Een matematisch model van de grondwaterstromingen in het kwartaire reservoir ten oosten van De Haan

A mathematical model has been developed to simulate groundwater flow in the Quaternary aquifer system east of De Haan (Belgium). The estimated lateral variations of the hydraulic parameters have repeatedly been adjusted by comparing the calculated hydraulic-head configuration to the observed one. After this calibration of the model was achieved, the influence of groundwater extraction has been examined. Even at pumping rates as low as 250.000 m³/year, artificial replenishment of the aquifer system will be necessary in order to avoid flow of salt water towards the wells

Salt water intrusion modeling in the Flemish coastal plain based on a hydrogeological database

The Flemish Environment Agency (VMM) is responsible for providing recommendations related to the withdrawal of groundwater in the phreatic aquifer of the Flemish Coastal Plain. To assess the impact of this withdrawal on the freshwater heads and on the distribution of fresh and salt water in the aquifer, the agency uses a 3D density dependent groundwater flow model MOCDENS3D (Lebbe & Oude Essink 1999). Although a large number of hydrogeological data were already collected and stored in a database of the agency, the draw up of the input file for this model was very time consuming. Therefore, an interface was needed between the model and the hydrogeological database to reduce the time for the set up of the needed input files

Avelumab in European patients (pts) with metastatic Merkel cell carcinoma (mMCC): Experience from an ad-hoc expanded access program (EAP)

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Novel conopeptides of largely unexplored Indo Pacific <i>Conus</i> sp.

Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of targets. As such, cone snail peptides represent an interesting treasure for drug development. Here, we report five novel peptides isolated from the venom of Conus longurionis, Conus asiaticus and Conus australis. Lo6/7a and Lo6/7b were retrieved from C. longurionis and have a cysteine framework VI/VII. Lo6/7b has an exceptional amino acid sequence because no similar conopeptide has been described to date (similarity percentage C. asiaticus, has a typical framework III Cys arrangement, classifying the peptide in the M-superfamily. Asi14a, another peptide of C. asiaticus, belongs to framework XIV peptides and has a unique amino acid sequence. Finally, AusB is a novel conopeptide from C. australis. The peptide has only one disulfide bond, but is structurally very different as compared to other disulfide-poor peptides. The peptides were screened on nAChRs, NaV and KV channels depending on their cysteine framework and proposed classification. No targets could be attributed to the peptides, pointing to novel functionalities. Moreover, in the quest of identifying novel pharmacological targets, the peptides were tested for antagonistic activity against a broad panel of Gram-negative and Gram-positive bacteria, as well as two yeast strains

Merkel-cell carcinoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up

: • This ESMO Clinical Practice Guideline provides key recommendations for managing Merkel-cell carcinoma (MCC). • Recommendations are based on available scientific data and the multidisciplinary group of experts’ collective opinion. • The guideline covers clinical and pathological diagnosis, staging and risk assessment, treatment and follow-up. • Algorithms for the management of locoregional and inoperable/metastatic disease are provided. • A multidisciplinary team with a high level of expertise in MCC should diagnose and make decisions about therapy