Lumped element kinetic inductance detectors maturity for space-borne instruments in the range between 80 and 180 GHz

This work intends to give the state-of-the-art of our knowledge of the performance of LEKIDs at millimetre wavelengths (from 80 to 180~GHz). We evaluate their optical sensitivity under typical background conditions and their interaction with ionising particles. Two LEKID arrays, originally designed for ground-based applications and composed of a few hundred pixels each, operate at a central frequency of 100, and 150~GHz ($\Delta \nu / \nu$ about 0.3). Their sensitivities have been characterised in the laboratory using a dedicated closed-circle 100~mK dilution cryostat and a sky simulator, allowing for the reproduction of realistic, space-like observation conditions. The impact of cosmic rays has been evaluated by exposing the LEKID arrays to alpha particles ($^{241}$Am) and X sources ($^{109}$Cd) with a readout sampling frequency similar to the ones used for Planck HFI (about 200~Hz), and also with a high resolution sampling level (up to 2~MHz) in order to better characterise and interpret the observed glitches. In parallel, we have developed an analytical model to rescale the results to what would be observed by such a LEKID array at the second Lagrangian point.Comment: 7 pages, 2 tables, 13 figure

When, why and how tumour clonal diversity predicts survival

The utility of intratumour heterogeneity as a prognostic biomarker is the subject of ongoing clinical investigation. However, the relationship between this marker and its clinical impact is mediated by an evolutionary process that is not well understood. Here, we employ a spatial computational model of tumour evolution to assess when, why and how intratumour heterogeneity can be used to forecast tumour growth rate and progression‐free survival. We identify three conditions that can lead to a positive correlation between clonal diversity and subsequent growth rate: diversity is measured early in tumour development; selective sweeps are rare; and/or tumours vary in the rate at which they acquire driver mutations. Opposite conditions typically lead to negative correlation. In cohorts of tumours with diverse evolutionary parameters, we find that clonal diversity is a reliable predictor of both growth rate and progression‐free survival. We thus offer explanations—grounded in evolutionary theory—for empirical findings in various cancers, including survival analyses reported in the recent TRACERx Renal study of clear‐cell renal cell carcinoma. Our work informs the search for new prognostic biomarkers and contributes to the development of predictive oncology

Niobium Silicon alloys for Kinetic Inductance Detectors

We are studying the properties of Niobium Silicon amorphous alloys as a candidate material for the fabrication of highly sensitive Kinetic Inductance Detectors (KID), optimized for very low optical loads. As in the case of other composite materials, the NbSi properties can be changed by varying the relative amounts of its components. Using a NbSi film with T_c around 1 K we have been able to obtain the first NbSi resonators, observe an optical response and acquire a spectrum in the band 50 to 300 GHz. The data taken show that this material has very high kinetic inductance and normal state surface resistivity. These properties are ideal for the development of KID. More measurements are planned to further characterize the NbSi alloy and fully investigate its potential.Comment: Accepted for publication on Journal of Low Temperature Physics. Proceedings of the LTD15 conference (Caltech 2013

Bi-layer Kinetic Inductance Detectors for space observations between 80-120 GHz

We have developed Lumped Element Kinetic Inductance Detectors (LEKID) sensitive in the frequency band from 80 to 120~GHz. In this work, we take advantage of the so-called proximity effect to reduce the superconducting gap of Aluminium, otherwise strongly suppressing the LEKID response for frequencies smaller than 100~GHz. We have designed, produced and optically tested various fully multiplexed arrays based on multi-layers combinations of Aluminium (Al) and Titanium (Ti). Their sensitivities have been measured using a dedicated closed-circle 100 mK dilution cryostat and a sky simulator allowing to reproduce realistic observation conditions. The spectral response has been characterised with a Martin-Puplett interferometer up to THz frequencies, and with a resolution of 3~GHz. We demonstrate that Ti-Al LEKID can reach an optical sensitivity of about $1.4$ $10^{-17}$~$W/Hz^{0.5}$ (best pixel), or $2.2$ $10^{-17}$~$W/Hz^{0.5}$ when averaged over the whole array. The optical background was set to roughly 0.4~pW per pixel, typical for future space observatories in this particular band. The performance is close to a sensitivity of twice the CMB photon noise limit at 100~GHz which drove the design of the Planck HFI instrument. This figure remains the baseline for the next generation of millimetre-wave space satellites.Comment: 7 pages, 9 figures, submitted to A&

Robust, Universal Tree Balance Indices

Balance indices that quantify the symmetry of branching events and the compactness of trees are widely used to compare evolutionary processes or tree-generating algorithms. Yet existing indices are not defined for all rooted trees, are unreliable for comparing trees with different numbers of leaves, and are sensitive to the presence or absence of rare types. The contributions of this article are twofold. First, we define a new class of robust, universal tree balance indices. These indices take a form similar to Colless’ index but can account for population sizes, are defined for trees with any degree distribution, and enable meaningful comparison of trees with different numbers of leaves. Second, we show that for bifurcating and all other full m-ary cladograms (in which every internal node has the same out-degree), one such Colless-like index is equivalent to the normalised reciprocal of Sackin’s index. Hence we both unify and generalise the two most popular existing tree balance indices. Our indices are intrinsically normalised and can be computed in linear time. We conclude that these more widely applicable indices have potential to supersede those in current use

Measurement of the binding energy of ultracold 87Rb133Cs molecules using an offset-free optical frequency comb

We report the binding energy of Rb87Cs133 molecules in their rovibrational ground state measured using an offset-free optical frequency comb based on difference frequency generation technology. We create molecules in the absolute ground state using stimulated Raman adiabatic passage (STIRAP) with a transfer efficiency of 88%. By measuring the absolute frequencies of our STIRAP lasers, we find the energy-level difference from an initial weakly bound Feshbach state to the rovibrational ground state with a resolution of ∼5 kHz over an energy-level difference of more than 114THz; this lets us discern the hyperfine splitting of the ground state. Combined with theoretical models of the Feshbach-state binding energies and ground-state hyperfine structure, we determine a zero-field binding energy of h×114268135.24(4)(3)MHz. To our knowledge, this is the most accurate determination to date of the dissociation energy of a molecule

Malaria control – two years' use of insecticide treated bednets compared with insecticide house spraying in Kwazulu-Natal

Objectives_ The objective of this study was to produce data indicating whether insecticide-treated bednets should replac insecticide house spraying as a malaria control method in South Africa_ We report 2 years of preliminary data on malaria incidence comparing areas receiving insecticidetreated bednets and those subjected to house spraying in northern KwaZulu-Natal.Design, setting and subjects. In order to measure significant reductions in malaria incidence between the two interventions, a geographical information system (GIS) was used to identify and create seven pairs of geographical blood ; (areas) in the malaria high-risk areas of Ndumu and Makani in Ingwavuma magisterial district, KwaZulu-Natal, Individual blocks were then randomly allocated to either insecticide-treated bednets or house spraying with deltamethrin. Malaria cases were either routinely recorded by surveillance agents at home or were reported to the nearest health facility_Results and conclusions. The results show that 2 years' use of insecticide-treated bednets by communities in Ndumu and Makanis, KwaZulu-Natal, significantly reduced the malaria incidence both in 1997 (rate ratio (RR) =0_879, 95% confidence interval (Cn 0.80 - 0.95, P =0.04) and in 1998 (RR = 0.667, Cl 0_61 - 0.72, P = 0.0001). Using a t-test, these significant reductions were further confirmed by an assessment of the rate of change between 1996 and 1998, showing a 16% reduction in malaria incidence in blocks using bednets and an increase of 45% in sprayed areas (t = 2.534, P = 0.026 (12 df». In order to decide whether bednets : should replace house spraying in South Africa, we need more : data on the efficacy of treated bednets, their long-term acceptability and the cost of the two interventions

Light echoes reveal an unexpectedly cool Eta Carinae during its 19th-century Great Eruption

Eta Carinae (Eta Car) is one of the most massive binary stars in the Milky Way. It became the second-brightest star in the sky during its mid-19th century "Great Eruption," but then faded from view (with only naked-eye estimates of brightness). Its eruption is unique among known astronomical transients in that it exceeded the Eddington luminosity limit for 10 years. Because it is only 2.3 kpc away, spatially resolved studies of the nebula have constrained the ejected mass and velocity, indicating that in its 19th century eruption, Eta Car ejected more than 10 M_solar in an event that had 10% of the energy of a typical core-collapse supernova without destroying the star. Here we report the discovery of light echoes of Eta Carinae which appear to be from the 1838-1858 Great Eruption. Spectra of these light echoes show only absorption lines, which are blueshifted by -210 km/s, in good agreement with predicted expansion speeds. The light-echo spectra correlate best with those of G2-G5 supergiant spectra, which have effective temperatures of ~5000 K. In contrast to the class of extragalactic outbursts assumed to be analogs of Eta Car's Great Eruption, the effective temperature of its outburst is significantly cooler than allowed by standard opaque wind models. This indicates that other physical mechanisms like an energetic blast wave may have triggered and influenced the eruption.Comment: Accepted for publication by Nature; 4 pages, 4 figures, SI: 6 pages, 3 figures, 5 table

Microfabrication technology for large LEKID arrays : from NIKA2 to future applications

The Lumped Element Kinetic Inductance Detectors (LEKID)demonstrated full maturity in the NIKA (New IRAM KID Arrays)instrument. These results allow directly comparing LEKID performance with other competing technologies (TES, doped silicon) in the mm and sub-mm range. A continuing effort is ongoing to improve the microfabrication technologies and concepts in order to satisfy the requirements of new instruments. More precisely, future satellites dedicated to CMB (Cosmic Microwave Background) studies will require the same focal plane technology to cover, at least, the frequency range of 60 to 600 GHz. Aluminium LEKID developed for NIKA have so far demonstrated, under real telescope conditions, performance approaching photon-noise limitation in the band 120-300 GHz. By implementing superconducting bi-layers we recently demonstrated LEKID arrays working in the range 80-120 GHz and with sensitivities approaching the goals for CMB missions. NIKA itself (350 pixels) is followed by a more ambitious project requiring several thousands (3000-5000) pixels. NIKA2 has been installed in October 2015 at the IRAM 30-m telescope. We will describe in detail the technological improvements that allowed a relatively harmless 10-fold up-scaling in pixels count without degrading the initial sensitivity. In particular we will briefly describe a solution to simplify the difficult fabrication step linked to the slot-line propagation mode in coplanar waveguide

Mapping malaria risk in the Highlands of Africa

Includes CD-ROM in front pocketCD-ROM contains report in Adobe Acrobat format; requires Acrobat v. 4.