Fostering Energy Efficiency in manufacturing plants through economical breakthroughs in power and flow rate measurement

International audienceThe ability to measure, monitor and control energy consumption at several key locations in a manufacturing plant is a major prerequisite for any efficient energy management program. To identify and evaluate energy savings, one must get a clear view of how the energy is used. Furthermore, measuring energy flows is one of the necessary conditions for long lasting energy-efficient solutions. Most of the time energy managers are reluctant to put in place power and flow rate measuring devices either because of their cost or because this implies disrupting production. To find acceptable and economical solutions for long lasting energy measurements in Industry, EDF R&D launched a 3-year collaborative research project called CHIC. This project is funded by the French National Research Agency (ANR) and involves 7 partners. Its total budget amounts to 2.55 M€. Because energy measuring devices acceptability relies mostly on their ability to be installed without disrupting production as well as on their installation and maintenance costs, two non intrusive and low cost technologies will be explored within the project: A physical approach is being used to build a clamp-on power meter that could be installed around multi-conductors power cables without interrupting power supply, A software based approach is being used to build power and flow meters that derive the sought-for variable from models and from simple and easy to collect other physical measurements (e.g. command signals, etc...). Introductio

Applications in a Mobile Environment

jlemouel @ irisa.fr Abstract tation power, available memory, storage capabilities, Mqbile computing is a domain in great expansion. Wireless *tworks and Portable Information Appliances (PIAs) are d~veloping very rapidly. More and more mobile users woulJ like to perform their multimedia applications with the samef acility as on their desktop station. Use of such applica.ons in a mobile environment raises new challenges. Thes applications are interactive and extremely costly in syste and network resources, whereas PIAs resources are poor 4Znd wireless networks offer a very variable quality of connl:!ction. In this pape1; we propose an adaptive and dynamid distribution of applications on the local environment to ov4rcome the poorness of available resources on PIAs, and tq reduce and regulate variability effects. I

Improvement of the QoS via an Adaptive and Dynamic Distribution of Applications in a Mobile Environment

Mobile computing is a domain in great expansion. Wireless networks and Portable Information Appliances (PIAs) are developing very rapidly. More and more mobile users would like to perform their multimedia applications with the same facility as on their desktop station. Use of such applications in a mobile environment raises new challenges. These applications are interactive and extremely costly in system and network resources, whereas PIAs resources are poor and wireless networks offer a very variable quality of connection. In this paper, we propose an adaptive and dynamic distribution of applications on the local environment to overcome the poorness of available resources on PIAs, and to reduce and regulate variability effects

Transcriptional regulation of small HSP—HSF1 and beyond

International audienceThe members of the small heat shock protein (sHSP) family are molecular chaperones that play major roles in development, stress responses, and diseases, and have been envisioned as targets for therapy, particularly in cancer. The molecular mechanisms that regulate their transcription, in normal, stress, or pathological conditions, are characterized by extreme complexity and subtlety. Although historically linked to the heat shock transcription factors (HSFs), the stress-induced or developmental expression of the diverse members, including HSPB1/Hsp27/Hsp25, αA-crystallin/HSPB4, and αB-crystallin/HSPB5, relies on the combinatory effects of many transcription factors. Coupled with remarkably different cis-element architectures in the sHsp regulatory regions, they confer to each member its developmental expression or stress-inducibility. For example, multiple regulatory pathways coordinate the spatio-temporal expression of mouse αA-, αB-crystallin, and Hsp25 genes during lens development, through the action of master genes, like the large Maf family proteins and Pax6, but also HSF4. The inducibility of Hsp27 and αB-crystallin transcription by various stresses is exerted by HSF-dependent mechanisms, by which concomitant induction of Hsp27 and αB-crystallin expression is observed. In contrast, HSF-independent pathways can lead to αB-crystallin expression, but not to Hsp27 induction. Not surprisingly, deregulation of the expression of sHSP is associated with various pathologies, including cancer, neurodegenerative, or cardiac diseases. However, many questions remain to be addressed, and further elucidation of the developmental mechanisms of sHsp gene transcription might help to unravel the tissue- and stage-specific functions of this fascinating class of proteins, which might prove to be crucial for future therapeutic strategies. This article is part of a Directed Issue entitled: Small HSPs in physiology and pathology

Immediate perturbation of DNA methylation upon acute prenatal alcohol exposure in the mouse developing brain cortex

Funding information VM was funded by the Agence Nationale de la Recherche « HSF-EPISAME », SAMENTA ANR-13-SAMA-0008-01) and CNRS. AD was supported by a Doctoral Fellowship from the French Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI) and FM from a Doctoral Fellowship from the CNRS. This study contributes to the Université de Paris IdEx #ANR-18-IDEX-0001 funded by the French Government through its "Investments for the Future" program. DSD benefited from a CNRS Délégation de Recherche (2018-2020). OTT benefited from travel grants from Université Paris Diderot

Profound and sustained response with next-generation ALK inhibitors in patients with relapsed or progressive ALK-positive anaplastic large cell lymphoma with central nervous system involvement

International audienc

Two Monogenetic Disorders, Activated PI3-Kinase-δ Syndrome 2 and Smith–Magenis Syndrome, in One Patient: Case Report and a Literature Review of Neurodevelopmental Impact in Primary Immunodeficiencies Associated With Disturbed PI3K Signaling

International audienceActivated PI3-kinase-δ syndrome 2 (APDS2) is caused by autosomal dominant mutations in the PIK3R1 gene encoding the p85α, p55α, and p50α regulatory subunits. Most diagnosed APDS2 patients carry mutations affecting either the splice donor or splice acceptor sites of exon 11 of the PIK3R1 gene responsible for an alternative splice product and a shortened protein. The clinical presentation of APDS2 patients is highly variable, ranging from mild to profound combined immunodeficiency features as massive lymphoproliferation, increased susceptibility to bacterial and viral infections, bronchiectasis, autoimmune manifestations, and occurrence of cancer. Non-immunological features such as growth retardation and neurodevelopmental delay have been reported for APDS2 patients. Here, we describe a patient suffering from an APDS2 associated with a Smith–Magenis syndrome (SMS), a complex genetic disorder affecting, among others, neurological manifestations and review the literature describing neurodevelopmental impacts in APDS2 and other PIDs/monogenetic disorders associated with dysregulated PI3K signaling

Le livre et ses espaces

LA CONNAISSANCE DU LIVRE se rattache ici à la mise en jeu dialectique de termes apparemment éloignés : « livre » et « espace ». Le livre ne se réduit donc pas à son support matériel. Notre intention n’est pas non plus de délimiter tous les espaces possibles du livre qu’ils soient physique, esthétique, littéraire, métaphysique ou anthropologique. Il s’agit plutôt de proposer au lecteur un voyage à travers l’espace dans le livre - la page, le texte…, l’espace pour le livre - la bibliothèque, la collection…, l’espace hors du livre - l’œuvre d’art, l’hypertexte… Le livre utopique de Lévinas, Blanchot ou Deleuze, la poésie plastique de Mallarmé, Apollinaire ou Claudel, le récit littéraire de Kundera, Le Clézio, ou Perec, l’espace pictural de Matisse, Kandinsky ou Gris, seront autant de jalons pour mieux mesurer l’étendue de ces espaces infinis que le livre invente