Tacit knowledge and the biological weapons regime

Bioterrorism has become increasingly salient in security discourse in part because of perceived changes in the capacity and geography of life science research. Yet its salience is founded upon a framing of changes in science and security that does not always take into consideration the somewhat slippery concept of ‘tacit knowledge’, something poorly understood, disparately conceptualised and often marginalised in discussions on state and non-state biological weapons programmes. This paper looks at how changes in science and technology—particularly the evolution of information and communications technology—has contributed to the partial erosion of aspects of tacit knowledge and the implications for the biological weapons regime. This paper concludes by arguing that the marginalisation of tacit knowledge weakens our understanding of the difficulties encountered in biological weapons programmes and can result in distorted perceptions of the threat posed by dual-use biotechnology in the 21st century

Enacting communication cycles after prediabetes: Mothers’ stories of diabetes risk and seeking support

Background: Diabetes is a family systems experience of multiple intergenerational relationships. Communicating about diabetes as a familial risk helps individuals perceive greater control over preventing diabetes. Aim: The present study investigates how mothers disclose their prediabetes to their family and the precipitating family communication, with the goal to interrupt the multigenerational legacy of diabetes. Method: Data were collected from a Family Medicine outpatient clinic. Semi-structured interviews were conducted to illicit information about mother-child communication about diabetes. Sort and Sift, Think and Shift analysis provided rich descriptions of mothers’ experiences. Results: The sample consisted of 9 women with prediabetes, aged 42-70, who had at least one child. Eight participants described at least 2 generations of family members with a diabetes-related diagnosis (prediabetes, type 2 diabetes mellitus, and gestational diabetes). First, we present two contextual factors that preexisted the prediabetes diagnosis, which influenced the disclosure decision: general health communication approach and personal evaluation of diabetes. Second, we present the communication cycles that supported self-management. Discussion: Continual communication cycles with family and clinicians can support mothers with prediabetes to enact self-management behaviors and delay the onset of type 2 diabetes mellitus. Conclusion: Mothers need family members to respond favorably to complete a positive communication cycle that can generate continuous emotional, social, and instrumental support

GreenLife: A Sustainable Retail Space

GreenLife is the name of the retail interior design project that embodies this thesis. Using interior design as a medium to influence customers,I sought to create an environment that promotes a connection to nature and an awareness of creative possiblities within the context of a store. It addresses the problem of personal social responsiblity by using shopping, a dominant activity in the western world, as a tool for change. As a project, GreenLife attempts to answer three questions: How does design inform cultural experience? How can a connection with nature inform consumerism? Can a store transcend its purpose from filling materialistic needs to become a place of fulfilment? I theorize that if offered a desireable alternative to products that create excess waste and harm our surroundings, an individual will choose the green option, because it will satisfy both a materialistic want and an emotional desire to feel good by personally contributing to help our environment. If these options are presented with a sense of beauty, fun and exploration, it can change how we culturally perceive social responsibility, removing guilt and making it a matter of course. GreenLife is a store designed as a model home with all products set up in a testable format. The interactive nature of the design is intended to provide education and a sense of security within a pleasureable experience, allowing people to confidently choose to live green in their own homes, and to thoughtfully consider the possiblities in other aspects of their lives

Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications

Täuber S, Lieres E, Grünberger A. Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications. Small. 2020;16(16): 1906670.Microfluidic single‐cell cultivation (MSCC) is an emerging field within fundamental as well as applied biology. During the last years, most MSCCs were performed at constant environmental conditions. Recently, MSCC at oscillating and dynamic environmental conditions has started to gain significant interest in the research community for the investigation of cellular behavior. Herein, an overview of this topic is given and microfluidic concepts that enable oscillating and dynamic control of environmental conditions with a focus on medium conditions are discussed, and their application in single‐cell research for the cultivation of both mammalian and microbial cell systems is demonstrated. Furthermore, perspectives for performing MSCC at complex dynamic environmental profiles of single parameters and multiparameters (e.g., pH and O2) in amplitude and time are discussed. The technical progress in this field provides completely new experimental approaches and lays the foundation for systematic analysis of cellular metabolism at fluctuating environments

Stimuli-responsive drug delivery systems using gold nanoparticles and phospholipid vesicles

In the near future, new pharmaceutical therapeutics will evolve to contain complicated protein molecules, gene therapies, SI-RNA etc., which must be transported in extremely specific environments such as a specific pH level or sodium concentration. The problem is that throughout the body there are many different environments that a drug could pass through. For example, gastric acid can have pH levels as low as 1 where blood is around 7.4. This is a problem because as the drugs pass through these harsh environments they may become rendered useless. Furthermore, these new therapeutics are not compatible with conventional drug delivery mechanisms and new strategies for drug delivery are required. To solve these problem DPPC/DPPG phospholipid vesicles are being used with Au nanoparticles to transport these drugs. The DPPC/DPPG vesicles encapsulate the drug of choice and protect it from the harsh environments of the body. The Au nanoparticles can be designed to either embedded in the lipid bilayer of the vesicles or decorate the vesicle exterior. When radiation is applied, the nanoparticles are excited and cause a disruption in the vesicle structure, leading to the release of the drug into the body. Our research is centered around how the stability of the lipid vesicles changes based on the size, surface chemistry, and distribution of the nanoparticles

Planning for Detroit's Tax-Reverted Properties: Possibilities fo rthe Wayne County Land Bank

http://deepblue.lib.umich.edu/bitstream/2027.42/110958/1/planning_for_detroit_s_tax_reverted_properties2006.pd

Novel Human Rhinoviruses and Exacerbation of Asthma in Children1

To determine links between human rhinoviruses (HRV) and asthma, we used data from a case–control study, March 2003–February 2004, among children with asthma. Molecular characterization identified several likely new HRVs and showed that association with asthma exacerbations was largely driven by HRV-A and a phylogenetically distinct clade of 8 strains, genogroup C

Intermediate Tail Dependence: A Review and Some New Results

The concept of intermediate tail dependence is useful if one wants to quantify the degree of positive dependence in the tails when there is no strong evidence of presence of the usual tail dependence. We first review existing studies on intermediate tail dependence, and then we report new results to supplement the review. Intermediate tail dependence for elliptical, extreme value and Archimedean copulas are reviewed and further studied, respectively. For Archimedean copulas, we not only consider the frailty model but also the recently studied scale mixture model; for the latter, conditions leading to upper intermediate tail dependence are presented, and it provides a useful way to simulate copulas with desirable intermediate tail dependence structures.Comment: 25 pages, 1 figur

Design summary of the magnet support structures for the proton storage ring injection line upgrade

This report summarizes the technical engineering and design issues associated with the Proton Storage Ring (PSR) Injection Line upgrade of the Los Alamos Neutron Science Center (LANSCE). The main focus is on the engineering design calculations of several magnet support structures. The general procedure based upon a set number of design criteria is outlined, followed by a case-by-case summary of the engineering design analyses, reutilization or fabrication callouts and design safety factors

Uncovering Burdens, Examining Needs, and Shedding Assumptions of Evidence-Based Social Support Programs for Mothers: A Descriptive Qualitative Study in a Remote Community

Many studies have demonstrated a significant burden of maternal stress and depression for women living on the Galápagos Islands. Here, we aim to uncover burdens and needs of women with young children on San Cristóbal Island and then explore options for implementing evidence-based programs of social support to meet these needs. We conducted 17 semi-structured qualitative interviews with mothers of young children, healthcare workers, and community stakeholders. We then used Summary Oral Reflective Analysis (SORA), an interactive methodology, for qualitative analysis. Despite initial reports of a low-stress environment, women described many sources of stress and concerns for their own and their children’s health and well-being. We uncovered three broad areas of need for mothers of young children: (1) the need for information and services, (2) the need for trust, and (3) the need for space. In response to these concerns, mothers, healthcare workers, and community leaders overwhelmingly agreed that a social support program would be beneficial for the health of mothers and young children. Still, they expressed concern over the feasibility of such a program. To address these feasibility concerns, we propose that a web-based education and social support intervention led by nurses would best meet mothers’ needs. Women could learn about child health and development, develop strong, trusting friendships with other mothers, and have their own space to speak freely among experts and peers