1,873 research outputs found
Reading in Minecraft: A Generation Alpha Case Study
This qualitative case study reports the Four Resource Model (FRM) reading practices used by a millennial while playing the game Minecraft. The FRM skills of code breaker, text participant, text user and text analyst were investigated through data generated by observation, field notes, semi-structured interviews and a researcher reflective journal. The data was analysed using interpretative phenomenological analysis. Four key themes emerged: language and articulation; social and mentor integration; real-world connection; and, parent and child viewpoints. Across these themes the FRM reading practices are being used by this child to make meaning while playing Minecraft. This game presents a multimodal text which this child is able to successfully navigate while designing and creating a digital story in virtual spaces
Multiple imputation of missing covariates for the Cox proportional hazards cure model
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134146/1/sim7048_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134146/2/sim7048.pd
Awareness of moderate-to-vigorous physical activity: can information on guidelines prevent overestimation?
Background: Mass-media campaigns such as Change4Life use messaging to promote physical activity guidelines. Raising knowledge of MVPA guidelines within UK adults is a main goal of current mass media campaigns aimed at increasing engagement in MVPA. As this may help to inform accurate perceptions of adults' own MVPA level it is an important area of investigation. Subjective norms, health status and normal walking intensity may also influence adult's awareness of their own MVPA behaviour. The aim of this study was to examine the hypothesis that greater knowledge of MVPA guidelines, supportive subjective norms, lower self-reported health status and intensity of typical walking pace are associated with accurate awareness of MVPA engagement within a sample of UK adults. Methods: A cross-sectional study of UK adults was conducted. UK adults who subscribed to the National Academic Mailing List Service (JISCMail) were sent an invitation to complete an online survey. 1,724 UK adults completed the online survey which included items on minutes spent in MVPA, awareness of MVPA using constructs highlighted by the precaution adoption process model, subjective norms, knowledge of guidelines, health status and demographics. Results: The sample was 70% female, 57% aged under 45, 93% White and 69% in full-time employment. 62% reported their health to be above average, while 62% demonstrated accurate awareness of their own physical activity level, only 18% correctly reported the MVPA guidelines and 51% reported high subjective norms towards MVPA. Logistic regression analyses identified high subjective norms (OR = 1.84, CI: 1.29, 2.63, p = .001), average or below average health status (OR = .71, CI: .53 .97, p = .001), and a self-reported regular walking pace of moderate-to-vigorous (OR = 1.31, CI: 1.05, 1.63, p = .02) to be associated with accurate MVPA awareness. Knowledge of MVPA guidelines was not associated with MVPA awareness. Conclusions: Mass media campaigns, such as Change4Life, inform the general public of MVPA guidelines. Campaign messages may be more influential targeting subjective norms instead of knowledge of guidelines, thereby raising awareness of personal MVPA behaviour amongst inactive adults and increasing motivation to engage in more MVPA
The S. pombe translation initiation factor eIF4G is sumoylated and associates with the SUMO protease Ulp2
SUMO is a small post-translational modifier, that is attached to lysine residues in target proteins. It acts by altering proteinprotein
interactions, protein localisation and protein activity. SUMO chains can also act as substrates for ubiquitination,
resulting in proteasome-mediated degradation of the target protein. SUMO is removed from target proteins by one of a
number of specific proteases. The processes of sumoylation and desumoylation have well documented roles in DNA
metabolism and in the maintenance of chromatin structure. To further analyse the role of this modification, we have
purified protein complexes containing the S. pombe SUMO protease, Ulp2. These complexes contain proteins required for
ribosome biogenesis, RNA stability and protein synthesis. Here we have focussed on two translation initiation factors that
we identified as co-purifying with Ulp2, eIF4G and eIF3h. We demonstrate that eIF4G, but not eIF3h, is sumoylated. This
modification is increased under conditions that produce cytoplasmic stress granules. Consistent with this we observe partial
co-localisation of eIF4G and SUMO in stressed cells. Using HeLa cells, we demonstrate that human eIF4GI is also sumoylated;
in vitro studies indicate that human eIF4GI is modified on K1368 and K1588, that are located in the C-terminal eIF4A- and
Mnk-binding sites respectively
The Next Generation Virgo Cluster Survey. IX. Estimating the Efficiency of Galaxy Formation on the Lowest-Mass Scales
The Next Generation Virgo Cluster Survey has recently determined the
luminosity function of galaxies in the core of the Virgo cluster down to
unprecedented magnitude and surface brightness limits. Comparing simulations of
cluster formation to the derived central stellar mass function, we attempt to
estimate the stellar-to-halo-mass ratio (SHMR) for dwarf galaxies, as it would
have been before they fell into the cluster. This approach ignores several
details and complications, e.g., the contribution of ongoing star formation to
the present-day stellar mass of cluster members, and the effects of adiabatic
contraction and/or violent feedback on the subhalo and cluster potentials. The
final results are startlingly simple, however; we find that the trends in the
SHMR determined previously for bright galaxies appear to extend down in a
scale-invariant way to the faintest objects detected in the survey. These
results extend measurements of the formation efficiency of field galaxies by
two decades in halo mass, or five decades in stellar mass, down to some of the
least massive dwarf galaxies known, with stellar masses of .Comment: 18 pages, 12 figures; published in ApJ July 1st 201
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