Creative methods of noospheric learning through art assets: Case study of authentic education

In this article authors discuss the methodology of evaluating noospheric insights in higher education students through art assets. A very important goal of students’ inclusion into the authentic context of ecological education is being achieved. As a result of this study, evaluation criteria were determined, such as imagination, emotionality, originality, abstraction. For the more in-depth development of the evaluation procedure the following methods were used: educational experiment, observation, questionnaires, semantic differential (SD), method of setting the attitude on associative transformation of the object being perceived, creative methods. Authors determined the levels of student’s noospheric insights formation (high, above average, average, low) for the following evaluation of correlation between the categories of singular, special and common in students’ aesthetical insights. The results, including content and structural, functional components, are described in this article, allowing to connect the process of noosperic insights mastering by students with the authentic context of education

Hypercoordinated Carbon in 2,8,9-Sila- and Thia-Substituted Carbatranes

Ab initio methods demonstrate that internally protonated forms (a) of the molecules of carbatranes XC(SiH2CH2CH2)3N (X = H, F) are significantly more favorable than their externally protonated forms (b). The quantum-topological AIM approach suggests that the main reason for that is the formation of a medium-strength hydrogen C···H+N bond unknown previously in the silacarbanyl cations a

Meso-substituted cationic 3- and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy (APDT) is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms. Among the photosensitizers (PSs), compounds based on cationic porphyrins/ metalloporphyrins are most successfully used to inactivate microorganisms. Series of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in Armenia. The aim of this work was to determine and test the most effective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive microorganisms. It was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria, including the methicillin-resistant S. aureus strain. Zinc complexes of porphyrins are more phototoxic than metal-free porphyrin analogs. The effectiveness of these Zn-metalloporphyrins on bacteria is consistent with the level of singlet oxygen generation. It was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors: The presence in the porphyrin macrocycle of a positive charge (+4), a central metal atom (Zn2+) and hydrophobic peripheral functional groups as well as high values of quantum yields of singlet oxygen. The results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins can find wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APD

Drugst.One -- A plug-and-play solution for online systems medicine and network-based drug repurposing

In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.Comment: 45 pages, 6 figures, 7 table

Implementing Integrated Technologies in Aesthetic Development of Primary Schoolchildren

The relevance of problem of aesthetic development of primary schoolchildren by means of integrated technology is caused by the necessity to find new ways allowing to create a holistic picture of images embodied in the art. Development of theoretical positions of this phenomenon is based on: 1) influence of association on the development of mental processes of the individual; 2) integration of arts mutually complementing and enriching the holistic vision of artistic image. However, these areas have not been developed in primary school practice. The aim of the study is to implement the main areas of integrated technology in the aesthetic development of primary schoolchildren. The study used both theoretical and empirical methods. The importance of implementing integrated technology is determined by the necessity to find the main areas ensuring aesthetic development of children. Due to the new knowledge about content and structure of integrated technology, practical significance of the study lies in the possibility to implement the main structural components of integrated technology in professional activities of teachers. Determining specifics of the aesthetic development of primary schoolchildren should begin by clarifying the content of its components. Specifics of targeted, methodological, meaningful, procedural and effective components of integrated technology should be taken into account. Complementary techniques should be used to determine the criterion

Aesthetic Education of Bachelors by Means of Information Technologies

The relevance of the study is due to the need of using forms integrating modern world achievements in the theory and aesthetic education of bachelors in a new individual-group format. The aim of the study is theoretically justify and implement the directions of using information technologies in aesthetic education of bachelors. Research methods: a) theoretical: analysis, interpretation; b) empirical: questionnaire, pedagogical experiment; c) mathematical: the criterion of angular transformation of Fisher (280 people). The article theoretically substantiates the possibilities of using information technologies in aesthetic education of bachelors. New knowledge about their implementation in the following directions has received: 1) determining cultural foundations of aesthetic education of bachelors, 2) integrative processes in the understanding of artistic images; 3) value-meaning understanding of art based on subject-object reflection of reality. The criterion of forming aesthetic education of bachelors (motivational, figurative, value-meaning, creative) and levels are determined: high, figurative, low; the relationship between possession of information technologies and aesthetic education of bachelors is established. The practical significance of the results of the study is using diagnostic techniques, information technologies in aesthetic education of bachelors. Aesthetic education of bachelors should begin with determining its main components and introducing modern information technologies. It is necessary to use several complementary techniques to determine the criterion of using information technologies

Hypercoordinated Carbon in 2,8,9-Sila- and Thia-Substituted Carbatranes

Ab initio methods demonstrate that internally protonated forms (a) of the molecules of carbatranes XC(SiH2CH2CH2)3N (X = H, F) are significantly more favorable than their externally protonated forms (b). The quantum-topological AIM approach suggests that the main reason for that is the formation of a medium-strength hydrogen C···H+N bond unknown previously in the silacarbanyl cations a.Reprinted (adapted) with permission from Organometallics 26 (2007): 4568, doi:10.1021/om700306x. Copyright 2007 American Chemical Society.</p

Acid Mine Drainage Contamination of the Ur Impoundment: Environmental Geochemistry

Water, particulate matter, and bottom sediments of the Ur impoundment used for fishing have been analyzed in terms of environmental geochemistry. The impoundment is located within the dispersion train of gold-bearing sulfide tailings at the Ur ore field and has been contaminated by acid mine drainage (AMD). The depth-dependent distribution of elements in the bottom sediments corresponds to (1) pre-mining, (2) early mining, and (3) post-mining (present) stages. Sediment enrichment in Cu, Cd, Fe, Pb, Zn, As and Hg depends on their speciation and migration patterns in water. The concentrations of many elements in water and bottom sediments exceed maximum allowable values. Hg occurring as the most toxic methyl compound poses the greatest hazard