the ROOTS corpus, a dataset comprising
hundreds of sources in 46 natural and 13 programming languages (59 in total).
We find that BLOOM achieves competitive performance on a wide variety of
benchmarks, with stronger results after undergoing multitask prompted
finetuning. To facilitate future research and applications using LLMs, we
publicly release our models and code under the Responsible AI License
36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE
- Author
- Abdel-Azim Tarek Ahmed Adel
- Abdool-Carrim Abu
- Abdool-Gaffar Mohamed
- Abdullah Nik Azim Nik
- Abiko Akihiko
- Abril Juan Moreno Hoyos
- Acevedo David - Riesco
- Adademir Taylan
- Adler David
- Ageno Walter
- Ageno Walter
- Agnelli Giancarlo
- Ahmed Mostafa Shawky
- Aksoy Ahmet
- Aktogu Serir Ozkan
- Ali Gholam
- Alikhan Raz
- Allen Gregory
- Amann-Vesti Beatrice
- Angchaisuksiri Pantep
- Angchaisuksiri Pantep
- Arouni Amy
- Ayala-Paredes Félix
- Azeddine Addala
- Balthazar Yohan
- Bang Soo-Mee
- Banyai Martin
- Barbarash Olga
- Barrionuevo Marcelo Raul
- Battaloglu Bektas
- Bax W.A.
- Behrens Steffen
- Belenky Dmitry
- Benitez Juan Carlos Álvarez
- Berli Mario Alberto
- Bernadette Peuch
- Berni Andrea
- Beyer-Westendorf Jan
- Beyers Adriaan
- Bezuidenhout Abraham
- Bidi Claude Luyeye
- Binet Laure
- Biss Tina
- Blasco Luis Manuel Hernandez
- Blessing Erwin
- Blombery Peter
- Bono Julio
- Boomars Karin
- Boondumrongsagoon Juree
- Borges Lohana
- Bosch Manuel Monreal
- Botha Louis
- Bounameaux Henri
- Bounameaux Henri
- Boussy Tim
- Bowers Margaret
- Boyarkin Mikhail
- Brauer Cornelia
- Burbury Kate
- Burianova Hana
- Burov Yuriy
- Béatrice Terriat
- Cader Cas
- Canevascini Reto
- Capiau Luc
- Cappelli Roberto
- Carine Boulon
- Carrier Marc
- Carroll Patrick
- Casabella Tomas Smith
- Cattaneo Marco
- Cech Vladimir
- Cervera Luis Flota
- Cha Seung Ick
- Chacko Joseph
- Chang Kuan-Cheng
- Chansung Kanchana
- Chao Ting-Hsing
- Chauhan Anoop
- Chayangsu Sunee
- Chetanachan Mariam
- Chew Lee Ping
- Chiang Chern-En
- Chiang Chern-En
- Chiu Kuan-Ming
- Choi Won Il
- Christian Ponchaux
- Christophe Brousse
- Christophe Seinturier
- Chunilal Sanjeev
- Clark Amanda
- Colak Abdurrahim
- Correa João Antônio
- Cosmi Benilde
- Cosmi Franco
- Coufal Zdenek
- Creagh Desmond
- Cristina Leone Maria
- Cuneo Carlos Alberto
- D'Angelo Armando
- Dalmau Garcia-Bragado
- Damien Garrigues
- Darius Harald
- Datta Sudip
- De Backer Wilfried
- De La Azuela Tenorio Isabel M.
- de Leon Raul Franco Diaz
- de los Rios Ibarra Manuel
- De Pauw Michel
- De Raedt Herbert
- De Vleeschauwer Philippe
- Dees Adriaan
- del Toro Jorge
- del Toro Jorge
- Diaz Carlos Jerjes Sanchez
- Diaz Enrique Diaz
- Dogan Emre
- Dominique Brisot
- Dominique Elkouri
- Dominique Stephan
- Donders Servaas
- Dorokhov Dmitry
- Duchateau Johan
- Duda Norberto
- el Bary Mostafa Soliman Abd
- El-Dessoki Mohamed
- Elali Hallah
- ElDin Hesham Salah
- Elisa Chevrier
- Emmanuel Messas
- Erdelyi Barbara
- Erdkamp Frans
- Esheiba Ehab M.
- Esperón Guillermo Antonio Llamas
- Essameldin Sherif Mohamed
- Everington Tamara
- Faghih Markus
- Falanga Anna
- Farjat Alfredo E.
- Fedele Jose Luis
- Ferkl Richard
- Fernandez Alberto Alfredo
- Fernandez Manuel Núñez
- Ferrini Piera Maria
- Ferroni Fabian
- Filho Jose Dalmo Araujo
- Fixley Mark
- Fletcher John Perry
- Flores Oscar Nandayapa
- Francis Couturaud
- Francois Bergmann Jean
- Franow Hendrik
- Gad Amr
- Gaffney Mary Elizabeth
- Galvar Javier Tristan
- Galvez Angel
- Gamba Marco Antonio Alcocer
- Gan Gin Gin
- Gerdes Victor
- Gerofke Hagen
- Gibbs Harry
- Gibbs Harry
- Gogia Harinder S.
- Goldhaber Samuel Z.
- Gordeev Ivan
- Goto Shinya
- Goto Shinya
- Griffin Sam
- Grochenig Ernst
- Gujral Jaspal
- Gur Ozcan
- Gurbuz Orcun
- Gustin Michel
- Guzman Luis Alberto
- Ha Chung Yin
- Haas Sylvia
- Haddad Ghassan
- Hagemann Dirk
- Hainaut Philippe
- Hameed Muhammad
- Hart Terence
- Hasanoglu Hatice
- Hashas Erman
- Haverkamp Wilhelm
- Helene Desmurs-Clavel
- Henry Fitjerald
- Herdy Artur
- Hirano Masao
- Ho Prahlad
- Ho Wai Khoon
- Hollanders Geert
- Homza Miroslav
- Horacek Thomas
- Hsia Chien-Hsun
- Huang Chi-Hung
- Huang Chien-Lung
- Huang Chun-Yao
- Humphrey Julian
- Hunt Beverley
- Husin Azlan
- Hwang Hun Gyu
- Iamsai Piriyaporn
- Imberti Davide
- Isabelle Mahe
- Isbir Selim
- Jacobson Barry
- Jansky Petr
- Jean-Léopold Siwe-Nana
- Jean-Manuel Kubina
- Jean-Paul Guillot
- Jeanneret-Gris Christina
- Jerwan-Keim Reinhold
- Jiang Weihong
- Jimenez David
- Jing Zhicheng
- Jing Zhicheng
- Joh Jin Hyun
- Kakkar Ajay K.
- Kamalov Gadel
- Kanda Junji
- Kanemoto Masashi
- Kanitsap Nonglak
- Kanko Muhip
- Karaarslan Kemal
- Kassis Jeannine
- Kato Atsushi
- Kayani Gloria
- Kaye-Eddie Grace
- Kazakov Andrey
- Keeling David
- Kelly Allan
- Khan Mohamed
- Kho Bonnie Chi Shan
- Khotuntsov Alexey
- Kim Ho Young
- Kim Igor
- Kim JangYong
- Kim Jin Seok
- Kim Moo Hyun
- Kim Yang-Ki
- Kiris Ilker
- Klamroth Robert
- Kleiban Andres Javier
- Klein Garry
- Kondo Katsuhiro
- Koretzky Martin
- Korte Wolfgang
- Koto Modise
- Koura Firas
- Kovacs Michael
- Krasavin Vladimir
- Krichell Alan
- Kroeger Knut
- Kroening Ralf
- Krupicka Jiri
- Kubat Emre
- Kucera Dusan
- Kuki Shintaro
- Kuo Jen-Yuan
- Kvasnicka Jan
- Kwok Chi-Hang Kevin
- Kwon JiHyun
- Lai Wen-Ter
- Lang Pavel
- Lara Jose Gomez
- Lastuvka Jiri
- Lawall Holger
- Le Gal Gregoire
- Le Roux Dirk
- Leahy Michael
- Lee Jae Hoon
- Lee Moon-Hee
- Levy Michael
- Libov Igor
- Lin Wei-Hsiang
- Lockman Ann
- Lodigiani Corrado
- Looi Irene
- Lopes Renato D.
- Loualidi Ab
- Lunn Charles
- Luo Canhua
- Luvhengo Thifhelimbilu
- López Luciano Eduardo
- Maasdorp Shaun
- MacCallum Peter
- Machowski Andrew
- Maheshwari Uma
- Majumder Mujibur
- Makruasi Nisa
- Malek Wagih Fawzy Abdel
- Marchena Pablo Javier
- Marie-Antoinette Sevestre-Pietri
- Marino Javier
- Martinez Rafael
- Matsuoka Shunzo
- Mazzone Antonino
- McRae Simon
- Mellor Stuart
- Mendes Robert
- Merli Geno
- Michèle Escande Orthlieb
- Middeldorp Saskia
- Miranda Raimundo Tirado
- Mohamed Ahmed
- Mohamed Monniaty
- Moia Marco
- Motte Serge
- Moustafa Moustafa A.
- Mumoli Nicola
- Mun Yeung-Chul
- Munch Michael
- Muntaner Juan
- Muntaner Juan Antonio
- Murena-Schmidt Renate
- Mustafa Bisher
- Mutirangura Pramook
- Myriam Martin
- Møller Dorthe
- Na Sang Hoon
- Nagib Mohamed Ayman Fakhry
- Nakamura Hiroaki
- Nakamura Mashio
- Nakazawa Satoshi
- Nam Seung-Hyun
- Natha Bhavesh
- Nicolas Falvo
- Nielsen Jørn
- Norasetthada Lalita
- Nordin Nordiana
- Numbenjapon Tontanai
- Nyvad Ole
- Ohler Hans-Juergen
- Ohnuma Yasushi
- Olsen Michael
- Onodera Tomoya
- Opitz Christian
- Oropallo Alisha
- Otero Remedios
- Oto Oztekin
- Paez Jorge Guillermo Chavez
- Panchenko Elizaveta
- Park Jin Hyun
- Park Yong
- Paruk Nishen
- Patanasing Siriwimon
- Peromingo Jose Antonio Diaz
- Petrov Dmitry
- Pharr Walter
- Plassmann Georg
- Platt George
- Podpera Ivo
- Poirier Germain
- Poli Daniela
- Porreca Ettore
- Prandoni Paolo
- Prisco Domenico
- Prosecky Robert
- Pumprla Jiri
- Ratsela Rapule
- Raymundo Selma
- Reyes Raquel Lopez
- Reynolds Tim
- Ria Luigi
- Riera-Mestre Antoni
- Rojnuckarin Ponlapat
- Salem Ayman Abd Elhamid Ebrahim Mahmoud
- Santoro Rita
- Saraiva Jose
- Sathar Jameela
- Savas Ismail
- Schellong Sebastian
- Schellong Sebastian
- Schiavi Lilia Beatriz
- Schmidt Andor
- Schroe Herman
- Schul Marlin
- Schwencke Carsten
- Scott David
- Shah Gaurand
- Shibata Yoshisato
- Shih Jhih-Yuan
- Shim Hyeok
- Sholkamy Sherif Mohamed
- Shyu Kou-Gi
- Singh Rupesh
- Singh Suaran Singh Gurcharan
- Skowasch Dirk
- Slocombe Alison
- Smith Clifford
- Sokurenko German
- Soliman Mosaad
- Solymoss Susan
- Song Ik-Chan
- Sonkin Igor
- Souto Joan Carlos
- Spacek Rudolf
- Staroverov Ilya
- Staub Daniel
- Striekwold Harry
- Stuecker Markus
- Subbotin Yuriy
- Suchkov Igor
- Sun Shenghua
- Surinach Jose Maria
- Suwanban Tawatchai
- Svatopluk Koscál
- Svobodova Jaromira
- Tahar Mersel
- Takeuchi Kensuke
- Tanabe Yasuhiro
- ten Cate Hugo
- ten Cate Hugo
- Testa Sophie
- Theodoro Daniel
- Tian Hongyan
- Tick Lidwine
- Timmermans Luc
- Ting Seng Kiat
- Tiraferri Eros
- Toh Cheng Hock
- Toh See Guan
- Tolstikhin Vladimir
- Tosetto Alberto
- Toufek Berremeli
- Trimarco Bruno
- Tse Eric
- Tse Eric Wai Choi
- Tseng Wei-Kung
- Turker Hatice
- Turpie Alexander G.G.
- Ueng Kwo-Chang
- Usandizaga Esther
- Van Betsbrugge Michiel
- Van Herreweghe Rika
- Vandenbosch Kristel
- Vanwelden Jan
- Verhamme Peter
- Verhamme Peter
- Vesely Jiri
- Viboonjuntra Pongtep
- Vilamajo Oscar Gomez
- von Bilderling Peter Baron
- Wang Haofu
- Wang Shenming
- Ward Chris
- Watanabe Akinori
- Watt Simon
- Weitz Jeffrey I.
- Welker James
- Wells Rachel
- Wern Kwan Jing
- White Richard
- Wilson Benedicte
- Wong Lily Lee Lee
- Wong Raymond Siu Ming
- Wongkhantee Somchai
- Wu Chau-Chung
- Wu Chih-Cheng
- Wu Cynthia
- Yang Jinghua
- Yang Zhenwen
- Yang Zhongqi
- Yavuz Celal
- Yeo Erik
- Yhim Ho-Young
- Yiu Kai Hang
- Yoshida Shuichi
- Yoshida Winston
- Zaidman Cesar Javier
- Zateyshchikov Dmitry
- Zeller Thomas
- Zemek Stanislav
- Zhang Lei
- Zhang Weihua
- Zhu Hong
- Zidan Hesham
- Zidel Brian
- Zrazhevskiy Konstantin
- Zubareva Nadezhda
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/11/2022
- Field of study
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Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
- Abbasciano Isabella
- Abrantes Catarina
- Accarino Simone
- Adler Sharon
- Adoberg Annika
- Afsari Rouzbeh
- Ahmad Syeda
- Ahmed Jafar
- Ahn Wooin
- Ajayi Bamidele
- Aksamit Dariusz
- Al Chalabi Saif
- Alamartine Eric
- Alchi Bassam
- Ali Mohammad
- Aliotta Roberta
- Almaani Salem
- Almeida Catarina
- Almeida Edgar
- Alpers Charles E
- Alvarez Francisco de la Prada
- Alves Patricia
- Annese Francesca
- Appel Gerald
- Arduan Alberto Ortiz
- Arena Maria
- Arevalo Marta Calvo
- Arfaania Dariush
- Arias Carlos
- Aristoy Emma Calatayud
- Asakiene Egle
- Ashley Sarah
- Assefi Ali
- Atenza Alba
- Auerbach Asta
- Augustyniak-Bartosik Hanna
- Avella Monroy
- Ayling-Smith Jonathan
- Ayoub Isabelle
- Ayvazyan Christine
- Baccaro Rocco
- Bailey Asha
- Baker Bruce
- Balamuthusamy Saravanan
- Ballarin Jose
- Barata Rui
- Barbic Jerko
- Barisic Dunja
- Barratt Jonathan
- Barreto Jose Carlos de Jesus
- Barrios Clara
- Belingheri Mirco
- Benesova Anna
- Bernabeu Ana Avila
- Bernhardt Wanja
- Bhadra Shamik
- Biancone Luigi
- Bieler Stewart
- Blanchard Anne
- Boaglio Elena
- Bolignano Davide
- Bomback Andrew
- Bonilla Gustavo Andres Useche
- Bordoli Monica
- Bose Bhadran
- Boudville Neil
- Brandon Donald
- Brown Karen
- Broyet Christian
- Bucknall Thomas
- Buffet Alexandre
- Bumblyte' Inga Arune
- Burdese Manuel
- Burgos Natalia Allende
- Burguet Laure
- Burtey Stephane
- Busch Martin
- Cakiroglu Figen
- Campbell Victoria
- Canetta Pietro
- Capaccio Flavia
- Carbonell Juan
- Cardoso Filipa
- Carro Clara Garcia
- Carroll Robert
- Carron Pierre-Louis
- Carullo Nazareno
- Cassia Matthias
- Caster Dawn
- Castillo Belen Vizcaino
- Catucci Davide
- Cavalli Andrea
- Chae Dong-Wan
- Chakera Aron
- Chan Anthony Ting Pong
- Chan Doris
- Chan Gary Chi Wang
- Chan Lai Wan
- Chang Jae Hyun
- Chang Ming-Shan
- Chapman Fiona
- Charytan Chaim
- Chaudhry Asghar
- Cheetham Melissa
- Chen Cheng-Hsu
- Chen Chien-Liang
- Chen Hsin-Yu
- Chen Hung-Chun
- Chen Hung-Yuan
- Chenine Leila
- Cheung Chee Kay
- Cheung Siu Fai
- Chiche-Jourde Noemie
- Chiu Hsien-Fu
- Chiu Ian
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- Trimarchi Hernán
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- Tseng Po-Yu
- Tumlin James
- Tumlin James A
- Tung Kuei-Ting
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- Udani Suneel
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- Viaene Liesbeth
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- Vila Maria Antonia Munar
- Vilayur Eswari
- Villanueva Caridad Martinez
- Villarroya Cristina Medrano
- Villen Alejandro Soria
- Viramontes Veronica
- Vita Caterina
- Vujcic Dunja
- Wahba Mona
- Wan Susan
- Wang Chih-Hsien
- Warling Xavier
- Waters Gerald
- Waugh Jane
- Weiland Lea
- Weiner Stefan
- Weinreich Thomas
- Werth Stephan Christian
- Wickens Olivia
- Wijeratne Vidu
- Wilder Karen
- Willcocks Lisa
- Williams Allister
- Winiarska Agata
- Wirtz Nikolaus
- Wolf Gunter
- Wolf Lothar
- Wong Muh Geot
- Wong Sze Ho Sunny
- Wong Yick Hei
- Workeneh Biruh
- Wu Hon-Yen
- Wu Ming-Ju
- Wyndham Roger
- Yang Jihyun
- Yang Ju-Yeh
- Yeap Chii
- Yim Ka Fai
- Yong Kenneth
- Yoo Tae-Hyun
- Yoon Songuk
- Yu Tung-Min
- Yue Tak Tai Andrew
- Zakari Michel
- Zakauskiene Urte
- Zaoui Philippe
- Zbrzezniak Justyna
- Zielinska Dorota
- Zizzi Carlotta Federica
- Publication venue
- Publication date
- 01/11/2023
- Field of study
BackgroundSparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.MethodsPROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.FindingsBetween Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.InterpretationOver 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function
BLOOM: A 176B-Parameter Open-Access Multilingual Language Model
- Author
- Abdollahi Arezoo
- Abdulmumin Idris
- Abrar Nafis
- Adelani David Ifeoluwa
- Aghagol Arash
- Aji Alham Fikri
- Ajibade Benjamin
- Akiki Christopher
- Akinlolu Martha
- Al-Shaibani Maged S.
- Albanie Samuel
- Alfassy Amit
- Alizadeh Samira
- Allal Loubna Ben
- Almubarak Khalid
- Altay Gabriel
- Alyafeai Zaid
- Ammanamanchi Pawan Sasanka
- Amuok Priscilla
- An Ran
- Antverg Omer
- Bach Stephen H.
- Bajaj Yash Shailesh
- Bamberger Zachary
- Bari M Saiful
- Barth Fabio
- Baruwa Ahmed
- Bawden Rachel
- Baylor Emi
- Bayrak Giyaseddin
- Behroozi Bahareh
- Beilharz Benjamin
- Bekman Stas
- Belinkov Yonatan
- Belkada Younes
- Bello Imane
- Beltagy Iz
- Ben-David Srulik
- Benyamina Hamza
- Bers Tali
- Bharati Sushil
- Bhattacharjee Joydeep
- Bhattacharya Indrani
- Biderman Stella
- Bogdanov Eli
- Bommasani Rishi
- Bose Shamik
- Bourfoune Hatim
- Bras Mathilde
- Brito Caio
- Broad Nicholas Michio
- Brody Shaked
- Bulchandani Lokesh
- Burns Gully
- Burynok Mykola
- Cahyawijaya Samuel
- Callahan Alison
- Canalli Rodrigo
- Carpuat Marine
- Casper Jared
- Castagné Roman
- Castillo Maria A
- Chaffin Antoine
- Chandrasekhar Ramya
- Chang Jonathan
- Chen Kimbo
- Cheng Newton
- Cheveleva Anastasia
- Chhablani Gunjan
- Chim Jenny
- Chung Hyung Won
- Clinciu Miruna
- Clive Jordan
- Coavoux Maximin
- Colombo Pierre
- Contractor Danish
- Cornette Pierre
- Cullan Michael
- Dahlberg Nathan
- Danchev Valentin
- Dash Ishani
- Datta Debajyoti
- David Davis
- de Bykhovetz Madeleine Hahn
- de Gibert Ona
- de la Rosa Javier
- de Toni Francesco
- de Wolf Michiel
- del Moral Albert Villanova
- Deshmukh Shlok S
- Dettmers Tim
- Dey Manan
- Dodge Jesse
- Dupont Gérard
- Dutra Livia
- Eisenberg Renata
- Elbadri Maraim
- Elkott Nour
- Elsahar Hady
- Emezue Chris
- Espejel Omar
- Fahmy Nour
- Fan Angela
- Faranak Amy
- Feizpour Amir
- Ferrandis Carlos Muñoz
- Fevry Thibault
- Forde Jessica Zosa
- Fourrier Clémentine
- Freidank Moritz
- Fries Jason Alan
- Frohberg Jörg
- Fuhrimann Florian
- Fung Pascale
- Gallé Matthias
- Gandhi Sanchit
- Gao Leo
- Garda Samuele
- Garrette Dan
- Gehrmann Sebastian
- Gerchick Marissa
- Ghaleb Mustafa
- Ghauri Muhammed
- Gigant Théo
- Giorgi John
- Gokaslan Aaron
- Golde Jonas
- Gonzalez-Dios Itziar
- Grandury María
- Hajihosseini Azadeh
- Haller Patrick
- Hao Ryan
- Harliman Rheza
- Hazan Liam
- Heinzerling Benjamin
- Henderson Peter
- Hesslow Daniel
- Hevia Anthony
- Huang Max
- Ilić Suzana
- Jain Chirag
- Jauhar Mohammad A.
- Jernite Yacine
- Jiang Mike Tian-Jian
- Johnson Isaac
- Jones Hessie
- Kainuma Tomoya
- Kalo Jan-Christoph
- Kang Jihyun
- Kang Myungsun
- Kasai Jungo
- Kashyap Abhinav Ramesh
- Kasner Zdeněk
- Kassner Nora
- Kawamura Ken
- Khamis Nurulaqilla
- Khan Ammar
- Kiblawi Sid
- Kiela Douwe
- Kim Ethan
- Kim Najoung
- Kim Taewoon
- Klamm Christopher
- Kromann Rasmus
- Kruszewski Germán
- Kumar Srishti
- Kusa Wojciech
- Labrak Yanis
- Lacroix Rémi
- Laippala Veronika
- Lansky David
- Laud Tanmay
- Launay Julien
- Laurençon Hugo
- Lavallée Pierre François
- Le Thanh
- Le Trieu
- Lee Wilson Y.
- Leong Colin
- Lepercq Violette
- Levkovizh Efrat
- Lhoest Quentin
- Li Conglong
- Ligozat Anne-Laure
- Limisiewicz Tomasz
- Liu Lu
- Liu Minna
- Lo Kyle
- Longpre Shayne
- Lovering Charles
- Luccioni Alexandra Sasha
- López Roberto Luis
- Manica Matteo
- Manjavacas Enrique
- Martin Robert
- Masoud Maraim
- Mckenna Michael
- Mcmillan-Major Angelina
- Mielke Sabrina J.
- Mieskes Margot
- Mihaljcic Mina
- Mikhailov Vladislav
- Miranda-Escalada Antonio
- Mirza Fatima
- Mishra Mayank
- Mishra Shubhanshu
- Mitchell Margaret
- Molano Daniel
- Mou Chenghao
- Muellner Nikolaus
- Muennighoff Niklas
- Muhammad Shamsuddeen Hassan
- Muñoz Manuel Romero
- Nagel Sebastian
- Narayanan Deepak
- Natan Eyal Bar
- Nayak Nihal
- Neeraj Trishala
- Nejadgholi Isar
- Nezhurina Marianna
- Nguyen Duong A.
- Nguyen Huu
- Nguyen Olivier
- Nguyen Zach
- Nikoulina Vassilina
- Nikpoor Somaieh
- Nitzav Ariel Kreisberg
- Novikova Jekaterina
- Névéol Aurélie
- Ononiwu Frankline
- Ortiz Suarez Pedro
- Osei Salomey
- Ott Simon
- Oyebade Tobi
- Ozoani Ezinwanne
- Pai Suhas
- Pais Shani
- Palasciano Alfredo
- Pandey Harshit
- Passmore Jesse
- Patil Suraj
- Patry Nicolas
- Pavlick Ellie
- Periñán Daniel León
- Pestana Amanda
- Peyrounette Myriam
- Phan Long
- Phang Jason
- Pistilli Giada
- Ponferrada Eduardo González
- Posada Jose David
- Prabhu Vrinda
- Press Ofir
- Protasov Vitaly
- Pruksachatkun Yada
- Pyysalo Sampo
- Pàmies Marc
- Qiu Mike
- Radev Dragomir
- Raffel Colin
- Raja Arun
- Rajani Nazneen
- Rajbhandari Samyam
- Rasley Jeff
- Raunak Vikas
- Reiter Ehud
- Requena Stéphane
- Rezanejad Habib
- Ribeiro Rui
- Rieser Verena
- Roberts Adam
- Rogers Anna
- Roy Sourav
- Rozen Jos
- Rueda Alice
- Rush Alexander M.
- Ruwase Olatunji
- Ryabinin Max
- Sagot Benoît
- Salesky Elizabeth
- Samagaio Mairon
- Samuel Olanrewaju
- Samwald Matthias
- Sang-Aroonsiri Sinee
- Sanh Victor
- Sanseviero Omar
- Santilli Andrea
- Santos Ana
- Sanz Julio Bonis
- Saulnier Lucile
- Saxena Bharat
- Scao Teven Le
- Schick Timo
- Schoelkopf Hailey
- Schweter Stefan
- Scialom Thomas
- Sedenko Irina
- Seelam Natasha
- Seltzer Josh
- Serikov Oleg
- Sharma Abheesht
- Sharma Shanya
- Shavrina Tatiana
- Shen Sheng
- Shinzato Luisa
- Shoeybi Mohammad
- Shubber Sarmad
- Shukla Anima
- Si Chenglei
- Silberberg Stanislav
- Simhi Adi
- Singh Amanpreet
- Singh Ayush
- Singh Mayank
- Sivaraman Karthik Rangasai
- Smith Shaden
- Solaiman Irene
- Soroa Aitor
- Stiegler Arnaud
- Strobelt Hendrik
- Su Rosaline
- Su Ruisi
- Subramani Nishant
- Subramonian Arjun
- Sun Zhiqing
- Sutawika Lintang
- Szczechla Eliza
- Sänger Mario
- Tae Jaesung
- Takeuchi Maiko
- Taktasheva Ekaterina
- Talat Zeerak
- Tammour Aycha
- Tan Edward
- Tan Samson
- Tan Zhe
- Tang Xiangru
- Tanguy Ludovic
- Tazi Nouamane
- Teehan Ryan
- Thakker Urmish
- Thrush Tristan
- Tobing Joseph
- Tojarieh Hadar
- Torrent Tiago Timponi
- Tow Jonathan
- Tran Hieu
- Tunuguntla Deepak
- Unldreaj Antigona
- Uri Yallow
- van der Wal Oskar
- van Strien Daniel
- Venkatraman Yash
- Viguier Sylvain
- Villegas Paulo
- Voloshina Ekaterina
- von Platen Patrick
- von Werra Leandro
- Vrabec Helena U.
- Vu Minh Chien
- Wang Bo
- Wang Han
- Wang Silas
- Wang Thomas
- Weber Leon
- Webson Albert
- Weinberg Michael
- Winata Genta Indra
- Wolf Thomas
- Xie Zhongli
- Xu Canwen
- Xu Chuxin
- Xu Yifan
- Xu Yingxin
- Xu Yu
- Yang Yoyo
- Ye Zifan
- Yong Zheng-Xin
- Yu Dian
- Yu Ian
- Yun Tian
- Yvon François
- Zhang Minjia
- Zhang Rui
- Zhang Ruochen
- Zhou Chenxi
- Zhu Jian
- Zink Sydney
- Šaško Mario
- Publication venue
- HAL CCSD
- Publication date
- 12/11/2022
- Field of study
Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License
BLOOM: A 176B-Parameter Open-Access Multilingual Language Model
- Author
- :
- Abdollahi Arezoo
- Abdulmumin Idris
- Abrar Nafis
- Adelani David Ifeoluwa
- Aghagol Arash
- Aji Alham Fikri
- Ajibade Benjamin
- Akiki Christopher
- Akinlolu Martha
- Al-shaibani Maged S.
- Albanie Samuel
- Alfassy Amit
- Alizadeh Samira
- allal Loubna Ben
- Almubarak Khalid
- Altay Gabriel
- Alyafeai Zaid
- Ammanamanchi Pawan Sasanka
- Amuok Priscilla
- An Ran
- Antverg Omer
- Bach Stephen H.
- Bajaj Yash Shailesh
- Bamberger Zachary
- Bari M Saiful
- Barth Fabio
- Baruwa Ahmed
- Bawden Rachel
- Baylor Emi
- Bayrak Giyaseddin
- Behroozi Bahareh
- Beilharz Benjamin
- Bekman Stas
- Belinkov Yonatan
- Belkada Younes
- Bello Imane
- Beltagy Iz
- Ben-David Srulik
- Benyamina Hamza
- Bers Tali
- Bharati Sushil
- Bhattacharjee Joydeep
- Bhattacharya Indrani
- Biderman Stella
- Bogdanov Eli
- Bommasani Rishi
- Bose Shamik
- Bourfoune Hatim
- Bras Mathilde
- Brito Caio
- Broad Nicholas Michio
- Brody Shaked
- Bulchandani Lokesh
- Burns Gully
- Burynok Mykola
- Cahyawijaya Samuel
- Callahan Alison
- Canalli Rodrigo
- Carpuat Marine
- Casper Jared
- Castagné Roman
- Castillo Maria A
- Chaffin Antoine
- Chandrasekhar Ramya
- Chang Jonathan
- Chen Kimbo
- Cheng Newton
- Cheveleva Anastasia
- Chhablani Gunjan
- Chim Jenny
- Chung Hyung Won
- Clinciu Miruna
- Clive Jordan
- Coavoux Maximin
- Colombo Pierre
- Contractor Danish
- Cornette Pierre
- Cullan Michael
- Dahlberg Nathan
- Danchev Valentin
- Dash Ishani
- Datta Debajyoti
- David Davis
- de Bykhovetz Madeleine Hahn
- de Gibert Ona
- de la Rosa Javier
- De Toni Francesco
- De Wolf Michiel
- del Moral Albert Villanova
- Deshmukh Shlok S
- Dettmers Tim
- Dey Manan
- Dodge Jesse
- Dupont Gérard
- Dutra Livia
- Eisenberg Renata
- Elbadri Maraim
- Elkott Nour
- Elsahar Hady
- Emezue Chris
- Espejel Omar
- Fahmy Nour
- Fan Angela
- Faranak Amy
- Feizpour Amir
- Ferrandis Carlos Muñoz
- Fevry Thibault
- Forde Jessica Zosa
- Fourrier Clémentine
- Freidank Moritz
- Fries Jason Alan
- Frohberg Jörg
- Fuhrimann Florian
- Fung Pascale
- Gallé Matthias
- Gandhi Sanchit
- Gao Leo
- Garda Samuele
- Garrette Dan
- Gehrmann Sebastian
- Gerchick Marissa
- Ghaleb Mustafa
- Ghauri Muhammed
- Gigant Théo
- Giorgi John
- Gokaslan Aaron
- Golde Jonas
- Gonzalez-Dios Itziar
- Grandury María
- HajiHosseini Azadeh
- Haller Patrick
- Hao Ryan
- Harliman Rheza
- Hazan Liam
- Heinzerling Benjamin
- Henderson Peter
- Hesslow Daniel
- Hevia Anthony
- Huang Max
- Ilić Suzana
- Jain Chirag
- Jauhar Mohammad A.
- Jernite Yacine
- Jiang Mike Tian-Jian
- Johnson Isaac
- Jones Hessie
- Kainuma Tomoya
- Kalo Jan-Christoph
- Kang Jihyun
- Kang Myungsun
- Kasai Jungo
- Kashyap Abhinav Ramesh
- Kasner Zdeněk
- Kassner Nora
- Kawamura Ken
- Khamis Nurulaqilla
- Khan Ammar
- Kiblawi Sid
- Kiela Douwe
- Kim Ethan
- Kim Najoung
- Kim Taewoon
- Klamm Christopher
- Kromann Rasmus
- Kruszewski Germán
- Kumar Srishti
- Kusa Wojciech
- Labrak Yanis
- Lacroix Rémi
- Laippala Veronika
- Lansky David
- Laud Tanmay
- Launay Julien
- Laurençon Hugo
- Lavallée Pierre François
- Le Thanh
- Le Trieu
- Lee Wilson Y.
- Leong Colin
- Lepercq Violette
- Levkovizh Efrat
- Lhoest Quentin
- Li Conglong
- Ligozat Anne-Laure
- Limisiewicz Tomasz
- Liu Lu
- Liu Minna
- Lo Kyle
- Longpre Shayne
- Lovering Charles
- Luccioni Alexandra Sasha
- López Roberto Luis
- Manica Matteo
- Manjavacas Enrique
- Martin Robert
- Masoud Maraim
- McKenna Michael
- McMillan-Major Angelina
- Mielke Sabrina J.
- Mieskes Margot
- Mihaljcic Mina
- Mikhailov Vladislav
- Miranda-Escalada Antonio
- Mirkin Shachar
- Mirza Fatima
- Mishra Mayank
- Mishra Shubhanshu
- Mitchell Margaret
- Molano Daniel
- Mou Chenghao
- Muellner Nikolaus
- Muennighoff Niklas
- Muhammad Shamsuddeen Hassan
- Muñoz Manuel Romero
- Nagel Sebastian
- Narayanan Deepak
- Natan Eyal Bar
- Nayak Nihal
- Neeraj Trishala
- Nejadgholi Isar
- Nezhurina Marianna
- Nguyen Duong A.
- Nguyen Huu
- Nguyen Olivier
- Nguyen Zach
- Nikoulina Vassilina
- Nikpoor Somaieh
- Nitzav Ariel Kreisberg
- Novikova Jekaterina
- Névéol Aurélie
- Ononiwu Frankline
- Osei Salomey
- Ott Simon
- Oyebade Tobi
- Ozoani Ezinwanne
- Pai Suhas
- Pais Shani
- Palasciano Alfredo
- Pandey Harshit
- Passmore Jesse
- Patil Suraj
- Patry Nicolas
- Pavlick Ellie
- Periñán Daniel León
- Pestana Amanda
- Peyrounette Myriam
- Phan Long
- Phang Jason
- Pistilli Giada
- Ponferrada Eduardo González
- Posada Jose David
- Prabhu Vrinda
- Press Ofir
- Protasov Vitaly
- Pruksachatkun Yada
- Pyysalo Sampo
- Pàmies Marc
- Qiu Mike
- Radev Dragomir
- Raffel Colin
- Raja Arun
- Rajani Nazneen
- Rajbhandari Samyam
- Rasley Jeff
- Raunak Vikas
- Reiter Ehud
- Requena Stéphane
- Rezanejad Habib
- Ribeiro Rui
- Rieser Verena
- Roberts Adam
- Rogers Anna
- Roy Sourav
- Rozen Jos
- Rueda Alice
- Rush Alexander M.
- Ruwase Olatunji
- Ryabinin Max
- Sagot Benoît
- Salesky Elizabeth
- Samagaio Mairon
- Samuel Olanrewaju
- Samwald Matthias
- Sang-aroonsiri Sinee
- Sanh Victor
- Sanseviero Omar
- Santilli Andrea
- Santos Ana
- Sanz Julio Bonis
- Saulnier Lucile
- Saxena Bharat
- Scao Teven Le
- Schick Timo
- Schoelkopf Hailey
- Schweter Stefan
- Scialom Thomas
- Sedenko Irina
- Seelam Natasha
- Seltzer Josh
- Serikov Oleg
- Sharma Abheesht
- Sharma Shanya
- Shavrina Tatiana
- Shen Sheng
- Shinzato Luisa
- Shoeybi Mohammad
- Shubber Sarmad
- Shukla Anima
- Si Chenglei
- Silberberg Stanislav
- Simhi Adi
- Singh Amanpreet
- Singh Ayush
- Singh Mayank
- Sivaraman Karthik Rangasai
- Smith Shaden
- Solaiman Irene
- Soroa Aitor
- Stiegler Arnaud
- Strobelt Hendrik
- Su Rosaline
- Su Ruisi
- Suarez Pedro Ortiz
- Subramani Nishant
- Subramonian Arjun
- Sun Zhiqing
- Sutawika Lintang
- Szczechla Eliza
- Sänger Mario
- Tae Jaesung
- Takeuchi Maiko
- Taktasheva Ekaterina
- Talat Zeerak
- Tammour Aycha
- Tan Edward
- Tan Samson
- Tan Zhe
- Tang Xiangru
- Tanguy Ludovic
- Tazi Nouamane
- Taşar Davut Emre
- Teehan Ryan
- Thakker Urmish
- Thrush Tristan
- Tobing Joseph
- Tojarieh Hadar
- Torrent Tiago Timponi
- Tow Jonathan
- Tran Hieu
- Tunuguntla Deepak
- Unldreaj Antigona
- Uri Yallow
- van der Wal Oskar
- van Strien Daniel
- Venkatraman Yash
- Viguier Sylvain
- Villegas Paulo
- Voloshina Ekaterina
- von Platen Patrick
- Von Werra Leandro
- Vrabec Helena U.
- Vu Minh Chien
- Wang Bo
- Wang Han
- Wang Silas
- Wang Thomas
- Weber Leon
- Webson Albert
- Weinberg Michael
- Winata Genta Indra
- Wolf Thomas
- Workshop BigScience
- Xie Zhongli
- Xu Canwen
- Xu Chuxin
- Xu Yifan
- Xu Yingxin
- Xu Yu
- Yang Yoyo
- Ye Zifan
- Yong Zheng-Xin
- Yu Dian
- Yu Ian
- Yun Tian
- Yvon François
- Zhang Minjia
- Zhang Rui
- Zhang Ruochen
- Zhou Chenxi
- Zhu Jian
- Zink Sydney
- Šaško Mario
- Publication venue
- HAL CCSD
- Publication date
- 12/11/2022
- Field of study
Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
- Aaron Fearday (17386231)
- Abdallah Geara (17386297)
- Adam Morris (2043517)
- Adriana Fernandes (8856416)
- Adriana Sierra Ochoa (17386699)
- Aejin Kim (2175798)
- Agata Winiarska (17387086)
- Aine Maire De Bhailis (17386168)
- Ajay Dhaygude (10682946)
- Alastair Gillies (17386309)
- Alba Atenza (17385991)
- Alberto Ortiz Arduan (17385973)
- Alejandro Soria Villen (17387041)
- Alessia Fornoni (519467)
- Alex Mercer (59669)
- Alexandre Buffet (14930766)
- Alexandre Karras (506611)
- Alfred Rodriguez (17386840)
- Ali Assefi (17385988)
- Allister Williams (17387083)
- Allyson Medina (17386612)
- Alvaro Vaz (17387023)
- Alvita Vickiene (6473255)
- Amanda Hall (210816)
- Amanda Mather (285324)
- Amanda Siriwardana (17386933)
- Amar Mahdi (10295868)
- Amy Henderson (17386369)
- Amy Hudson (8412594)
- An Vanacker (17387017)
- Ana Avila Bernabeu (17386036)
- Ana Carolina Figueiredo (17386246)
- Ana Cortesão Costa (5670833)
- Ana Farinha (17386228)
- Ana Marta Gomes (2851424)
- Ana Messias (17386621)
- Ana Natario (17386672)
- Ana Perez de Jose (17386768)
- Ana Savuk (17386891)
- Ana Vilar Gimeno (17386312)
- Andrea Cavalli (102196)
- Andrea Solazzo (4768362)
- Andrew Bomback (17386042)
- Andrew Henderson (2641108)
- Andrew McNally (1982641)
- Angel Forcen (17386264)
- Angel Sevillano (17386918)
- Angus Ritchie (9950267)
- Angus Turnbull (17387002)
- Anna Benesova (17386033)
- Anna Jander (17386405)
- Anna Ricchiuto (17386831)
- Anne Blanchard (480536)
- Anne-Elisabeth Heng (4164625)
- Annegret Koch (17386468)
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- Annie Reynolds (8204301)
- Annika Adoberg (17385931)
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- Arun Gopu (17386342)
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- Arvind Ponnusamy (400089)
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- Bart Maes (17381011)
- Bassam Alchi (8830256)
- Belen Vizcaino Castillo (17386096)
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- Bhavna Pandya (17386720)
- Biruh Workeneh (17387098)
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- Bojan Jelakovic (7918907)
- Brad H Rovin (10218491)
- Brad Rovin (8412759)
- Bradley Nelson (3827992)
- Brendon Neuen (17386678)
- Brian Snow (17386948)
- Britt Newsome (17386681)
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- Bruce Cooper (151851)
- Bruce Julian (17386426)
- Bruce Spinowitz (6409616)
- Camille Lanaret (17386510)
- Caridad Martinez Villanueva (17387035)
- Carlos Arias (304158)
- Carlos Gonzalez (115102)
- Carlotta Federica Zizzi (17387131)
- Carmelita Marcantoni (17386579)
- Carmen Sivo (17386939)
- Carol Pollock (279260)
- Carole Philipponnet (5285909)
- Caroline Dudreuilh (7053749)
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- Chen Au Peh (17385913)
- Chen Peh (17386753)
- Cheng-Hsu Chen (546162)
- Cheuk Chun Szeto (5204135)
- Chi Kwan Darwin Lam (17386507)
- Chi-Chih Hung (106523)
- Chia-Tien Hsu (9597998)
- Chiara Cogno (17386144)
- Chien-Liang Chen (803676)
- Chien-Wei Huang (803672)
- Chih-Hsien Wang (438024)
- Chih-Yang Hsu (803675)
- Chii Yeap (17387104)
- Christian Broyet (17386057)
- Christian Combe (162087)
- Christiane Kettner (17386450)
- Christine Ayvazyan (17386006)
- Christophe Mariat (20472)
- Christopher Goldsmith (17386327)
- Christopher Keller (2135830)
- Chukwuma Chukwu (10703470)
- Ciro Esposito (812584)
- Claire Rigothier (162048)
- Clara Barrios (499063)
- Clara Garcia Carro (17386081)
- Clara Pardinhas (17386726)
- Clarisse Greze (17386351)
- Clement Dumond (17386210)
- Clementine Nicolo (17386687)
- Colin Geddes (8401272)
- Constantina Chrysochou (4096549)
- Cristina Medrano Villarroya (17387038)
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- Damien Thibaudin (6652541)
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- Dana Rizk (14302688)
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- David Semple (17386909)
- Davide Bolignano (665855)
- Davide Catucci (8214825)
- Davina Ngoi Wah Lie (17386534)
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- Dawn Caster (17386093)
- Didem Tez (17386990)
- Diliana Draganova (17386201)
- Dimitrios Moutzouris (17386660)
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- Eduardo Gutierrez Martinez (17386588)
- Eduardo Parra Moncasi (17386645)
- Eduardo Verde Moreno (17386654)
- Egle Asakiene (17385985)
- Elaine Phua (17386780)
- Elder Mendoza (17386618)
- Elena Boaglio (11721858)
- Elena Goma (17386330)
- Elena Gutierrez Solis (17386954)
- Eleni Stamellou (452849)
- Elizabeth Curry (17386156)
- Elizabeth Hendren (17386372)
- Elizabeth Stallworthy (17386957)
- Ellen McCarthy (17386600)
- Elsa Sofia Quadrado Soares (17386951)
- Elviira Seppet (17386912)
- Elzbieta Felicjanczuk (17386237)
- Emily McQuarrie (17386609)
- Emma Calatayud Aristoy (17385982)
- Emma Diletta Stea (14114145)
- Emma O'Lone (17386696)
- Eric Alamartine (15897599)
- Eric Firre (17386249)
- Eric Koester (17386471)
- Eric Thervet (497038)
- Erica Daina (17386159)
- Erika Perez (17386765)
- Esther Tamarit (17386975)
- Eswari Vilayur (8606958)
- Euan Noble (17386690)
- Eva Rodriguez Garcia (17386843)
- Evangelina Merida Herrero (17386381)
- Ewa Satora (17386888)
- Fabiola Alonso Garcia (17386288)
- Fahameedah Kamal (17386438)
- Faisal Fakih (17386225)
- Farah Latif (11996872)
- Farid Ghalli (17386303)
- Federica Di Maio (17386183)
- Federica Papadia (17386723)
- Federica Urciuolo (17387014)
- Fernando Nolasco (12732100)
- Figen Cakiroglu (17386075)
- Filipa Cardoso (181702)
- Fiona Chapman (12096401)
- Flavia Capaccio (17386078)
- Ford Sightler (17386927)
- Francesca Annese (17385967)
- Francesca Deodato (17386177)
- Francesco Giaroni (7318220)
- Francisco de la Prada Alvarez (17385961)
- Franziska Sarnow (17386882)
- Gabriel Contreras (17386153)
- Gabriel Doctor (3468062)
- Gabriele Donati (17386195)
- Gaia Coppock (17380987)
- Gary Chi Wang Chan (9082187)
- Gemma Patella (8906870)
- Georg Schlieper (721165)
- Georgina Irish (17386396)
- Gerald Appel (17385970)
- Gerald Waters (17387059)
- Gert Meeus (17386615)
- Giuseppe Remuzzi (180748)
- Grant Luxton (17386552)
- Guillaume Claisse (17386129)
- Guillaume Jeantet (17386414)
- Gunjan Garg (17386294)
- Gunter Wolf (2679817)
- Gustavo Andres Useche Bonilla (17386045)
- Hajeong Lee (286887)
- Han Ro (304022)
- Hanna Augustyniak-Bartosik (17385997)
- Hans Schmidt-Guertler (17386900)
- Haresh Selvaskandan (7669754)
- Harold Giles (17386306)
- Heather Green (17386348)
- Helen Pilmore (17386786)
- Helena Marco Rusinol (17386855)
- Helena Sousa (10092899)
- Helena Sá (17386858)
- Helmut Reichel (15917925)
- Hernán Trimarchi (7803695)
- Hesham Mohey (17386636)
- Hiddo JL Heerspink (8335752)
- Hon Tang (17386981)
- Hon-Yen Wu (286645)
- Hoon Young Choi (9194354)
- Howard Lifland (17386537)
- Howard Trachtman (792031)
- Hsien-Fu Chiu (4753323)
- Hsin-Yu Chen (2165956)
- Hua-Chang Fang (803678)
- Hung-Chun Chen (106543)
- Hung-Tien Kuo (106539)
- Hung-Yuan Chen (315717)
- Hye Ryoun Jang (8845448)
- Hyeong Cheon Park (13776409)
- Hyun Hee Lee (9009827)
- Hyung Wook Kim (10035228)
- Hyung-seok Lee (17386522)
- Ian Chiu (17386120)
- Ian Dittmer (13410392)
- Ian Fraser (4708297)
- Iara Da Silva Santos (17386876)
- Indranil Dasgupta (3343091)
- Inga Arune Bumblyte' (17386063)
- Ingrid Masson (6501308)
- Ingrid Prkacin (17386804)
- Irene Agraz Pamplona (17386717)
- Irene L Noronha (15277288)
- Irina Suyumova (17386972)
- Isabella Abbasciano (9524821)
- Isabelle Ayoub (800894)
- Ivan Durlen (17386213)
- Ivan Kruljac (17386486)
- Ivan Rychlik (126460)
- Ivana Mikacic (17386627)
- Ivica Horvatic (17386390)
- Ivon Maritza Bobadilla Rico (17386834)
- Jae Hyun Chang (9009821)
- Jafar Ahmed (17385940)
- Jai Radhakrishnan (2827253)
- James A Tumlin (17385925)
- James Sullivan (2883074)
- James Tumlin (6427517)
- Jana Uhlinova (17387008)
- Jane Waugh (17387062)
- Janson Leung (17386531)
- Javad Mojarrab (17386639)
- Jean-Emmanuel Serre (6437384)
- Jeffrey Glaze (17386318)
- Jeffrey Tsun Kit Ha (17386360)
- Jer-Chia Tsai (106527)
- Jerko Barbic (17386021)
- Jerry Meng (2200843)
- Jigar Kadakia (17386435)
- Jihyun Yang (6943178)
- JiYong Jung (17386429)
- Joana de Sousa Soares Felgueiras (17386234)
- Joana Gameiro (6302495)
- Joana Marques (2368660)
- Johann Konstantin Herfurth (17386378)
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- Jonathan Barratt (3387179)
- Jonathan Erlich (8878460)
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- Jonay Pantoja Perez (17386762)
- Jong Cheol Jeong (1372383)
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- Valentin Mayet (17386597)
- Valérie de Précigout (17386171)
- Veronica Viramontes (17387044)
- Victor Fernandez (17386243)
- Victoria Campbell (239881)
- Vidu Wijeratne (17387077)
- Viet Nguyen (79713)
- Vittoria Esposito (5787344)
- Vladimir Tesar (156920)
- Vlado Perkovic (141532)
- Wai Lim (3583598)
- Wai Ping Law (12288571)
- Wan-Chuan Tsai (5476856)
- Wanja Bernhardt (245782)
- Wenceslao Adrian Aguilera Morales (17386651)
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- William Paxton (17386750)
- Wim Lemahieu (3547811)
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- Wooin Ahn (17385943)
- Wookyung Chung (610342)
- Xavier Warling (17387056)
- Yahsou Delmas (4034183)
- Yan Li (23143)
- Yelena Drexler (12365018)
- Yen-Ling Chiu (442530)
- Yeong Hoon Kim (8962688)
- Yi-Wen Chiu (106535)
- Yick Hei Wong (12288568)
- Yonatan Peleg (9922071)
- Young Rim Song (13242926)
- Young Youl Hyun (13016397)
- Yu-Sen Peng (315725)
- Yunmi Kim (3040866)
- Yusuf Eqbal (17386222)
- Yvonne Shen (17386921)
- Zivka Dika (10281479)
- Zoltan Endre (714028)
- Zvonimir Sitas (17386936)
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background
Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.
Methods
PROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.
Findings
Between Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.
Interpretation
Over 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function.</p
Health-status outcomes with invasive or conservative care in coronary disease
- Author
- Alexander K.P.
- Baloch K.
- Bangalore S.
- Boden W.E.
- Cohen D.J.
- Diaz A.
- Gosselin G.
- Harrell F.E.
- Hochman J.S.
- ISCHEMIA Research Group: Joseph Ricci A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Raba\ue7a, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fern\ue1ndez Mart\uednez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, Andr\ue9 Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej \u141abyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Pe\uf1aranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezi\u144ska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard J\ue4ger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Car\uedsi A Polanczyk, Carita Krannila, Carla Vicente, Carl-\uc9ric Gagn\ue9, Carlo Briguori, Carlos Pe\uf1a Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Bj\uf6rklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adri\ue1n Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Nicollet, Eric Peterson, Erick Alex\ue1nderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, F Marin Ortu\uf1o, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Fl\ue1via Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidovi\u107, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Llad\uf3, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, Jo\ue3o Reynaldo Abbud, Jo\ue3o V Vitola, Joaqu\uedn V Pe\uf1afiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Vieira, Jos\ue9 M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padr\uf3, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio C\ue9sar Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna \u141oboz-Grudzie\u144, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kuku\u142a, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Lo\uefc Bi\ue8re, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de P\ue1dua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Vald\ue9s Ch\ue1varri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena \u141anocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Ma\u142gorzta Celi\u144ska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Val\ue9rio Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Mar\ueda Fernanda Canales, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moys\ue9s de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Ca\uf1avate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdo\u144czyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula Garc\ueda-Gonz\ue1lez, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vu\u10di\u107, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto Ren\ue9 Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth P\ue9rez-Fern\ue1ndez, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simovi\u107, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, T\ue9odora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nu\uf1ez, Virginia Fern\ue1ndez-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-R\uedos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek P\ue9pin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
- Jones P.G.
- Mark D.B
- Maron D.J.
- Mavromatis K.
- Mavromichalis S.
- Newman J.D.
- O'Brien S.M.
- Reynolds H.R.
- Rosenberg Y.
- Spertus J.A.
- Stone G.W.
- Weintraub W.S.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline
Initial invasive or conservative strategy for stable coronary disease
- Author
- Alexander K.P.
- Ali Z.A.
- Bangalore S.
- Berger J.S.
- Berman D.S.
- Bhargava B.
- Bockeria O.
- Boden W.E.
- Broderick S.
- Bruce Ferguson T.
- Chaitman B.R.
- Demkow M.
- Doerr R.
- Elghamaz A.
- Gabriel Steg P.
- Goodman S.G.
- Gosselin G.
- Harrell F.E.
- Harrington R.A.
- Held C.
- Hochman J.S.
- Hueb W.A.
- ISCHEMIA Research Group: Joseph Ricci A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Raba\ue7a, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fern\ue1ndez Mart\uednez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, Andr\ue9 Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej \u141abyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Pe\uf1aranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezi\u144ska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard J\ue4ger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Car\uedsi A Polanczyk, Carita Krannila, Carla Vicente, Carl-\uc9ric Gagn\ue9, Carlo Briguori, Carlos Pe\uf1a Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Bj\uf6rklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adri\ue1n Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Nicollet, Eric Peterson, Erick Alex\ue1nderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, F Marin Ortu\uf1o, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Fl\ue1via Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidovi\u107, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Llad\uf3, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, Jo\ue3o Reynaldo Abbud, Jo\ue3o V Vitola, Joaqu\uedn V Pe\uf1afiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Vieira, Jos\ue9 M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padr\uf3, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio C\ue9sar Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna \u141oboz-Grudzie\u144, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kuku\u142a, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Lo\uefc Bi\ue8re, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de P\ue1dua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Vald\ue9s Ch\ue1varri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena \u141anocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Ma\u142gorzta Celi\u144ska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Val\ue9rio Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Mar\ueda Fernanda Canales, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moys\ue9s de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Ca\uf1avate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdo\u144czyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula Garc\ueda-Gonz\ue1lez, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vu\u10di\u107, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto Ren\ue9 Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth P\ue9rez-Fern\ue1ndez, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simovi\u107, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, T\ue9odora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nu\uf1ez, Virginia Fern\ue1ndez-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-R\uedos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek P\ue9pin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
- Jeffries N.O.
- John Mancini G.B.
- Keltai M.
- Kirby R.
- Kohsaka S.
- Krishnan M.N.
- Kwong R.Y.
- Lopes R.D.
- Lopez-Sendon J.
- Maggioni A.P.
- Mark D.B.
- Maron D.J.
- Mavromatis K.
- Mavromichalis S.
- Miller T.D.
- Min J.K.
- Moorthy N.
- Newman J.D.
- O'Brien S.M.
- Peteiro J.
- Picard M.H.
- Reynolds H.R.
- Rockhold F.W.
- Rosenberg Y
- Ruzyllo W.
- Selvanayagam J.B.
- Senior R.
- Shaw L.J.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Szwed H.
- White H.D.
- Williams D.O.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, 121.8 percentage points; 95% CI, 124.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used