Colombia: Seeking Prosperity Through Peace

PreprintThe recent global transition to a more diffuse distribution of economic power points to a shift in the balance of global growth from rich to low- and middle- income economies. Colombia may be a prime example as its recent rapid per capita income growth of 10.2% on average since 1999 points to the potential for Colombia's convergence to the ranks of rich countries. However, Colombia's economic growth has been constrained by over 40 years of a costly and ineffective drug war policy that has failed. The illicit activity of drug production and trafficking grosses approximately $10-$20 billion a year; it does not enter into the GDP accounting. In addition, the FARC (Revolutionary Armed Forces of Colombia) has stifled Colombia's drive towards economic prosperity. Barring the social and political impasse, the economy would flourish

Bicultural Competence and the Latino 2.5 Generation: The Acculturative Advantages and Challenges of Having One Foreign-Born and One U.S.-Born Parent

The 2.5 generation refers to individuals who have one parent born in the United States and one born in another country. The presence of both native-born and foreign-born parents has the potential to enhance bicultural adaptation. Across two studies with Latino young adults, we examine the extent to which the 2.5 generation is distinct from members of other generations with regard to cultural orientation, acculturative stress, and parent ethnic socialization. Results suggest that the 2.5-generation individuals report greater native cultural orientation, ethnic identity, and parental socialization compared with third-generation individuals, along with greater American orientation than first-generation individuals. The 2.5 generation also reports less language use and more acculturative stress due to Spanish competency pressures than firstand second-generation individuals. These results demonstrate that the 2.5-generation individuals may have some bicultural advantages compared with third-generation individuals; however, they may also experience similar challenges with regard to language maintenance

Bicultural Competence and the Latino 2.5 Generation: The Acculturative Advantages and Challenges of Having One Foreign-Born and One U.S.-Born Parent

The 2.5 generation refers to individuals who have one parent born in the United States and one born in another country. The presence of both native-born and foreign-born parents has the potential to enhance bicultural adaptation. Across two studies with Latino young adults, we examine the extent to which the 2.5 generation is distinct from members of other generations with regard to cultural orientation, acculturative stress, and parent ethnic socialization. Results suggest that the 2.5-generation individuals report greater native cultural orientation, ethnic identity, and parental socialization compared with third-generation individuals, along with greater American orientation than first-generation individuals. The 2.5 generation also reports less language use and more acculturative stress due to Spanish competency pressures than firstand second-generation individuals. These results demonstrate that the 2.5-generation individuals may have some bicultural advantages compared with third-generation individuals; however, they may also experience similar challenges with regard to language maintenance

Pathogenicity Levels of Colombian Strains of Candida auris and Brazilian Strains of Candida haemulonii Species Complex in Both Murine and Galleria mellonella Experimental Models

Candida auris and Candida haemulonii complex (C. haemulonii, C. haemulonii var. vulnera and C. duobushaemulonii) are phylogenetically related species that share some physiological features and habits. In the present study, we compared the virulence of these yeast species using two different experimental models: (i) Galleria mellonella larvae to evaluate the survival rate, fungal burden, histopathology and phagocytosis index and (ii) BALB/c mice to evaluate the survival. In addition, the fungal capacity to form biofilm over an inert surface was analyzed. Our results showed that in both experimental models, the animal survival rate was lower when infected with C. auris strains than the C. haemulonii species complex. The hemocytes of G. mellonella showed a significantly reduced ability to phagocytize the most virulent strains forming the C. haemulonii species complex. Interestingly, for C. auris, it was impossible to measure the phagocytosis index due to a general lysis of the hemocytes. Moreover, it was observed a greater capability of biofilm formation by C. auris compared to C. haemulonii species complex. In conclusion, we observed that C. auris and C. haemulonii complex have different levels of pathogenicity in the experimental models employed in the present study

Real-time monitoring of fenitrothion in water samples using a silicon nanophotonic biosensor

[EN] Due to the large quantities of pesticides extensively used and their impact on the environment and human health, a prompt and reliable sensing technique could constitute an excellent tool for in-situ monitoring. With this aim, we have applied a highly sensitive photonic biosensor based on a bimodal waveguide interferometer (BiMW) for the rapid, label-free, and speci¿c quanti¿cation of fenitrothion (FN) directly in tap water samples. After an optimization protocol, the biosensor achieved a limit of detection (LOD) of 0.29 ng mL¿¿1 (1.05 nM) and a half-maximal inhibitory concentration (IC50)of 1.71 ng mL¿¿1 (6.09 nM) using a competitive immunoassay and employing diluted tap water. Moreover, the biosensor was successfully employed to determine FN concentration in blind tap water samples obtaining excellent recovery percentages with a time-to-result of only 20 min without any sample pre-treatment. The features of the biosensor suggest its potential application for real time, fast and sensitive screening of FN in water samples as an analytical tool for the monitoring of the water quality.This work received financial support from DIONISOS Project (Retos Colaboracion RTC-2017-6222-5). The ICN2 is funded by the CERCA programme/Generalitat de Catalunya. The ICN2 is supported by the Severo Ochoa Centres of Excellence programme, funded by the Spanish Research Agency (AEI, grant no. SEV-2017-0706)Ramirez-Priego, P.; Estévez, M.; Díaz-Luisravelo, HJ.; Manclus Ciscar, JJ.; Montoya, Á.; Lechuga, LM. (2021). Real-time monitoring of fenitrothion in water samples using a silicon nanophotonic biosensor. Analytica Chimica Acta. 1152:1-9. https://doi.org/10.1016/j.aca.2021.338276S191152Sánchez-Santed, F., Colomina, M. T., & Herrero Hernández, E. (2016). Organophosphate pesticide exposure and neurodegeneration. Cortex, 74, 417-426. doi:10.1016/j.cortex.2015.10.003Chough, S. 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The Burst Cluster: Dark Matter in a Cluster Merger Associated with the Short Gamma Ray Burst, GRB 050509B

We have identified a merging galaxy cluster with evidence of two distinct sub-clusters. The X-ray and optical data suggest that the subclusters are moving away from each other after closest approach. This cluster merger was discovered from observations of the well localized short-duration gamma-ray burst (GRB), GRB 050509B. The Swift/Burst Alert Telescope (BAT) source position is coincident with a cluster of galaxies ZwCl 1234.0+02916. The subsequent Swift/X-Ray Telescope (XRT) localization of the X-ray afterglow found the GRB coincident with 2MASX J12361286+2858580, a giant red elliptical galaxy in the cluster. Deep multi-epoch optical images were obtained to constrain the evolution of the GRB afterglow, including a 27480s exposure in the F814W band with Hubble Space Telescope Advanced Camera for Surveys (ACS), among the deepest imaging ever obtained towards a known galaxy cluster in a single passband. We perform a weak gravitational lensing analysis, including mapping the total mass distribution of the merger system. Combined with Chandra X-ray Observatory and Swift/XRT observations, we investigate the dynamical state of the merger to probe the nature of the dark matter component. Our weak gravitational lensing measurements reveal a separation of the X-ray centroid of the western subcluster from the center of the mass and galaxy light distributions, similar to that of the famous "Bullet cluster". We conclude that the "Burst cluster" is another candidate merger system for determining the nature of dark matter and for studying the environment of short GRBs. We discuss connections between the cluster dynamical state and/or matter composition and compact object mergers, the leading model for the origin of short GRBs. Finally, we present results from a weak lensing survey based on archival Very Large Telescope (VLT) images in the areas of 5 other short GRBs.Comment: 17 pages, 7 figures, accepted by Ap

Renal volume of five-year-old preterm children are not different than full-term controls

Objective: In previous studies, smaller renal volumes were reported in prematurely born infants, however, these renal volumes were not corrected for body surface area, the main determinant of renal size. Given the rapid growth of the renal cortex after premature birth, the authors hypothesized that corrected volumes would not differ from healthy controls. Methods: Ambispective cohort study with prospective follow-up of prematurely born babies in a large specialized center and retrospectively recruited healthy control group. Children were assessed for renal length and renal volumes at age 5 by three independent ultrasonographers. Detailed anthropometry, blood pressure and renal function were also obtained. Age independent z-scores were calculated for all parameters and compared using descriptive statistics. Results: Eighty-nine premature study participants (median 32 weeks gestational age) and 33 healthy controls (median 38 weeks gestational age) were studied. Study participants did not differ in age, sex, Afro-Colombian descent, height, blood pressure, serum creatinine, or new Schwartz eGFR. Premature study participants had a significantly lower weight (17.65 ± 2.93 kg) than controls (19.05 ± 2.81 kg, p = 0.0072) and lower body surface area. The right renal volumes were significantly smaller (39.4 vs 43.4 mL), but after correction for body surface area, the renal volume and renal length z-scores were identical for both kidneys (mean right kidney -0.707 vs -0.507; mean left kidney -0.498 vs -0.524, respectively). Conclusion: Renal volumes need to be corrected to body surface area. After correction for body surface area, 5-year-old healthy and prematurely born children have comparable renal volumes

Technology for monitoring everyday prosthesis use: a systematic review

BACKGROUND Understanding how prostheses are used in everyday life is central to the design, provision and evaluation of prosthetic devices and associated services. This paper reviews the scientific literature on methodologies and technologies that have been used to assess the daily use of both upper- and lower-limb prostheses. It discusses the types of studies that have been undertaken, the technologies used to monitor physical activity, the benefits of monitoring daily living and the barriers to long-term monitoring. METHODS A systematic literature search was conducted in PubMed, Web of Science, Scopus, CINAHL and EMBASE of studies that monitored the activity of prosthesis-users during daily-living. RESULTS 60 lower-limb studies and 9 upper-limb studies were identified for inclusion in the review. The first studies in the lower-limb field date from the 1990s and the number has increased steadily since the early 2000s. In contrast, the studies in the upper-limb field have only begun to emerge over the past few years. The early lower-limb studies focused on the development or validation of actimeters, algorithms and/or scores for activity classification. However, most of the recent lower-limb studies used activity monitoring to compare prosthetic components. The lower-limb studies mainly used step-counts as their only measure of activity, focusing on the amount of activity, not the type and quality of movements. In comparison, the small number of upper-limb studies were fairly evenly spread between development of algorithms, comparison of everyday activity to clinical scores, and comparison of different prosthesis user populations. Most upper-limb papers reported the degree of symmetry in activity levels between the arm with the prosthesis and the intact arm. CONCLUSIONS Activity monitoring technology used in conjunction with clinical scores and user feedback, offers significant insights into how prostheses are used and whether they meet the user’s requirements. However, the cost, limited battery-life and lack of availability in many countries mean that using sensors to understand the daily use of prostheses and the types of activity being performed has not yet become a feasible standard clinical practice. This review provides recommendations for the research and clinical communities to advance this area for the benefit of prosthesis users