Active learning in the detection of anomalies in cryptocurrency transactions

The cryptocurrency market has grown significantly, and this quick growth has given rise to scams. It is necessary to put fraud detection mechanisms in place. The challenge of inadequate labeling is addressed in this work, which is a barrier to the training of high-performance supervised classifiers. It aims to lessen the necessity for laborious and time-consuming manual labeling. Some unlabeled data points have labels that are more pertinent and informative for the supervised model to learn from. The viability of utilizing unsupervised anomaly detection algorithms and active learning strategies to build an iterative process of acquiring labeled transactions in a cold start scenario, where there are no initial-labeled transactions, is being investigated. Investigating anomaly detection capabilities for a subset of data that maximizes supervised models’ learning potential is the goal. The anomaly detection algorithms under performed, according to the results. The findings underscore the need that anomaly detection algorithms be reserved for situations involving cold starts. As a result, using active learning techniques would produce better outcomes and supervised machine learning model performance.FCT - Fundação para a Ciência e a Tecnologia(UIDB/00319/2020

Study of Intelligent Control Techniques Applied to a Stirring Tank with Heat Exchanger

This work presents a study and evaluation of intelligent control techniques applied to the problem of temperature control of a stirring tank with heat exchanger. This problem is represented by the example provided and documented by MathWorks in MATLAB/Simulink software, called Heatex. The intelligent techniques used are Fuzzy Logic Controller (FLC), Fuzzy Cognitive Maps (FCM), Artificial Neural Networks (ANN) and the combination of these. The proportional-integral (PI) controller provided in the Heatex example is considered as a reference basis during the evaluation of the intelligent control techniques in different test scenarios. The metrics Integral of Absolute Error (IAE) and Integral Time-weighted Absolute Error (ITAE), as well as the parameters overshoot percentage and settling time are the criteria used to evaluate the control techniques performance

Influence of ohmic heating on production of whey protein aggregates

Ohmic Heating (OH) and its associated non-thermal effects due to the presence of an electrical field and frequency has been triggering the use of this technology for whey protein functionalization. Whey proteins have increasingly been used as functional ingredients in several food formulations presenting high nutritional and biological value (i.e., digestibility, amino acid pattern, and sensory characteristics). The purpose of this study was to characterize early steps of whey protein isolate denaturation and aggregation kinetics under the influence of OH treatments by combining different thermal and electrical effects. A multivariate characterization was performed in order to identify a global pattern in denaturation behaviour of WPI under OH applied by linking different structural stages, such as protein unfolding, exposure of protein hydrophobic core, loss of protein solubility and formation of protein aggregates. Results shows that exposure of reactive free thiol groups involved in molecular unfolding of β-lactoglobulin (β- lg) can be reduced from 10 to 20 % with OH. The presence of a moderate electric field (up to 12 V/cm) during heating also contributes to a change in the protein aggregation kinetics, as well as in the shape of the produced whey aggregates. Size growth was significantly reduced from 178 nm to 25 nm (p < 0.05) under influence of OH and transmission electron microscopy (TEM) discloses the appearance of β-lg small fibrillar aggregates upon the influence of OH. As conclusion, OH and its capability of fast heating coupled with treatments under relatively low electrical field strength, contributed to a synergistic effect yielding protein solutions with less protein aggregates and high amount of soluble proteins during early stages of heating. These fibril aggregates have a recognized potential to form physical gels, acting as thickeners or gelling agents in foods, and can be also used for encapsulation of bioactive ingredients. OH provide a novel method for production of a whey protein matrix with distinctive features and gel-forming properties

Myosteatosis in a systemic inflammation-dependent manner predicts favorable survival outcomes in locally advanced esophageal cancer

Increased adiposity and its attendant metabolic features as well as systemic inflammation have been associated with prognosis in locally advanced esophageal cancer (LAEC). However, whether myosteatosis and its combination with systemic inflammatory markers are associated with prognosis of esophageal cancer is unknown. Our study aimed to investigate the influence of myosteatosis and its association with systemic inflammation on progression-free survival (PFS) and overall survival (OS) in LAEC patients treated with definitive chemoradiotherapy (dCRT). We retrospectively gathered information on 123 patients with LAEC submitted to dCRT at the University of Campinas Hospital. Computed tomography (CT) images at the level of L3 were analyzed to assess muscularity and adiposity. Systemic inflammation was mainly measured by calculating the neutrophil-to-lymphocyte ratio (NLR). Median PFS for patients with myosteatosis (n = 72) was 11.0 months vs 4.0 months for patients without myosteatosis (n = 51) (hazard ratio [HR]: 0.53; 95% confidence interval [CI], 0.34-0.83; P = .005). Myosteatosis was also independently associated with a favorable OS. Systemic inflammation (NLR > 2.8) was associated with a worse prognosis. The combination of myosteatosis with systemic inflammation revealed that the subgroup of patients with myosteatosis and without inflammation presented less than half the risk of disease progression (HR: 0.47; 95% CI: 0.26-0.85; P = .013) and death (HR: 0.39; 95% CI, 0.21-0.72; P = .003) compared with patients with inflammation. This study demonstrated that myosteatosis without systemic inflammation was independently associated with favorable PFS and OS in LAEC patients treated with dCRT81669676976FAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulo2018/23428-

A educação física e desporto em Portugal como parte do processo educativo : a ESEC e a sua oferta formativa

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Bothrops jararaca Peptide with Anti-Hypertensive Action Normalizes Endothelium Dysfunction Involved in Physiopathology of Preeclampsia

Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, is a major cause of fetal and maternal morbidity and mortality especially in developing countries. Bj-PRO-10c, a proline-rich peptide isolated from Bothrops jararaca venom, has been attributed with potent anti-hypertensive effects. Recently, we have shown that Bj-PRO-10c-induced anti-hypertensive actions involved NO production in spontaneous hypertensive rats. Using in vitro studies we now show that Bj-PRO-10c was able to increase NO production in human umbilical vein endothelial cells from hypertensive pregnant women (HUVEC-PE) to levels observed in HUVEC of normotensive women. Moreover, in the presence of the peptide, eNOS expression as well as argininosuccinate synthase activity, the key rate-limiting enzyme of the citrulline-NO cycle, were enhanced. In addition, excessive superoxide production due to NO deficiency, one of the major deleterious effects of the disease, was inhibited by Bj-PRO-10c. Bj-PRO-10c induced intracellular calcium fluxes in both, HUVEC-PE and HUVEC, which, however, led to activation of eNOS expression only in HUVEC-PE. Since Bj-PRO-10c promoted biological effects in HUVEC from patients suffering from the disorder and not in normotensive pregnant women, we hypothesize that Bj-PRO-10c induces its anti-hypertensive effect in mothers with preeclampsia. Such properties may initiate the development of novel therapeutics for treating preeclampsia

Bothrops jararaca Peptide with Anti-Hypertensive Action Normalizes Endothelium Dysfunction Involved in Physiopathology of Preeclampsia

Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, is a major cause of fetal and maternal morbidity and mortality especially in developing countries. Bj-PRO-10c, a proline-rich peptide isolated from Bothrops jararaca venom, has been attributed with potent anti-hypertensive effects. Recently, we have shown that Bj-PRO-10c-induced anti-hypertensive actions involved NO production in spontaneous hypertensive rats. Using in vitro studies we now show that Bj-PRO-10c was able to increase NO production in human umbilical vein endothelial cells from hypertensive pregnant women (HUVEC-PE) to levels observed in HUVEC of normotensive women. Moreover, in the presence of the peptide, eNOS expression as well as argininosuccinate synthase activity, the key rate-limiting enzyme of the citrulline-NO cycle, were enhanced. In addition, excessive superoxide production due to NO deficiency, one of the major deleterious effects of the disease, was inhibited by Bj-PRO-10c. Bj-PRO-10c induced intracellular calcium fluxes in both, HUVEC-PE and HUVEC, which, however, led to activation of eNOS expression only in HUVEC-PE. Since Bj-PRO-10c promoted biological effects in HUVEC from patients suffering from the disorder and not in normotensive pregnant women, we hypothesize that Bj-PRO-10c induces its anti-hypertensive effect in mothers with preeclampsia. Such properties may initiate the development of novel therapeutics for treating preeclampsia

Formiga : atividade físico-desportiva, alimentação e estilos de vida saudável em crianças dos 3 aos 9 anos de idade

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Desporto, lazer e educação : uma perspetiva a partir dos desportos de natureza

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