379 research outputs found
Produit de solubilité de la calcite et constantes de dissociation de CaHCO3+ et CaCO30 entre 5 et 75 °C
Les valeurs du produit de solubilité de la calcite et des constantes de dissociation de CaHCO3+ et CaCO30, notées K3 et K4, ont été déterminées à différentes températures comprises entre 5 et 75 °C (la calcite est instable aux températures plus élevées) à partir des mesures [(Ca2+)T, pH] de solubilité de ce sel dans l'eau carboniquement pure. Les résultats obtenus ont permis d'établir les relations empiriques suivantes :pKs= 7,8156 + 0,03111 T + (1 502/T) - 5,518 log TpK3= 6,2447 + 0,00437 T + (864,479/T) - 0,363 log TpK4= 2,89636 + 0,00707 T + (102,87/T) - 0,44176 log Texpressions dans lesquelles T désigne la température absolue (K) et log le logarithme décimal.Des variations de pKS avec la température nous avons déduit, à 25 °C, les grandeurs thermodynamiques relatives à la dissolution de la calcite :∆H0 = -2510 cal. mol-1, ∆S0 = -47,2 cal. mol-1. K-1et ∆C∘p = -73,9 cal. mol-1. K-1The values of the solubility product of calcite and dissociation constants of CaHCO3+ and CaCO30, K3 and K4 respectively, were determined at several temperatures between 5 and 75 °C (calcite becomes unstable at higher temperatures) from measurements [(Ca2+)T, pH] of calcite solubility using carbonically pure water. The results obtained lead to the following empirical expressions for the dependence of equilibrium constants on the temperature :pKs= 7,8156 + 0,03111 T + (1 502/T) - 5,518 log TpK3= 6,2447 + 0,00437 T + (864,479/T) - 0,363 log TpK4= 2,89636 + 0,00707 T + (102,87/T) - 0,44176 log Twhere log T is the common logarithm of the absolute temperature T(K).Using this expression of pKS, the calculated thermodynamic properties of the calcite dissolution reaction at 25 °C are :∆H0 = -2510 cal. mol-1, ∆S0 = -47,2 cal. mol-1. K-1et ∆C∘p = -73,9 cal. mol-1. K-
Méthode de mesure des conductivités bidomaines anisotropes du tissu cardiaque
Les méthodes de mesure d'impédance -- Notions relatives aux tissus biologiques -- Évaluation des paramètres passifs du tissu -- Modèles bidomaines capacitifs pour la mesure des conductivités myocardiques -- Situation de l'article dans la thèse -- Glossary of terms -- The standard bidomain model -- The direct current approach -- The alternating current approach -- Three dimensional Fourier transform solution -- The bidomain model including intracellular capacitance -- Three dimensional numerical bidomain model -- Parameter estimation -- Mesure des conductivités du myocarde avec la technique à huit électrodes dans le domaine fréquentiel -- Measurement theory -- Alternating current bidomain model -- Biodomain model with complex intracellular medium -- La méthode de mesure
Norwalk Virus–specific Binding to Oyster Digestive Tissues
Specific binding of virus to oysters can selectively concentrate a human pathogen
Assessment of human enteric viruses in cultured and wild bivalve molluscs
Standard and real-time reverse transcription-PCR (rRT-PCR) procedures were used to monitor cultured and wild bivalve molluscs from the RÃa de Vigo (NW Spain) for the main human enteric RNA viruses, specifically, norovirus (NoV), hepatitis Avirus (HAV), astrovirus (AsV), rotavirus (RT), enterovirus (EV), and Aichi virus (AiV). The results showed the presence of at least one enteric virus in 63.4% of the 41 samples analyzed. NoV GII was the most prevalent virus, detected in 53.7% of the samples, while NoV GI, AsV, EV, and RV were found at lower percentages (7.3, 12.2, 12.2, and 4.9%, respectively). In general, samples obtained in the wild were more frequently contaminated than those from cultured (70.6 vs. 58.3%) molluscs and were more readily contaminated with more than one virus. However, NoV GI was detected in similar amounts in cultured and wild samples (6.4 × 102 to 3.3 × 103 RNA copies per gram of digestive tissue) while the concentrations of NoV GII were higher in cultured (from 5.6 × 101 to 1.5 × 104 RNA copies per gram of digestive tissue) than in wild (from 1.3 × 102 to 3.4 × 104 RNA copies per gram of digestive tissue) samples. [Int Microbiol 2009; 12(3):145-151
Element resolved ultrafast demagnetization rates in ferrimagnetic CoDy
Femtosecond laser induced ultrafast magnetization dynamics have been studied
in multisublattice CoxDy1-x alloys. By performing element and time-resolved
X-ray spectroscopy, we distinguish the ultrafast quenching of Co3d and Dy4f
magnetic order when the initial temperatures are below (T=150K) or above
(T=270K) the temperature of magnetic compensation (Tcomp). In accordance with
former element-resolved investigations and theoretical calculations, we observe
different dynamics for Co3d and Dy4f spins. In addition we observe that, for a
given laser fluence, the demagnetization amplitudes and demagnetization times
are not affected by the existence of a temperature of magnetic compensation.
However, our experiment reveals a twofold increase of the ultrafast
demagnetization rates for the Dy sublattice at low temperature. In parallel, we
measure a constant demagnetization rate of the Co3d sublattice above and below
Tcomp. This intriguing difference between the Dy4f and Co3d sublattices calls
for further theoretical and experimental investigations.Comment: 6 Figure, 2 Table
Magnetic switching in granular FePt layers promoted by near-field laser enhancement
Light-matter interaction at the nanoscale in magnetic materials is a topic of
intense research in view of potential applications in next-generation
high-density magnetic recording. Laser-assisted switching provides a pathway
for overcoming the material constraints of high-anisotropy and high-packing
density media, though much about the dynamics of the switching process remains
unexplored. We use ultrafast small-angle x-ray scattering at an x-ray
free-electron laser to probe the magnetic switching dynamics of FePt
nanoparticles embedded in a carbon matrix following excitation by an optical
femtosecond laser pulse. We observe that the combination of laser excitation
and applied static magnetic field, one order of magnitude smaller than the
coercive field, can overcome the magnetic anisotropy barrier between "up" and
"down" magnetization, enabling magnetization switching. This magnetic switching
is found to be inhomogeneous throughout the material, with some individual FePt
nanoparticles neither switching nor demagnetizing. The origin of this behavior
is identified as the near-field modification of the incident laser radiation
around FePt nanoparticles. The fraction of not-switching nanoparticles is
influenced by the heat flow between FePt and a heat-sink layer
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission
Objective:Rare inherited missense variants inSLC32A1, the gene that encodes the vesicular gamma-aminobutyric acid(GABA) transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus. We aimed to clarifyif de novo missense variants inSLC32A1can also cause epilepsy with impaired neurodevelopment.Methods:Using exome sequencing, we identified four individuals with a developmental and epileptic encephalopathyand de novo missense variants inSLC32A1. To assess causality, we performed functional evaluation of the identifiedvariants in a murine neuronal cell culture model.Results:The main phenotype comprises moderate-to-severe intellectual disability, infantile-onset epilepsy within thefirst 18 months of life, and a choreiform, dystonic, or dyskinetic movement disorder. In silico modeling and functionalanalyses reveal that three of these variants, which are located in helices that line the putative GABA transport pathway,result in reduced quantal size, consistent with impairedfilling of synaptic vesicles with GABA. The fourth variant,located in the vesicular gamma-aminobutyric acid N-terminus, does not affect quantal size, but increases presynapticrelease probability, leading to more severe synaptic depression during high-frequency stimulation. Thus, variants invesicular gamma-aminobutyric acid can impair GABAergic neurotransmission through at least two mechanisms, byaffecting synaptic vesiclefilling and by altering synaptic short-term plasticity.Interpretation:This work establishes de novo missense variants inSLC32A1as a novel cause of a developmental andepileptic encephalopathy
Multi-tasking to Correct: Motion-Compensated MRI via Joint Reconstruction and Registration
This work addresses a central topic in Magnetic Resonance Imaging (MRI) which
is the motion-correction problem in a joint reconstruction and registration
framework. From a set of multiple MR acquisitions corrupted by motion, we aim
at - jointly - reconstructing a single motion-free corrected image and
retrieving the physiological dynamics through the deformation maps. To this
purpose, we propose a novel variational model. First, we introduce an
fidelity term, which intertwines reconstruction and registration along with the
weighted total variation. Second, we introduce an additional regulariser which
is based on the hyperelasticity principles to allow large and smooth
deformations. We demonstrate through numerical results that this combination
creates synergies in our complex variational approach resulting in higher
quality reconstructions and a good estimate of the breathing dynamics. We also
show that our joint model outperforms in terms of contrast, detail and blurring
artefacts, a sequential approach.Cambridge Cancer Centre, CMIH and CCIMI, University of Cambridge
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