Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain.

Alois Alzheimer is best known for his description of neurofibrillary changes in brain neurons of a demented patient, identifying a novel disease, soon named after him by Kraepelin. However, the range of his studies was broad, including vascular brain diseases, published between 1894 and 1902. Alzheimer described the clinical picture of Arteriosclerotic atrophy of the brain, differentiating it from other similar disorders. He stated that autopsy allowed pathological distinction between arteriosclerosis and syphilis, thereby achieving some of his objectives of segregating disorders and separating them from syphilis. His studies contributed greatly to establishing the key information on vascular brain diseases, predating the present state of knowledge on the issue, while providing early descriptions of what would be later regarded as the dimensional presentation of the now called "Vascular cognitive impairment", constituted by a spectrum that includes a stage of "Vascular cognitive impairment not dementia" and another of "Vascular dementia"

Alzheimer and vascular brain diseases: Focal and diffuse subforms.

Alois Alzheimer is best known for his description of the pre-senile neurodegenerative disease named after him. However, his previous interest in vascular brain diseases, underlying cognitive and behavioral changes, was very strong. Besides describing the Arteriosclerotic atrophy of the brain and the arteriosclerotic subtype of Senile dementia which he viewed as main forms of vascular brain diseases, he also identified and described a series of conditions he considered subforms. These may be divided, as suggested by the authors of the present paper, into 3 groups: gliosis and sclerosis, subcortical atrophies, and apoplectic. The subforms of the three groups present characteristic neuropathological features and clinical, cognitive and behavioral manifestations. These provide the basis, together with part of the main forms, for the contemporary condition known as Vascular Cognitive Impairment

Alzheimer and vascular brain disease: Senile dementia.

Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases. He described Senile dementia, a highly heterogeneous condition, and was able not only to distinguish it from syphilitic brain disease, but also to discriminate two clinicopathological subtypes, that may be labeled a "arteriosclerotic subtype", comparable to the present clinicopathological continuum of "Vascular cognitive impairment", and another as a "neurodegenerative subtype", characterized by primary [cortical] ganglion cell [nerve cells] degeneration, possibly foreshadowing a peculiar presenile disease that he was to describe some years later and would carry his name. He also considered the possibility of a senile presentation of this disease subtype, which was described by Oskar Fischer a short time later. Considering the clinicopathological overlapping features of the "arteriosclerotic subtype" of Senile dementia with Arteriosclerotic atrophy of the brain, it might be possible to consider that both represent a single condition

Correction function in the Lidar equation and the solution techniques for CO2 Lidar date reduction

For lidar systems with long laser pulses the unusual behavior of the near-range signals causes serious difficulties and large errors in reduction. The commonly used lidar equation is no longer applicable since the convolution of the laser pulse with the atmospheric parameter distributions should be taken into account. It is important to give more insight into this problem and find the solution techniques. Starting from the original equation, a general form is suggested for the single scattering lidar equation where a correction function Cr is introduced. The correction Function Cr(R) derived from the original equation indicates the departure from the normal lidar equation. Examples of Cr(R) for a coaxial CO2 lidar system are presented. The Differential Absorption Lidar (DIAL) errors caused by the differences of Cr(R) for H2O measurements are plotted against height

How to combine probabilistic and fuzzy uncertainties in fuzzy control

Fuzzy control is a methodology that translates natural-language rules, formulated by expert controllers, into the actual control strategy that can be implemented in an automated controller. In many cases, in addition to the experts' rules, additional statistical information about the system is known. It is explained how to use this additional information in fuzzy control methodology

Brainstem: Neglected Locus in Neurodegenerative Diseases

The most frequent neurodegenerative diseases (NDs) are Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD–TDP). Neuropathologically, NDs are characterized by abnormal intracellular and extra-cellular protein deposits and by disease-specific neuronal death. Practically all terminal stages of NDs are clinically associated with dementia. Therefore, major attention was directed to protein deposits and neuron loss in supratentorial (telencephalic) brain regions in the course of NDs. This was also true for PD, although the pathological hallmark of PD is degeneration of pigmented neurons of the brainstem’s substantia nigra (SN). However, PD pathophysiology was explained by dopamine depletion in the telencephalic basal ganglia due to insufficiency and degeneration of the projection neurons located in SN. In a similar line of argumentation AD- and FTLD-related clinical deficits were exclusively explained by supratentorial allo- and neo-cortical laminar neuronal necrosis. Recent comprehensive studies in AD and PD early stages found considerable and unexpected involvement of brainstem nuclei, which could have the potential to profoundly change our present concepts on origin, spread, and early clinical diagnosis of these diseases. In contrast with PD and AD, few studies addressed brainstem involvement in the course of the different types of FTLD–TDP. Some of the results, including ours, disclosed a higher and more widespread pathology than anticipated. The present review will focus mainly on the impact of brainstem changes during the course of the most frequent NDs including PD, AD, and FTLD–TDP, with special emphasis on the need for more comprehensive research on FTLDs

The Evolution of the Flute

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How to control if even experts are not sure: Robust fuzzy control

In real life, the degrees of certainty that correspond to one of the same expert can differ drastically, and fuzzy control algorithms translate these different degrees of uncertainty into different control strategies. In such situations, it is reasonable to choose a fuzzy control methodology that is the least vulnerable to this kind of uncertainty. It is shown that this 'robustness' demand leads to min and max for &- and V-operations, to 1-x for negation, and to centroid as a defuzzification procedure

Performative Rituals for Conception and Childbirth in England, 900-1500.

This study proposes that performative rituals-that is, verbal and physical acts that reiterate prior uses-enabled medieval women and men to negotiate the dangers and difficulties of conception and childbirth. It analyzes the rituals implicated in charms, prayers, amulets, and prayer rolls and traces the circulation of such rituals within medieval English society. Manuscript records from the Anglo-Saxon period to the late Middle Ages offer evidence of the interaction of oral and written means of communicating these rituals. Certain rituals were long-lived, though variants were introduced over time that reflected changing religious attitudes and the involvement of various interested parties, including local healers, doctors, and medical practitioners, as well as monks, friars, and users of vernacular remedy books. Although many of those who recommended or provided assistance through performative rituals were males, the practices often devolved upon women themselves, and their female companions or attendants.This research was supported by Wellcome Trust grant 088708.This is the final version of the article. It first appeared from Johns Hopkins University Press via http://dx.doi.org/10.1353/bhm.2015.007

The role of gender in the processing of dating scripts

The issues under investigation were gender differences in either content or memory discrimination of dating scripts and general examination for differences in memory of typical and atypical events using the script pointer plus tag (SP+T) hypothesis. A total of 52 female and 54 male undergraduates participated. Subjects were enrolled in introductory psychology classes at a large midwest university and were primarily Caucasian, single, and between the ages of 18-21 years. In Phase 1 and Phase 2 of the study, items that would possibly occur in 4 different dating scenarios were generated and then rated for typicality. Males and females both generated and rated items similarly in the first 2 phases. In Phase 3, the taped dating stories were presented along with a single-item recognition test which included many of these typical and atypical events. Analyses showed that memory discrimination varied significantly with gender, F(1, 51) = 4.07, p \u3c .05, and typicality, F(1, 51) = 395.80, p \u3c .0001, and a significant gender x typicality interaction was found, F(1, 51) = 7.17, p \u3c .01. Females displayed better memory discrimination overall, especially on atypical items. It was concluded that further investigation on possible gender differences in role, meaning, attention, and social norm affectation of dating scripts may explain differences in memory discrimination