The VIRMOS deep imaging survey: I. overview and survey strategy

This paper presents the CFH12K-VIRMOS survey: a deep B, V, R and I imaging survey in four fields totalling more than 17 deg^2, conducted with the 30x40 arcmin^2 field CFH-12K camera. The survey is intended to be a multi-purpose survey used for a variety of science goals, including surveys of very high redshift galaxies and weak lensing studies. Four high galactic latitude fields, each 2x2 deg^2, have been selected along the celestial equator: 0226-04, 1003+01, 1400+05, and 2217+00. The 16 deg^2 of the "wide" survey are covered with exposure times of 2h, 1.5h, 1h, 1h, while the 1.3x1 deg^2 area of the "deep" survey at the center of the 0226-04 field is covered with exposure times of 7h, 4.5h, 3h, 3h, in B,V,R and I respectively. The data is pipeline processed at the Terapix facility at the Institut d'Astrophysique de Paris to produce large mosaic images. The catalogs produced contain the positions, shape, total and aperture magnitudes for the 2.175 million objects. The depth measured (3sigma in a 3 arc-second aperture) is I_{AB}=24.8 in the ``Wide'' areas, and I_{AB}=25.3 in the deep area. Careful quality control has been applied on the data as described in joint papers. These catalogs are used to select targets for the VIRMOS-VLT Deep Survey, a large spectroscopic survey of the distant universe (Le F\`evre et al., 2003). First results from the CFH12K-VIRMOS survey have been published on weak lensing (e.g. van Waerbeke & Mellier 2003). Catalogs and images are available through the VIRMOS database environment under Oracle ({\tt http://www.oamp.fr/virmos}). They will be open for general use on July 1st, 2003.Comment: 17 pages including 9 figures, submitted to A&

Neuropathological and Reelin Deficiencies in the Hippocampal Formation of Rats Exposed to MAM; Differences and Similarities with Schizophrenia

Adult rats exposed to methylazoxymethanol (MAM) at embryonic day 17 (E17) consistently display behavioral characteristics similar to that observed in patients with schizophrenia and replicate neuropathological findings from the prefrontal cortex of psychotic individuals. However, a systematic neuropathological analysis of the hippocampal formation and the thalamus in these rats is lacking. It is also unclear if reelin, a protein consistently associated with schizophrenia and potentially involved in the mechanism of action of MAM, participates in the neuropathological effects of this compound. Therefore, a thorough assessment including cytoarchitectural and neuromorphometric measurements of eleven brain regions was conducted. Numbers of reelin positive cells and reelin expression and methylation levels were also studied.Compared to untreated rats, MAM-exposed animals showed a reduction in the volume of entorhinal cortex, hippocampus and mediodorsal thalamus associated with decreased neuronal soma. The entorhinal cortex also showed laminar disorganization and neuronal clusters. Reelin methylation in the hippocampus was decreased whereas reelin positive neurons and reelin expression were unchanged.Our results indicate that E17-MAM exposure reproduces findings from the hippocampal formation and the mediodorsal thalamus of patients with schizophrenia while providing little support for reelin's involvement. Moreover, these results strongly suggest MAM-treated animals have a diminished neuropil, which likely arises from abnormal neurite formation; this supports a recently proposed pathophysiological hypothesis for schizophrenia

Cosmic Shear Statistics and Cosmology

We report a measurement of cosmic shear correlations using an effective area of 6.5 sq. deg. of the VIRMOS deep imaging survey in progress at the Canada-France-Hawaii Telescope. We measured various shear correlation functions, the aperture mass statistic and the top-hat smoothed variance of the shear with a detection significance exceeding 12 sigma for each of them. We present results on angular scales from 3 arc-seconds to half a degree. The consistency of different statistical measures is demonstrated and confirms the lensing origin of the signal through tests that rely on the scalar nature of the gravitational potential. For Cold Dark Matter models we find $\sigma_8 \Omega_0^{0.6}=0.43^{+0.04}_{-0.05}$ at the 95% confidence level. The measurement over almost three decades of scale allows to discuss the effect of the shape of the power spectrum on the cosmological parameter estimation. The degeneracy on sigma_8-Omega_0 can be broken if priors on the shape of the linear power spectrum (that can be parameterized by Gamma) are assumed. For instance, with Gamma=0.21 and at the 95% confidence level, we obtain 0.60.65 and Omega_0<0.4 for flat (Lambda-CDM) models. From the tangential/radial modes decomposition we can set an upper limit on the intrinsic shape alignment, which was recently suggested as a possible contribution to the lensing signal. Within the error bars, there is no detection of intrinsic shape alignment for scales larger than 1'.Comment: 13 pages, submitted to A&

Cosmic Shear Analysis with CFHTLS Deep data

We present the first cosmic shear measurements obtained from the T0001 release of the Canada-France-Hawaii Telescope Legacy Survey. The data set covers three uncorrelated patches (D1, D3 and D4) of one square degree each observed in u*, g', r', i' and z' bands, out to i'=25.5. The depth and the multicolored observations done in deep fields enable several data quality controls. The lensing signal is detected in both r' and i' bands and shows similar amplitude and slope in both filters. B-modes are found to be statistically zero at all scales. Using multi-color information, we derived a photometric redshift for each galaxy and separate the sample into medium and high-z galaxies. A stronger shear signal is detected from the high-z subsample than from the low-z subsample, as expected from weak lensing tomography. While further work is needed to model the effects of errors in the photometric redshifts, this results suggests that it will be possible to obtain constraints on the growth of dark matter fluctuations with lensing wide field surveys. The various quality tests and analysis discussed in this work demonstrate that MegaPrime/Megacam instrument produces excellent quality data. The combined Deep and Wide surveys give sigma_8= 0.89 pm 0.06 assuming the Peacock & Dodds non-linear scheme and sigma_8=0.86 pm 0.05 for the halo fitting model and Omega_m=0.3. We assumed a Cold Dark Matter model with flat geometry. Systematics, Hubble constant and redshift uncertainties have been marginalized over. Using only data from the Deep survey, the 1 sigma upper bound for w_0, the constant equation of state parameter is w_0 < -0.8.Comment: 14 pages, 16 figures, accepted A&

Very weak lensing in the CFHTLS Wide: Cosmology from cosmic shear in the linear regime

We present an exploration of weak lensing by large-scale structure in the linear regime, using the third-year (T0003) CFHTLS Wide data release. Our results place tight constraints on the scaling of the amplitude of the matter power spectrum sigma_8 with the matter density Omega_m. Spanning 57 square degrees to i'_AB = 24.5 over three independent fields, the unprecedented contiguous area of this survey permits high signal-to-noise measurements of two-point shear statistics from 1 arcmin to 4 degrees. Understanding systematic errors in our analysis is vital in interpreting the results. We therefore demonstrate the percent-level accuracy of our method using STEP simulations, an E/B-mode decomposition of the data, and the star-galaxy cross correlation function. We also present a thorough analysis of the galaxy redshift distribution using redshift data from the CFHTLS T0003 Deep fields that probe the same spatial regions as the Wide fields. We find sigma_8(Omega_m/0.25)^0.64 = 0.785+-0.043 using the aperture-mass statistic for the full range of angular scales for an assumed flat cosmology, in excellent agreement with WMAP3 constraints. The largest physical scale probed by our analysis is 85 Mpc, assuming a mean redshift of lenses of 0.5 and a LCDM cosmology. This allows for the first time to constrain cosmology using only cosmic shear measurements in the linear regime. Using only angular scales theta> 85 arcmin, we find sigma_8(Omega_m/0.25)_lin^0.53 = 0.837+-0.084, which agree with the results from our full analysis. Combining our results with data from WMAP3, we find Omega_m=0.248+-0.019 and sigma_8 = 0.771+-0.029.Comment: 23 pages, 16 figures (A&A accepted

GPIIb/IIIa Receptor Antagonism Using Small Molecules Provides no Additive Long-Term Protection after Percutaneous Coronary Intervention as Compared to Clopidogrel Plus Aspirin

Background: There is some controversy as to whether tirofiban or eptifibatide, two small anti-aggregating drugs (AAD), may reduce the incidence of composite ischemic events within one year in patients undergoing percutaneous coronary intervention (PCI) in the real clinical world. Methods: We compared consecutive patients on oral double AAD (with clopidogrel and aspirin) who underwent PCI (n=207) and patients who were on single AAD and received a second AAD, just prior to PCI, and either high-dose tirofiban or double-bolus eptifibatide (double AAD plus small molecules group, n=666). The primary end point (incidence of composite ischemic events within one year) included death, acute myocardial infarction, unstable angina, stent thrombosis or repeat PCI or coronary bypass surgery (related to the target vessel PCI failure) and was modelled by Cox's regression. Results: There were 89 composite ischemic events: 24 (11.6%) in double AAD alone and 65 (9.8%) in double AAD plus small molecules groups (log-rank test: p=0.36). Incidences by type of ischemic events were similar between the 2 groups. Based on 21 potential covariates fitted simultaneously, adjusted hazard ratios (HR and 95% confidence intervals) showed that age (HR 1.03, 1.01-1.06, p=0.01), diabetes (HR 1.68, 1.01-2.79, p=0.05) and intra aortic balloon pump (HR 5.12, 2.36-11.10, p=0.0001) were significant risk factors whereas thrombolysis by tenecteplase (HR 0.35, 0.13-0.98, p=0.05) and having had hypertension or anti-hypertensive treatment (HR 0.58, 0.36-0.93, p=0.03) were significant protectors for events. Whether small molecules were present provided a non significant additional benefit as compared to double AAD alone (HR 0.83, 0.51-1.36, p=0.46). Pre-PCI CK-MB were not useful to predict events (HR 1.01, 0.99-1.01, p=0.17). Conclusions: In clinical world patients undergoing PCI (rescue plus primary <13%) while on double AAD, based on clopidogrel plus aspirin, small molecules (tirofiban or eptifibatide) provided no additive long-term protection against the occurrence of composite ischemic events whereas thrombolysis by tenecteplase did. © Schiariti et al

Relationship between PPI and baseline startle response

Prepulse inhibition (PPI) of the startle response to a sudden noise is the reduction in startle observed when the noise is preceded shortly by a mild sensory event, which is often a tone. A part of the literature is based on the assumption that PPI is independent of the baseline startle. A simple model is presented and experimental validation provided. The model is based on the commonly accepted observation that the neuronal circuit of PPI differs from that of startle. But, by using a common output, the measures of both phenomena become linked to each other. But, how can we interpret the numerous experimental data showing PPI to be independent of the startle level? It is suggested that in a number of such cases the baseline startle would have been stabilized by a ceiling effect in the startle/PPI neuronal networks. Reducing the startle level, for example in a PPI evaluation procedure, may disclose properties of startle masked by this ceiling effect. Disclosure of habituation to the startle eliciting noise produced an increase of PPI along its initial measurements. Taken together, even if the neuronal process that sustains startle and PPI are distinct, separating them experimentally requires careful parametric methods and caution in the interpretation of the corresponding observations