Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine.

One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones. Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances, the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis. This work has translated to methods and advances in bone tissue engineering. In this review, we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine

Muon g-2: Review of Theory and Experiment

A review of the experimental and theoretical determinations of the anomalous magnetic moment of the muon is given. The anomaly is defined by a=(g-2)/2, where the Land\'e g-factor is the proportionality constant that relates the spin to the magnetic moment. For the muon, as well as for the electron and tauon, the anomaly a differs slightly from zero (of order 10^{-3}) because of radiative corrections. In the Standard Model, contributions to the anomaly come from virtual `loops' containing photons and the known massive particles. The relative contribution from heavy particles scales as the square of the lepton mass over the heavy mass, leading to small differences in the anomaly for e, \mu, and \tau. If there are heavy new particles outside the Standard Model which couple to photons and/or leptons, the relative effect on the muon anomaly will be \sim (m_\mu/ m_e)^2 \approx 43\times 10^3 larger compared with the electron anomaly. Because both the theoretical and experimental values of the muon anomaly are determined to high precision, it is an excellent place to search for the effects of new physics, or to constrain speculative extensions to the Standard Model. Details of the current theoretical evaluation, and of the series of experiments that culminates with E821 at the Brookhaven National Laboratory are given. At present the theoretical and the experimental values are known with a similar relative precision of 0.5 ppm. There is, however, a 3.4 standard deviation difference between the two, strongly suggesting the need for continued experimental and theoretical studyComment: 103 pages, 57 figures, submitted to Reports on Progress in Physics Final version as published, several minor clarifications to text and a number of references were correcte

k-server via multiscale entropic regularization

We present an $O((\log k)^2)$-competitive randomized algorithm for the $k$-server problem on hierarchically separated trees (HSTs). This is the first $o(k)$-competitive randomized algorithm for which the competitive ratio is independent of the size of the underlying HST. Our algorithm is designed in the framework of online mirror descent where the mirror map is a multiscale entropy. When combined with Bartal's static HST embedding reduction, this leads to an $O((\log k)^2 \log n)$-competitive algorithm on any $n$-point metric space. We give a new dynamic HST embedding that yields an $O((\log k)^3 \log \Delta)$-competitive algorithm on any metric space where the ratio of the largest to smallest non-zero distance is at most $\Delta$

Fibrations in CICY Threefolds

In this work we systematically enumerate genus one fibrations in the class of 7,890 Calabi-Yau manifolds defined as complete intersections in products of projective spaces, the so-called CICY threefolds. This survey is independent of the description of the manifolds and improves upon past approaches that probed only a particular algebraic form of the threefolds (i.e. searches for "obvious" genus one fibrations as in [1,2]). We also study K3-fibrations and nested fibration structures. That is, K3 fibrations with potentially many distinct elliptic fibrations. To accomplish this survey a number of new geometric tools are developed including a determination of the full topology of all CICY threefolds, including triple intersection numbers. In 2,946 cases this involves finding a new "favorable" description of the manifold in which all divisors descend from a simple ambient space. Our results consist of a survey of obvious fibrations for all CICY threefolds and a complete classification of all genus one fibrations for 4,957 "Kahler favorable" CICYs whose Kahler cones descend from a simple ambient space. Within the CICY dataset, we find 139,597 obvious genus one fibrations, 30,974 obvious K3 fibrations and 208,987 nested combinations. For the Kahler favorable geometries we find a complete classification of 377,559 genus one fibrations. For one manifold with Hodge numbers (19,19) we find an explicit description of an infinite number of distinct genus-one fibrations extending previous results for this particular geometry that have appeared in the literature. The data associated to this scan is available at http://www1.phys.vt.edu/cicydata .Comment: 54 pages, 4 tables, 4 figure

Manufacturing Mechatronics Using Thermal Spray Shape Deposition

A new technology for manufacturing mechatronics is described. The technique is based on recursive masking and deposition of thermally sprayed materials. Using these methods, mechanical structures can be created that embed and interconnect electronic components. This results in highly integrated mechatronic devices. A simple, electromechanical artifact was designed and produced to assess the feasibility of these techniques. The details and limitations of this project will be discussed. Areas of future research are identified which are aimed at realizing the full potential of this emerging manufacturing process.Mechanical Engineerin

The Physics Case for the New Muon (g-2) Experiment

This White Paper briefly reviews the present status of the muon (g-2) experiment and the physics motivation for a new effort. The present comparison between experiment and theory indicates a tantalizing $3.4 \sigma$ deviation. An improvement in precision on this comparison by a factor of 2--with the central value remaining unchanged--will exceed the ``discovery'' threshold, with a sensitivity above $6 \sigma$. The 2.5-fold reduction improvement goal of the new Brookhaven E969 experiment, along with continued steady reduction of the standard model theory uncertainty, will achieve this more definitive test. Already, the (g-2) result is arguably the most compelling indicator of physics beyond the standard model and, at the very least, it represents a major constraint for speculative new theories such as supersymmetry or extra dimensions. In this report, we summarize the present experimental status and provide an up-to-date accounting of the standard model theory, including the expectations for improvement in the hadronic contributions, which dominate the overall uncertainty. Our primary focus is on the physics case that motivates improved experimental and theoretical efforts. Accordingly, we give examples of specific new-physics implications in the context of direct searches at the LHC as well as general arguments about the role of an improved (g-2) measurement. A brief summary of the plans for an upgraded effort complete the report.Comment: 18 pages, 7 figure

Mean field approaches to the totally asymmetric exclusion process with quenched disorder and large particles

The process of protein synthesis in biological systems resembles a one dimensional driven lattice gas in which the particles (ribosomes) have spatial extent, covering more than one lattice site. Realistic, nonuniform gene sequences lead to quenched disorder in the particle hopping rates. We study the totally asymmetric exclusion process with large particles and quenched disorder via several mean field approaches and compare the mean field results with Monte Carlo simulations. Mean field equations obtained from the literature are found to be reasonably effective in describing this system. A numerical technique is developed for computing the particle current rapidly. The mean field approach is extended to include two-point correlations between adjacent sites. The two-point results are found to match Monte Carlo simulations more closely

Detection of Illegal Race Walking: A Tool to Assist Coaching and Judging

Current judging of race walking in international competitions relies on subjective human observation to detect illegal gait, which naturally has inherent problems. Incorrect judging decisions may devastate an athlete and possibly discredit the international governing body. The aim of this study was to determine whether an inertial sensor could improve accuracy, monitor every step the athlete makes in training and/or competition. Seven nationally competitive race walkers performed a series of legal, illegal and self-selected pace races. During testing, athletes wore a single inertial sensor (100 Hz) placed at S1 of the vertebra and were simultaneously filmed using a high-speed camera (125 Hz). Of the 80 steps analyzed the high-speed camera identified 57 as illegal, the inertial sensor misidentified four of these measures (all four missed illegal steps had 0.008 s of loss of ground contact) which is considerably less than the best possible human observation of 0.06 s. Inertial sensor comparison to the camera found the typical error of estimate was 0.02 s (95% confidence limits 0.01–0.02), with a bias of 0.02 (±0.01). An inertial sensor can thus objectively improve the accuracy in detecting illegal steps (loss of ground contact) and, along with the ability to monitor every step of the athlete, could be a valuable tool to assist judges during race walk events

Exploring the effects of trunk acceleration on saddle position and the drag coefficient

Triathletes often use a time trial bicycle with an increased seat tube angle combined with aerodynamic handlebars that allow for a decreased upper body and trunk to improve aerodynamics. In this respect, the adjustment of the seat tube and saddle is an important feature of fitting bicycle to triathlete to positively impact performance. Limited published evidence concerning trunk acceleration, saddle position and aerodynamics by way of the drag coefficient (Cd) in triathlon cycling makes comparisons difficult. Therefore, an overground varied cycle cadence in a previously validated saddle position was conducted to detect differences in trunk acceleration magnitude whilst a multivariable linear regression was used to estimate Cd based on saddle position, trunk acceleration and cadence. Data was collected by a trunk-mounted triaxial accelerometer to estimate kinematic determinants of triathlete cycling performance in conjunction with trunk acceleration magnitude and cadence that contribute to Cd. Seven participants completed a 1 x 5 km overground cycling trial at varied cadence on a characteristic triathlon circuit. Multiple linear regression was used to estimate that cycling at higher cadences increased trunk acceleration magnitude with a projected Cd of 0.277. Longitudinal trunk acceleration represented 39% of the outcome variable explained by the model. To illustrate the practical relevance of the statistical models, mean total trunk acceleration and cadence were applied to predict Cd. Higher magnitudes of total trunk acceleration combined with cycling at a cadence of 95-100 rev/min¹ resulted in greater Cd (0.283)