27 research outputs found
Considerations for Treatment Development in Rhabdomyosarcoma: In Vitro Assessment of Novel DNA Binding Drugs
Structure factor of polymers interacting via a short range repulsive potential: application to hairy wormlike micelles
We use the Random Phase Approximation (RPA) to compute the structure factor,
S(q), of a solution of chains interacting through a soft and short range
repulsive potential V. Above a threshold polymer concentration, whose magnitude
is essentially controlled by the range of the potential, S(q) exhibits a peak
whose position depends on the concentration. We take advantage of the close
analogy between polymers and wormlike micelles and apply our model, using a
Gaussian function for V, to quantitatively analyze experimental small angle
neutron scattering profiles of semi-dilute solutions of hairy wormlike
micelles. These samples, which consist in surfactant self-assembled flexible
cylinders decorated by amphiphilic copolymer, provide indeed an appropriate
experimental model system to study the structure of sterically interacting
polymer solutions
SERIES: eHealth in primary care. Part 3: eHealth education in primary care
Background: Education is essential to the integration of eHealth into primary care, but eHealth is not yet embedded in medical education. Objectives: In this opinion article, we aim to support organisers of Continuing Professional Development (CPD) and teachers delivering medical vocational training by providing recommendations for eHealth education. First, we describe what is required to help primary care professionals and trainees learn about eHealth. Second, we elaborate on how eHealth education might be provided. Discussion: We consider four essential topics. First, an understanding of existing evidence-based eHealth applications and conditions for successful development and implementation. Second, required digital competencies of providers and patients. Third, how eHealth changes patient-provider and provider-provider relationships and finally, understanding the handling of digital data. Educational activities to address these topics include eLearning, blended learning, courses, simulation exercises, real-life practice, supervision and reflection, role modelling and community of practice learning. More specifically, a CanMEDS framework aimed at defining curriculum learning goals can support eHealth education by
Formation d'Ă©mulsions dans l'entrefer de deux cĂŽnes rotatifs
National audienceThe apparatus allows both the thermal treatment and the emulsion of a product. The mixture goes through the interstice of two cones, the fixed external cone can be heated or cooled whereas the internal one rotates at a high speed. The apparatus offers a non neglibible exchange surface and permits to reach high shearing rates which ease the fractioning of drops. The study was conducted using a mixture made of water and 5% liquid paraffin. A correlation is suggested to account for the influence of different parameters (rotation speed, flow and size of the interstice).L'appareil mis au point permet Ă la fois le traitement thermique et l'Ă©mulsion d'un produit. Le mĂ©lange passe dans l'entrefer de deux cĂŽnes, le cĂŽne extĂ©rieur fixe peut ĂȘtre chauffĂ© ou refroidi et le cĂŽne intĂ©rieur tourne Ă grande vitesse. Le dispositif offre une surface d'Ă©change non nĂ©gligeable et permet d'atteindre des taux de cisaillement Ă©levĂ©s qui facilitent le fractionnement des gouttes. L'Ă©tude a portĂ© sur un mĂ©lange d'eau et de 5% d'huile de paraffine. Une corrĂ©lation est proposĂ©e pour tenir compte de l'influence de diffĂ©rents paramĂštres (vitesse de rotation, dĂ©bit et dimension de l'entrefer)
Anthracycline antibiotic arugomycin binds in both grooves of the DNA helix simultaneously: an NMR and molecular modelling study
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Potential of lead elemental and isotopic signatures for authenticity and geographical origin of Bordeaux wines
International audienceLead concentrations and lead isotope ratios of 43 authentic Bordeaux wines from prestigious chĂąteaux and 14 suspicious Bordeaux origin were determined to evaluate their potential for authenticity and geographical origin assessment. Results have shown that the total Pb concentrations in Bordeaux wines drastically decreased over the previous 50âŻyears with a clear shift of isotopic signatures towards geogenic values corresponding to an overall trend of European environmental lead monitoring. The Pb isotopic ratios determined in both series of samples clearly demonstrated that suspicious Bordeaux wines displayed Pb isotopic signatures statistically distinctive from those obtained for authentic wines. This observation was confirmed by the three-isotope mixing lines obtained between the geogenic and the anthropogenic Pb isotopes data that characterize European and Asian sources. The use these specific three-isotope plots allows a non-ambiguous discrimination between authentic Pauillac AOC and the counterfeited ones
Influence of carriage of hemoglobin AS and the Fcg receptor IIa-R131 allele on levels of immunoglobulin G2 antibodies to plasmodium falciparum merozoite antigens in Gabonese children.
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