The first international workshop on the role and impact of mathematics in medicine: a collective account

The First International Workshop on The Role and Impact of Mathematics in Medicine (RIMM) convened in Paris in June 2010. A broad range of researchers discussed the difficulties, challenges and opportunities faced by those wishing to see mathematical methods contribute to improved medical outcomes. Finding mechanisms for inter- disciplinary meetings, developing a common language, staying focused on the medical problem at hand, deriving realistic mathematical solutions, obtainin

Cryo-EM structure of a fungal mitochondrial calcium uniporter.

The mitochondrial calcium uniporter (MCU) is a highly selective calcium channel localized to the inner mitochondrial membrane. Here, we describe the structure of an MCU orthologue from the fungus Neosartorya fischeri (NfMCU) determined to 3.8 Å resolution by phase-plate cryo-electron microscopy. The channel is a homotetramer with two-fold symmetry in its amino-terminal domain (NTD) that adopts a similar structure to that of human MCU. The NTD assembles as a dimer of dimers to form a tetrameric ring that connects to the transmembrane domain through an elongated coiled-coil domain. The ion-conducting pore domain maintains four-fold symmetry, with the selectivity filter positioned at the start of the pore-forming TM2 helix. The aspartate and glutamate sidechains of the conserved DIME motif are oriented towards the central axis and separated by one helical turn. The structure of NfMCU offers insights into channel assembly, selective calcium permeation, and inhibitor binding

ASSESSMENT OF PROCEDURAL ASPECTS AND QUALITY CONTROL IN HUMAN PLACENTAL RNA ISOLATION PROTOCOLS

poster abstractHigh quality RNA is of paramount importance in accurately interpreting gene expression changes in the placenta throughout pregnancy, as well as in common placental pathologies. The purpose of this study was to develop a standard operating procedure for the collection of human placental tissue and isolation of high quality RNA for pregnancy-related molecular studies. To accomplish this task, we compared several different parameters to minimize RNA degradation, including preservation (liquid nitrogen vs. RNAlater), dis-ruption (mortar/pestle vs. homogenization), and isolation (Trizol vs. RNeasy). We performed 150 RNA isolations from 30 term placentas. The overall yield was 365 ± 197 ng RNA per mg of tissue. The A260/280 ratio for all samples was 2.11 ± 0.1 (mean ± s.d.) and the RQI was 7.1 ± 1.4. No significant differences in RNA purity, yield, or quality were observed between different placental collections or RNA isolation techniques. However, poor RQI values of 2.7 to 3.3 were obtained after brief thawing of frozen placental samples. We also compared storage of RNAlater stabilized tissue at 4 de-grees or room temperature for 1 day, 7 days, and 30 days. The integrity of RNA stored at room temperature for 1 day was significantly better (P‹0.05 RQI 7.3 ± 0.58, mean ± s.d) than RNA stored at room temperature for 30 days (RQI 5.0 ±1.2, mean ± s.d). The results of these studies will be useful for establishing standard procedures for placenta collection for pregnancy biobanks

The transition temperature of the dilute interacting Bose gas

We show that the critical temperature of a uniform dilute Bose gas must increase linearly with the s-wave scattering length describing the repulsion between the particles. Because of infrared divergences, the magnitude of the shift cannot be obtained from perturbation theory, even in the weak coupling regime; rather, it is proportional to the size of the critical region in momentum space. By means of a self-consistent calculation of the quasiparticle spectrum at low momenta at the transition, we find an estimate of the effect in reasonable agreement with numerical simulations.Comment: 4 pages, Revtex, to be published in Physical Review Letter

Lyman alpha emitting galaxies at 0.2 < z < 0.35 from GALEX spectroscopy

The GALEX (Galaxy Evolution Explorer) spectroscopic survey mode, with a resolution of about 8 A in the FUV (1350 - 1750 A) and about 20 A in the NUV (1950 - 2750 A) is used for a systematic search of Ly-a emitting galaxies at low redshift. This aims at filling a gap between high-redshift surveys and a small set of objects studied in detail in the nearby universe. A blind search of 7018 spectra extracted in 5 deep exposures (5.65 sq.deg) has resulted in 96 Ly-a emitting galaxy candidates in the FUV domain, after accounting for broad-line AGNs. The Ly-a EWs (equivalent width) are consistent with stellar population model predictions and show no trends as a function of UV color or UV luminosity, except a possible decrease in the most luminous that may be due to small-number statistics. Their distribution in EW is similar to that at z about 3 but their fraction among star-forming galaxies is smaller. Avoiding uncertain candidates, a sub-sample of 66 objects in the range 0.2 < z < 0.35 has been used to build a Ly-a LF (luminosity function). The incompleteness due to objects with significant Ly-a emission but a UV continuum too low for spectral extraction has been evaluated. A comparison with H-a LF in the same redshift domain is consistent with an average Ly-a/H-a of about 1 in about 15 % of the star-forming galaxies. A comparison with high-redshift Ly-a LFs implies an increase of the Ly-a luminosity density by a factor of about 16 from z about 0.3 to z about 3. By comparison with the factor 5 increase of the UV luminosity density in the same redshift range, this suggests an increase of the average Ly-a escape fraction with redshift.Comment: 18 pages, 9 figures, accepted for publication in Ap

Strangeness Conservation in Hot Nuclear Fireballs

A constraint between thermal fireball parameters arises from the requirement that the balance of strangeness in a fireball is (nearly) zero. We study the impact of this constraint on (multi-)strange (anti-)baryon multiplicities and compare the hadron gas and quark-gluon plasma predictions. We explore the relation between the entropy content and particle multiplicities and show that the data are compatible with the quark-gluon plasma hypothesis, but appear to be inconsistent with the picture of an equilibrated hadron gas fireball. We consider the implications of the results on the dynamics of evolution and decay of the particle source.Comment: 35 pages, 11 postscript figures, report PAR/LPTHE/92--2

Radiatively-induced Magnetic moment in four-dimensional anisotropic QED in an external magnetic field

We discuss one-loop radiatively-induced magnetic moment in four-dimensional quantum electrodynamics (QED) with anisotropic coupling, and examine various cases which may be of interest in effective gauge theories of antiferromagnets, whose planar limit coresponds to highly anisotropic QED couplings. We find a different scaling with the magnetic field intensity in case there are extra statistical gauge interactions in the model with spontaneous symmetry breaking. Such a case is encountered in the CP-1 sigma-model sector of effective spin-charge separated gauge theories of antiferromagnetic systems. Our work provides therefore additional ways of possible experimental probing of the gauge nature of such systems.Comment: 14 pages Latex, no figure