Impact of Immigrant Entrepreneurs and Workers in Leisure and Hospitality Businesses: Massachusetts and New England

This report examines the role and impact of immigrant entrepreneurs and workers on Leisure and Hospitality businesses in New England, particularly Massachusetts. A significant portion of state economies in New England, especially in Massachusetts, relies heavily on the employment of the foreign-born. As the native workforce ages and population growth declines, businesses are becoming increasingly dependent upon the availability of the foreign-born. This development has facilitated an increasingly significant presence and role of immigrant entrepreneurs in Leisure and Hospitality businesses that is documented for the first time in this report

ImaYDiT - Imagining young disabled people's transitions in a time of major societal change: Research project report

ImaYDiT was funded by DRILL – Disability Research for Independent Living and Learning. This is supported by the Big Lottery Fund. WiltsCIL staff, members of WiltsCIL CoproductionGroup and researchers at UWE came up with the original idea for this project. We wanted to support young disabled people to explore and re-imagine their adult lives and have the best future. This involved taking an ‘assets-based’ approach. This is where we focus on what people can do- rather than what they can’t do – which is a ‘deficit approach’. We also thought that there is not enough research about the whole of young disabled people’s lives. Instead a lot of research only concentrates on transitions through the benefits and service system.Wiltshire Social Services and the Wiltshire Parent Council helped steer the project because, where we could, we also wanted to put young disabled people’s hopes and dreams into action.We want to understand how this group of young disabled people can be supported to become the next generation who are aware of their rights, with ambitions for their futures and able to establish meaningful and independent adult lives

Northern Hemisphere Stratosphere-Troposphere Circulation Change in CMIP6 Models: 2. Mechanisms and Sources of the Spread

Previous studies showed that changes in the strength of the Northern Hemisphere wintertime stratospheric polar vortex can affect near‐surface weather on various timescales. However, climate models do not agree on whether the polar vortex will weaken or strengthen during the 21st century. Here, we use Climate Model Intercomparison Project Phase 5 (CMIP5) and Phase 6 (CMIP6) experiments to better understand how the polar vortex will respond to future greenhouse gas emissions. We show that changes in the propagation of large‐scale atmospheric waves can explain nearly half of the spread in the vortex strength projections by the end of the 21st century by CMIP6 models. Increased upward propagation of the waves to the stratosphere leads to vortex weakening while increased equatorward propagation within the stratosphere leads to strengthening. We identify three factors associated with projected changes in the vortex strength across CMIP6 models: projected rates of global warming, projected rates of subtropical jet stream strengthening and model errors in lower stratospheric winds in the past climate. Stronger global warming rates and stronger past lower stratospheric winds are associated with vortex strengthening, while larger strengthening of the subtropical jet stream is associated with weakening. However, these relationships are weak in CMIP5 model

Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B.

Viral infection triggers activation of the integrated stress response (ISR). In response to viral double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the translation initiation factor eIF2, converting it from a translation initiator into a potent translation inhibitor and this restricts the synthesis of viral proteins. Phosphorylated eIF2 (eIF2-P) inhibits translation by binding to eIF2's dedicated, heterodecameric nucleotide exchange factor eIF2B and conformationally inactivating it. We show that the NSs protein of Sandfly Fever Sicilian virus (SFSV) allows the virus to evade the ISR. Mechanistically, NSs tightly binds to eIF2B (KD = 30 nM), blocks eIF2-P binding, and rescues eIF2B GEF activity. Cryo-EM structures demonstrate that SFSV NSs and eIF2-P directly compete, with the primary NSs contacts to eIF2Bα mediated by five 'aromatic fingers'. NSs binding preserves eIF2B activity by maintaining eIF2B's conformation in its active A-State

The Ecobiomics project:Advancing metagenomics assessment of soil health and freshwater quality in Canada

Transformative advances in metagenomics are providing an unprecedented ability to characterize the enormous diversity of microorganisms and invertebrates sustaining soil health and water quality. These advances are enabling a better recognition of the ecological linkages between soil and water, and the biodiversity exchanges between these two reservoirs. They are also providing new perspectives for understanding microorganisms and invertebrates as part of interacting communities (i.e. microbiomes and zoobiomes), and considering plants, animals, and humans as holobionts comprised of their own cells as well as diverse microorganisms and invertebrates often acquired from soil and water. The Government of Canada's Genomics Research and Development Initiative (GRDI) launched the Ecobiomics Project to coordinate metagenomics capacity building across federal departments, and to apply metagenomics to better characterize microbial and invertebrate biodiversity for advancing environmental assessment, monitoring, and remediation activities. The Project has adopted standard methods for soil, water, and invertebrate sampling, collection and provenance of metadata, and nucleic acid extraction. High-throughput sequencing is located at a centralized sequencing facility. A centralized Bioinformatics Platform was established to enable a novel government-wide approach to harmonize metagenomics data collection, storage and bioinformatics analyses. Sixteen research projects were initiated under Soil Microbiome, Aquatic Microbiome, and Invertebrate Zoobiome Themes. Genomic observatories were established at long-term environmental monitoring sites for providing more comprehensive biodiversity reference points to assess environmental change

Supplementary Table 2 from Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma

Primers</p

Supplementary Data 2 from Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma

GSEA Hallmark Gene Sets</p

Supplementary Figures S1-S11 from Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma

Supplementary Figures 1-11, which support data and conclusions provided in the main figures</p

Supplementary Data 5 from Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma

GSEA of genes associated with BATF expression in CoMMpass</p