Reinforcement of anticipatory eating by short as well as long fasts

Rats can learn to anticipate the omission of subsequent meals by increasing food intake. Our previous reports have analysed group means at each trial but that does not allow for rats learning at different speeds. This paper presents instead a rat-by-rat analysis of all the raw data from previous experiments. The re-analysis supports the published evidence that the capacity for reinforcement generated by withholding of food is greater after a longer fast than after a shorter fast, but that the learning is quicker after the shorter fast. The individualised analyses also extend the evidence that the pattern of learning, extinction and re-learning with shorter fasts is similar to that with longer fasts. These findings indicate that, contrary to our previous interpretation, a single learning mechanism can explain the effects of both durations of food deprivation

The critical equation of state of the three-dimensional O(N) universality class: N>4

We determine the scaling equation of state of the three-dimensional O(N) universality class, for N=5, 6, 32, 64. The N=5 model is relevant for the SO(5) theory of high-T_c superconductivity, while the N=6 model is relevant for the chiral phase transition in two-color QCD with two flavors. We first obtain the critical exponents and the small-field, high-temperature, expansion of the effective potential (Helmholtz free energy) by analyzing the available perturbative series, in both fixed-dimension and epsilon-expansion schemes. Then, we determine the critical equation of state by using a systematic approximation scheme, based on polynomial representations valid in the whole critical region, which satisfy the known analytical properties of the equation of state, take into account the Goldstone singularities at the coexistence curve and match the small-field, high-temperature, expansion of the effective potential. This allows us also to determine several universal amplitude ratios. We also compare our approximate solutions with those obtained in the large-N expansion, up to order 1/N, finding good agreement for N\gtrsim 32.Comment: 27 pages, 8 figures. v2: Improved presentation, updated references. Nucl. Phys. B in pres

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat

Peer reviewedPublisher PD

Food after deprivation rewards the earlier eating

Food intake can be increased by learning to anticipate the omission of subsequent meals. We present here a new theory that such anticipatory eating depends on an associative process of instrumental reinforcement by the nutritional repletion that occurs when access to food is restored. Our evidence over the last decade from a smooth-brained omnivore has been that food after deprivation rewards intake even when those reinforced ingestive responses occur long before the physiological signals from renewed assimilation. Effects of food consumed after self-deprivation might therefore reward extra eating in human beings, through brain mechanisms that could operate outside awareness. That would have implications for efforts to reduce body weight. This food reward mechanism could be contributing to the failure of the dietary component of interventions on obesity within controlled trials of the management or prevention of disorders such as hypertension, atherosclerosis and type 2 diabetes

From constructive field theory to fractional stochastic calculus. (II) Constructive proof of convergence for the L\'evy area of fractional Brownian motion with Hurst index α∈(1/8,1/4)\alpha\in(1/8,1/4)

{Let $B=(B_1(t),...,B_d(t))$ be a $d$-dimensional fractional Brownian motion with Hurst index $\alpha<1/4$, or more generally a Gaussian process whose paths have the same local regularity. Defining properly iterated integrals of $B$ is a difficult task because of the low H\"older regularity index of its paths. Yet rough path theory shows it is the key to the construction of a stochastic calculus with respect to $B$, or to solving differential equations driven by $B$. We intend to show in a series of papers how to desingularize iterated integrals by a weak, singular non-Gaussian perturbation of the Gaussian measure defined by a limit in law procedure. Convergence is proved by using "standard" tools of constructive field theory, in particular cluster expansions and renormalization. These powerful tools allow optimal estimates, and call for an extension of Gaussian tools such as for instance the Malliavin calculus. After a first introductory paper \cite{MagUnt1}, this one concentrates on the details of the constructive proof of convergence for second-order iterated integrals, also known as L\'evy area

Massive Field-Theory Approach to Surface Critical Behavior in Three-Dimensional Systems

The massive field-theory approach for studying critical behavior in fixed space dimensions $d<4$ is extended to systems with surfaces.This enables one to study surface critical behavior directly in dimensions $d<4$ without having to resort to the $\epsilon$ expansion. The approach is elaborated for the representative case of the semi-infinite |\bbox{\phi}|^4 $n$-vector model with a boundary term {1/2} c_0\int_{\partial V}\bbox{\phi}^2 in the action. To make the theory uv finite in bulk dimensions $3\le d<4$, a renormalization of the surface enhancement $c_0$ is required in addition to the standard mass renormalization. Adequate normalization conditions for the renormalized theory are given. This theory involves two mass parameter: the usual bulk `mass' (inverse correlation length) $m$, and the renormalized surface enhancement $c$. Thus the surface renormalization factors depend on the renormalized coupling constant $u$ and the ratio $c/m$. The special and ordinary surface transitions correspond to the limits $m\to 0$ with $c/m\to 0$ and $c/m\to\infty$, respectively. It is shown that the surface-enhancement renormalization turns into an additive renormalization in the limit $c/m\to\infty$. The renormalization factors and exponent functions with $c/m=0$ and $c/m=\infty$ that are needed to determine the surface critical exponents of the special and ordinary transitions are calculated to two-loop order. The associated series expansions are analyzed by Pad\'e-Borel summation techniques. The resulting numerical estimates for the surface critical exponents are in good agreement with recent Monte Carlo simulations. This also holds for the surface crossover exponent $\Phi$.Comment: Revtex, 40 pages, 3 figures, and 8 pictograms (included in equations

Quantum Bubble Nucleation beyond WKB: Resummation of Vacuum Bubble Diagrams

On the basis of Borel resummation, we propose a systematical improvement of bounce calculus of quantum bubble nucleation rate. We study a metastable super-renormalizable field theory, $D$ dimensional O(N) symmetric $\phi^4$ model ($D<4$) with an attractive interaction. The validity of our proposal is tested in D=1 (quantum mechanics) by using the perturbation series of ground state energy to high orders. We also present a result in D=2, based on an explicit calculation of vacuum bubble diagrams to five loop orders.Comment: 19 pages, 5 figures, PHYZZ

On the nature of the finite-temperature transition in QCD

We discuss the nature of the finite-temperature transition in QCD with N_f massless flavors. Universality arguments show that a continuous (second-order) transition must be related to a 3-D universality class characterized by a complex N_f X N_f matrix order parameter and by the symmetry-breaking pattern [SU(N_f)_L X SU(N_f)_R]/Z(N_f)_V -> SU(N_f)_V/Z(N_f)_V, or [U(N_f)_L X U(N_f)_R]/U(1)_V -> U(N_f)_V/U(1)_V if the U(1)_A symmetry is effectively restored at T_c. The existence of any of these universality classes requires the presence of a stable fixed point in the corresponding 3-D Phi^4 theory with the expected symmetry-breaking pattern. Otherwise, the transition is of first order. In order to search for stable fixed points in these Phi^4 theories, we exploit a 3-D perturbative approach in which physical quantities are expanded in powers of appropriate renormalized quartic couplings. We compute the corresponding Callan-Symanzik beta-functions to six loops. We also determine the large-order behavior to further constrain the analysis. No stable fixed point is found, except for N_f=2, corresponding to the symmetry-breaking pattern [SU(2)_L X SU(2)_R]/Z(2)_V -> SU(2)_V/Z(2)_V equivalent to O(4) -> O(3). Our results confirm and put on a firmer ground earlier analyses performed close to four dimensions, based on first-order calculations in the framework of the epsilon=4-d expansion. These results indicate that the finite-temperature phase transition in QCD is of first order for N_f>2. A continuous transition is allowed only for N_f=2. But, since the theory with symmetry-breaking pattern [U(2)_L X U(2)_R]/U(1)_V -> U(2)_V/U(1)_V does not have stable fixed points, the transition can be continuous only if the effective breaking of the U(1)_A symmetry is sufficiently large.Comment: 30 pages, 3 figs, minor correction

Food after deprivation rewards the earlier eating

Food intake can be increased by learning to anticipate the omission of subsequent meals. We present here a new theory that such anticipatory eating depends on an associative process of instrumental reinforcement by the nutritional repletion that occurs when access to food is restored. Our evidence over the last decade from a smooth-brained omnivore has been that food after deprivation rewards intake even when those reinforced ingestive responses occur long before the physiological signals from renewed assimilation. Effects of food consumed after self deprivation might therefore reward extra eating in human beings, through brain mechanisms that could operate outside awareness. That would have implications for efforts to reduce body weight. This food reward mechanism could be contributing to the failure of the dietary component of interventions on obesity within controlled trials of the management or prevention of disorders such as hypertension, atherosclerosis and type 2 diabetes

Cell-Free DNA Genomic Profiling and Its Clinical Implementation in Advanced Prostate Cancer.

Most men with prostate cancer (PCa), despite potentially curable localized disease at initial diagnosis, progress to metastatic disease. Despite numerous treatment options, choosing the optimal treatment for individual patients remains challenging. Biomarkers guiding treatment sequences in an advanced setting are lacking. To estimate the diagnostic potential of liquid biopsies in guiding personalized treatment of PCa, we evaluated the utility of a custom-targeted next-generation sequencing (NGS) panel based on the AmpliSeq HD Technology. Ultra-deep sequencing on plasma circulating free DNA (cfDNA) samples of 40 metastatic castration-resistant PCa (mCRPC) and 28 metastatic hormone-naive PCa (mCSPC) was performed. CfDNA somatic mutations were detected in 48/68 (71%) patients. Of those 68 patients, 42 had matched tumor and cfDNA samples. In 21/42 (50%) patients, mutations from the primary tumor tissue were detected in the plasma cfDNA. In 7/42 (17%) patients, mutations found in the primary tumor were not detected in the cfDNA. Mutations from primary tumors were detected in all tested mCRPC patients (17/17), but only in 4/11 with mCSPC. AR amplifications were detected in 12/39 (31%) mCRPC patients. These results indicate that our targeted NGS approach has high sensitivity and specificity for detecting clinically relevant mutations in PCa