Effect of biologically oriented preparation technique on the stress concentration of endodontically treated upper central incisor restored with zirconia crown: 3d-fea

The aim of this study was to evaluate the effect of biologically oriented preparation technique on the stress concentration of endodontically treated upper central incisors restored with zirconia crown (yttria-stabilized zirconia polycrystalline ceramic) through finite element analysis (FEA). Four models of maxillary central incisors containing enamel, dentin, periodontal ligament, cortical and medullary bone were created in CAD. Each model received a polymeric core-build up with nanofilled dental resin composite. The evaluated models were SM—preparation in shoulder 90°; CM—chamfer preparation; BOPT—biologically oriented preparation technique and BOPTB—BOPT preparation 1 mm below the cement-enamel junction. All models received zirconia crowns (5Y-TZP), fiberglass post and 1 mm ferrule. The models were imported into the analysis software with parameters for mechanical structural testing using the maximum principal stress and the tensile strength as the analysis criteria. Then, load of 150 N was applied at the cingulum with 45° slope to the long axis of the tooth, with the fixed base for each model. The type of marginal preparation affected the stresses concentration in endodontically treated teeth and in the zirconia crown margin. Considering the stress magnitude only, BOPT is a viable option for anterior monolithic zirconia crowns; however, with the highest stress magnitude at the restoration margin

A persistent excess of galaxy-galaxy strong lensing observed in galaxy clusters

Previous studies have revealed that the estimated probability of galaxy-galaxy strong lensing in observed galaxy clusters exceeds the expectations from the $\Lambda$ Cold Dark Matter cosmological model by one order of magnitude. We aim to understand the origin of this excess by analyzing a larger set of simulated galaxy clusters and investigating how the theoretical expectations vary under different adopted prescriptions and numerical implementations of star formation and feedback in simulations. We perform a ray-tracing analysis of 324 galaxy clusters from the Three Hundred project, comparing the Gadget-X and Gizmo-Simba runs. These simulations, which start from the same initial conditions, are performed with different implementations of hydrodynamics and galaxy formation models tailored to match different observational properties of the Intra-Cluster-Medium and cluster galaxies. We find that galaxies in the Gizmo-Simba simulations develop denser stellar cores than their Gadget-X counterparts. Consequently, their probability for galaxy-galaxy strong lensing is higher by a factor of $\sim 3$. This increment is still insufficient to fill the gap with observations, as a discrepancy by a factor $\sim 4$ still persists. In addition, we find that several simulated galaxies have Einstein radii that are too large compared to observations. We conclude that a persistent excess of galaxy-galaxy strong lensing exists in observed galaxy clusters. The origin of this discrepancy with theoretical predictions is still unexplained in the framework of the cosmological hydrodynamical simulations. This might signal a hitherto unknown issue with either the simulation methods or our assumptions regarding the standard cosmological model.Comment: 6 pages, 2 figures, accepted for publication on A&A Letters. See companion paper Srivastava et al. (2023

Galaxies in the central regions of simulated galaxy clusters

In this paper, we assess the impact of numerical resolution and of the implementation of energy input from AGN feedback models on the inner structure of cluster sub-haloes in hydrodynamic simulations. We compare several zoom-in re-simulations of a sub-sample of the cluster-sized haloes studied in Meneghetti et al. (2020), obtained by varying mass resolution, softening length and AGN energy feedback scheme. We study the impact of these different setups on the subhalo abundances, their radial distribution, their density and mass profiles and the relation between the maximum circular velocity, which is a proxy for subhalo compactness. Regardless of the adopted numerical resolution and feedback model, subhaloes with masses Msub < 1e11Msun/h, the most relevant mass-range for galaxy-galaxy strong lensing, have maximum circular velocities ~30% smaller than those measured from strong lensing observations of Bergamini et al. (2019). We also find that simulations with less effective AGN energy feedback produce massive subhaloes (Msub> 1e11 Msun/h ) with higher maximum circular velocity and that their Vmax - Msub relation approaches the observed one. However the stellar-mass number count of these objects exceeds the one found in observations and we find that the compactness of these simulated subhaloes is the result of an extremely over-efficient star formation in their cores, also leading to larger-than-observed subhalo stellar mass. We conclude that simulations are unable to simultaneously reproduce the observed stellar masses and compactness (or maximum circular velocities) of cluster galaxies. Thus, the discrepancy between theory and observations that emerged from the analysis of Meneghetti et al. (2020) persists. It remains an open question as to whether such a discrepancy reflects limitations of the current implementation of galaxy formation models or the LCDM paradigm.Comment: 11 pages, 10 figures, abstract is redacted to fit arXiv character count limi

The probability of galaxy-galaxy strong lensing events in hydrodynamical simulations of galaxy clusters

Meneghetti et al. (2020) recently reported an excess of galaxy-galaxy strong lensing (GGSL) in galaxy clusters compared to expectations from the LCDM cosmological model. Theoretical estimates of the GGSL probability are based on the analysis of numerical hydrodynamical simulations in the LCDM cosmology. We quantify the impact of the numerical resolution and AGN feedback scheme adopted in cosmological simulations on the predicted GGSL probability and determine if varying these simulation properties can alleviate the gap with observations. We repeat the analysis of Meneghetti et al. (2020) on cluster-size halos simulated with different mass and force resolutions and implementing several independent AGN feedback schemes. We find that improving the mass resolution by a factor of ten and twenty-five, while using the same galaxy formation model that includes AGN feedback, does not affect the GGSL probability. We find similar results regarding the choice of gravitational softening. On the contrary, adopting an AGN feedback scheme that is less efficient at suppressing gas cooling and star formation leads to an increase in the GGSL probability by a factor between three and six. However, we notice that such simulations form overly massive subhalos whose contribution to the lensing cross-section would be significant while their Einstein radii are too large to be consistent with the observations. The primary contributors to the observed GGSL cross-sections are subhalos with smaller masses, that are compact enough to become critical for lensing. The population with these required characteristics appears to be absent in simulations.Comment: 13 pages, 11 figures. Submitted for publication on Astronomy and Astrophysic

Segmental transverse colectomy. Minimally invasive versus open approach: results from a multicenter collaborative study

none65noThe role of minimally invasive surgery in the treatment of transverse colon cancer is still controversial. The aim of this study is to investigate the advantages of a totally laparoscopic technique comparing open versus laparoscopic/robotic approach. Three hundred and eighty-eight patients with transverse colon cancer, treated with a segmental colon resection, were retrospectively analyzed. Demographic data, tumor stage, operative time, intraoperative complications, number of harvested lymph nodes and recovery outcomes were recorded. Recurrences and death were also evaluated during the follow-up. No differences were found between conventional and minimally invasive surgery, both for oncological long-term outcomes (recurrence rate p = 0.28; mortality p = 0.62) and postoperative complications (overall rate p = 0.43; anemia p = 0.78; nausea p = 0.68; infections p = 0.91; bleeding p = 0.62; anastomotic leak p = 0.55; ileus p = 0.75). Nevertheless, recovery outcomes showed statistically significant differences in favor of minimally invasive surgery in terms of time to first flatus (p = 0.001), tolerance to solid diet (p = 0.017), time to first mobilization (p = 0.001) and hospital stay (p = 0.004). Compared with laparoscopic approach, robotic surgery showed significantly better results for time to first flatus (p = 0.001), to first mobilization (p = 0.005) and tolerance to solid diet (p = 0.001). Finally, anastomosis evaluation confirmed the superiority of intracorporeal approach which showed significantly better results for time to first flatus (p = 0.001), to first mobilization (p = 0.003) and tolerance to solid diet (p = 0.001); moreover, we recorded a statistical difference in favor of intracorporeal approach for infection rate (p = 0.04), bleeding (p = 0.001) and anastomotic leak (p = 0.03). Minimally invasive approach is safe and effective as the conventional open surgery, with comparable oncological results but not negligible advantages in terms of recovery outcomes. Moreover, we demonstrated that robotic approach may be considered a valid option and an intracorporeal anastomosis should always be preferred.noneMilone, Marco; Degiuli, Maurizio; Velotti, Nunzio; Manigrasso, Michele; Vertaldi, Sara; D'Ugo, Domenico; De Palma, Giovanni Domenico; Dario Bruzzese, Giuseppe Servillo, Giuseppe De Simone, Katia Di Lauro, Silvia Sofia, Marco Ettore Allaix, Mario Morino, Rossella Reddavid, Carlo Alberto Ammirati, Stefano Scabini, Gabriele Anania, Cristina Bombardini, Andrea Barberis, Roberta Longhin, Andrea Belli, Francesco Bianco, Giampaolo Formisano, Giuseppe Giuliani, Paolo Pietro Bianchi, Davide Cavaliere, Leonardo Solaini, Claudio Coco, Gianluca Rizzo, Andrea Coratti, Raffaele De Luca, Michele Simone, Alberto Di Leo, Giovanni De Manzoni, Paola De Nardi, Ugo Elmore, Riccardo Rosati, Andrea Vignali, Paolo Delrio, Ugo Pace, Daniela Rega, Antonio Di Cataldo, Giovanni Li Destri, Annibale Donini, Luigina Graziosi, Andrea Fontana, Michela Mineccia, Sergio Gentilli, Manuela Monni, Mario Guerrieri, Monica Ortenzi, Francesca Pecchini, Micaela Piccoli, Italy. Corrado Pedrazzani, Giulia Turri, Sara Pollesel, Franco Roviello, Marco Rigamonti, Michele Zuolo, Mauro Santarelli, Federica Saraceno, Pierpaolo Sileri Giuseppe Sigismondo Sica, Luigi Siragusa Salvatore Pucciarelli, Matteo ZuinMilone, Marco; Degiuli, Maurizio; Velotti, Nunzio; Manigrasso, Michele; Vertaldi, Sara; D'Ugo, Domenico; De Palma, Giovanni Domenico; Dario Bruzzese, Giuseppe Servillo, Giuseppe De Simone, Katia Di Lauro, Silvia Sofia, Marco Ettore Allaix, Mario Morino, Rossella Reddavid, Carlo Alberto Ammirati, Stefano Scabini, Gabriele Anania, Cristina Bombardini, Andrea Barberis, Roberta Longhin, Andrea Belli, Francesco Bianco, Giampaolo Formisano, Giuseppe Giuliani, Paolo Pietro Bianchi, Davide Cavaliere, Leonardo Solaini, Claudio Coco, Gianluca Rizzo, Andrea Coratti, Raffaele De Luca, Michele Simone, Alberto Di Leo, Giovanni De Manzoni, Paola De Nardi, Ugo Elmore, Riccardo Rosati, Andrea Vignali, Paolo Delrio, Ugo Pace, Daniela Rega, Antonio Di Cataldo, Giovanni Li Destri, Annibale Donini, Luigina Graziosi, Andrea Fontana, Michela Mineccia, Sergio Gentilli, Manuela Monni, Mario Guerrieri, Monica Ortenzi, Francesca Pecchini, Micaela Piccoli, Italy. Corrado Pedrazzani, Giulia Turri, Sara Pollesel, Franco Roviello, Marco Rigamonti, Michele Zuolo, Mauro Santarelli, Federica Saraceno, Pierpaolo Sileri Giuseppe Sigismondo Sica, Luigi Siragusa Salvatore Pucciarelli, Matteo Zui

Annali storici di Principato Citra, A. 7, n. 1.1 (2009)

A. 7, n. 1.1 (2009): G. Guardia, Editoriale, P. 3 ; R. Salati, Le ambre "tipo Roscigno”, P. 5 ; E. Bianco, La viabilità medievale nel Parco Nazionale del Cilento e Vallo di Diano. Il territorio del Comune di Gioi, P. 33 ; D. Petrone, Le case-torri nel territorio ebolitano, P. 51 ; A. Capano, Pollica e i suoi casali nel Catasto provvisorio del 1815. Il Sessantotto a Salerno. In margine ad un Convegno e ad un libro, P. 69 ; Francesco Sofia, Il '68: alcune riflessioni, P. 95 ; G. Acocella, Un '68 "cattolico"? P. 104 ; P. Cantillo, La profezia di una società estetica, P. 108 ; G. Foscari, Il '68, P. 112 ; M. La Via, Dal mito degli anni '60 alla utopie del '68, P. 113 ; P. Lucia, Miti, utopie, speranze di una generazione, P. 117 ; L. Marinucci, Donne, istituzioni, movimenti civili: una questione ancora attuale. La Mostra "Le frodi alimentari nella provincia di Salerno fra '800 e '900" tenutasi a Salerno il 16 ottobre 2008, a cura di Caterina Aliberti e Francesco Innnella, P. 121 ; C. Aliberti - F. Innella, La Mostra "Le frodi alimentari nella Provincia di Salerno tra Ottocento e Novecento", P. 126 ; I. Ascione, Le frodi alimentari nella provincia di Salerno fra Ottocento e Novecento, P. 128 ; A. Vacca, Inganni cibici, P. 131 ; V. Ferrara, Le attività operative del Comando Carabinieri Politiche Agricole e Alimentari e del Nucleo Antifrodi Carabinieri di Salerno. Il XIV Festival "Linea d'ombra" - Festival culture giovani, P. 134 ; P. D'Antonio, Caos: tra Filosofia, Scienza e Arte, P. 150 ; S. Metetich, Al caos, al caos! Così è (se vi piace), P. 151 ; P. Simone Di Chiara, Il caos, P. 153 ; F.M. Iandiorio, M. Autuori, P.S. Di Chiara, Il caos della natura fra letteratura e percezione, P. 154 ; S. Maritato, D. Di Stefano, A. Di Lauro, M. Massa, Caos e/è cinema, P. 156 ; F. Bonifacio, M. Talento, A. Catoio, Obiettivo caotico, P. 158 ; M. Radano, Per una "memoria" del territorio. Le celebrazioni per il Millenario di Guarrazzano di Stella Cilento (1009-2009), P. 160

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic