TakeCARE, a Video to Promote Bystander Behavior on College Campuses: Replication and Extension

Previous research has demonstrated that college students who view TakeCARE, a video bystander program designed to encourage students to take action to prevent sexual and relationship violence (i.e., bystander behavior), display more bystander behavior relative to students who view a control video. The current study aimed to replicate and extend these findings by testing two different methods of administering TakeCARE and examining moderators of TakeCARE’s effects on bystander behavior. Students at four universities (n = 557) were randomly assigned to one of three conditions: (a) view TakeCARE in a monitored computer lab, (b) view TakeCARE at their own convenience after receiving an email link to the video, or (c) view a video about study skills (control group). Participants completed measures of bystander behavior at baseline and at a 1-month follow-up. Participants in both TakeCARE conditions reported more bystander behavior at follow-up assessments, compared with participants in the control condition. The beneficial effect of TakeCARE did not differ significantly across administration methods. However, the effects of TakeCARE on bystander behavior were moderated by students’ perceptions of campus responsiveness to sexual violence, with more potent effects when students perceived their institution as responsive to reports of sexual violence

Measurements of Forbush decreases at Mars: both by MSL on ground and by MAVEN in orbit

The Radiation Assessment Detector (RAD), on board Mars Science Laboratory's (MSL) Curiosity rover, has been measuring ground level particle fluxes along with the radiation dose rate at the surface of Mars since August 2012. Similar to neutron monitors at Earth, RAD sees many Forbush decreases (FDs) in the galactic cosmic ray (GCR) induced surface fluxes and dose rates. These FDs are associated with coronal mass ejections (CMEs) and/or stream/corotating interaction regions (SIRs/CIRs). Orbiting above the Martian atmosphere, the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft has also been monitoring space weather conditions at Mars since September 2014. The penetrating particle flux channels in the Solar Energetic Particle (SEP) instrument onboard MAVEN can also be employed to detect FDs. For the first time, we study the statistics and properties of a list of FDs observed in-situ at Mars, seen both on the surface by MSL/RAD and in orbit detected by the MAVEN/SEP instrument. Such a list of FDs can be used for studying interplanetary CME (ICME) propagation and SIR evolution through the inner heliosphere. The magnitudes of different FDs can be well-fitted by a power-law distribution. The systematic difference between the magnitudes of the FDs within and outside the Martian atmosphere may be mostly attributed to the energy-dependent modulation of the GCR particles by both the pass-by ICMEs/SIRs and the Martian atmosphere

How do organisms affect and respond to climate change?

Life on Earth is diverse at many levels, meaning there is a lot of variety within species and there are many different kinds of species. This biodiversity provides many of the resources that humans need and enhances our quality of life. All of Earth’s organisms are affected by Earth’s climate, but they also influence Earth’s climate. In this article, we show how research on plants, animals, and microbes helps us better understand how living things can both impact and respond to climate change. This research also gives us insight into what the future might be like for life on Earth. Such knowledge will help us to protect our planet—and the living things on it—from the harmful effects of future climate change

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers

Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine threonine kinase belonging to the PIKK family (phosphoinositide 3-kinase-like-family of protein kinase), is a critical component of the non-homologous end joining (NHEJ) pathway required for the repair of DNA double strand breaks. DNA-PKcs may be involved in breast cancer pathogenesis. Methods: We evaluated clinicopathological significance of DNA-PKcs protein expression in 1161 tumours and DNA-PKcs mRNA expression in 1950 tumours. We correlated DNA-PKcs to other markers of aggressive phenotypes, DNA repair, apoptosis and cell cycle regulation. Results: Low DNA-PKcs protein expression was associated with higher tumour grade, higher mitotic index, tumour de-differentiation and tumour type (ps<0.05). Absence of BRCA1, low XRCC1/SMUG1/APE1/Polβ were also more likely in low DNA-PKcs expressing tumours (ps<0.05). Low DNA-PKcs protein expression was significantly associated with worse breast cancer specific survival (BCCS) in univariate and multivariate analysis (ps<0.01). At the mRNA level, low DNA-PKcs was associated with PAM50.Her2 and PAM50.LumA molecular phenotypes (ps<0.01) and poor BCSS. In patients with ER positive tumours who received endocrine therapy, low DNA-PKcs (protein and mRNA) was associated with poor survival. In ER negative patients, low DNA-PKcs mRNA remains significantly associated with adverse outcome. Conclusions: Our study suggests that low DNA-PKcs expression may have prognostic and predictive significance in breast cancers

Mars Upper Atmospheric Responses to the 10 September 2017 Solar Flare: A Global, Time‐Dependent Simulation

We report the first global, time‐dependent simulation of the Mars upper atmospheric responses to a realistic solar flare event, an X8.2 eruption on 10 September 2017. The Mars Global Ionosphere‐Thermosphere Model runs with realistically specified flare irradiance, giving results in reasonably good agreement with the Mars Atmosphere and Volatile EvolutioN spacecraft measurements. It is found that the ionized and neutral regimes of the upper atmosphere are significantly disturbed by the flare but react differently. The ionospheric electron density enhancement is concentrated below ∼110‐km altitude due to enhanced solar X‐rays, closely following the time evolution of the flare. The neutral atmospheric perturbation increases with altitude and is important above ∼150‐km altitude, in association with atmospheric upwelling driven by solar extreme ultraviolet heating. It takes ∼2.5 hr past the flare peak to reach the maximum disturbance and then additional ∼10 hr to generally settle down to preflare levels.Key PointsIonospheric perturbation follows the flare in time and is concentrated mostly below 110‐km altitudeNeutral atmospheric perturbation increases with altitude and is important above 150‐km altitudeIt takes the neutral atmosphere 2.5 hr to reach the perturbation peak and 10 more hours to generally recoverPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151860/1/grl59414_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151860/2/grl59414-sup-0001-Text_SI-S01.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151860/3/grl59414.pd

Work-Life Balance Starts with Proper Deadlines and Exemplary Agencies

Diversity, equity and inclusion (DEI) programs can only be implemented successfully if proper work-life balance is possible in Heliophysics (and in STEM field in general). One of the core issues stems from the culture of "work-above-life" associated with mission concepts, development, and implementation but also the expectations that seem to originate from numerous announcements from NASA (and other agencies). The benefits of work-life balance are well documented; however, the entire system surrounding research in Heliophysics hinders or discourages proper work-life balance. For example, there does not seem to be attention paid by NASA Headquarters (HQ) on the timing of their announcements regarding how it will be perceived by researchers, and how the timing may promote a culture where work trumps personal life. The same is true for remarks by NASA HQ program officers during panels or informal discussions, where seemingly innocuous comments may give a perception that work is expected after "normal" work hours. In addition, we are calling for work-life balance plans and implementation to be one of the criteria used for down-selection and confirmation of missions (Key Decision Points: KDP-B, KDP-C).Comment: White paper submitted to the Decadal Survey for Solar and Space Physics (Heliophysics) 2024-2033; 6 page

Clinical course, costs and predictive factors for response to treatment in carpal tunnel syndrome: The PALMS study protocol

Background Carpal tunnel syndrome (CTS) is the most common neuropathy of the upper limb and a significant contributor to hand functional impairment and disability. Effective treatment options include conservative and surgical interventions, however it is not possible at present to predict the outcome of treatment. The primary aim of this study is to identify which baseline clinical factors predict a good outcome from conservative treatment (by injection) or surgery in patients diagnosed with carpal tunnel syndrome. Secondary aims are to describe the clinical course and progression of CTS, and to describe and predict the UK cost of CTS to the individual, National Health Service (NHS) and society over a two year period. Methods/Design In this prospective observational cohort study patients presenting with clinical signs and symptoms typical of CTS and in whom the diagnosis is confirmed by nerve conduction studies are invited to participate. Data on putative predictive factors are collected at baseline and follow-up through patient questionnaires and include standardised measures of symptom severity, hand function, psychological and physical health, comorbidity and quality of life. Resource use and cost over the 2 year period such as prescribed medications, NHS and private healthcare contacts are also collected through patient self-report at 6, 12, 18 and 24 months. The primary outcome used to classify treatment success or failures will be a 5-point global assessment of change. Secondary outcomes include changes in clinical symptoms, functioning, psychological health, quality of life and resource use. A multivariable model of factors which predict outcome and cost will be developed. Discussion This prospective cohort study will provide important data on the clinical course and UK costs of CTS over a two-year period and begin to identify predictive factors for treatment success from conservative and surgical interventions

New Observations Needed to Advance Our Understanding of Coronal Mass Ejections

Coronal mass ejections (CMEs) are large eruptions from the Sun that propagate through the heliosphere after launch. Observational studies of these transient phenomena are usually based on 2D images of the Sun, corona, and heliosphere (remote-sensing data), as well as magnetic field, plasma, and particle samples along a 1D spacecraft trajectory (in-situ data). Given the large scales involved and the 3D nature of CMEs, such measurements are generally insufficient to build a comprehensive picture, especially in terms of local variations and overall geometry of the whole structure. This White Paper aims to address this issue by identifying the data sets and observational priorities that are needed to effectively advance our current understanding of the structure and evolution of CMEs, in both the remote-sensing and in-situ regimes. It also provides an outlook of possible missions and instruments that may yield significant improvements into the subject.Comment: White Paper submitted to the Heliophysics 2024-2033 Decadal Survey, 9 pages, 4 figure

Design principles for riboswitch function

Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the construction of tunable regulatory components based on its rich regulatory capacity and our current understanding of the sequence–function relationship. One prominent example of RNA-based regulatory components is riboswitches, genetic elements that mediate ligand control of gene expression through diverse regulatory mechanisms. While characterization of natural and synthetic riboswitches has revealed that riboswitch function can be modulated through sequence alteration, no quantitative frameworks exist to investigate or guide riboswitch tuning. Here, we combined mathematical modeling and experimental approaches to investigate the relationship between riboswitch function and performance. Model results demonstrated that the competition between reversible and irreversible rate constants dictates performance for different regulatory mechanisms. We also found that practical system restrictions, such as an upper limit on ligand concentration, can significantly alter the requirements for riboswitch performance, necessitating alternative tuning strategies. Previous experimental data for natural and synthetic riboswitches as well as experiments conducted in this work support model predictions. From our results, we developed a set of general design principles for synthetic riboswitches. Our results also provide a foundation from which to investigate how natural riboswitches are tuned to meet systems-level regulatory demands