Beyond flood hazard. Mapping the loss probability of pedestrians to improve risk estimation and communication

This is the final version. Available on open access from Elsevier via the DOI in this recordData availability: Data will be made available on request.The effective communication of flood hazard and risk is a necessary step to foster preparedness and resilience, hence reducing the detrimental impacts of flooding events. Classical flood maps, which show flow depth and velocity, have often proved to be incomprehensible to the majority of people. Some recent studies used color maps to convey the spatial distribution of diverse hazard indexes that, accounting for both water depth and velocity, are intended to communicate the hazard degree in a more intelligible way. It is first shown that these hazard indexes have some inherent limitations, as for example the implicit assumption of a linear relationship between flood hazard and flow velocity. As an alternative, we propose to map the loss probability (LP) of pedestrians exposed to floodwaters, which is a physics-based and data-consistent risk index accounting for both hazard and vulnerability. LP can be easily computed and allows for a sounder estimation and a more effective communication of flood risk to the general public.European UnionEuropean Union Horizon 202

A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Its homeostasis is maintained by neuronal and glial GABA transporters (GATs). The four GATs identified in humans are GAT1 (SLC6A1), GAT2 (SLC6A13), GAT3 (SLC6A11), and betaine/GABA transporter-1 BGT-1 (SLC6A12) which are all members of the solute carrier 6 (SLC6) family of sodium-dependent transporters. While GAT1 has been investigated extensively, the other GABA transporters are less studied and their role in CNS is not clearly defined. Altered GABAergic neurotransmission is involved in different diseases, but the importance of the different transporters remained understudied and limits drug targeting. In this review, the well-studied GABA transporter GAT1 is compared with the less-studied BGT-1 with the aim to leverage the knowledge on GAT1 to shed new light on the open questions concerning BGT-1. The most recent knowledge on transporter structure, functions, expression, and localization is discussed along with their specific role as drug targets for neurological and neurodegenerative disorders. We review and discuss data on the binding sites for Na+, Cl-, substrates, and inhibitors by building on the recent cryo-EM structure of GAT1 to highlight specific molecular determinants of transporter functions. The role of the two proteins in GABA homeostasis is investigated by looking at the transport coupling mechanism, as well as structural and kinetic transport models. Furthermore, we review information on selective inhibitors together with the pharmacophore hypothesis of transporter substrates

Photometric observations of comet 81P/Wild 2 during the 2010 perihelion passage

Context. The Jupiter-family comet 81P/Wild 2, target of the NASA Stardust mission, is very important in the context of the studies of pristine objects in the solar system. First, it was only recently deflected into the present orbit, having spent at least 300 yr at higher heliocentric distance prior to the orbital change in 1974. It is therefore likely that the comet experienced a recent activation with consequent low alteration of its original material. Second, it is the only comet whose coma material was brought back to Earth for laboratory analysis. We observed the object between 2010 February 9 and September 9 for a total of 11 nights during the 2010 perihelion passage. Aims. The goals of the campaign were the characterization of the comet's dust activity and the comparison with previous apparitions to derive hints on the secular behavior of the object. Methods. Broadband R-and I-images were acquired using three instruments: ALFOSC, CAMELOT, and TCP. The first one is mounted at the Nordic Optical Telescope on La Palma, while the second and the third are mounted at the Instituto de Astrofisica de Canarias 0.82-m telescope on Tenerife. We analyzed the presence and variability of dust structures in the coma with image-enhancing techniques, the radial profile of the dust brightness, and we measured the dust production rate and the dust reddening. Results. We found evidence of a long-lasting sunward fan and anti-solar tail activity throughout all our observations up to a heliocentric distance of 2.42 AU. Afρ measurements suggest a pre-perihelion peak of the activity, caused by a seasonal effect, plus two post-perihelion outbursts. Both spatial and Afρ radial profiles indicate a steady-state coma at nucleocentric distances greater than ~1000-2000 km. The color analysis reveals a moderately reddened dust with a 6-9%/1000 reddening, consistent with the current picture of cometary dust. The second outburst emitted dust with lower reddening. Conclusions. The comparison with previous perihelion passages points toward a recurrent main activity always driven by the same areas on the nucleus, producing dust with similar characteristics and in similar coma structures in different years. Our Afρ measurement at the longest heliocentric distance suggests the comet was less dust-productive in 2010, pointing toward a possible secular aging of the object and its activity. The change of dust colors during the unusual second outburst suggests that an internal part of the nucleus has different physical properties compared with those that produce the recurrent main activity, pointing toward a heterogeneous comet. © ESO, 2012

Influence of Bed Roughness on Flow and Turbulence Structure Around a Partially-Buried, Isolated Freshwater Mussel

The present study uses eddy-resolving numerical simulations to investigate how bed roughness affects flow and turbulence structure around an isolated, partially-buried mussel (Unio elongatulus) aligned with the incoming flow. The rough-bed simulations resolve the flow past the exposed part of a gravel bed, whose surface is obtained from a laboratory experiment that also provides some additional data for validation of the numerical model. Results are also discussed for the limiting case of a horizontal smooth bed. Additionally, the effects of varying the level of burial of the mussel inside the substrate and the discharge through the two mussel siphons are investigated via a set of simulations in which the ratio between the median diameter of the (gravel) particles forming the rough bed, d50, and the height of the exposed part of the mussel, h, varies between 0.10 and 0.22. The increase of the bed roughness is associated with a strong amplification of the turbulence kinetic energy in the near-wake region. Increasing the bed roughness and/or reducing h intensifies the interactions of the eddies generated by the bed particles with the base and tip vortices induced by the active filtering and by the mussel shell, respectively, which, in turn, induces a more rapid dissipation of these vortices. Increasing the bed roughness also reduces the strength of the main downwelling flow region forming in the wake. The strong downwelling near the symmetry plane is the main reason why the symmetric wake shedding mode dominates in the smooth bed simulations with negligible active filtering. By contrast, the anti-symmetric wake shedding mode dominates in the simulations conduced with a high value of the bed roughness. The mean streamwise drag force coefficient for the emerged part of the shell and the dilution of the excurrent siphon jet increase with increasing bed roughness

Phobos as a D-type captured asteroid, spectral modeling from 0.25 to 4.0 μm

This paper describes the spectral modeling of the surface of Phobos in the wavelength range between 0.25 and 4.0 μm. We use complementary data to cover this spectral range: the OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System on board the ESA Rosetta spacecraft) reflectance spectrum that Pajola et al. merged with the VSK-KRFM-ISM (Videospectrometric Camera (VSK)-Combined Radiometer and Photometer for Mars (KRFM)-Imaging Spectrometer for Mars (ISM) on board the USSR Phobos 2 spacecraft) spectra by Murchie & Erard and the IRTF (NASA Infrared Telescope Facility, Hawaii, USA) spectra published by Rivkin et al. The OSIRIS data allow the characterization of an area of Phobos covering from 86.°8 N to 90° S in latitude and from 126° W to 286° W in longitude. This corresponds chiefly to the trailing hemisphere, but with a small sampling of the leading hemisphere as well. We compared the OSIRIS results with the Trojan D-type asteroid 624 Hektor and show that the overall slope and curvature of the two bodies over the common wavelength range are very similar. This favors Phobos being a captured D-type asteroid as previously suggested. We modeled the OSIRIS data using two models, the first one with a composition that includes organic carbonaceous material, serpentine, olivine, and basalt glass, and the second one consisting of Tagish Lake meteorite and magnesium-rich pyroxene glass. The results of these models were extended to longer wavelengths to compare the VSK-KRFM-ISM and IRTF data. The overall shape of the second model spectrum between 0.25 and 4.0 μm shows curvature and an albedo level that match both the OSIRIS and Murchie & Erard data and the Rivkin et al. data much better than the first model. The large interval fit is encouraging and adds weight to this model, making it our most promising fit for Phobos. Since Tagish Lake is commonly used as a spectral analog for D-type asteroids, this provides additional support for compositional similarities between Phobos and D-type asteroids. © 2013. The American Astronomical Society. All rights reserved

A portrait of 4979 Otawara, target of the Rosetta space mission

A physical portrait based on spectral and photometric data of 4979 Otawara, the first asteroid target of the Rosetta mission, is presented. The aim of this work is to investigate the composition of 4979 Otawara and to evaluate its rotation pole orientation. The spectroscopic observations obtained at the Palomar 200″ and IRTF telescopes cover the wavelength range 0.4 to 2.5 μm, and provide a definitive classification of Otawara as an S-type asteroid. An analysis of band depths and slopes places Otawara in the S(IV) subgroup, suggesting a similarity to ordinary chondrite meteorites. Moreover we present new photometric data, obtained at the Asiago Observatory and at the TNG telescope, that allow confirmation of the fast rotational period of 2.707 ± 0.005 hours, and a first indication of the spin vector of Otawara

Shape modeling technique KOALA validated by ESA Rosetta at (21) Lutetia

We present a comparison of our results from ground-based observations of asteroid (21) Lutetia with imaging data acquired during the flyby of the asteroid by the ESA Rosetta mission. This flyby provided a unique opportunity to evaluate and calibrate our method of determination of size, 3-D shape, and spin of an asteroid from ground-based observations. We present our 3-D shape-modeling technique KOALA which is based on multi-dataset inversion. We compare the results we obtained with KOALA, prior to the flyby, on asteroid (21) Lutetia with the high-spatial resolution images of the asteroid taken with the OSIRIS camera on-board the ESA Rosetta spacecraft, during its encounter with Lutetia. The spin axis determined with KOALA was found to be accurate to within two degrees, while the KOALA diameter determinations were within 2% of the Rosetta-derived values. The 3-D shape of the KOALA model is also confirmed by the spectacular visual agreement between both 3-D shape models (KOALA pre- and OSIRIS post-flyby). We found a typical deviation of only 2 km at local scales between the profiles from KOALA predictions and OSIRIS images, resulting in a volume uncertainty provided by KOALA better than 10%. Radiometric techniques for the interpretation of thermal infrared data also benefit greatly from the KOALA shape model: the absolute size and geometric albedo can be derived with high accuracy, and thermal properties, for example the thermal inertia, can be determined unambiguously. We consider this to be a validation of the KOALA method. Because space exploration will remain limited to only a few objects, KOALA stands as a powerful technique to study a much larger set of small bodies using Earth-based observations.Comment: 15 pages, 8 figures, 2 tables, accepted for publication in P&S

Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2.

BACKGROUND: Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy of OBV/PTV/r + DSV ±RBV for HCV genotype 1, and OBV/PTV/r + RBV for HCV genotype 4, in human immunodeficiency virus (HIV)-1 coinfected patients with or without compensated cirrhosis. METHODS: TURQUOISE-I, Part 2 is a phase 3 multicenter study. Patients with or without cirrhosis were HCV treatment-naive or -experienced, on an HIV-1 antiretroviral regimen containing atazanavir, raltegravir, dolutegravir, or darunavir (for genotype 4 only), and had plasma HIV-1 ribonucleic acid <40 copies/mL at screening. Patients received OBV/PTV/r ± DSV ±RBV for 12 or 24 weeks. RESULTS: In total, 228 patients were treated according to guidelines. Sustained virologic response at posttreatment week 12 (SVR12) was achieved by 194 of 200 (97%) and 27 of 28 (96%) patients with HCV genotype 1 and genotype 4 infection, respectively. There were 2 virologic failures: 1 breakthrough and 1 relapse in a cirrhotic and a noncirrhotic patient with genotype 1b and 1a infection, respectively. One reinfection occurred at posttreatment week 12 in a genotype 1a-infected patient. Excluding nonvirologic failures, the SVR12 rates were 98% (genotype 1) and 100% (genotype 4). Adverse events were mostly mild in severity and did not lead to discontinuation. Laboratory abnormalities were rare. CONCLUSIONS: The OBV/PTV/r ±DSV was well tolerated and yielded high SVR12 rates in patients with HCV genotype 1 or genotype 4/HIV-1 coinfection. The OBV/PTV/r ± DSV ±RBV is a potent HCV treatment option for patients with HIV-1 coinfection, regardless of treatment experience