Investigation of gravity wave activity based on NDMC, NDACC and CTBTO measurements

GRIPS (Ground based Infrared P-branch Spectrometer) airglow measurements allow the derivation of kinetic temperature in the mesopause region during night with a temporal resolution of 10s to 15s. Amongst others, these time series can be used for the investigation of atmospheric dynamics like gravity wave activity. GRIPS measurements are performed in the framework of NDMC – the international Network for the Detection of Mesospheric Change. The project ARISE combines NDMC, NDACC (Network for the Detection of Atmospheric Composition Change) and CTBTO (Comprehensive Nuclear-Test-Ban Treaty Organization)measurements to infer a new 3D image of atmospheric dynamics from ground to mesopause. In this context, GRIPS data of about two to three years collected at the Observatory Haute-Provence, France and Catania, Italy are utilized to derive an index for shortand long-period gravity wave activity on daily and seasonal base. This time period includes also a stratospheric warming event. Potential energy density is calculated and compared with NDACC measurements at Haute-Provence; differences are discussed. For the measurements at the Italian station, comparisons of gravity wave and volcanic activity relying on infrasound array and seismic measurements are performed. First hints for volcanic induced mesopause gravity wave activity are presented

Gpr37l1 Modulates Seizure Susceptibility: Evidence from Mouse Studies and Analyses of a Human Gpr37l1 Variant

Progressive myoclonus epilepsies (PMEs) are disorders characterized by myoclonic and generalized seizures with progressive neurological deterioration. While several genetic causes for PMEs have been identified, the underlying causes remain unknown for a substantial portion of cases. Here we describe several affected individuals from a large, consanguineous family presenting with a novel PME in which symptoms begin in adolescence and result in death by early adulthood. Whole exome analyses revealed that affected individuals have a homozygous variant in GPR37L1 (c.1047G \u3e T [Lys349Asn]), an orphan G protein-coupled receptor (GPCR) expressed predominantly in the brain. In vitro studies demonstrated that the K349N substitution in Gpr37L1 did not grossly alter receptor expression, surface trafficking or constitutive signaling in transfected cells. However, in vivo studies revealed that a complete loss of Gpr37L1 function in mice results in increased seizure susceptibility. Mice lacking the related receptor Gpr37 also exhibited an increase in seizure susceptibility, while genetic deletion of both receptors resulted in an even more dramatic increase in vulnerability to seizures. These findings provide evidence linking GPR37L1 and GPR37 to seizure etiology and demonstrate an association between a GPR37L1 variant and a novel progressive myoclonus epilepsy

Lavoisier: A Low Altitude Balloon Network for Probing the Deep Atmosphere and Surface of Venus

The in-situ exploration of the low atmosphere and surface of Venus is clearly the next step of Venus exploration. Understanding the geochemistry of the low atmosphere, interacting with rocks, and the way the integrated Venus system evolved, under the combined effects of inner planet cooling and intense atmospheric greenhouse, is a major challenge of modern planetology. Due to the dense atmosphere (95 bars at the surface), balloon platforms offer an interesting means to transport and land in-situ measurement instruments. Due to the large Archimede force, a 2 cubic meter He-pressurized balloon floating at 10 km altitude may carry up to 60 kg of payload. LAVOISIER is a project submitted to ESA in 2000, in the follow up and spirit of the balloon deployed at cloud level by the Russian Vega mission in 1986. It is composed of a descent probe, for detailed noble gas and atmosphere composition analysis, and of a network of 3 balloons for geochemical and geophysical investigations at local, regional and global scales

Oxidation of Alcohols and Activated Alkanes with Lewis Acid-Activated TEMPO

The reactivity of MCl3(η(1)-TEMPO) (M = Fe, 1; Al, 2; TEMPO = 2,2,6,6-tetramethylpiperidine-N-oxyl) with a variety of alcohols, including 3,4-dimethoxybenzyl alcohol, 1-phenyl-2-phenoxyethanol, and 1,2-diphenyl-2-methoxyethanol, was investigated using NMR spectroscopy and mass spectrometry. Complex 1 was effective in cleanly converting these substrates to the corresponding aldehyde or ketone. Complex 2 was also able to oxidize these substrates; however, in a few instances the products of overoxidation were also observed. Oxidation of activated alkanes, such as xanthene, by 1 or 2 suggests that the reactions proceed via an initial 1-electron concerted proton-electron transfer (CPET) event. Finally, reaction of TEMPO with FeBr3 in Et2O results in the formation of a mixture of FeBr3(η(1)-TEMPOH) (23) and [FeBr2(η(1)-TEMPOH)]2(μ-O) (24), via oxidation of the solvent, Et2O

Transform tectonics and thermal rejuvenation on the Côte d'Ivoire-Ghana margin, west Africa

Formation of a pronounced basement ridge along many transform continental margins has been attributed to a variety of processes during continental break-up, including transpressional crustal thickening, and thermal rejuvenation and igneous underplating during passage of a spreading ridge. ODP drill holes on the Côte d’Ivoire-Ghana margin now provide the first opportunity to quantify the vertical motions along this type of margin. Apatite fission-track dating of detrital sands suggests that large amounts of erosion occurred on the flanks of an intra-continental wrench zone that predated margin formation. Rapid cooling of >120°C at 120–115 Ma corresponds to erosion of 3.5–5 km along the conjugate Brazilian margin, reflecting c. 1 km of tectonically driven uplift, subaerial erosion, and isostatic uplift due to unloading. Following rift initiation at 120 Ma (Aptian), an oceanic spreading axis passed adjacent to this part of the margin at 90 Ma (Cenomanian). Maximum uplift during the ridge-transform intersection was 390 m, considerably less than the 2000+ m predicted by heat conduction models in local isostatic equilibrium. The modern ridge is partially the product of thicker crust (22 km) underlying the ridge than the adjacent Deep Ivorian Basin (19 km), and partially related to flexural unloading of the transform ridge between the end of intra-continental wrenching and ridge-transform intersection. Flexural coupling between the continental and oceanic plates since ridge-transform intersection has caused a progressive depression of the offshore margin, estimated at about 650 m in the study area

Investigation of gravity wave activity based on NDMC, NDACC and CTBTO measurements

GRIPS (Ground based Infrared P-branch Spectrometer) airglow measurements allow the derivation of kinetic temperature in the mesopause region during night with a temporal resolution of 10s to 15s. Amongst others, these time series can be used for the investigation of atmospheric dynamics like gravity wave activity. GRIPS measurements are performed in the framework of NDMC – the international Network for the Detection of Mesospheric Change. The project ARISE combines NDMC, NDACC (Network for the Detection of Atmospheric Composition Change) and CTBTO (Comprehensive Nuclear-Test-Ban Treaty Organization)measurements to infer a new 3D image of atmospheric dynamics from ground to mesopause. In this context, GRIPS data of about two to three years collected at the Observatory Haute-Provence, France and Catania, Italy are utilized to derive an index for shortand long-period gravity wave activity on daily and seasonal base. This time period includes also a stratospheric warming event. Potential energy density is calculated and compared with NDACC measurements at Haute-Provence; differences are discussed. For the measurements at the Italian station, comparisons of gravity wave and volcanic activity relying on infrasound array and seismic measurements are performed. First hints for volcanic induced mesopause gravity wave activity are presented.PublishedVienna, Austria2A. Fisica dell'alta atmosferaope