Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

Project 8k, 8k streaming video and audio over optical networks at the 2009 CineGrid workshop [video]

In this presentation, Jeff and Laurin discuss the technical challenges and successes, and the partnerships that emerged from a broad spectrum of entities to produce the live event at the CineGrid Workshop. In addition, they share the artistry of capturing and exhibiting an underwater habitat in 4K, and offer a unique opportunity rarely, if ever, seen to view undersea habitats through the lens of a two 4K cameras at 60 frames per second in ultra-high resolutions

From Aquarium Tank to Think Tank: Inspiring Conservation of the Oceans using 8K Streaming Video over [video]

In this presentation, Jeff and Laurin discuss the technical challenges and successes, and the partnerships that emerged from a broad spectrum of entities to produce the live event at the CineGrid Workshop. In addition, they share the artistry of capturing and exhibiting an underwater habitat in 4K, and offer a unique opportunity rarely, if ever, seen to view undersea habitats through the lens of a two 4K cameras at 60 frames per second in ultra-high resolutions