Retention behavior of conjugated and isolated n-alkadienes. Identification of n-nona- and n-decadienes by capillary gas chromatography using structure-retention correlations and mass spectrometry

The isomerization products of n-C8---C10 a,¿-alkadienes were separated on a high-efficiency squalane column (195 m × 0.25 mm I.D.) with 500,000 effective plates. Of the 102 possible n-C8---C10 dienes with isolated and conjugated double bonds, only nine groups of isomers were not separated. All isomers, except those with cumulated double bonds, were identified (23 octadienes, 33 nonadienes and 46 decadienes). The n-octadienes were identified by matching measured and published retention data. Because of the lack of standards, retention data and mass spectra of n-nona- and decadienes, and because the previously reported identification method for n-dienes up to C8 was succesful, the problem of the identification of C9---C10 n-alkadienes was solved similarly by using structure-retention correlations and combined capillary gas chromatography-mass spectrometry. Based on these results, the retention behaviour of the conjugated and isolated n-alkadienes, on squalane stationary phase, is generalized

Weyl approach to representation theory of reflection equation algebra

The present paper deals with the representation theory of the reflection equation algebra, connected with a Hecke type R-matrix. Up to some reasonable additional conditions the R-matrix is arbitrary (not necessary originated from quantum groups). We suggest a universal method of constructing finite dimensional irreducible non-commutative representations in the framework of the Weyl approach well known in the representation theory of classical Lie groups and algebras. With this method a series of irreducible modules is constructed which are parametrized by Young diagrams. The spectrum of central elements s(k)=Tr_q(L^k) is calculated in the single-row and single-column representations. A rule for the decomposition of the tensor product of modules into the direct sum of irreducible components is also suggested.Comment: LaTeX2e file, 27 pages, no figure

Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma.

International audienceWe attempted to describe, in a series of clear cell renal cell carcinoma (RCC), the relationship between CAIX expression, VHL gene mutations, tumor characteristics and outcome. Radical nephrectomy was performed in 100 patients. Genomic DNA was extracted from frozen tumor samples. Four amplimers covering the whole coding sequence of the VHL gene were synthesized by PCR and sequenced. The monoclonal antibody M75 was used to evaluate CAIX protein expression immunohistochemically. VHL mutations were identified in 58 patients (58%) and high CAIX expression (>85%) was observed in 78 (78%). Tumors with VHL mutation showed higher CAIX expression than those without (p = 0.02). Low CAIX expression and absence of VHL mutation were associated with a more advanced tumors e.g., higher T stages and presence of metastases. VHL mutation and high CAIX expression predicted longer progression-free survival (p = 0.037) and disease-specific survival (p = 0.001), respectively. In combination, they defined three prognostic groups (p = 0.002): (i) good prognosis, defined as VHL mutation and high CAIX (2-year survival: 86%), (ii) intermediate prognosis with either VHL mutation or high CAIX (69%), and (iii) poor prognosis with no VHL mutation and low CAIX (45%, median survival 18 months). CAIX expression, but not VHL mutational status, was an independent prognostic factor in multivariate analysis. Taken together, CAIX expression and VHL mutational status are able to stratify patients with clear cell RCC into distinct groups with regards to clinicopathological variables and prognosis, with low CAIX expression and absence of VHL mutation being associated with a poor clinicopathological phenotype and diminished survival

Transvenous Lead Extraction in Patients with Cardiac Implantable Device: The Impact of Systemic and Local Infection on Clinical Outcomes. An ESC‐EHRA ELECTRa (European Lead Extraction Controlled) Registry Substudy

Background: Infections of cardiac implantable devices (CIEDI) have poor outcomes despite improvement in lead extraction (TLE) procedures. Methods: To explore the influence of CIEDI on the outcomes of TLE and the differences between patients with systemic (Sy) vs. local (Lo) CIEDI, we performed a sub‐analysis of the EORP ELECTRa (European Lead Extraction ConTRolled) Registry. Results: Among 3555 patients enrolled by 73 centers in 19 Countries, the indication for TLE was CIEDI in 1850: 1170 with Lo‐CIEDI and 680 with Sy‐CIEDI. Patients with CIEDI had a worse in‐hospital prognosis in terms of major complications (3.57% vs. 1.71%; p = 0.0007) and mortality (2.27% vs. 0.49%; p < 0.0001). Sy‐CIEDI was an independent predictor of in‐hospital death (H.R. 2.14; 95%CI 1.06–4.33. p = 0.0345). Patients with Sy‐CIEDI more frequently had an initial CIED implant and a higher prevalence of comorbidities, while subjects with Lo‐CIEDI had a higher prevalence of previous CIED procedures. Time from signs of CIEDI and TLE was longer for Lo‐CIEDI despite a shorter pre‐TLE antibiotic treatment. Conclusions: Patients with CIEDI have a worse in‐hospital prognosis after TLE, especially for patients with Sy‐CIEDI. These results raise the suspicion that in a relevant group of patients CIEDI can be systemic from the beginning without progression from Lo‐CIEDI. Future research is needed to characterize this subgroup of patients

High-resolution tSZ cartography of clusters of galaxies with NIKA at the IRAM 30-m telescope

The thermal Sunyaev-Zeldovich effect (tSZ) is a powerful probe to study clusters of galaxies and is complementary with respect to X-ray, lensing or optical observations. Previous arcmin resolution tSZ observations ({\it e.g.} SPT, ACT and Planck) only enabled detailed studies of the intra-cluster medium morphology for low redshift clusters ($z < 0.2$). Thus, the development of precision cosmology with clusters requires high angular resolution observations to extend the understanding of galaxy cluster towards high redshift. NIKA2 is a wide-field (6.5 arcmin field of view) dual-band camera, operated at $100 \ {\rm mK}$ and containing $\sim 3300$ KID (Kinetic Inductance Detectors), designed to observe the millimeter sky at 150 and 260 GHz, with an angular resolution of 18 and 12 arcsec respectively. The NIKA2 camera has been installed on the IRAM 30-m telescope (Pico Veleta, Spain) in September 2015. The NIKA2 tSZ observation program will allow us to observe a large sample of clusters (50) at redshift ranging between 0.5 and 1. As a pathfinder for NIKA2, several clusters of galaxies have been observed at the IRAM 30-m telescope with the NIKA prototype to cover the various configurations and observation conditions expected for NIKA2.Comment: Proceedings of the 28th Texas Symposium on Relativistic Astrophysics, Geneva, Switzerland, December 13-18, 201

High angular resolution Sunyaev-Zel'dovich observations of MACS J1423.8+2404 with NIKA: Multiwavelength analysis

The prototype of the NIKA2 camera, NIKA, is an instrument operating at the IRAM 30-m telescope, which can observe simultaneously at 150 and 260GHz. One of the main goals of NIKA2 is to measure the pressure distribution in galaxy clusters at high resolution using the thermal SZ (tSZ) effect. Such observations have already proved to be an excellent probe of cluster pressure distributions even at high redshifts. However, an important fraction of clusters host submm and/or radio point sources, which can significantly affect the reconstructed signal. Here we report on <20" resolution observations at 150 and 260GHz of the cluster MACSJ1424, which hosts both radio and submm point sources. We examine the morphology of the tSZ signal and compare it to other datasets. The NIKA data are combined with Herschel satellite data to study the SED of the submm point source contaminants. We then perform a joint reconstruction of the intracluster medium (ICM) electronic pressure and density by combining NIKA, Planck, XMM-Newton, and Chandra data, focusing on the impact of the radio and submm sources on the reconstructed pressure profile. We find that large-scale pressure distribution is unaffected by the point sources because of the resolved nature of the NIKA observations. The reconstructed pressure in the inner region is slightly higher when the contribution of point sources are removed. We show that it is not possible to set strong constraints on the central pressure distribution without accurately removing these contaminants. The comparison with X-ray only data shows good agreement for the pressure, temperature, and entropy profiles, which all indicate that MACSJ1424 is a dynamically relaxed cool core system. The present observations illustrate the possibility of measuring these quantities with a relatively small integration time, even at high redshift and without X-ray spectroscopy.Comment: 15 pages, 17 figures, submitted to A&

Fast-TIPL Occurs for Salient Images without a Memorization Requirement in Men but Not in Women

Recent research of task-irrelevant perceptual learning (TIPL) demonstrates that stimuli that are consistently presented at relevant point in times (e.g. with task-targets or rewards) are learned, even in the absence of attention to these stimuli. However, different research paradigms have observed different results for how salient stimuli are learned; with some studies showing no learning, some studies showing positive learning and others showing negative learning effects. In this paper we focused on how the level of processing of stimuli impacts fast-TIPL. We conducted three different experiments in which the level of processing of the information paired with a target was manipulated. Our results indicated that fast-TIPL occurs when participants have to memorize the information presented with the target, but also when they just have to process this information for a secondary task without an explicit memorization of those stimuli. However, fast-TIPL does not occur when participants have to ignore the target-paired information. This observation is consistent with recent models of TIPL that suggest that attentional signals can either enhance or suppress learning depending on whether those stimuli are distracting or not to the subjects' objectives. Our results also revealed a robust gender effect in fast-TIPL, where male subjects consistently show fast-TIPL, whereas the observation of fast-TIPL is inconsistent in female subjects

Microfabrication technology for large LEKID arrays : from NIKA2 to future applications

The Lumped Element Kinetic Inductance Detectors (LEKID)demonstrated full maturity in the NIKA (New IRAM KID Arrays)instrument. These results allow directly comparing LEKID performance with other competing technologies (TES, doped silicon) in the mm and sub-mm range. A continuing effort is ongoing to improve the microfabrication technologies and concepts in order to satisfy the requirements of new instruments. More precisely, future satellites dedicated to CMB (Cosmic Microwave Background) studies will require the same focal plane technology to cover, at least, the frequency range of 60 to 600 GHz. Aluminium LEKID developed for NIKA have so far demonstrated, under real telescope conditions, performance approaching photon-noise limitation in the band 120-300 GHz. By implementing superconducting bi-layers we recently demonstrated LEKID arrays working in the range 80-120 GHz and with sensitivities approaching the goals for CMB missions. NIKA itself (350 pixels) is followed by a more ambitious project requiring several thousands (3000-5000) pixels. NIKA2 has been installed in October 2015 at the IRAM 30-m telescope. We will describe in detail the technological improvements that allowed a relatively harmless 10-fold up-scaling in pixels count without degrading the initial sensitivity. In particular we will briefly describe a solution to simplify the difficult fabrication step linked to the slot-line propagation mode in coplanar waveguide

NIKA2: a mm camera for cluster cosmology

Galaxy clusters constitute a major cosmological probe. However, Planck 2015 results have shown a weak tension between CMB-derived and cluster-derived cosmological parameters. This tension might be due to poor knowledge of the cluster mass and observable relationship. As for now, arcmin resolution Sunyaev-Zeldovich (SZ) observations ({\it e.g.} SPT, ACT and Planck) only allowed detailed studies of the intra cluster medium for low redshift clusters ($z0.5$) high resolution and high sensitivity SZ observations are needed. With both a wide field of view (6.5 arcmin) and a high angular resolution (17.7 and 11.2 arcsec at 150 and 260 GHz), the NIKA2 camera installed at the IRAM 30-m telescope (Pico Veleta, Spain) is particularly well adapted for these observations. The NIKA2 SZ observation program will map a large sample of clusters (50) at redshifts between 0.5 and 0.9. As a pilot study for NIKA2, several clusters of galaxies have been observed with the pathfinder, NIKA, at the IRAM 30-m telescope to cover the various configurations and observation conditions expected for NIKA2.

Nika2: A mm camera for cluster cosmology

Galaxy clusters constitute a major cosmological probe. However, Planck 2015 results have shown a weak tension between CMB-derived and cluster-derived cosmological parameters. This tension might be due to poor knowledge of the cluster mass and observable relationship. As for now, arcmin resolution Sunyaev-Zeldovich (SZ) observations (e.g. SPT, ACT and Planck) only allowed detailed studies of the intra cluster medium for low redshift clusters (z 0:5) high resolution and high sensitivity SZ observations are needed. With both a wide field of view (6.5 arcmin) and a high angular resolution (17.7 and 11.2 arcsec at 150 and 260 GHz), the NIKA2 camera installed at the IRAM 30-m telescope (Pico Veleta, Spain) is particularly well adapted for these observations. The NIKA2 SZ observation program will map a large sample of clusters (50) at redshifts between 0.5 and 0.9. As a pilot study for NIKA2, several clusters of galaxies have been observed with the pathfinder, NIKA, at the IRAM 30-m telescope to cover the various configurations and observation conditions expected for NIKA2