Developing a Philippine Local Government Bond Market

The 1991 Local Government has initiated comprehensive changes in Philippine public administration such as decentralization and greater local autonomy. However, the macroeconomic picture has been characterized by volatile inflation, foreign exchange and interest rate. Against this backdrop, this paper investigates issues that affect the market development for LGU bonds. It also identifies the constraints in the design of LGU bond issue and assesses its marketability.local government unit, financial economy, financial system, decentralization, bond market

Developing a Philippine Local Government Bond Market

The 1991 Local Government has initiated comprehensive changes in Philippine public administration such as decentralization and greater local autonomy. However, the macroeconomic picture has been characterized by volatile inflation, foreign exchange and interest rate. Against this backdrop, this paper investigates issues that affect the market development for LGU bonds. It also identifies the constraints in the design of LGU bond issue and assesses its marketability.financial economy, financial system, decentralization, bond market, Local Government Units (LGUs)

RANCANG BANGUN SISTEM INFORMASI RESERVASI DAN REFUND TIKET PESAWAT TERBANG SERTA PENDAPATAN DAN PIUTANG KEUANGAN PADA PT. SUMAN TOUR

Tidak dapat dipungkiri lagi saat ini dunia teknologi informasi sudah berkembang dengan sangat pesat. Dari jaman pertama kali ketika komputer pertama kali diciptakan, komputer hanya dapat dimiliki oleh kalangan menengah keatas. Namun bila kita melihat saat ini, kini hampir setiap orang menenteng komputer jinjing mereka masing-masing. Perkembang teknologi informasi (TI) ini juga sangat terasa di dunia bisnis. Saat ini hampir semua sektor bisnis mulai mengintegrasikan TI pada operasional bisnis mereka masing-masing. Dunia bisnis yang dituntut untuk selalu efektif dan melakukan perubahan, saat ini dituntut juga untuk mengintegrasikan TI sebagai bagian dari mengikuti jaman. Industri penerbangan juga tidak lepas dari sentuhan ajaib TI ini. Agen pesawat terbang yang merupakan bagian penting dari industri penerbangan, satu demi satu mulai mengintegrasikan TI ke dalam bisnis mereka. Mulai dari agen pesawat dengan skala besar samapai yang skala kecil. Diharapkan dengan mengintegrasikan TI dalam bisnis mereka, bisnis agen pesawat terbang dapat menjadi lebih efektif dan sesuai dengan perkembangan jaman

Does hostile campaigning work?

A new Polis report by Laya Maheshwari looks at the topic of hostile campaigning in the corporate sector and explores where the line is drawn between confrontation and bullying

Rules of the House: Strategy, Tactic, and Violence in One World By Night, World of Darkness, Live-Action Role-Play Games

The following thesis focuses on governance of institutionalized play in three World of Darkness live-action role-play (larp) games (ethnographic field work conducted between May and August of 2016), whose players have willingly allowed the international organization of One World by Night – an organization made up of their peers – to unify them in such a way as to create connection, community, and shared story across the world. I analyze four locii within these games (the book, the organization, the storyteller, and the player) using Michel de Certeau’s, The Practice of Everyday Life, translated by Steven Rendall, specifically focusing on the roles of the tactician and the strategist, to illustrate how the varying levels of power within these games work with, and pull against, each other. As the field work was originally conducted to investigate violence within these physical role-play games, the heart of this thesis, and one of the threads that connects each chapter, is a discussion of violence, used to confirm the serious attitude these games can sometimes engender. Though Michele de Certeau may not be a name generally associated with the discussion of gaming, it is my hope to show that gaming communities can be analyzed using the same theories anthropologists might use to examine any other community or society, as gaming communities are not separate from the rest of the world, but an integral part of the system

Exploring the role of STAG3 in mammalian meiosis

In the intricate realm of biology, meiosis stands as the remarkable process responsible for generating genetically diverse haploid gametes from diploid cells. In 2000, Pezzi et al., identified STAG3 as a novel meiotic-specific synaptonemal-complex associated protein belonging to the highly conserved family of stromalin nuclear proteins. Later, over the years, research groups characterised the depletion phenotype of STAG3 in mice, where deficiency of STAG3 causes severe chromosomal defects and early meiotic arrest. These studies together collectively highlighted STAG3 as the most important meiotic cohesin. Traditionally, the role of the cohesin complex was understood as maintaining cohesion between chromatids during cell division. However, over the years, this perception has evolved significantly, expanding to include the regulation of dynamic chromosomal configurations during meiosis. With the realisation of STAG3's importance in meiotic progression, the next pressing question becomes: how does STAG3 coordinate this intricate process? This study sought to address that question by examining the STAG3 interactome in male germ cells, aiming to uncover novel pathways through which STAG3 contributes to maintaining meiotic progression. Through successful purification of the STAG3-REC8 complex, its ability to form functional complexes in-vitro was demonstrated. During my PhD thesis, I discovered links between STAG3 and DNA repair mechanisms beyond the well-known homologous recombination /non-homologous end joining pathway in meiotic recombination. By looking at the meiotic-specific protein interactome bound to the STAG3-REC8 complex through Mass Spectroscopic analysis, we identified STAG3 involvement in PARP-1-mediated repair of DNA double-strand breaks occurring outside of the programmed DSB repair during the zygotene stage of prophase I. PARP-1 is an ADP-ribose polymerase which acts as a first responder that detects DNA damage and facilitates the activation of the DNA repair pathway. STAG3 shows a preferential interaction with PARP-1 when spermatocytes are challenged with extensive DNA damage. Furthermore, the interaction of SMC3, another component of the cohesin complex, with PARP-1 during DNA damage suggests that STAG3, as part of the cohesin complex, contributes to DNA damage repair in spermatocytes. To gain deeper insights into the distinctive characteristics of STAG3, an extensive analysis of spermatogenesis in mice expressing a C-terminus truncated form of STAG3 was performed. The C-terminal region of STAG3 is not conserved among the stromalin family members, and hence it was speculated that this region might have unique functions to meiosis. Removal of the C-terminal end comprising 47 amino acids led to an early meiotic arrest, mirroring the phenotype in most cohesin subunit deletion mutants. The phenotype observed mimics the complete STAG3 depletion phenotype to some extent. The truncated STAG3 resulted in an arrest at a late zygotene/early pachytene-like stage during meiotic prophase I. One of the most notable observations was the significant reduction in the length of the axial elements (AE) in this mutant. Despite stable expression of and localisation of STAG3 to the axis, the axis length decreased by over 60%. This mutation compromised synaptonemal complex formation, leading to the early meiotic arrest. Although SYCP1 loads onto the axis and initiate synapsis, the shortened axial elements could not synapse, marked by HORMAD-1, a well-known asynapsis marker. The average number of SYCP3-marked stretches was 35 in this mutant. The increased number of AE and shortened axis length did not result from chromosome fragmentation because most chromosomes/axes had intact telomere and centromeric signals, validated by RAP1 and ACA foci, respectively. Centromeric and telomeric cohesion may be partially affected as some chromosome showed aberrant telomeric and centromeric defects. C terminal truncated STAG3 impairs synapsis between homologous chromosomes, but the sister chromatid cohesion remains largely unaffected. Also, this deletion did not affect the loading of the cohesin complex subunits onto the chromosome axis. The early meiotic arrest resulted in underdeveloped gonads, leading to infertility in otherwise healthy mice. Taken together, these results suggest novel roles for STAG3 in meiosis, and the meiotic-specific C terminal region of STAG3 is critical for proper meiotic progression in mice

Urbanization in Central Asia; a GIS Analysis of Ulaanbaatar, Mongolia

Urbanization presents problems for developing countries around the world. Cities undergoing urbanization are typically receiving an influx of immigrants from rural areas and a high natural increase rate. They experience problems such as poor sanitation, lack of waste management services, lack of improved water, lack of electricity, informal housing and economic activities, and congestion. However, urbanization in post socialist Central Asia is unique. While these problems are present in these cities, including Almaty, Astana, Bishkek, and Ulaanbaatar, their histories and political systems have created unique urban environments with their own sets of problems. Soviet influence combined with their nomadic cultural heritage has urban spaces with a unique set of challenges. Mongolia, in particular, has created urban environments unlike any other cities in the world, and has a very unique set of problems. This research aims to determine the viability and social and economic sustainability of these cities, as well as residential satisfaction in these cities. In addition, it offers suggestions as to how Ulaanbaatar’s supporters and government officials can work to improve Ulaanbaatar’s infrastructure, and discusses potential solutions to combat the public health crisis concerning Ulaanbaatar’s air pollution

Stroke Recovery

For years the brain was thought not to be regenerative, yet research has highlighted the role of neuroplasticity, neurogenesis, and deep brain stimulation in promoting brain recovery and enhancing stroke rehabilitation. Neuroplasticity is the brain’s ability to reorganize neural pathways in response to environmental or structural changes. Stroke recovery is possible due to the plasticity of the brain; the brain can create new neural pathways and neurons. Traditionally it was believed that humans were limited to generating new neurons in the brain, recent studies have shown that neurogenesis occurs throughout adulthood, particularly in the hippocampus, a region as- sociated with learning and memory. Lastly, we discuss a neurosurgical technique Deep Brain Stimulation that involves the placement of electrodes in specific brain regions in order to stimulate neural activity. By understanding these mechanisms, more effective and personalized rehabilitation programs can help stroke survivors recover and live a long-accomplished life

‘MOTIDUPAPA’ STRATEGI PEWARISAN TRADISI TUJA’I KEPADA GENERASI MUDA PADA MASYARAKAT GORONTALO

One of the oral literatures which is still used in Gorontalo custom event is Tuja'i Molo'opu. Oral literature is uttered at the ceremonial of official’s reception in Gorontalo. As other traditions are changing, Tuja'i Molo'opu also along with the changes of the society. Therefore, it needs to be held as the Foundation for preservation of the study of oral literature Tuja'i Molo'opu. Thus, the ceremony Tuja'i Molo'opu this is not the complement of Molo'opu ceremony, but contain a moral, and ethical, and history of his supporters. The theory used in this research is the theory of orality Albert Bates Lord and Ruth Finnegan. To apply this theory is used Ethnographic aproach to explore data on composition and transmission, as the cultural aspects of the community of Gorontalo. Aspects of orality in this tuja'i Molo'opu covering composition. Composition is composing of oral literature, starting from: (1) the composition of the characters, (2) development techniques, (3) and repetition of the scene. In addition, transmission or starting inheritance from: (1) the transmission of natural processes, (2) a transmission process through training, (3) studing of acting, and (3) learning to talk