Things in Culture, Culture in Things

This volume addresses the dynamics of materiality over time and space. In cross-cultural, multi-temporal and interdisciplinary studies the authors examine how things gain meaning and status, generate a multitude of emotions, and feed into the propagation of myths, narratives and discourses. The book is divided according to four themes: soft objects, stoic stories, consuming and the collectable, and waste and technologies. The first section discusses the meanings of the lived environment on the individual and national levels. The second section provides specific examples on the role of things in identity construction. The third section focuses on historical and contemporary aspects of consumption and collecting. The phenomena under scrutiny in the fourth section are moral dilemmas associated with and representations of dirt/waste and advancements in science and technology. Presenting diverse case studies of material culture, the volume points to rich interdisciplinary approaches in cultural theory

Forum: Rethinking Euro-Anthropology : Part 1

Introduction to forum discussion on the meaning of European Anthropology.Non peer reviewe

Locating European anthropology

Sarah Green and Patrick Laviolette were editors of the journal Social Anthropology/Anthropologie Sociale when this article was written.This commentary revisits the “Rethinking Euro-anthropology” Forums published in the journal Social Anthropology/Anthropologie Sociale. It reconsiders three specific issues: who are the subjects of European anthropology, who are its others, and who are its authors? Noting that European anthropology does not imply a spatial fixity (there is no “there there” in European anthropology), we suggest instead that European anthropological scholarship is the outcome of diverse forms of crossborder and transborder exchanges. Yet as a project that is both intellectual and political, we further discuss some of the contradictions, ambiguities and paradoxes behind this “worlding” of the discipline. By observing that E(e)uropean anthropology in particular should constantly strive to relate the locating endeavours of ethical practice, empirical evidence, historical reflection and humanistic theorising, we call for innovative forms of academic collaboration, narrative creations and belonging to/with places.Peer reviewe

Editorial : A note from the new editorial team

Discussion of first issue co-edited by myself and Patrick LavioletteNon peer reviewe

Editorial

Editorial to introduce Volume 23, Issue 4.Non peer reviewe

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank

Kim Valette et al. perform a genomic study on asthma integrating genome-wide association study, functional mapping using lung and blood transcriptome-wide profiles, as well as Mendelian randomization. They show candidate causal genes expressed in lung and blood tissues that are putative therapeutic targets for asthma

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors

The crystal structure of acetylcholine-binding protein (AChBP) from the mollusk Lymnaea stagnalis is the established model for the ligand binding domains of the ligand-gated ion channel family, which includes nicotinic acetylcholine, 5-hydroxytryptamine (5-H

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

Opiates are essential for treating pain, but termination of opiate therapy can cause a debilitating withdrawal syndrome in chronic users. To alleviate or avoid the aversive symptoms of withdrawal, many of these individuals continue to use opiates. Withdrawal is therefore a key determinant of opiate use in dependent individuals, yet its underlying mechanisms are poorly understood and effective therapies are lacking. Here, we identify the pannexin-1 (Panx1) channel as a therapeutic target in opiate withdrawal. We show that withdrawal from morphine induces long-term synaptic facilitation in lamina I and II neurons within the rodent spinal dorsal horn, a principal site of action for opiate analgesia. Genetic ablation of Panx1 in microglia abolished the spinal synaptic facilitation and ameliorated the sequelae of morphine withdrawal. Panx1 is unique in its permeability to molecules up to 1 kDa in size and its release of ATP. We show that Panx1 activation drives ATP release from microglia during morphine withdrawal and that degrading endogenous spinal ATP by administering apyrase produces a reduction in withdrawal behaviors. Conversely, we found that pharmacological inhibition of ATP breakdown exacerbates withdrawal. Treatment with a Panx1-blocking peptide (10panx) or the clinically used broad-spectrum Panx1 blockers, mefloquine or probenecid, suppressed ATP release and reduced withdrawal severity. Our results demonstrate that Panx1-mediated ATP release from microglia is required for morphine withdrawal in rodents and that blocking Panx1 alleviates the severity of withdrawal without affecting opiate analgesia